Mutagenetix > Incidental Mutation

Incidental Mutation 'R9720:Taar7a'

730728

Institutional Source

Beutler Lab

Gene Symbol

Taar7a

Ensembl Gene

ENSMUSG00000095647

Gene Name

trace amine-associated receptor 7A

Synonyms

Taar7a, LOC215856

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

R9720 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

23992405-23993481 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23992835 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 216 (I216T)

Ref Sequence

ENSEMBL: ENSMUSP00000077616 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078532]

AlphaFold

Q5QD12

Predicted Effect

probably benign
Transcript: ENSMUST00000078532
AA Change: I216T

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000077616
Gene: ENSMUSG00000095647
AA Change: I216T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	54	344	9.2e-10	PFAM
Pfam:7TM_GPCR_Srx	56	261	5.2e-9	PFAM
Pfam:7tm_1	64	326	3.2e-58	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.8%
20x: 99.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acaca	T	G	11: 84,263,357	V968G	probably damaging	Het
Adam33	A	G	2: 131,058,316	V110A		Het
Adamts2	T	C	11: 50,776,127	M417T	probably damaging	Het
Adgrv1	A	G	13: 81,592,574	I145T	probably damaging	Het
Ampd3	C	A	7: 110,777,849	H16N	probably benign	Het
Ank3	A	T	10: 69,989,505	S1335C		Het
Ankrd26	G	A	6: 118,521,941	S1208L	probably damaging	Het
Atmin	G	A	8: 116,954,914		probably null	Het
AU018091	T	C	7: 3,159,432	T323A	probably benign	Het
Barx2	A	G	9: 31,854,111		probably null	Het
Brpf3	A	G	17: 28,807,356	I468V	probably benign	Het
Cacna1g	T	A	11: 94,411,471	H1985L	probably benign	Het
Cass4	T	C	2: 172,427,648	V550A	probably benign	Het
Ccdc88a	A	G	11: 29,463,813	S784G	probably benign	Het
Cd300ld2	C	T	11: 115,012,292		probably null	Het
Cgn	G	A	3: 94,779,311	A227V	probably benign	Het
Clcn7	G	T	17: 25,155,497	R524L	probably damaging	Het
Cldn22	G	A	8: 47,824,751	A75T	probably benign	Het
Ddb1	A	G	19: 10,608,360	D146G	probably benign	Het
Dhx32	C	A	7: 133,723,128	E607*	probably null	Het
Egfem1	A	G	3: 29,662,431	Y350C	probably damaging	Het
Eri2	T	A	7: 119,787,753	D181V	probably damaging	Het
Gabrg2	T	C	11: 41,971,846	N137S	probably damaging	Het
Gar1	C	T	3: 129,826,848	G197S	unknown	Het
Ggta1	G	T	2: 35,413,406	D91E	probably benign	Het
Hap1	T	A	11: 100,355,870	I70F	probably benign	Het
Hars2	A	G	18: 36,787,554	Y150C	probably damaging	Het
Igsf9b	G	A	9: 27,309,514	V59I	probably damaging	Het
Il15	T	G	8: 82,331,979	K142Q	probably damaging	Het
Klhl23	T	C	2: 69,824,460	Y225H	possibly damaging	Het
Krt6b	T	A	15: 101,679,791	I145F	probably benign	Het
Lgals3bp	T	A	11: 118,393,257	T499S	probably benign	Het
Lrriq4	A	G	3: 30,659,928	N490S	probably damaging	Het
Ltbr	G	A	6: 125,307,385	R365W	probably damaging	Het
Mical3	A	G	6: 120,958,277	S1763P	probably damaging	Het
Ncoa6	A	G	2: 155,408,384	V1000A	probably damaging	Het
Nefm	A	G	14: 68,121,344	S414P	probably benign	Het
Nphs1	T	C	7: 30,466,074	V622A	possibly damaging	Het
Olfr214	T	C	6: 116,557,055	V210A	possibly damaging	Het
Olfr809	T	C	10: 129,776,712	V281A	probably benign	Het
Pde4dip	T	C	3: 97,695,971	D2234G	probably damaging	Het
Pde6c	A	T	19: 38,169,439	Y637F	probably benign	Het
Pigg	T	A	5: 108,319,934	C266*	probably null	Het
Pkdrej	A	T	15: 85,818,296	D1146E	possibly damaging	Het
Pkp2	T	C	16: 16,269,720	V756A	probably benign	Het
Pole	C	T	5: 110,337,043	T2245I	probably benign	Het
Ppil2	T	C	16: 17,093,026	T259A	probably damaging	Het
Ppm1g	A	C	5: 31,203,570		probably null	Het
Ppp1r36	A	G	12: 76,438,524	I340M	possibly damaging	Het
Pvr	G	A	7: 19,909,196	R371*	probably null	Het
Rassf9	G	A	10: 102,512,508		probably benign	Het
Rtl1	A	C	12: 109,593,448	N652K	possibly damaging	Het
Sall4	G	C	2: 168,750,240	S998C	probably damaging	Het
Sdk1	T	C	5: 142,212,041	Y2150H	probably damaging	Het
Serpinb3b	A	T	1: 107,155,939	I170K	probably benign	Het
Shank2	A	T	7: 144,128,400	D390V	probably damaging	Het
Slc39a4	A	G	15: 76,616,730	V11A	probably benign	Het
Synj2	C	T	17: 5,990,309	T220I	probably benign	Het
Tas2r122	G	T	6: 132,711,671	D86E	probably benign	Het
Tbxa2r	T	A	10: 81,333,184	C236S	probably benign	Het
Trav13-4-dv7	C	A	14: 53,757,829	T80K	probably benign	Het
Trav6d-5	T	A	14: 52,795,620	C109S	probably damaging	Het
Trio	A	G	15: 27,847,409	M982T	probably benign	Het
Uhrf1bp1l	T	A	10: 89,805,357	S797T	probably benign	Het
Unc80	A	T	1: 66,644,326	T2176S	possibly damaging	Het
Zfp120	A	T	2: 150,117,277	I397K	probably benign	Het

Other mutations in Taar7a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00476:Taar7a	APN	10	23992396	unclassified	probably benign
IGL02408:Taar7a	APN	10	23992602	missense	probably benign
PIT4434001:Taar7a	UTSW	10	23993421	missense	probably benign
R0422:Taar7a	UTSW	10	23993274	missense	probably benign	0.02
R1029:Taar7a	UTSW	10	23992541	missense	possibly damaging	0.65
R1742:Taar7a	UTSW	10	23993219	missense	probably damaging	0.98
R2104:Taar7a	UTSW	10	23993061	missense	probably damaging	0.99
R2421:Taar7a	UTSW	10	23992517	missense	probably damaging	1.00
R3907:Taar7a	UTSW	10	23992559	missense	probably benign	0.25
R4021:Taar7a	UTSW	10	23993386	missense	probably benign	0.00
R5180:Taar7a	UTSW	10	23993148	missense	probably damaging	1.00
R5486:Taar7a	UTSW	10	23992458	missense	probably benign	0.00
R5507:Taar7a	UTSW	10	23992631	missense	probably damaging	0.98
R5587:Taar7a	UTSW	10	23992828	missense	probably benign	0.00
R5766:Taar7a	UTSW	10	23993362	missense	probably benign	0.01
R5861:Taar7a	UTSW	10	23992439	missense	probably benign
R7201:Taar7a	UTSW	10	23992460	missense	probably benign	0.04
R7506:Taar7a	UTSW	10	23992994	missense	possibly damaging	0.50
R8810:Taar7a	UTSW	10	23993381	missense	probably benign	0.20
R9015:Taar7a	UTSW	10	23992835	missense	probably damaging	0.97
R9172:Taar7a	UTSW	10	23992779	missense	probably benign	0.16
R9686:Taar7a	UTSW	10	23993411	missense	probably benign	0.01
R9717:Taar7a	UTSW	10	23992901	missense	probably benign	0.01
X0064:Taar7a	UTSW	10	23992617	missense	probably damaging	1.00
Z1177:Taar7a	UTSW	10	23992892	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- CTGCAATGCCCAGGGTTTTG -3'
(R):5'- TATATTGCAGTCAGTGACCCC -3'

Sequencing Primer
(F):5'- CCCAGGGTTTTGGCTGC -3'
(R):5'- AGTCAGTGACCCCCTGAC -3'

Posted On

2022-10-06