Incidental Mutation 'R9721:Olfr1406'
ID 730766
Institutional Source Beutler Lab
Gene Symbol Olfr1406
Ensembl Gene ENSMUSG00000058981
Gene Name olfactory receptor 1406
Synonyms MOR267-5, GA_x6K02T2R7CC-664297-665229
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.109) question?
Stock # R9721 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 173181853-173190640 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to A at 173184348 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 29 (V29F)
Ref Sequence ENSEMBL: ENSMUSP00000144530 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072395] [ENSMUST00000201132] [ENSMUST00000215878]
AlphaFold E9Q8X1
Predicted Effect probably benign
Transcript: ENSMUST00000072395
AA Change: V29F

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000072231
Gene: ENSMUSG00000058981
AA Change: V29F

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 3.9e-55 PFAM
Pfam:7tm_1 41 289 2.7e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000201132
AA Change: V29F

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000144530
Gene: ENSMUSG00000058981
AA Change: V29F

DomainStartEndE-ValueType
Pfam:7tm_4 31 88 5.4e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215878
AA Change: V29F

PolyPhen 2 Score 0.074 (Sensitivity: 0.93; Specificity: 0.85)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik A T 3: 124,419,283 Y120N probably benign Het
2410089E03Rik A G 15: 8,225,409 T27A unknown Het
4931428F04Rik A T 8: 105,283,188 D376E probably benign Het
AI314180 A T 4: 58,850,938 S412T probably benign Het
Alox8 T A 11: 69,197,085 H131L probably benign Het
Atp13a1 A G 8: 69,799,437 E588G probably damaging Het
AU040320 G A 4: 126,839,648 V654M probably damaging Het
Bicra A G 7: 15,979,176 L982P probably damaging Het
Cdh11 A T 8: 102,679,625 V72E probably damaging Het
Cfap65 T C 1: 74,919,342 T869A probably benign Het
Ddx19a A G 8: 110,978,475 F338S probably damaging Het
Dhrs7c T A 11: 67,815,078 V219E probably damaging Het
Dhx33 A G 11: 71,001,598 V115A probably damaging Het
Dst A G 1: 34,192,785 D3153G probably benign Het
Eif5b T C 1: 38,037,659 probably null Het
Ep300 A G 15: 81,608,315 N284S unknown Het
Fam83a A G 15: 57,986,117 N19S probably benign Het
Fgd5 A T 6: 91,988,297 T504S probably benign Het
Flt4 G A 11: 49,644,433 probably null Het
Ggta1 G T 2: 35,413,406 D91E probably benign Het
Gls A G 1: 52,212,268 V310A probably damaging Het
Gm13178 A T 4: 144,703,372 V349D possibly damaging Het
Gm5414 A T 15: 101,628,147 C14* probably null Het
Gm906 T C 13: 50,246,652 Y546C possibly damaging Het
Gm9887 C G 12: 69,371,855 A202P unknown Het
Ifi214 T C 1: 173,527,913 T110A possibly damaging Het
Il4i1 A G 7: 44,839,689 R293G probably benign Het
Itpr1 A T 6: 108,406,102 T1464S probably damaging Het
Kif18a T C 2: 109,293,055 S225P probably damaging Het
Kif21a A T 15: 90,971,127 I678N probably damaging Het
Klf11 T A 12: 24,660,241 D429E probably damaging Het
Kntc1 A G 5: 123,801,885 T1581A probably benign Het
Lama2 T C 10: 27,467,342 N45D possibly damaging Het
Lrrk1 T C 7: 66,274,875 I1319V probably damaging Het
Ltbr G A 6: 125,307,385 R365W probably damaging Het
Malrd1 C T 2: 15,696,827 T751I unknown Het
Mgat5b T C 11: 116,966,769 L363P probably damaging Het
Mphosph9 A T 5: 124,298,675 S535R possibly damaging Het
Nckap5 C T 1: 126,027,280 D512N probably damaging Het
Ngef T A 1: 87,479,135 D637V probably damaging Het
Nup93 T C 8: 94,303,685 Y391H probably damaging Het
Olfr1215 T C 2: 89,001,716 T191A Het
Olfr1469 A T 19: 13,410,970 T134S probably benign Het
Pcdhb4 C A 18: 37,309,852 D738E possibly damaging Het
Pfpl G C 19: 12,428,933 E183Q probably damaging Het
Phactr3 G A 2: 178,256,250 E86K probably damaging Het
Psd C T 19: 46,323,189 D351N probably benign Het
Pzp A G 6: 128,495,191 probably null Het
Rerg T A 6: 137,056,417 K106* probably null Het
Samd9l T C 6: 3,375,854 E469G possibly damaging Het
Smok2b C A 17: 13,234,978 Y8* probably null Het
Spn A G 7: 127,136,265 S357P probably benign Het
Tek T G 4: 94,804,302 W216G possibly damaging Het
Trpm3 A T 19: 22,889,398 H531L probably benign Het
Trpm6 A G 19: 18,829,972 M1027V probably benign Het
Tsc2 G A 17: 24,599,642 R1408* probably null Het
Unc13b A G 4: 43,101,869 N155D probably benign Het
Vmn1r52 G A 6: 90,179,026 C104Y probably damaging Het
Xylt1 A T 7: 117,549,020 E273V probably damaging Het
Zc3h4 C A 7: 16,434,845 Q1035K unknown Het
Zcchc11 T A 4: 108,555,581 M1493K probably benign Het
Zfp14 A T 7: 30,039,184 S125R probably benign Het
Other mutations in Olfr1406
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00946:Olfr1406 APN 1 173183623 missense probably benign 0.45
IGL01609:Olfr1406 APN 1 173184276 missense probably benign 0.00
IGL01996:Olfr1406 APN 1 173183727 missense probably benign 0.00
F5770:Olfr1406 UTSW 1 173183964 missense probably benign 0.05
PIT4378001:Olfr1406 UTSW 1 173183814 missense probably benign 0.00
R0053:Olfr1406 UTSW 1 173184278 missense probably benign 0.35
R0800:Olfr1406 UTSW 1 173184060 missense probably damaging 1.00
R1793:Olfr1406 UTSW 1 173184409 missense probably benign
R2230:Olfr1406 UTSW 1 173183615 missense probably benign 0.04
R2232:Olfr1406 UTSW 1 173183615 missense probably benign 0.04
R5395:Olfr1406 UTSW 1 173183680 nonsense probably null
R5455:Olfr1406 UTSW 1 173184251 missense probably damaging 1.00
R5457:Olfr1406 UTSW 1 173183613 missense probably damaging 1.00
R5558:Olfr1406 UTSW 1 173184018 missense probably benign 0.01
R5760:Olfr1406 UTSW 1 173183751 missense probably benign 0.05
R6285:Olfr1406 UTSW 1 173183910 missense probably damaging 1.00
R7159:Olfr1406 UTSW 1 173184323 missense possibly damaging 0.95
R7676:Olfr1406 UTSW 1 173183553 nonsense probably null
R8700:Olfr1406 UTSW 1 173183862 missense probably benign
R8829:Olfr1406 UTSW 1 173183891 missense probably benign 0.06
R9785:Olfr1406 UTSW 1 173183891 missense probably benign 0.06
R9788:Olfr1406 UTSW 1 173183891 missense probably benign 0.06
R9789:Olfr1406 UTSW 1 173183891 missense probably benign 0.06
V7580:Olfr1406 UTSW 1 173183964 missense probably benign 0.05
V7581:Olfr1406 UTSW 1 173183964 missense probably benign 0.05
V7582:Olfr1406 UTSW 1 173183964 missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- AGATGGTTTGGCTCAGACCTAC -3'
(R):5'- ATATAGGGAGTTTGAGCTGAGTCTC -3'

Sequencing Primer
(F):5'- TTTGGCTCAGACCTACAAGGCTG -3'
(R):5'- GCTGAGTCTCTGCTGTACTCAAAG -3'
Posted On 2022-10-06