Incidental Mutation 'R9722:Fbxo2'
ID 730840
Institutional Source Beutler Lab
Gene Symbol Fbxo2
Ensembl Gene ENSMUSG00000041556
Gene Name F-box protein 2
Synonyms FBX2, Fbs1, NFB42, Prpl4
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.226) question?
Stock # R9722 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 148245078-148250881 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 148248883 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 125 (R125H)
Ref Sequence ENSEMBL: ENSMUSP00000037377 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047951] [ENSMUST00000057907] [ENSMUST00000105705] [ENSMUST00000122913] [ENSMUST00000129253] [ENSMUST00000151127] [ENSMUST00000151246] [ENSMUST00000167160] [ENSMUST00000172472] [ENSMUST00000173352]
AlphaFold Q80UW2
PDB Structure Structural basis of sugar-recognizing ubiquitin ligase [X-RAY DIFFRACTION]
Structural basis of sugar-recognizing ubiquitin ligase [X-RAY DIFFRACTION]
Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase [X-RAY DIFFRACTION]
Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase [X-RAY DIFFRACTION]
Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase [X-RAY DIFFRACTION]
Crystal Structure of the Sugar Recognizing SCF Ubiquitin Ligase at 1.7 Resolution [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000047951
AA Change: R125H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000037377
Gene: ENSMUSG00000041556
AA Change: R125H

DomainStartEndE-ValueType
Pfam:F-box 50 97 3.8e-9 PFAM
Pfam:F-box-like 51 97 9.3e-8 PFAM
FBA 114 297 3.81e-104 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000057907
SMART Domains Protein: ENSMUSP00000054022
Gene: ENSMUSG00000029001

DomainStartEndE-ValueType
FBOX 9 50 1.37e-2 SMART
FBA 68 252 2.24e-110 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000105705
SMART Domains Protein: ENSMUSP00000101330
Gene: ENSMUSG00000029001

DomainStartEndE-ValueType
FBOX 9 50 1.37e-2 SMART
FBA 68 196 2.79e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000122913
SMART Domains Protein: ENSMUSP00000120874
Gene: ENSMUSG00000029001

DomainStartEndE-ValueType
FBOX 9 50 1.37e-2 SMART
Pfam:FBA 68 115 3e-14 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000129253
SMART Domains Protein: ENSMUSP00000117013
Gene: ENSMUSG00000029001

DomainStartEndE-ValueType
FBOX 9 50 1.37e-2 SMART
FBA 68 213 1.15e-57 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000151127
SMART Domains Protein: ENSMUSP00000134064
Gene: ENSMUSG00000029001

DomainStartEndE-ValueType
FBOX 9 50 1.37e-2 SMART
FBA 68 235 4.09e-63 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000151246
SMART Domains Protein: ENSMUSP00000114571
Gene: ENSMUSG00000029001

DomainStartEndE-ValueType
FBOX 9 50 1.37e-2 SMART
FBA 68 231 1.43e-85 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167160
SMART Domains Protein: ENSMUSP00000126551
Gene: ENSMUSG00000029001

DomainStartEndE-ValueType
FBOX 9 50 1.37e-2 SMART
FBA 68 252 2.24e-110 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000172472
SMART Domains Protein: ENSMUSP00000133966
Gene: ENSMUSG00000029001

DomainStartEndE-ValueType
FBOX 9 50 1.37e-2 SMART
Pfam:FBA 68 126 3.4e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173352
SMART Domains Protein: ENSMUSP00000134624
Gene: ENSMUSG00000029001

DomainStartEndE-ValueType
FBOX 62 103 1.37e-2 SMART
FBA 121 254 3.86e-50 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted mutation are behaviorally normal but display accelerated, age-related hearing loss associated with cochlear degeneration. Cellular degeneration begins at 2 months in the supporting cells of the organ of Corti and progresses to cochlear hair cells and the spiral ganglion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9330159F19Rik A T 10: 29,094,269 (GRCm39) I52F probably benign Het
Abcc3 A T 11: 94,250,072 (GRCm39) L1017Q probably damaging Het
Antxr2 T C 5: 98,096,186 (GRCm39) D366G possibly damaging Het
Astn2 C T 4: 65,831,978 (GRCm39) V563I probably benign Het
Atrn C A 2: 130,803,536 (GRCm39) D575E probably damaging Het
Baz1a C T 12: 54,946,882 (GRCm39) D1228N probably benign Het
Canx A G 11: 50,195,301 (GRCm39) S256P probably benign Het
Ccnt2 T A 1: 127,729,925 (GRCm39) D267E probably damaging Het
Cd209c G T 8: 3,995,905 (GRCm39) R2S probably benign Het
Cyfip2 T C 11: 46,087,135 (GRCm39) T1252A probably benign Het
Dchs2 A G 3: 83,261,301 (GRCm39) Y2523C probably benign Het
Dmxl2 G A 9: 54,323,892 (GRCm39) P990L probably benign Het
Dnajc9 T C 14: 20,438,279 (GRCm39) I108V probably benign Het
Eif2d T C 1: 131,092,948 (GRCm39) probably null Het
Ephb2 T C 4: 136,384,768 (GRCm39) D881G probably damaging Het
Esr1 A G 10: 4,951,215 (GRCm39) N531S probably benign Het
Foxred1 C T 9: 35,117,300 (GRCm39) S277N possibly damaging Het
Gemin5 T C 11: 58,041,418 (GRCm39) E518G probably damaging Het
Gm17655 A G 5: 110,194,226 (GRCm39) Y519H probably benign Het
Igkv4-57-1 A T 6: 69,521,493 (GRCm39) W70R probably damaging Het
Krtap4-13 A G 11: 99,700,180 (GRCm39) S160P unknown Het
Map3k3 A G 11: 106,033,361 (GRCm39) I205V possibly damaging Het
Map3k4 A C 17: 12,490,523 (GRCm39) F303V probably benign Het
Mpdz T C 4: 81,304,504 (GRCm39) Q132R probably damaging Het
Myo10 T A 15: 25,801,227 (GRCm39) V1472E probably damaging Het
Nckap1 G A 2: 80,401,568 (GRCm39) Q39* probably null Het
Nog A G 11: 89,192,396 (GRCm39) S151P probably damaging Het
Obox6 G A 7: 15,568,831 (GRCm39) S15F probably benign Het
Odf2 A G 2: 29,813,594 (GRCm39) H647R possibly damaging Het
Or6c74 A G 10: 129,869,500 (GRCm39) R2G probably benign Het
Pcdhga11 T C 18: 37,890,398 (GRCm39) S469P possibly damaging Het
Pcnx4 T C 12: 72,603,039 (GRCm39) Y434H probably damaging Het
Pfpl G C 19: 12,406,297 (GRCm39) E183Q probably damaging Het
Pglyrp3 A G 3: 91,938,695 (GRCm39) K290R possibly damaging Het
Phactr3 G A 2: 177,898,043 (GRCm39) E86K probably damaging Het
Piezo1 A C 8: 123,225,497 (GRCm39) L530R Het
Pigg A T 5: 108,495,767 (GRCm39) I935F possibly damaging Het
Pofut2 T C 10: 77,102,759 (GRCm39) S282P possibly damaging Het
Ppfia1 A G 7: 144,071,402 (GRCm39) S337P probably benign Het
Sdr16c5 A T 4: 4,005,595 (GRCm39) D246E probably benign Het
Sgsm1 T A 5: 113,428,207 (GRCm39) H327L possibly damaging Het
Slc39a4 A G 15: 76,500,211 (GRCm39) I113T possibly damaging Het
Slc5a7 A G 17: 54,603,985 (GRCm39) probably null Het
Snx11 A G 11: 96,661,925 (GRCm39) S86P probably benign Het
Srm T A 4: 148,676,245 (GRCm39) probably null Het
Tas2r126 T C 6: 42,412,082 (GRCm39) I205T possibly damaging Het
Tek T G 4: 94,692,539 (GRCm39) W216G possibly damaging Het
Tenm3 A T 8: 48,753,849 (GRCm39) S851R probably benign Het
Tnip2 A G 5: 34,654,212 (GRCm39) V288A probably benign Het
Tpx2 T A 2: 152,733,476 (GRCm39) probably null Het
Trim33 C A 3: 103,261,146 (GRCm39) T1115K possibly damaging Het
Tspan13 T A 12: 36,074,017 (GRCm39) I40F probably damaging Het
Ube2v2 T C 16: 15,394,899 (GRCm39) I91V probably benign Het
Vmn1r22 A T 6: 57,877,631 (GRCm39) F115L probably benign Het
Vmn2r7 G A 3: 64,598,407 (GRCm39) P717S probably damaging Het
Zan T C 5: 137,387,324 (GRCm39) T4910A unknown Het
Zfp599 T A 9: 22,160,741 (GRCm39) T475S probably damaging Het
Zfp638 T A 6: 83,923,301 (GRCm39) F700I probably damaging Het
Zfp985 A C 4: 147,667,618 (GRCm39) K162T possibly damaging Het
Other mutations in Fbxo2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01286:Fbxo2 APN 4 148,250,163 (GRCm39) missense probably benign 0.01
IGL01690:Fbxo2 APN 4 148,249,581 (GRCm39) critical splice donor site probably null
R0085:Fbxo2 UTSW 4 148,249,367 (GRCm39) splice site probably null
R1083:Fbxo2 UTSW 4 148,250,234 (GRCm39) splice site probably null
R2879:Fbxo2 UTSW 4 148,250,468 (GRCm39) missense probably damaging 1.00
R4583:Fbxo2 UTSW 4 148,249,356 (GRCm39) missense possibly damaging 0.54
R5108:Fbxo2 UTSW 4 148,250,486 (GRCm39) missense probably damaging 1.00
R6529:Fbxo2 UTSW 4 148,249,511 (GRCm39) missense probably damaging 1.00
R6715:Fbxo2 UTSW 4 148,250,226 (GRCm39) missense probably benign 0.00
R7772:Fbxo2 UTSW 4 148,248,783 (GRCm39) missense probably damaging 1.00
R9147:Fbxo2 UTSW 4 148,250,166 (GRCm39) missense probably damaging 0.96
R9148:Fbxo2 UTSW 4 148,250,166 (GRCm39) missense probably damaging 0.96
R9176:Fbxo2 UTSW 4 148,250,147 (GRCm39) missense probably damaging 1.00
R9422:Fbxo2 UTSW 4 148,248,616 (GRCm39) missense unknown
Z1177:Fbxo2 UTSW 4 148,249,519 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- GTTTGGGAGTCACAGCTTTCC -3'
(R):5'- ATGCCTTGGGAAGAGAGACTC -3'

Sequencing Primer
(F):5'- GGGAGTCACAGCTTTCCCTTAC -3'
(R):5'- CTTGGGAAGAGAGACTCCCCAG -3'
Posted On 2022-10-06