Incidental Mutation 'R9725:Prcp'
ID 730990
Institutional Source Beutler Lab
Gene Symbol Prcp
Ensembl Gene ENSMUSG00000061119
Gene Name prolylcarboxypeptidase (angiotensinase C)
Synonyms 2510048K03Rik, 2610104A14Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R9725 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 92524461-92583789 bp(+) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) G to T at 92567035 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000075429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076052] [ENSMUST00000207594]
AlphaFold Q7TMR0
Predicted Effect probably null
Transcript: ENSMUST00000076052
SMART Domains Protein: ENSMUSP00000075429
Gene: ENSMUSG00000061119

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:Peptidase_S37 20 211 1.4e-4 PFAM
Pfam:Peptidase_S28 53 475 3.4e-92 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207594
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit decreased body length, weight, and fat pads with resistance to diet-induced obesity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 T G 16: 14,290,797 (GRCm39) I1469S possibly damaging Het
Aff1 A T 5: 103,994,931 (GRCm39) D1043V probably damaging Het
Ahnak T A 19: 8,991,607 (GRCm39) I4297N probably damaging Het
Ahnak A G 19: 8,981,533 (GRCm39) N939S probably benign Het
Camk2b T C 11: 5,922,634 (GRCm39) N465S possibly damaging Het
Carns1 A G 19: 4,216,548 (GRCm39) S545P probably damaging Het
Cdh23 T A 10: 60,432,561 (GRCm39) Q121L probably benign Het
Cfap221 G T 1: 119,862,352 (GRCm39) Q577K probably benign Het
Dlg1 T G 16: 31,665,683 (GRCm39) L680R probably benign Het
Fahd2a T C 2: 127,278,304 (GRCm39) E301G probably benign Het
Fn3k T A 11: 121,341,191 (GRCm39) L282H probably damaging Het
Fubp1 T A 3: 151,927,823 (GRCm39) I424N probably damaging Het
Gkn1 A G 6: 87,323,289 (GRCm39) S175P probably damaging Het
Gm12695 A G 4: 96,616,466 (GRCm39) S456P probably damaging Het
Kcna5 T C 6: 126,511,844 (GRCm39) T95A probably benign Het
Kcnj13 G T 1: 87,314,737 (GRCm39) T83K probably benign Het
Kif19b G A 5: 140,460,651 (GRCm39) R439H probably benign Het
Klra10 C T 6: 130,252,849 (GRCm39) G142R probably benign Het
Krt14 T C 11: 100,097,902 (GRCm39) N127S probably damaging Het
Layn T C 9: 50,968,775 (GRCm39) M323V probably benign Het
Lrrd1 A G 5: 3,901,147 (GRCm39) D484G probably benign Het
Lrrtm2 A G 18: 35,345,788 (GRCm39) C505R probably damaging Het
Ms4a14 A T 19: 11,280,729 (GRCm39) S610T probably benign Het
Myo5b A G 18: 74,856,841 (GRCm39) N1282S probably benign Het
Naip5 A T 13: 100,358,784 (GRCm39) D817E possibly damaging Het
Ndufs2 A G 1: 171,074,629 (GRCm39) L10P possibly damaging Het
Nxn T C 11: 76,169,362 (GRCm39) D139G probably damaging Het
Or3a1b A G 11: 74,012,612 (GRCm39) T166A probably benign Het
Or5b105 G A 19: 13,080,272 (GRCm39) T132I possibly damaging Het
Or6aa1 A C 7: 86,043,973 (GRCm39) H244Q probably damaging Het
Pcdhb22 G T 18: 37,652,794 (GRCm39) V164F probably damaging Het
Plch2 T C 4: 155,084,992 (GRCm39) T417A probably damaging Het
Rasgrp2 A G 19: 6,454,694 (GRCm39) Y178C probably damaging Het
Rasgrp2 A G 19: 6,463,907 (GRCm39) N535S probably benign Het
Rgs20 G T 1: 4,980,793 (GRCm39) Y208* probably null Het
Slc39a10 A G 1: 46,849,223 (GRCm39) C798R probably damaging Het
Slco2b1 A G 7: 99,335,265 (GRCm39) S172P probably benign Het
Styk1 GTCTCTTCATGATT GT 6: 131,278,610 (GRCm39) probably benign Het
Styk1 CTCTTCATGATTTTCTT CTCTT 6: 131,278,612 (GRCm39) probably benign Het
Tmc2 T A 2: 130,089,881 (GRCm39) I622N probably damaging Het
Trav16n A G 14: 53,588,559 (GRCm39) S5G probably benign Het
Tti1 C T 2: 157,849,304 (GRCm39) R645H probably benign Het
Ttll3 A G 6: 113,386,114 (GRCm39) D649G probably damaging Het
Vcam1 C T 3: 115,922,287 (GRCm39) V79I possibly damaging Het
Vmn1r211 T C 13: 23,036,506 (GRCm39) I54V probably benign Het
Vmn1r238 A G 18: 3,122,577 (GRCm39) F279S probably benign Het
Vps33a A T 5: 123,669,135 (GRCm39) W589R possibly damaging Het
Zic1 A G 9: 91,246,875 (GRCm39) S66P probably damaging Het
Other mutations in Prcp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00765:Prcp APN 7 92,582,307 (GRCm39) missense probably benign 0.00
IGL01124:Prcp APN 7 92,559,416 (GRCm39) missense probably benign 0.01
IGL01538:Prcp APN 7 92,559,421 (GRCm39) missense probably benign 0.09
IGL02005:Prcp APN 7 92,577,032 (GRCm39) missense probably benign 0.01
IGL02160:Prcp APN 7 92,566,969 (GRCm39) missense probably benign 0.02
IGL02548:Prcp APN 7 92,550,382 (GRCm39) missense probably damaging 0.98
R0140:Prcp UTSW 7 92,577,819 (GRCm39) missense probably damaging 1.00
R0480:Prcp UTSW 7 92,568,290 (GRCm39) missense probably damaging 1.00
R0989:Prcp UTSW 7 92,559,424 (GRCm39) missense probably benign 0.04
R1216:Prcp UTSW 7 92,566,954 (GRCm39) missense probably benign
R1596:Prcp UTSW 7 92,567,042 (GRCm39) intron probably benign
R1823:Prcp UTSW 7 92,577,883 (GRCm39) missense probably damaging 0.98
R2132:Prcp UTSW 7 92,550,488 (GRCm39) missense probably benign 0.01
R2206:Prcp UTSW 7 92,577,820 (GRCm39) missense probably damaging 1.00
R4761:Prcp UTSW 7 92,566,933 (GRCm39) splice site probably null
R5000:Prcp UTSW 7 92,568,368 (GRCm39) missense probably damaging 0.99
R5320:Prcp UTSW 7 92,577,843 (GRCm39) missense probably benign 0.01
R5969:Prcp UTSW 7 92,566,974 (GRCm39) missense probably benign 0.01
R6013:Prcp UTSW 7 92,576,976 (GRCm39) missense possibly damaging 0.72
R6298:Prcp UTSW 7 92,577,841 (GRCm39) missense probably damaging 1.00
R7733:Prcp UTSW 7 92,550,506 (GRCm39) missense probably damaging 1.00
R7852:Prcp UTSW 7 92,577,900 (GRCm39) missense probably benign 0.33
R8032:Prcp UTSW 7 92,577,906 (GRCm39) missense probably damaging 1.00
R8317:Prcp UTSW 7 92,524,598 (GRCm39) missense probably benign 0.05
R8869:Prcp UTSW 7 92,559,518 (GRCm39) missense possibly damaging 0.75
R9038:Prcp UTSW 7 92,567,017 (GRCm39) missense probably benign
R9185:Prcp UTSW 7 92,582,257 (GRCm39) missense probably benign
R9333:Prcp UTSW 7 92,577,894 (GRCm39) missense probably damaging 0.98
R9643:Prcp UTSW 7 92,524,598 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTGATCATTTAGAGCTCTTGCAG -3'
(R):5'- ATATGTGGCAGTGTCAGGTTAC -3'

Sequencing Primer
(F):5'- AGCTTCTGCCCCTATCTGG -3'
(R):5'- GGCAGTGTGTACCTATAACTCCAG -3'
Posted On 2022-10-06