Mutagenetix > Incidental Mutation

Incidental Mutation 'R9725:Vmn1r211'

731000

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r211

Ensembl Gene

ENSMUSG00000063998

Gene Name

vomeronasal 1 receptor 211

Synonyms

V1rh20

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R9725 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

23035769-23036665 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 23036506 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 54 (I54V)

Ref Sequence

ENSEMBL: ENSMUSP00000073405 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073728] [ENSMUST00000228645]

AlphaFold

Q8R266

Predicted Effect

probably benign
Transcript: ENSMUST00000073728
AA Change: I54V

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000073405
Gene: ENSMUSG00000063998
AA Change: I54V

Domain	Start	End	E-Value	Type
Pfam:V1R	31	297	1.1e-40	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000228645
AA Change: I54V

PolyPhen 2 Score 0.032 (Sensitivity: 0.95; Specificity: 0.82)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc1	T	G	16: 14,290,797 (GRCm39)	I1469S	possibly damaging	Het
Aff1	A	T	5: 103,994,931 (GRCm39)	D1043V	probably damaging	Het
Ahnak	T	A	19: 8,991,607 (GRCm39)	I4297N	probably damaging	Het
Ahnak	A	G	19: 8,981,533 (GRCm39)	N939S	probably benign	Het
Camk2b	T	C	11: 5,922,634 (GRCm39)	N465S	possibly damaging	Het
Carns1	A	G	19: 4,216,548 (GRCm39)	S545P	probably damaging	Het
Cdh23	T	A	10: 60,432,561 (GRCm39)	Q121L	probably benign	Het
Cfap221	G	T	1: 119,862,352 (GRCm39)	Q577K	probably benign	Het
Dlg1	T	G	16: 31,665,683 (GRCm39)	L680R	probably benign	Het
Fahd2a	T	C	2: 127,278,304 (GRCm39)	E301G	probably benign	Het
Fn3k	T	A	11: 121,341,191 (GRCm39)	L282H	probably damaging	Het
Fubp1	T	A	3: 151,927,823 (GRCm39)	I424N	probably damaging	Het
Gkn1	A	G	6: 87,323,289 (GRCm39)	S175P	probably damaging	Het
Gm12695	A	G	4: 96,616,466 (GRCm39)	S456P	probably damaging	Het
Kcna5	T	C	6: 126,511,844 (GRCm39)	T95A	probably benign	Het
Kcnj13	G	T	1: 87,314,737 (GRCm39)	T83K	probably benign	Het
Kif19b	G	A	5: 140,460,651 (GRCm39)	R439H	probably benign	Het
Klra10	C	T	6: 130,252,849 (GRCm39)	G142R	probably benign	Het
Krt14	T	C	11: 100,097,902 (GRCm39)	N127S	probably damaging	Het
Layn	T	C	9: 50,968,775 (GRCm39)	M323V	probably benign	Het
Lrrd1	A	G	5: 3,901,147 (GRCm39)	D484G	probably benign	Het
Lrrtm2	A	G	18: 35,345,788 (GRCm39)	C505R	probably damaging	Het
Ms4a14	A	T	19: 11,280,729 (GRCm39)	S610T	probably benign	Het
Myo5b	A	G	18: 74,856,841 (GRCm39)	N1282S	probably benign	Het
Naip5	A	T	13: 100,358,784 (GRCm39)	D817E	possibly damaging	Het
Ndufs2	A	G	1: 171,074,629 (GRCm39)	L10P	possibly damaging	Het
Nxn	T	C	11: 76,169,362 (GRCm39)	D139G	probably damaging	Het
Or3a1b	A	G	11: 74,012,612 (GRCm39)	T166A	probably benign	Het
Or5b105	G	A	19: 13,080,272 (GRCm39)	T132I	possibly damaging	Het
Or6aa1	A	C	7: 86,043,973 (GRCm39)	H244Q	probably damaging	Het
Pcdhb22	G	T	18: 37,652,794 (GRCm39)	V164F	probably damaging	Het
Plch2	T	C	4: 155,084,992 (GRCm39)	T417A	probably damaging	Het
Prcp	G	T	7: 92,567,035 (GRCm39)		probably null	Het
Rasgrp2	A	G	19: 6,454,694 (GRCm39)	Y178C	probably damaging	Het
Rasgrp2	A	G	19: 6,463,907 (GRCm39)	N535S	probably benign	Het
Rgs20	G	T	1: 4,980,793 (GRCm39)	Y208*	probably null	Het
Slc39a10	A	G	1: 46,849,223 (GRCm39)	C798R	probably damaging	Het
Slco2b1	A	G	7: 99,335,265 (GRCm39)	S172P	probably benign	Het
Styk1	GTCTCTTCATGATT	GT	6: 131,278,610 (GRCm39)		probably benign	Het
Styk1	CTCTTCATGATTTTCTT	CTCTT	6: 131,278,612 (GRCm39)		probably benign	Het
Tmc2	T	A	2: 130,089,881 (GRCm39)	I622N	probably damaging	Het
Trav16n	A	G	14: 53,588,559 (GRCm39)	S5G	probably benign	Het
Tti1	C	T	2: 157,849,304 (GRCm39)	R645H	probably benign	Het
Ttll3	A	G	6: 113,386,114 (GRCm39)	D649G	probably damaging	Het
Vcam1	C	T	3: 115,922,287 (GRCm39)	V79I	possibly damaging	Het
Vmn1r238	A	G	18: 3,122,577 (GRCm39)	F279S	probably benign	Het
Vps33a	A	T	5: 123,669,135 (GRCm39)	W589R	possibly damaging	Het
Zic1	A	G	9: 91,246,875 (GRCm39)	S66P	probably damaging	Het

Other mutations in Vmn1r211

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Vmn1r211	APN	13	23,036,272 (GRCm39)	missense	probably benign	0.00
IGL01583:Vmn1r211	APN	13	23,036,571 (GRCm39)	missense	probably benign	0.40
IGL02735:Vmn1r211	APN	13	23,036,418 (GRCm39)	missense	probably damaging	1.00
IGL02794:Vmn1r211	APN	13	23,036,379 (GRCm39)	missense	possibly damaging	0.91
IGL02794:Vmn1r211	APN	13	23,036,377 (GRCm39)	missense	probably damaging	1.00
IGL02794:Vmn1r211	APN	13	23,036,376 (GRCm39)	missense	probably damaging	0.99
IGL03292:Vmn1r211	APN	13	23,036,613 (GRCm39)	missense	probably damaging	1.00
R1456:Vmn1r211	UTSW	13	23,036,415 (GRCm39)	missense	probably damaging	1.00
R1682:Vmn1r211	UTSW	13	23,035,813 (GRCm39)	missense	probably damaging	0.97
R1868:Vmn1r211	UTSW	13	23,035,779 (GRCm39)	missense	probably benign	0.07
R2002:Vmn1r211	UTSW	13	23,035,953 (GRCm39)	missense	probably damaging	1.00
R2037:Vmn1r211	UTSW	13	23,036,134 (GRCm39)	missense	probably damaging	0.98
R2655:Vmn1r211	UTSW	13	23,036,586 (GRCm39)	missense	probably benign	0.42
R4837:Vmn1r211	UTSW	13	23,036,296 (GRCm39)	missense	probably benign	0.41
R6284:Vmn1r211	UTSW	13	23,036,254 (GRCm39)	missense	probably damaging	0.99
R6701:Vmn1r211	UTSW	13	23,035,779 (GRCm39)	missense	probably benign	0.07
R6715:Vmn1r211	UTSW	13	23,035,949 (GRCm39)	missense	probably benign	0.00
R7058:Vmn1r211	UTSW	13	23,036,063 (GRCm39)	missense	probably benign	0.15
R7465:Vmn1r211	UTSW	13	23,036,086 (GRCm39)	missense	probably benign	0.13
R8085:Vmn1r211	UTSW	13	23,035,953 (GRCm39)	missense	probably damaging	1.00
R8720:Vmn1r211	UTSW	13	23,036,031 (GRCm39)	missense	probably damaging	1.00
R8730:Vmn1r211	UTSW	13	23,035,838 (GRCm39)	nonsense	probably null
R9120:Vmn1r211	UTSW	13	23,035,936 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGTTTGAGCCTCTGACACATTG -3'
(R):5'- AAAAGGCATTTCCCAGATCAAG -3'

Sequencing Primer
(F):5'- CACATTGAGTGTCTGGGACTG -3'
(R):5'- AGGCATTTCCCAGATCAAGTATTCC -3'

Posted On

2022-10-06