Incidental Mutation 'IGL01296:Olfr339'
ID 73104
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr339
Ensembl Gene ENSMUSG00000094464
Gene Name olfactory receptor 339
Synonyms MOR136-3, GA_x6K02T2NLDC-33116096-33117025
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # IGL01296
Quality Score
Status
Chromosome 2
Chromosomal Location 36418947-36426123 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 36421704 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 102 (Y102C)
Ref Sequence ENSEMBL: ENSMUSP00000149068 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071437] [ENSMUST00000216645]
AlphaFold Q8VGK8
Predicted Effect probably benign
Transcript: ENSMUST00000071437
AA Change: Y102C

PolyPhen 2 Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000071383
Gene: ENSMUSG00000094464
AA Change: Y102C

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.9e-55 PFAM
Pfam:7tm_1 41 290 5e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216645
AA Change: Y102C

PolyPhen 2 Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadl A G 1: 66,841,705 S301P probably damaging Het
Adam34 A G 8: 43,651,141 V489A possibly damaging Het
Adcy8 G A 15: 64,783,779 T617I probably damaging Het
Aggf1 T C 13: 95,353,971 D605G probably damaging Het
Atp10a T A 7: 58,813,625 F969I probably benign Het
Becn1 A T 11: 101,291,451 N97K probably damaging Het
Cd4 G A 6: 124,879,378 T50I probably benign Het
Crtac1 A T 19: 42,284,213 C578S probably damaging Het
Dcp1b A G 6: 119,215,358 K412E probably damaging Het
Dlg2 T A 7: 91,940,059 I327N probably damaging Het
Ehf T A 2: 103,268,155 probably null Het
Elavl4 T C 4: 110,206,612 N264S probably benign Het
Enpp2 A T 15: 54,875,669 I406N probably damaging Het
F10 A T 8: 13,055,383 Y316F possibly damaging Het
Fam20a A G 11: 109,685,351 I194T possibly damaging Het
Fcgbp T C 7: 28,089,647 V546A probably benign Het
Fras1 A T 5: 96,673,698 Q1438L probably null Het
Gm43638 T C 5: 87,460,592 I463V probably benign Het
Gm597 T C 1: 28,777,056 I632V probably benign Het
H2-T10 T C 17: 36,120,710 D84G probably benign Het
Itpr1 T C 6: 108,399,361 F1262L probably damaging Het
Lama1 A G 17: 67,745,051 N335D probably benign Het
Lasp1 T C 11: 97,836,190 V246A probably damaging Het
Lrrk2 A T 15: 91,683,142 I135L probably benign Het
Malrd1 G A 2: 16,101,957 probably null Het
Mctp2 T C 7: 72,228,526 K268R probably benign Het
Nbea A T 3: 56,031,536 H710Q probably benign Het
Notch3 G A 17: 32,166,757 R13C unknown Het
Ogfod1 A T 8: 94,055,671 probably benign Het
Olfr1465 A G 19: 13,314,126 L53P probably damaging Het
Olfr924 T C 9: 38,848,252 I46T probably damaging Het
Pgm3 A G 9: 86,561,879 V324A probably damaging Het
Ppfia2 A T 10: 106,858,207 I681F probably damaging Het
Prss23 T C 7: 89,509,887 K325E possibly damaging Het
Psmd7 T A 8: 107,586,617 probably benign Het
Rfx2 T A 17: 56,808,317 M1L possibly damaging Het
Rpa1 T C 11: 75,312,315 Y418C probably damaging Het
Rps6kc1 C T 1: 190,773,678 R1029H probably damaging Het
Sept10 A G 10: 59,166,600 V391A probably benign Het
Skint6 A G 4: 113,236,440 F169L probably benign Het
Slc44a4 C T 17: 34,921,698 T289I probably benign Het
Srl T C 16: 4,497,682 D32G probably damaging Het
Stxbp3-ps T A 19: 9,557,892 noncoding transcript Het
Sult1b1 T C 5: 87,514,956 D295G probably benign Het
Tmprss7 A G 16: 45,684,574 V151A probably damaging Het
Trmo A G 4: 46,387,589 L84P probably damaging Het
Vmn2r98 T A 17: 19,065,185 I89N probably damaging Het
Zcwpw1 G A 5: 137,796,799 A86T probably benign Het
Zkscan16 A G 4: 58,956,690 H324R possibly damaging Het
Other mutations in Olfr339
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01447:Olfr339 APN 2 36421454 missense probably damaging 0.97
IGL01845:Olfr339 APN 2 36422093 missense probably benign 0.27
IGL02728:Olfr339 APN 2 36422144 missense possibly damaging 0.95
IGL02941:Olfr339 APN 2 36422120 missense probably damaging 1.00
R0128:Olfr339 UTSW 2 36422287 missense probably benign 0.16
R0130:Olfr339 UTSW 2 36422287 missense probably benign 0.16
R1432:Olfr339 UTSW 2 36421643 missense probably damaging 1.00
R1451:Olfr339 UTSW 2 36421865 missense probably benign 0.01
R1656:Olfr339 UTSW 2 36421646 missense probably benign 0.00
R1854:Olfr339 UTSW 2 36421874 missense probably damaging 0.97
R2012:Olfr339 UTSW 2 36421919 missense probably benign 0.00
R2093:Olfr339 UTSW 2 36421929 missense probably benign 0.00
R2136:Olfr339 UTSW 2 36421938 missense probably damaging 1.00
R2282:Olfr339 UTSW 2 36422000 missense probably benign 0.00
R4363:Olfr339 UTSW 2 36421532 missense probably damaging 1.00
R4466:Olfr339 UTSW 2 36422296 missense probably benign 0.00
R4628:Olfr339 UTSW 2 36421857 nonsense probably null
R4839:Olfr339 UTSW 2 36422000 missense probably benign 0.00
R6023:Olfr339 UTSW 2 36421511 missense probably damaging 0.98
R6305:Olfr339 UTSW 2 36421622 missense probably damaging 1.00
R6486:Olfr339 UTSW 2 36421544 missense probably damaging 1.00
R6851:Olfr339 UTSW 2 36421820 missense probably damaging 0.97
R6864:Olfr339 UTSW 2 36421820 missense probably damaging 0.97
R7771:Olfr339 UTSW 2 36422144 missense possibly damaging 0.95
R8165:Olfr339 UTSW 2 36421703 missense probably damaging 1.00
R8307:Olfr339 UTSW 2 36422321 missense probably benign 0.03
R8961:Olfr339 UTSW 2 36422165 missense probably damaging 1.00
R9152:Olfr339 UTSW 2 36421427 missense possibly damaging 0.90
R9179:Olfr339 UTSW 2 36422114 missense probably damaging 1.00
R9544:Olfr339 UTSW 2 36421772 missense probably damaging 1.00
R9588:Olfr339 UTSW 2 36421772 missense probably damaging 1.00
R9690:Olfr339 UTSW 2 36421518 missense probably damaging 1.00
Posted On 2013-10-07