Incidental Mutation 'IGL01296:Olfr1465'
ID 73118
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1465
Ensembl Gene ENSMUSG00000062199
Gene Name olfactory receptor 1465
Synonyms MOR202-28, GA_x6K02T2RE5P-3645346-3644423
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # IGL01296
Quality Score
Status
Chromosome 19
Chromosomal Location 13312768-13315541 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 13314126 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 53 (L53P)
Ref Sequence ENSEMBL: ENSMUSP00000146645 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080142] [ENSMUST00000207340]
AlphaFold Q7TQR2
Predicted Effect probably damaging
Transcript: ENSMUST00000080142
AA Change: L53P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079039
Gene: ENSMUSG00000062199
AA Change: L53P

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 7.4e-47 PFAM
Pfam:7tm_1 39 288 3.7e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207340
AA Change: L53P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadl A G 1: 66,841,705 S301P probably damaging Het
Adam34 A G 8: 43,651,141 V489A possibly damaging Het
Adcy8 G A 15: 64,783,779 T617I probably damaging Het
Aggf1 T C 13: 95,353,971 D605G probably damaging Het
Atp10a T A 7: 58,813,625 F969I probably benign Het
Becn1 A T 11: 101,291,451 N97K probably damaging Het
Cd4 G A 6: 124,879,378 T50I probably benign Het
Crtac1 A T 19: 42,284,213 C578S probably damaging Het
Dcp1b A G 6: 119,215,358 K412E probably damaging Het
Dlg2 T A 7: 91,940,059 I327N probably damaging Het
Ehf T A 2: 103,268,155 probably null Het
Elavl4 T C 4: 110,206,612 N264S probably benign Het
Enpp2 A T 15: 54,875,669 I406N probably damaging Het
F10 A T 8: 13,055,383 Y316F possibly damaging Het
Fam20a A G 11: 109,685,351 I194T possibly damaging Het
Fcgbp T C 7: 28,089,647 V546A probably benign Het
Fras1 A T 5: 96,673,698 Q1438L probably null Het
Gm43638 T C 5: 87,460,592 I463V probably benign Het
Gm597 T C 1: 28,777,056 I632V probably benign Het
H2-T10 T C 17: 36,120,710 D84G probably benign Het
Itpr1 T C 6: 108,399,361 F1262L probably damaging Het
Lama1 A G 17: 67,745,051 N335D probably benign Het
Lasp1 T C 11: 97,836,190 V246A probably damaging Het
Lrrk2 A T 15: 91,683,142 I135L probably benign Het
Malrd1 G A 2: 16,101,957 probably null Het
Mctp2 T C 7: 72,228,526 K268R probably benign Het
Nbea A T 3: 56,031,536 H710Q probably benign Het
Notch3 G A 17: 32,166,757 R13C unknown Het
Ogfod1 A T 8: 94,055,671 probably benign Het
Olfr339 A G 2: 36,421,704 Y102C probably benign Het
Olfr924 T C 9: 38,848,252 I46T probably damaging Het
Pgm3 A G 9: 86,561,879 V324A probably damaging Het
Ppfia2 A T 10: 106,858,207 I681F probably damaging Het
Prss23 T C 7: 89,509,887 K325E possibly damaging Het
Psmd7 T A 8: 107,586,617 probably benign Het
Rfx2 T A 17: 56,808,317 M1L possibly damaging Het
Rpa1 T C 11: 75,312,315 Y418C probably damaging Het
Rps6kc1 C T 1: 190,773,678 R1029H probably damaging Het
Sept10 A G 10: 59,166,600 V391A probably benign Het
Skint6 A G 4: 113,236,440 F169L probably benign Het
Slc44a4 C T 17: 34,921,698 T289I probably benign Het
Srl T C 16: 4,497,682 D32G probably damaging Het
Stxbp3-ps T A 19: 9,557,892 noncoding transcript Het
Sult1b1 T C 5: 87,514,956 D295G probably benign Het
Tmprss7 A G 16: 45,684,574 V151A probably damaging Het
Trmo A G 4: 46,387,589 L84P probably damaging Het
Vmn2r98 T A 17: 19,065,185 I89N probably damaging Het
Zcwpw1 G A 5: 137,796,799 A86T probably benign Het
Zkscan16 A G 4: 58,956,690 H324R possibly damaging Het
Other mutations in Olfr1465
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01548:Olfr1465 APN 19 13313986 missense possibly damaging 0.95
IGL02548:Olfr1465 APN 19 13313938 missense probably damaging 0.98
IGL02663:Olfr1465 APN 19 13313379 missense probably benign 0.01
BB010:Olfr1465 UTSW 19 13314205 missense probably benign
BB020:Olfr1465 UTSW 19 13314205 missense probably benign
PIT4651001:Olfr1465 UTSW 19 13314192 missense probably benign 0.12
R0563:Olfr1465 UTSW 19 13313748 missense probably benign 0.28
R1803:Olfr1465 UTSW 19 13314171 missense possibly damaging 0.90
R2146:Olfr1465 UTSW 19 13314121 missense probably benign 0.23
R4674:Olfr1465 UTSW 19 13313814 missense probably benign 0.17
R4697:Olfr1465 UTSW 19 13313717 missense probably benign 0.39
R4825:Olfr1465 UTSW 19 13314320 splice site probably null
R4884:Olfr1465 UTSW 19 13313670 missense probably benign 0.28
R5647:Olfr1465 UTSW 19 13314189 missense probably damaging 1.00
R6401:Olfr1465 UTSW 19 13313514 missense probably damaging 1.00
R6913:Olfr1465 UTSW 19 13313634 missense probably benign 0.01
R6996:Olfr1465 UTSW 19 13313672 missense probably benign 0.15
R7933:Olfr1465 UTSW 19 13314205 missense probably benign
R8946:Olfr1465 UTSW 19 13314138 missense probably damaging 0.97
R8966:Olfr1465 UTSW 19 13313832 missense probably damaging 1.00
R9641:Olfr1465 UTSW 19 13313736 missense probably damaging 0.98
Posted On 2013-10-07