Incidental Mutation 'R9729:Vmn2r61'
| ID |
731218 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r61
|
| Ensembl Gene |
ENSMUSG00000090967 |
| Gene Name |
vomeronasal 2, receptor 61 |
| Synonyms |
Gprc2a-rs2, Casr-rs2, EG637873 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.101)
|
| Stock # |
R9729 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
41909477-41950179 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 41949917 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 779
(E779G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129576
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166131]
|
| AlphaFold |
L7N2B8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166131
AA Change: E779G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129576
Gene: ENSMUSG00000090967
AA Change: E779G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
471 |
4e-42 |
PFAM |
|
Pfam:NCD3G
|
514 |
567 |
1.9e-21 |
PFAM |
|
Pfam:7tm_3
|
600 |
835 |
6.2e-52 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173044
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4833439L19Rik |
A |
T |
13: 54,700,519 (GRCm39) |
M273K |
probably benign |
Het |
| Aar2 |
A |
G |
2: 156,393,361 (GRCm39) |
D250G |
probably benign |
Het |
| Acly |
T |
A |
11: 100,407,711 (GRCm39) |
Y213F |
probably benign |
Het |
| Adgrg5 |
G |
A |
8: 95,668,133 (GRCm39) |
M399I |
|
Het |
| Adhfe1 |
T |
C |
1: 9,623,634 (GRCm39) |
L95P |
probably damaging |
Het |
| Ano7 |
G |
A |
1: 93,322,180 (GRCm39) |
C396Y |
probably damaging |
Het |
| Apob |
T |
A |
12: 8,066,125 (GRCm39) |
Y4365N |
probably damaging |
Het |
| Arfgap3 |
C |
T |
15: 83,192,366 (GRCm39) |
R411H |
probably damaging |
Het |
| Bbs7 |
T |
C |
3: 36,661,818 (GRCm39) |
Y127C |
probably damaging |
Het |
| Cadps2 |
T |
C |
6: 23,382,982 (GRCm39) |
T793A |
probably benign |
Het |
| Casp8ap2 |
T |
A |
4: 32,643,807 (GRCm39) |
V960E |
possibly damaging |
Het |
| Cd200l1 |
G |
T |
16: 45,264,237 (GRCm39) |
T107N |
possibly damaging |
Het |
| Cdkl3 |
A |
G |
11: 51,895,770 (GRCm39) |
T6A |
probably benign |
Het |
| Cdkn2aip |
T |
C |
8: 48,166,654 (GRCm39) |
D51G |
probably benign |
Het |
| Cdpf1 |
G |
T |
15: 85,692,527 (GRCm39) |
S52* |
probably null |
Het |
| Celf5 |
T |
A |
10: 81,303,925 (GRCm39) |
D177V |
probably damaging |
Het |
| Cep164 |
A |
G |
9: 45,682,897 (GRCm39) |
V931A |
probably damaging |
Het |
| Cog6 |
T |
C |
3: 52,900,907 (GRCm39) |
D457G |
probably damaging |
Het |
| Col4a2 |
G |
T |
8: 11,496,157 (GRCm39) |
V1593L |
probably benign |
Het |
| Dlg5 |
C |
G |
14: 24,204,681 (GRCm39) |
M1287I |
probably benign |
Het |
| Dmrt1 |
T |
C |
19: 25,523,362 (GRCm39) |
S238P |
probably benign |
Het |
| Dpysl2 |
A |
G |
14: 67,099,927 (GRCm39) |
M103T |
probably benign |
Het |
| Emsy |
C |
A |
7: 98,262,256 (GRCm39) |
A608S |
probably benign |
Het |
| Entr1 |
A |
G |
2: 26,278,645 (GRCm39) |
F21S |
unknown |
Het |
| Entrep2 |
C |
T |
7: 64,806,056 (GRCm39) |
G6S |
probably benign |
Het |
| Exoc5 |
A |
T |
14: 49,253,086 (GRCm39) |
C576S |
probably damaging |
Het |
| F830016B08Rik |
G |
A |
18: 60,433,558 (GRCm39) |
V214M |
possibly damaging |
Het |
| Fignl1 |
A |
G |
11: 11,752,219 (GRCm39) |
S279P |
probably benign |
Het |
| Gimap1 |
A |
G |
6: 48,719,386 (GRCm39) |
R71G |
unknown |
Het |
| Gm26727 |
A |
T |
2: 67,263,263 (GRCm39) |
M88K |
probably damaging |
Het |
| Gm45861 |
T |
A |
8: 28,045,436 (GRCm39) |
W1066R |
unknown |
Het |
| Gpr15 |
A |
G |
16: 58,538,249 (GRCm39) |
L280S |
possibly damaging |
Het |
| Grin1 |
C |
T |
2: 25,187,422 (GRCm39) |
W629* |
probably null |
Het |
| Grk5 |
C |
T |
19: 61,078,467 (GRCm39) |
P508L |
possibly damaging |
Het |
| Hgf |
A |
T |
5: 16,766,029 (GRCm39) |
D55V |
probably damaging |
Het |
| Hipk1 |
T |
A |
3: 103,668,890 (GRCm39) |
D502V |
probably damaging |
Het |
| Kmt2c |
T |
C |
5: 25,489,758 (GRCm39) |
K4394E |
probably damaging |
Het |
| Llgl2 |
A |
G |
11: 115,740,467 (GRCm39) |
T388A |
probably damaging |
Het |
| Lsm14a |
G |
T |
7: 34,088,898 (GRCm39) |
S2R |
probably damaging |
Het |
| Madd |
A |
T |
2: 91,000,544 (GRCm39) |
M507K |
possibly damaging |
Het |
| Map2k3 |
G |
T |
11: 60,837,472 (GRCm39) |
V191L |
|
Het |
| Mapk8ip1 |
A |
G |
2: 92,217,060 (GRCm39) |
S421P |
probably damaging |
Het |
| Marchf7 |
C |
T |
2: 60,064,785 (GRCm39) |
R354* |
probably null |
Het |
| Myc |
T |
G |
15: 61,859,935 (GRCm39) |
C204G |
probably damaging |
Het |
| Nampt |
A |
G |
12: 32,900,528 (GRCm39) |
H491R |
possibly damaging |
Het |
| Noct |
C |
T |
3: 51,157,267 (GRCm39) |
Q202* |
probably null |
Het |
| Nup210l |
C |
T |
3: 90,107,173 (GRCm39) |
P1570L |
probably benign |
Het |
| Or10b1 |
T |
A |
10: 78,355,949 (GRCm39) |
F169Y |
probably damaging |
Het |
| Osbpl10 |
G |
A |
9: 115,052,804 (GRCm39) |
V451M |
probably damaging |
Het |
| Osr2 |
T |
A |
15: 35,303,061 (GRCm39) |
F312Y |
probably benign |
Het |
| Parp16 |
A |
T |
9: 65,137,097 (GRCm39) |
I108F |
possibly damaging |
Het |
| Parp4 |
A |
G |
14: 56,885,888 (GRCm39) |
T1656A |
unknown |
Het |
| Pnpla8 |
A |
G |
12: 44,330,657 (GRCm39) |
I374V |
probably benign |
Het |
| Prss23 |
T |
C |
7: 89,159,931 (GRCm39) |
N46S |
probably benign |
Het |
| Ptger2 |
T |
C |
14: 45,226,476 (GRCm39) |
W19R |
possibly damaging |
Het |
| Rbl2 |
T |
C |
8: 91,805,527 (GRCm39) |
S195P |
probably damaging |
Het |
| Rnf169 |
C |
T |
7: 99,575,477 (GRCm39) |
V373I |
probably damaging |
Het |
| Sclt1 |
C |
A |
3: 41,629,837 (GRCm39) |
E325* |
probably null |
Het |
| Sergef |
C |
T |
7: 46,284,913 (GRCm39) |
S43N |
probably benign |
Het |
| Slc35f3 |
CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
8: 127,115,777 (GRCm39) |
|
probably benign |
Het |
| Slc3a2 |
T |
C |
19: 8,685,370 (GRCm39) |
D472G |
probably damaging |
Het |
| Slc43a3 |
T |
C |
2: 84,780,800 (GRCm39) |
F342L |
probably benign |
Het |
| Slc44a4 |
A |
T |
17: 35,140,670 (GRCm39) |
I288F |
probably benign |
Het |
| Snupn |
T |
A |
9: 56,877,915 (GRCm39) |
N151K |
possibly damaging |
Het |
| Srbd1 |
A |
T |
17: 86,437,550 (GRCm39) |
D264E |
probably benign |
Het |
| Srpra |
A |
T |
9: 35,125,569 (GRCm39) |
T378S |
probably benign |
Het |
| Stat4 |
A |
G |
1: 52,141,762 (GRCm39) |
D613G |
possibly damaging |
Het |
| Sycp2l |
C |
T |
13: 41,326,132 (GRCm39) |
P246L |
|
Het |
| Tcf20 |
T |
C |
15: 82,736,037 (GRCm39) |
R1805G |
probably benign |
Het |
| Tob1 |
T |
A |
11: 94,104,880 (GRCm39) |
F139I |
probably damaging |
Het |
| Traj9 |
A |
G |
14: 54,446,871 (GRCm39) |
T8A |
unknown |
Het |
| Trank1 |
G |
T |
9: 111,220,537 (GRCm39) |
D2425Y |
probably damaging |
Het |
| Ttn |
G |
A |
2: 76,738,071 (GRCm39) |
S4202L |
unknown |
Het |
| Ttn |
A |
T |
2: 76,577,267 (GRCm39) |
M24542K |
probably damaging |
Het |
| Vcam1 |
T |
C |
3: 115,911,105 (GRCm39) |
Y431C |
probably damaging |
Het |
| Vcpkmt |
G |
A |
12: 69,627,936 (GRCm39) |
R175C |
probably damaging |
Het |
| Vmn2r51 |
A |
T |
7: 9,839,479 (GRCm39) |
D36E |
probably benign |
Het |
| Zfp831 |
T |
C |
2: 174,487,938 (GRCm39) |
L871P |
possibly damaging |
Het |
|
| Other mutations in Vmn2r61 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00158:Vmn2r61
|
APN |
7 |
41,950,175 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL00824:Vmn2r61
|
APN |
7 |
41,916,438 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00903:Vmn2r61
|
APN |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01125:Vmn2r61
|
APN |
7 |
41,909,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01393:Vmn2r61
|
APN |
7 |
41,916,258 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01712:Vmn2r61
|
APN |
7 |
41,909,661 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01822:Vmn2r61
|
APN |
7 |
41,950,130 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01835:Vmn2r61
|
APN |
7 |
41,950,015 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL01844:Vmn2r61
|
APN |
7 |
41,909,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01953:Vmn2r61
|
APN |
7 |
41,949,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02032:Vmn2r61
|
APN |
7 |
41,949,466 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02054:Vmn2r61
|
APN |
7 |
41,926,158 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02569:Vmn2r61
|
APN |
7 |
41,926,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02697:Vmn2r61
|
APN |
7 |
41,924,892 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL02958:Vmn2r61
|
APN |
7 |
41,949,361 (GRCm39) |
missense |
probably benign |
|
|
IGL03290:Vmn2r61
|
APN |
7 |
41,915,408 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03337:Vmn2r61
|
APN |
7 |
41,916,509 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL03369:Vmn2r61
|
APN |
7 |
41,909,517 (GRCm39) |
missense |
probably benign |
|
|
IGL03402:Vmn2r61
|
APN |
7 |
41,909,679 (GRCm39) |
missense |
probably benign |
|
|
R0026:Vmn2r61
|
UTSW |
7 |
41,924,898 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0319:Vmn2r61
|
UTSW |
7 |
41,949,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0433:Vmn2r61
|
UTSW |
7 |
41,915,335 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0555:Vmn2r61
|
UTSW |
7 |
41,915,442 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0691:Vmn2r61
|
UTSW |
7 |
41,949,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1701:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1718:Vmn2r61
|
UTSW |
7 |
41,950,121 (GRCm39) |
missense |
probably benign |
|
|
R1835:Vmn2r61
|
UTSW |
7 |
41,916,076 (GRCm39) |
nonsense |
probably null |
|
|
R1920:Vmn2r61
|
UTSW |
7 |
41,949,710 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2069:Vmn2r61
|
UTSW |
7 |
41,949,425 (GRCm39) |
missense |
probably benign |
0.06 |
|
R2326:Vmn2r61
|
UTSW |
7 |
41,916,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Vmn2r61
|
UTSW |
7 |
41,949,529 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R3103:Vmn2r61
|
UTSW |
7 |
41,916,067 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3107:Vmn2r61
|
UTSW |
7 |
41,916,491 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,159 (GRCm39) |
missense |
probably benign |
|
|
R4426:Vmn2r61
|
UTSW |
7 |
41,950,157 (GRCm39) |
missense |
probably benign |
|
|
R4484:Vmn2r61
|
UTSW |
7 |
41,950,120 (GRCm39) |
missense |
probably benign |
|
|
R4748:Vmn2r61
|
UTSW |
7 |
41,916,565 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4835:Vmn2r61
|
UTSW |
7 |
41,916,459 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4863:Vmn2r61
|
UTSW |
7 |
41,950,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4923:Vmn2r61
|
UTSW |
7 |
41,916,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4968:Vmn2r61
|
UTSW |
7 |
41,949,478 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5114:Vmn2r61
|
UTSW |
7 |
41,949,953 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5297:Vmn2r61
|
UTSW |
7 |
41,909,646 (GRCm39) |
missense |
probably benign |
|
|
R5497:Vmn2r61
|
UTSW |
7 |
41,924,906 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5508:Vmn2r61
|
UTSW |
7 |
41,916,242 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5587:Vmn2r61
|
UTSW |
7 |
41,949,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,949,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5615:Vmn2r61
|
UTSW |
7 |
41,916,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5782:Vmn2r61
|
UTSW |
7 |
41,949,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6136:Vmn2r61
|
UTSW |
7 |
41,916,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6207:Vmn2r61
|
UTSW |
7 |
41,909,616 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6265:Vmn2r61
|
UTSW |
7 |
41,915,915 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6272:Vmn2r61
|
UTSW |
7 |
41,949,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Vmn2r61
|
UTSW |
7 |
41,916,659 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6469:Vmn2r61
|
UTSW |
7 |
41,915,283 (GRCm39) |
nonsense |
probably null |
|
|
R6554:Vmn2r61
|
UTSW |
7 |
41,926,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6699:Vmn2r61
|
UTSW |
7 |
41,949,580 (GRCm39) |
missense |
probably benign |
|
|
R6768:Vmn2r61
|
UTSW |
7 |
41,949,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6824:Vmn2r61
|
UTSW |
7 |
41,949,403 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6930:Vmn2r61
|
UTSW |
7 |
41,949,364 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7053:Vmn2r61
|
UTSW |
7 |
41,916,557 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7238:Vmn2r61
|
UTSW |
7 |
41,916,629 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7332:Vmn2r61
|
UTSW |
7 |
41,909,534 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7359:Vmn2r61
|
UTSW |
7 |
41,915,407 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7553:Vmn2r61
|
UTSW |
7 |
41,916,205 (GRCm39) |
missense |
not run |
|
|
R7710:Vmn2r61
|
UTSW |
7 |
41,916,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7732:Vmn2r61
|
UTSW |
7 |
41,916,097 (GRCm39) |
missense |
probably benign |
|
|
R7839:Vmn2r61
|
UTSW |
7 |
41,916,032 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7916:Vmn2r61
|
UTSW |
7 |
41,949,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8026:Vmn2r61
|
UTSW |
7 |
41,916,141 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8440:Vmn2r61
|
UTSW |
7 |
41,916,080 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8499:Vmn2r61
|
UTSW |
7 |
41,949,700 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8771:Vmn2r61
|
UTSW |
7 |
41,916,194 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8847:Vmn2r61
|
UTSW |
7 |
41,950,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8986:Vmn2r61
|
UTSW |
7 |
41,915,325 (GRCm39) |
nonsense |
probably null |
|
|
R9290:Vmn2r61
|
UTSW |
7 |
41,915,385 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9311:Vmn2r61
|
UTSW |
7 |
41,950,092 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9324:Vmn2r61
|
UTSW |
7 |
41,916,619 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9476:Vmn2r61
|
UTSW |
7 |
41,949,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Vmn2r61
|
UTSW |
7 |
41,916,626 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9619:Vmn2r61
|
UTSW |
7 |
41,926,136 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1088:Vmn2r61
|
UTSW |
7 |
41,949,388 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,916,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r61
|
UTSW |
7 |
41,909,585 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGGAATCTGGATTCTAACATCTCC -3'
(R):5'- GTGTGTCTGATGTCAATACAGGAG -3'
Sequencing Primer
(F):5'- CACCCTTCATTGATCAAGATACTCAG -3'
(R):5'- CTGGCCTTAACAAAATAATGTAGCAC -3'
|
| Posted On |
2022-10-06 |
Incidental Mutation