Mutagenetix > Incidental Mutation

Incidental Mutation 'R9729:Slc35f3'

731229

Institutional Source

Beutler Lab

Gene Symbol

Slc35f3

Ensembl Gene

ENSMUSG00000057060

Gene Name

solute carrier family 35, member F3

Synonyms

B230375D17Rik

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.136) question?

Stock #

R9729 (G1)

Quality Score

166.468

Status

Not validated

Chromosome

Chromosomal Location

126865734-127122717 bp(+) (GRCm39)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC to CTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC at 127115777 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000104390 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108759]

AlphaFold

Q1LZI2

Predicted Effect

probably benign
Transcript: ENSMUST00000108759

SMART Domains

Protein: ENSMUSP00000104390
Gene: ENSMUSG00000057060

Domain	Start	End	E-Value	Type
low complexity region	25	49	N/A	INTRINSIC
Pfam:EamA	67	223	3.2e-7	PFAM
Pfam:SLC35F	145	374	3.2e-6	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 78 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833439L19Rik	A	T	13: 54,700,519 (GRCm39)	M273K	probably benign	Het
Aar2	A	G	2: 156,393,361 (GRCm39)	D250G	probably benign	Het
Acly	T	A	11: 100,407,711 (GRCm39)	Y213F	probably benign	Het
Adgrg5	G	A	8: 95,668,133 (GRCm39)	M399I		Het
Adhfe1	T	C	1: 9,623,634 (GRCm39)	L95P	probably damaging	Het
Ano7	G	A	1: 93,322,180 (GRCm39)	C396Y	probably damaging	Het
Apob	T	A	12: 8,066,125 (GRCm39)	Y4365N	probably damaging	Het
Arfgap3	C	T	15: 83,192,366 (GRCm39)	R411H	probably damaging	Het
Bbs7	T	C	3: 36,661,818 (GRCm39)	Y127C	probably damaging	Het
Cadps2	T	C	6: 23,382,982 (GRCm39)	T793A	probably benign	Het
Casp8ap2	T	A	4: 32,643,807 (GRCm39)	V960E	possibly damaging	Het
Cd200l1	G	T	16: 45,264,237 (GRCm39)	T107N	possibly damaging	Het
Cdkl3	A	G	11: 51,895,770 (GRCm39)	T6A	probably benign	Het
Cdkn2aip	T	C	8: 48,166,654 (GRCm39)	D51G	probably benign	Het
Cdpf1	G	T	15: 85,692,527 (GRCm39)	S52*	probably null	Het
Celf5	T	A	10: 81,303,925 (GRCm39)	D177V	probably damaging	Het
Cep164	A	G	9: 45,682,897 (GRCm39)	V931A	probably damaging	Het
Cog6	T	C	3: 52,900,907 (GRCm39)	D457G	probably damaging	Het
Col4a2	G	T	8: 11,496,157 (GRCm39)	V1593L	probably benign	Het
Dlg5	C	G	14: 24,204,681 (GRCm39)	M1287I	probably benign	Het
Dmrt1	T	C	19: 25,523,362 (GRCm39)	S238P	probably benign	Het
Dpysl2	A	G	14: 67,099,927 (GRCm39)	M103T	probably benign	Het
Emsy	C	A	7: 98,262,256 (GRCm39)	A608S	probably benign	Het
Entr1	A	G	2: 26,278,645 (GRCm39)	F21S	unknown	Het
Entrep2	C	T	7: 64,806,056 (GRCm39)	G6S	probably benign	Het
Exoc5	A	T	14: 49,253,086 (GRCm39)	C576S	probably damaging	Het
F830016B08Rik	G	A	18: 60,433,558 (GRCm39)	V214M	possibly damaging	Het
Fignl1	A	G	11: 11,752,219 (GRCm39)	S279P	probably benign	Het
Gimap1	A	G	6: 48,719,386 (GRCm39)	R71G	unknown	Het
Gm26727	A	T	2: 67,263,263 (GRCm39)	M88K	probably damaging	Het
Gm45861	T	A	8: 28,045,436 (GRCm39)	W1066R	unknown	Het
Gpr15	A	G	16: 58,538,249 (GRCm39)	L280S	possibly damaging	Het
Grin1	C	T	2: 25,187,422 (GRCm39)	W629*	probably null	Het
Grk5	C	T	19: 61,078,467 (GRCm39)	P508L	possibly damaging	Het
Hgf	A	T	5: 16,766,029 (GRCm39)	D55V	probably damaging	Het
Hipk1	T	A	3: 103,668,890 (GRCm39)	D502V	probably damaging	Het
Kmt2c	T	C	5: 25,489,758 (GRCm39)	K4394E	probably damaging	Het
Llgl2	A	G	11: 115,740,467 (GRCm39)	T388A	probably damaging	Het
Lsm14a	G	T	7: 34,088,898 (GRCm39)	S2R	probably damaging	Het
Madd	A	T	2: 91,000,544 (GRCm39)	M507K	possibly damaging	Het
Map2k3	G	T	11: 60,837,472 (GRCm39)	V191L		Het
Mapk8ip1	A	G	2: 92,217,060 (GRCm39)	S421P	probably damaging	Het
Marchf7	C	T	2: 60,064,785 (GRCm39)	R354*	probably null	Het
Myc	T	G	15: 61,859,935 (GRCm39)	C204G	probably damaging	Het
Nampt	A	G	12: 32,900,528 (GRCm39)	H491R	possibly damaging	Het
Noct	C	T	3: 51,157,267 (GRCm39)	Q202*	probably null	Het
Nup210l	C	T	3: 90,107,173 (GRCm39)	P1570L	probably benign	Het
Or10b1	T	A	10: 78,355,949 (GRCm39)	F169Y	probably damaging	Het
Osbpl10	G	A	9: 115,052,804 (GRCm39)	V451M	probably damaging	Het
Osr2	T	A	15: 35,303,061 (GRCm39)	F312Y	probably benign	Het
Parp16	A	T	9: 65,137,097 (GRCm39)	I108F	possibly damaging	Het
Parp4	A	G	14: 56,885,888 (GRCm39)	T1656A	unknown	Het
Pnpla8	A	G	12: 44,330,657 (GRCm39)	I374V	probably benign	Het
Prss23	T	C	7: 89,159,931 (GRCm39)	N46S	probably benign	Het
Ptger2	T	C	14: 45,226,476 (GRCm39)	W19R	possibly damaging	Het
Rbl2	T	C	8: 91,805,527 (GRCm39)	S195P	probably damaging	Het
Rnf169	C	T	7: 99,575,477 (GRCm39)	V373I	probably damaging	Het
Sclt1	C	A	3: 41,629,837 (GRCm39)	E325*	probably null	Het
Sergef	C	T	7: 46,284,913 (GRCm39)	S43N	probably benign	Het
Slc3a2	T	C	19: 8,685,370 (GRCm39)	D472G	probably damaging	Het
Slc43a3	T	C	2: 84,780,800 (GRCm39)	F342L	probably benign	Het
Slc44a4	A	T	17: 35,140,670 (GRCm39)	I288F	probably benign	Het
Snupn	T	A	9: 56,877,915 (GRCm39)	N151K	possibly damaging	Het
Srbd1	A	T	17: 86,437,550 (GRCm39)	D264E	probably benign	Het
Srpra	A	T	9: 35,125,569 (GRCm39)	T378S	probably benign	Het
Stat4	A	G	1: 52,141,762 (GRCm39)	D613G	possibly damaging	Het
Sycp2l	C	T	13: 41,326,132 (GRCm39)	P246L		Het
Tcf20	T	C	15: 82,736,037 (GRCm39)	R1805G	probably benign	Het
Tob1	T	A	11: 94,104,880 (GRCm39)	F139I	probably damaging	Het
Traj9	A	G	14: 54,446,871 (GRCm39)	T8A	unknown	Het
Trank1	G	T	9: 111,220,537 (GRCm39)	D2425Y	probably damaging	Het
Ttn	G	A	2: 76,738,071 (GRCm39)	S4202L	unknown	Het
Ttn	A	T	2: 76,577,267 (GRCm39)	M24542K	probably damaging	Het
Vcam1	T	C	3: 115,911,105 (GRCm39)	Y431C	probably damaging	Het
Vcpkmt	G	A	12: 69,627,936 (GRCm39)	R175C	probably damaging	Het
Vmn2r51	A	T	7: 9,839,479 (GRCm39)	D36E	probably benign	Het
Vmn2r61	A	G	7: 41,949,917 (GRCm39)	E779G	probably damaging	Het
Zfp831	T	C	2: 174,487,938 (GRCm39)	L871P	possibly damaging	Het

Other mutations in Slc35f3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00687:Slc35f3	APN	8	127,108,903 (GRCm39)	missense	probably benign	0.02
IGL00956:Slc35f3	APN	8	127,108,963 (GRCm39)	missense	probably damaging	1.00
IGL01105:Slc35f3	APN	8	127,025,553 (GRCm39)	missense	probably damaging	1.00
IGL01710:Slc35f3	APN	8	127,115,900 (GRCm39)	missense	probably benign	0.00
IGL01771:Slc35f3	APN	8	127,115,951 (GRCm39)	missense	probably benign	0.00
IGL02254:Slc35f3	APN	8	127,115,862 (GRCm39)	missense	probably damaging	1.00
IGL02610:Slc35f3	APN	8	127,047,956 (GRCm39)	missense	probably damaging	1.00
R1666:Slc35f3	UTSW	8	127,115,960 (GRCm39)	missense	probably damaging	0.98
R2510:Slc35f3	UTSW	8	127,025,445 (GRCm39)	start gained	probably benign
R2520:Slc35f3	UTSW	8	127,121,312 (GRCm39)	missense	possibly damaging	0.81
R3807:Slc35f3	UTSW	8	127,115,978 (GRCm39)	missense	probably damaging	1.00
R4644:Slc35f3	UTSW	8	127,047,809 (GRCm39)	missense	possibly damaging	0.87
R4675:Slc35f3	UTSW	8	127,047,935 (GRCm39)	nonsense	probably null
R4976:Slc35f3	UTSW	8	127,116,020 (GRCm39)	splice site	probably null
R5037:Slc35f3	UTSW	8	127,116,011 (GRCm39)	missense	probably damaging	0.99
R5225:Slc35f3	UTSW	8	127,117,846 (GRCm39)	missense	probably damaging	0.98
R5259:Slc35f3	UTSW	8	127,115,872 (GRCm39)	missense	probably damaging	1.00
R5856:Slc35f3	UTSW	8	127,047,819 (GRCm39)	missense	probably benign	0.07
R5925:Slc35f3	UTSW	8	127,115,946 (GRCm39)	missense	probably benign	0.24
R6254:Slc35f3	UTSW	8	127,047,833 (GRCm39)	missense	possibly damaging	0.96
R6748:Slc35f3	UTSW	8	127,121,377 (GRCm39)	nonsense	probably null
R6785:Slc35f3	UTSW	8	127,121,198 (GRCm39)	missense	probably benign	0.02
R7002:Slc35f3	UTSW	8	127,115,773 (GRCm39)	critical splice acceptor site	unknown
R7291:Slc35f3	UTSW	8	127,121,297 (GRCm39)	missense	probably benign	0.02
R7411:Slc35f3	UTSW	8	127,115,777 (GRCm39)	critical splice acceptor site	probably benign
R7456:Slc35f3	UTSW	8	127,115,779 (GRCm39)	critical splice acceptor site	unknown
R7790:Slc35f3	UTSW	8	127,115,777 (GRCm39)	critical splice acceptor site	probably benign
R7852:Slc35f3	UTSW	8	127,121,219 (GRCm39)	missense	probably damaging	1.00
R8000:Slc35f3	UTSW	8	127,047,812 (GRCm39)	missense	probably benign
R8277:Slc35f3	UTSW	8	127,115,925 (GRCm39)	missense	possibly damaging	0.88
R8827:Slc35f3	UTSW	8	127,115,780 (GRCm39)	critical splice acceptor site	probably benign
R8983:Slc35f3	UTSW	8	127,115,775 (GRCm39)	critical splice acceptor site	probably benign
R9205:Slc35f3	UTSW	8	127,115,928 (GRCm39)	missense	probably damaging	0.96
R9355:Slc35f3	UTSW	8	127,108,967 (GRCm39)	missense	probably damaging	0.97
R9475:Slc35f3	UTSW	8	127,108,993 (GRCm39)	missense	probably damaging	1.00
R9492:Slc35f3	UTSW	8	127,048,026 (GRCm39)	missense	probably damaging	1.00
R9714:Slc35f3	UTSW	8	127,115,781 (GRCm39)	critical splice acceptor site	probably benign
R9769:Slc35f3	UTSW	8	127,121,336 (GRCm39)	missense	probably damaging	0.99
X0067:Slc35f3	UTSW	8	127,109,062 (GRCm39)	missense	probably damaging	0.99

Predicted Primers

Posted On

2022-10-06