Incidental Mutation 'R9108:Tanc2'
ID 731272
Institutional Source Beutler Lab
Gene Symbol Tanc2
Ensembl Gene ENSMUSG00000053580
Gene Name tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Synonyms 5730590C14Rik, 3526402J09Rik
MMRRC Submission
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9108 (G1)
Quality Score 130.008
Status Validated
Chromosome 11
Chromosomal Location 105480812-105820130 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to A at 105810580 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000100330]
AlphaFold A2A690
Predicted Effect probably benign
Transcript: ENSMUST00000089485
SMART Domains Protein: ENSMUSP00000086912
Gene: ENSMUSG00000053580

DomainStartEndE-ValueType
ANK 35 63 1.16e3 SMART
ANK 78 107 3.31e-1 SMART
ANK 111 140 7.71e-2 SMART
ANK 144 173 6.12e-5 SMART
ANK 177 206 8.99e-3 SMART
ANK 210 239 5.71e-5 SMART
ANK 243 272 2.11e2 SMART
Blast:TPR 289 322 3e-14 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000100330
SMART Domains Protein: ENSMUSP00000097904
Gene: ENSMUSG00000053580

DomainStartEndE-ValueType
low complexity region 32 50 N/A INTRINSIC
low complexity region 129 152 N/A INTRINSIC
low complexity region 362 375 N/A INTRINSIC
low complexity region 436 447 N/A INTRINSIC
low complexity region 823 834 N/A INTRINSIC
ANK 846 878 2.08e3 SMART
ANK 882 913 2.97e2 SMART
ANK 917 946 5.75e-1 SMART
ANK 950 979 8.62e1 SMART
ANK 990 1018 1.16e3 SMART
ANK 1033 1062 3.31e-1 SMART
ANK 1066 1095 7.71e-2 SMART
ANK 1099 1128 6.12e-5 SMART
ANK 1132 1161 8.99e-3 SMART
ANK 1165 1194 5.71e-5 SMART
ANK 1198 1227 2.11e2 SMART
TPR 1244 1277 3.89e1 SMART
TPR 1291 1324 3.61e-2 SMART
TPR 1325 1358 2.82e-4 SMART
low complexity region 1369 1406 N/A INTRINSIC
low complexity region 1533 1539 N/A INTRINSIC
low complexity region 1787 1802 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000146162
SMART Domains Protein: ENSMUSP00000123674
Gene: ENSMUSG00000053580

DomainStartEndE-ValueType
ANK 15 46 2.97e2 SMART
ANK 50 79 5.75e-1 SMART
ANK 83 112 8.62e1 SMART
ANK 123 151 1.16e3 SMART
ANK 166 195 3.31e-1 SMART
ANK 199 228 7.71e-2 SMART
ANK 232 261 6.12e-5 SMART
ANK 265 294 8.99e-3 SMART
ANK 298 327 5.71e-5 SMART
ANK 331 360 3.44e1 SMART
TPR 387 420 3.89e1 SMART
TPR 434 467 3.61e-2 SMART
TPR 468 501 2.82e-4 SMART
low complexity region 512 549 N/A INTRINSIC
low complexity region 676 682 N/A INTRINSIC
low complexity region 930 945 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (65/65)
MGI Phenotype PHENOTYPE: Mice homozygous for a gene trap vector die prior to E12. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik G A 18: 6,638,794 (GRCm39) V398M probably benign Het
4930568D16Rik G A 2: 35,244,942 (GRCm39) P137S probably damaging Het
Abcb9 T C 5: 124,228,176 (GRCm39) T22A possibly damaging Het
Abcg8 A C 17: 85,000,243 (GRCm39) I268L probably benign Het
Acvrl1 A G 15: 101,039,038 (GRCm39) Q445R probably damaging Het
Adam17 T C 12: 21,380,132 (GRCm39) N625D probably benign Het
Adamts9 C T 6: 92,857,721 (GRCm39) V856M probably damaging Het
Adar T C 3: 89,643,474 (GRCm39) C452R probably damaging Het
Adgra3 G T 5: 50,136,295 (GRCm39) A730D probably damaging Het
Adnp2 C T 18: 80,185,925 (GRCm39) R16Q probably damaging Het
Aox1 T C 1: 58,321,851 (GRCm39) C48R probably damaging Het
Cabin1 T C 10: 75,492,973 (GRCm39) E1774G possibly damaging Het
Capsl A T 15: 9,465,910 (GRCm39) I199F possibly damaging Het
Ccdc191 T A 16: 43,718,512 (GRCm39) D36E possibly damaging Het
Cep170 T A 1: 176,616,051 (GRCm39) K86* probably null Het
Cnnm1 T C 19: 43,464,649 (GRCm39) F736S possibly damaging Het
Col11a2 T A 17: 34,276,634 (GRCm39) V532E probably benign Het
Dnmt3l T C 10: 77,892,756 (GRCm39) probably null Het
Dync1h1 T A 12: 110,622,706 (GRCm39) probably benign Het
Dzank1 C A 2: 144,364,391 (GRCm39) V69L probably benign Het
Epor T G 9: 21,870,875 (GRCm39) E335A probably damaging Het
Fbxo46 A T 7: 18,870,308 (GRCm39) Y309F probably damaging Het
Fra10ac1 A T 19: 38,202,779 (GRCm39) probably benign Het
Gid8 G T 2: 180,352,132 (GRCm39) probably benign Het
Gm57858 T G 3: 36,080,036 (GRCm39) *240C probably null Het
Gnptab C T 10: 88,269,400 (GRCm39) S701L Het
Ifnl3 T C 7: 28,223,704 (GRCm39) L180P probably benign Het
Ikzf2 T A 1: 69,577,956 (GRCm39) I518F probably damaging Het
Ildr1 A G 16: 36,535,919 (GRCm39) T145A probably benign Het
Kiss1r A T 10: 79,754,336 (GRCm39) probably benign Het
Lhpp A G 7: 132,252,018 (GRCm39) D219G probably damaging Het
Lrp1 A T 10: 127,390,206 (GRCm39) M3071K probably damaging Het
Map6 T C 7: 98,986,103 (GRCm39) L872P probably damaging Het
Mgst2 T A 3: 51,589,233 (GRCm39) L82Q probably damaging Het
Mier2 A T 10: 79,377,756 (GRCm39) V399E probably benign Het
Nms T C 1: 38,985,147 (GRCm39) V91A possibly damaging Het
Nt5dc2 T A 14: 30,857,016 (GRCm39) Y145* probably null Het
Olfml2a A T 2: 38,831,753 (GRCm39) M111L probably benign Het
Or5p63 T C 7: 107,810,846 (GRCm39) N297D probably damaging Het
Or5p75-ps1 T A 7: 108,107,779 (GRCm39) L172Q unknown Het
Plod3 T C 5: 137,018,017 (GRCm39) I221T probably damaging Het
Polm T C 11: 5,779,872 (GRCm39) Q342R probably benign Het
Ppp2r5c A T 12: 110,521,303 (GRCm39) L275F probably damaging Het
Prdm12 C T 2: 31,533,929 (GRCm39) T182M possibly damaging Het
Rasgrp2 G A 19: 6,458,890 (GRCm39) V440M probably damaging Het
Rnf111 C T 9: 70,336,846 (GRCm39) G947D probably damaging Het
Runx3 A T 4: 134,882,692 (GRCm39) M143L probably damaging Het
Samd9l T C 6: 3,373,104 (GRCm39) S1386G possibly damaging Het
Saxo2 C T 7: 82,284,082 (GRCm39) V259I probably benign Het
Shroom3 T C 5: 93,087,975 (GRCm39) S242P probably damaging Het
Slc35e1 G A 8: 73,246,030 (GRCm39) P134L Het
Spata31d1a A G 13: 59,850,982 (GRCm39) V382A probably benign Het
Tenm3 A T 8: 48,766,271 (GRCm39) probably null Het
Trip10 C T 17: 57,560,519 (GRCm39) A123V probably damaging Het
Trmt13 A G 3: 116,375,129 (GRCm39) S460P probably damaging Het
Trpd52l3 A G 19: 29,981,329 (GRCm39) N28S probably benign Het
Tubb4a A G 17: 57,388,232 (GRCm39) F265L probably benign Het
Uba6 A T 5: 86,282,934 (GRCm39) C581S possibly damaging Het
Uckl1 A G 2: 181,211,293 (GRCm39) V512A probably damaging Het
Usp34 A T 11: 23,320,528 (GRCm39) M957L Het
Vmn2r57 T C 7: 41,078,192 (GRCm39) I89V possibly damaging Het
Zfp1005 T A 2: 150,109,969 (GRCm39) C220S possibly damaging Het
Zfp322a T C 13: 23,541,437 (GRCm39) I102V probably benign Het
Zzef1 A G 11: 72,790,604 (GRCm39) D2186G probably benign Het
Other mutations in Tanc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00501:Tanc2 APN 11 105,814,046 (GRCm39) missense probably benign 0.28
IGL00688:Tanc2 APN 11 105,689,516 (GRCm39) missense probably damaging 1.00
IGL00709:Tanc2 APN 11 105,689,621 (GRCm39) missense probably damaging 1.00
IGL01013:Tanc2 APN 11 105,515,891 (GRCm39) missense probably damaging 0.96
IGL01141:Tanc2 APN 11 105,777,300 (GRCm39) splice site probably benign
IGL01386:Tanc2 APN 11 105,777,207 (GRCm39) missense probably damaging 0.99
IGL01433:Tanc2 APN 11 105,701,348 (GRCm39) missense possibly damaging 0.75
IGL01562:Tanc2 APN 11 105,670,895 (GRCm39) missense probably benign 0.00
IGL01979:Tanc2 APN 11 105,667,746 (GRCm39) missense probably benign
IGL02104:Tanc2 APN 11 105,670,959 (GRCm39) unclassified probably benign
IGL02434:Tanc2 APN 11 105,670,868 (GRCm39) missense probably benign 0.14
IGL02534:Tanc2 APN 11 105,725,994 (GRCm39) missense probably damaging 1.00
IGL02568:Tanc2 APN 11 105,667,777 (GRCm39) missense probably benign 0.00
IGL03279:Tanc2 APN 11 105,803,918 (GRCm39) splice site probably null
R0595:Tanc2 UTSW 11 105,605,003 (GRCm39) splice site probably null
R1131:Tanc2 UTSW 11 105,725,828 (GRCm39) missense probably damaging 1.00
R1320:Tanc2 UTSW 11 105,777,270 (GRCm39) missense probably damaging 1.00
R1487:Tanc2 UTSW 11 105,814,460 (GRCm39) missense probably damaging 0.99
R1497:Tanc2 UTSW 11 105,812,963 (GRCm39) missense probably benign 0.21
R1692:Tanc2 UTSW 11 105,748,326 (GRCm39) missense probably benign
R1712:Tanc2 UTSW 11 105,790,606 (GRCm39) missense probably benign
R1793:Tanc2 UTSW 11 105,515,859 (GRCm39) critical splice acceptor site probably null
R1812:Tanc2 UTSW 11 105,777,212 (GRCm39) missense probably benign 0.01
R1905:Tanc2 UTSW 11 105,813,689 (GRCm39) missense possibly damaging 0.61
R1959:Tanc2 UTSW 11 105,801,121 (GRCm39) missense probably damaging 1.00
R1962:Tanc2 UTSW 11 105,689,558 (GRCm39) missense probably benign 0.14
R2122:Tanc2 UTSW 11 105,786,775 (GRCm39) missense probably damaging 1.00
R2174:Tanc2 UTSW 11 105,801,135 (GRCm39) missense probably benign 0.00
R2341:Tanc2 UTSW 11 105,725,877 (GRCm39) missense probably benign 0.09
R2497:Tanc2 UTSW 11 105,564,319 (GRCm39) critical splice donor site probably null
R3438:Tanc2 UTSW 11 105,748,401 (GRCm39) missense probably damaging 0.97
R3711:Tanc2 UTSW 11 105,689,516 (GRCm39) missense probably damaging 1.00
R3765:Tanc2 UTSW 11 105,805,796 (GRCm39) missense probably damaging 1.00
R3890:Tanc2 UTSW 11 105,689,504 (GRCm39) missense probably damaging 1.00
R4193:Tanc2 UTSW 11 105,804,888 (GRCm39) intron probably benign
R4609:Tanc2 UTSW 11 105,801,066 (GRCm39) missense probably benign 0.24
R4674:Tanc2 UTSW 11 105,758,306 (GRCm39) missense probably damaging 1.00
R4928:Tanc2 UTSW 11 105,758,588 (GRCm39) missense probably damaging 1.00
R5008:Tanc2 UTSW 11 105,515,886 (GRCm39) start codon destroyed probably null 0.46
R5010:Tanc2 UTSW 11 105,670,918 (GRCm39) missense probably damaging 1.00
R5135:Tanc2 UTSW 11 105,748,379 (GRCm39) missense possibly damaging 0.93
R5385:Tanc2 UTSW 11 105,667,672 (GRCm39) missense probably damaging 0.99
R5409:Tanc2 UTSW 11 105,758,311 (GRCm39) missense possibly damaging 0.93
R5419:Tanc2 UTSW 11 105,813,709 (GRCm39) missense probably benign 0.00
R5501:Tanc2 UTSW 11 105,805,811 (GRCm39) critical splice donor site probably null
R5590:Tanc2 UTSW 11 105,814,132 (GRCm39) missense probably damaging 0.99
R5651:Tanc2 UTSW 11 105,689,526 (GRCm39) missense probably benign 0.44
R5798:Tanc2 UTSW 11 105,812,681 (GRCm39) small deletion probably benign
R5876:Tanc2 UTSW 11 105,813,439 (GRCm39) missense possibly damaging 0.71
R5889:Tanc2 UTSW 11 105,812,633 (GRCm39) missense probably benign 0.23
R5958:Tanc2 UTSW 11 105,731,451 (GRCm39) missense probably benign 0.00
R5999:Tanc2 UTSW 11 105,758,543 (GRCm39) missense probably damaging 1.00
R6024:Tanc2 UTSW 11 105,814,498 (GRCm39) missense probably damaging 1.00
R6024:Tanc2 UTSW 11 105,758,543 (GRCm39) missense probably damaging 1.00
R6025:Tanc2 UTSW 11 105,787,373 (GRCm39) missense possibly damaging 0.68
R6025:Tanc2 UTSW 11 105,758,543 (GRCm39) missense probably damaging 1.00
R6048:Tanc2 UTSW 11 105,758,543 (GRCm39) missense probably damaging 1.00
R6049:Tanc2 UTSW 11 105,758,543 (GRCm39) missense probably damaging 1.00
R6185:Tanc2 UTSW 11 105,803,865 (GRCm39) missense probably damaging 1.00
R6335:Tanc2 UTSW 11 105,748,382 (GRCm39) missense probably damaging 0.99
R6821:Tanc2 UTSW 11 105,777,316 (GRCm39) splice site probably null
R6846:Tanc2 UTSW 11 105,689,479 (GRCm39) missense probably benign 0.34
R6857:Tanc2 UTSW 11 105,801,114 (GRCm39) missense possibly damaging 0.81
R6904:Tanc2 UTSW 11 105,726,056 (GRCm39) missense possibly damaging 0.89
R7009:Tanc2 UTSW 11 105,731,525 (GRCm39) missense possibly damaging 0.47
R7017:Tanc2 UTSW 11 105,813,934 (GRCm39) missense probably benign
R7371:Tanc2 UTSW 11 105,689,422 (GRCm39) missense probably benign
R7556:Tanc2 UTSW 11 105,799,857 (GRCm39) missense
R7630:Tanc2 UTSW 11 105,667,734 (GRCm39) missense probably benign 0.04
R7693:Tanc2 UTSW 11 105,814,293 (GRCm39) missense probably damaging 1.00
R7757:Tanc2 UTSW 11 105,667,684 (GRCm39) missense possibly damaging 0.81
R7807:Tanc2 UTSW 11 105,758,480 (GRCm39) missense probably benign 0.00
R7878:Tanc2 UTSW 11 105,804,241 (GRCm39) missense
R7895:Tanc2 UTSW 11 105,812,651 (GRCm39) missense probably damaging 1.00
R7952:Tanc2 UTSW 11 105,787,423 (GRCm39) missense probably damaging 1.00
R8099:Tanc2 UTSW 11 105,754,833 (GRCm39) missense probably benign 0.17
R8117:Tanc2 UTSW 11 105,725,988 (GRCm39) missense probably damaging 1.00
R8133:Tanc2 UTSW 11 105,814,048 (GRCm39) missense probably damaging 0.97
R8422:Tanc2 UTSW 11 105,726,014 (GRCm39) missense probably benign 0.10
R8527:Tanc2 UTSW 11 105,807,834 (GRCm39) missense probably damaging 0.96
R8542:Tanc2 UTSW 11 105,807,834 (GRCm39) missense probably damaging 0.96
R8834:Tanc2 UTSW 11 105,807,845 (GRCm39) missense
R8912:Tanc2 UTSW 11 105,758,153 (GRCm39) missense probably benign 0.01
R8927:Tanc2 UTSW 11 105,701,331 (GRCm39) missense probably damaging 0.99
R8928:Tanc2 UTSW 11 105,701,331 (GRCm39) missense probably damaging 0.99
R8968:Tanc2 UTSW 11 105,758,400 (GRCm39) missense possibly damaging 0.50
R9065:Tanc2 UTSW 11 105,689,518 (GRCm39) nonsense probably null
R9095:Tanc2 UTSW 11 105,758,104 (GRCm39) missense probably benign 0.00
R9131:Tanc2 UTSW 11 105,689,603 (GRCm39) missense probably benign
R9294:Tanc2 UTSW 11 105,777,284 (GRCm39) missense probably damaging 0.99
R9445:Tanc2 UTSW 11 105,758,290 (GRCm39) missense possibly damaging 0.80
X0027:Tanc2 UTSW 11 105,726,009 (GRCm39) missense probably benign 0.26
Predicted Primers PCR Primer
(F):5'- GGAAGCCAAGGTCTTGTGAG -3'
(R):5'- AGGTGTGCAGATGAGTCATTGC -3'

Sequencing Primer
(F):5'- CAAGGTCTTGTGAGCACAGC -3'
(R):5'- CAGATGAGTCATTGCAGAGATACAC -3'
Posted On 2022-10-10