Incidental Mutation 'IGL01296:Zcwpw1'
ID 73129
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zcwpw1
Ensembl Gene ENSMUSG00000037108
Gene Name zinc finger, CW type with PWWP domain 1
Synonyms LOC381678
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # IGL01296
Quality Score
Status
Chromosome 5
Chromosomal Location 137786060-137820883 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 137795061 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 86 (A86T)
Ref Sequence ENSEMBL: ENSMUSP00000048730 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035852]
AlphaFold Q6IR42
Predicted Effect probably benign
Transcript: ENSMUST00000035852
AA Change: A86T

PolyPhen 2 Score 0.423 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000048730
Gene: ENSMUSG00000037108
AA Change: A86T

DomainStartEndE-ValueType
Pfam:zf-CW 246 293 7.3e-18 PFAM
Pfam:PWWP 306 401 6.9e-22 PFAM
coiled coil region 440 462 N/A INTRINSIC
low complexity region 587 598 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127541
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128946
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200505
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadl A G 1: 66,880,864 (GRCm39) S301P probably damaging Het
Adam34 A G 8: 44,104,178 (GRCm39) V489A possibly damaging Het
Adcy8 G A 15: 64,655,628 (GRCm39) T617I probably damaging Het
Aggf1 T C 13: 95,490,479 (GRCm39) D605G probably damaging Het
Atp10a T A 7: 58,463,373 (GRCm39) F969I probably benign Het
Becn1 A T 11: 101,182,277 (GRCm39) N97K probably damaging Het
Cd4 G A 6: 124,856,341 (GRCm39) T50I probably benign Het
Crtac1 A T 19: 42,272,652 (GRCm39) C578S probably damaging Het
Dcp1b A G 6: 119,192,319 (GRCm39) K412E probably damaging Het
Dlg2 T A 7: 91,589,267 (GRCm39) I327N probably damaging Het
Ehf T A 2: 103,098,500 (GRCm39) probably null Het
Elavl4 T C 4: 110,063,809 (GRCm39) N264S probably benign Het
Enpp2 A T 15: 54,739,065 (GRCm39) I406N probably damaging Het
F10 A T 8: 13,105,383 (GRCm39) Y316F possibly damaging Het
Fam20a A G 11: 109,576,177 (GRCm39) I194T possibly damaging Het
Fcgbp T C 7: 27,789,072 (GRCm39) V546A probably benign Het
Fras1 A T 5: 96,821,557 (GRCm39) Q1438L probably null Het
Gm43638 T C 5: 87,608,451 (GRCm39) I463V probably benign Het
H2-T10 T C 17: 36,431,602 (GRCm39) D84G probably benign Het
Itpr1 T C 6: 108,376,322 (GRCm39) F1262L probably damaging Het
Lama1 A G 17: 68,052,046 (GRCm39) N335D probably benign Het
Lasp1 T C 11: 97,727,016 (GRCm39) V246A probably damaging Het
Lrrk2 A T 15: 91,567,345 (GRCm39) I135L probably benign Het
Malrd1 G A 2: 16,106,768 (GRCm39) probably null Het
Mctp2 T C 7: 71,878,274 (GRCm39) K268R probably benign Het
Nbea A T 3: 55,938,957 (GRCm39) H710Q probably benign Het
Notch3 G A 17: 32,385,731 (GRCm39) R13C unknown Het
Ogfod1 A T 8: 94,782,299 (GRCm39) probably benign Het
Or1j11 A G 2: 36,311,716 (GRCm39) Y102C probably benign Het
Or5b111 A G 19: 13,291,490 (GRCm39) L53P probably damaging Het
Or8d2 T C 9: 38,759,548 (GRCm39) I46T probably damaging Het
Pgm3 A G 9: 86,443,932 (GRCm39) V324A probably damaging Het
Ppfia2 A T 10: 106,694,068 (GRCm39) I681F probably damaging Het
Prss23 T C 7: 89,159,095 (GRCm39) K325E possibly damaging Het
Psmd7 T A 8: 108,313,249 (GRCm39) probably benign Het
Rfx2 T A 17: 57,115,317 (GRCm39) M1L possibly damaging Het
Rpa1 T C 11: 75,203,141 (GRCm39) Y418C probably damaging Het
Rps6kc1 C T 1: 190,505,875 (GRCm39) R1029H probably damaging Het
Septin10 A G 10: 59,002,422 (GRCm39) V391A probably benign Het
Skint6 A G 4: 113,093,637 (GRCm39) F169L probably benign Het
Slc44a4 C T 17: 35,140,674 (GRCm39) T289I probably benign Het
Spata31e5 T C 1: 28,816,137 (GRCm39) I632V probably benign Het
Srl T C 16: 4,315,546 (GRCm39) D32G probably damaging Het
Stxbp3-ps T A 19: 9,535,256 (GRCm39) noncoding transcript Het
Sult1b1 T C 5: 87,662,815 (GRCm39) D295G probably benign Het
Tmprss7 A G 16: 45,504,937 (GRCm39) V151A probably damaging Het
Trmo A G 4: 46,387,589 (GRCm39) L84P probably damaging Het
Vmn2r98 T A 17: 19,285,447 (GRCm39) I89N probably damaging Het
Zkscan16 A G 4: 58,956,690 (GRCm39) H324R possibly damaging Het
Other mutations in Zcwpw1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02316:Zcwpw1 APN 5 137,808,272 (GRCm39) unclassified probably benign
IGL02336:Zcwpw1 APN 5 137,808,376 (GRCm39) missense probably damaging 0.96
R0103:Zcwpw1 UTSW 5 137,808,375 (GRCm39) nonsense probably null
R0103:Zcwpw1 UTSW 5 137,808,375 (GRCm39) nonsense probably null
R0295:Zcwpw1 UTSW 5 137,815,734 (GRCm39) missense probably damaging 1.00
R0514:Zcwpw1 UTSW 5 137,794,945 (GRCm39) missense probably benign 0.26
R0685:Zcwpw1 UTSW 5 137,797,854 (GRCm39) missense probably benign 0.00
R0698:Zcwpw1 UTSW 5 137,815,783 (GRCm39) missense probably benign
R0727:Zcwpw1 UTSW 5 137,809,069 (GRCm39) unclassified probably benign
R1677:Zcwpw1 UTSW 5 137,795,022 (GRCm39) missense probably damaging 0.99
R1780:Zcwpw1 UTSW 5 137,794,914 (GRCm39) missense probably damaging 0.98
R1938:Zcwpw1 UTSW 5 137,809,884 (GRCm39) missense probably damaging 0.99
R2875:Zcwpw1 UTSW 5 137,808,304 (GRCm39) missense probably damaging 1.00
R4177:Zcwpw1 UTSW 5 137,798,395 (GRCm39) missense probably damaging 0.99
R5073:Zcwpw1 UTSW 5 137,793,781 (GRCm39) start codon destroyed probably null 0.81
R5913:Zcwpw1 UTSW 5 137,798,269 (GRCm39) missense probably benign 0.31
R6224:Zcwpw1 UTSW 5 137,810,298 (GRCm39) missense possibly damaging 0.63
R6542:Zcwpw1 UTSW 5 137,810,282 (GRCm39) missense probably damaging 0.98
R7204:Zcwpw1 UTSW 5 137,810,346 (GRCm39) missense probably damaging 0.98
R7542:Zcwpw1 UTSW 5 137,817,785 (GRCm39) missense probably benign 0.00
R7600:Zcwpw1 UTSW 5 137,798,396 (GRCm39) nonsense probably null
R7911:Zcwpw1 UTSW 5 137,795,032 (GRCm39) missense probably null 1.00
R7972:Zcwpw1 UTSW 5 137,799,323 (GRCm39) missense probably benign 0.13
R7988:Zcwpw1 UTSW 5 137,815,753 (GRCm39) missense possibly damaging 0.69
R8174:Zcwpw1 UTSW 5 137,817,839 (GRCm39) critical splice donor site probably null
R8713:Zcwpw1 UTSW 5 137,797,794 (GRCm39) missense probably benign 0.06
R8851:Zcwpw1 UTSW 5 137,820,626 (GRCm39) missense probably damaging 1.00
R9016:Zcwpw1 UTSW 5 137,798,340 (GRCm39) missense probably damaging 0.98
R9131:Zcwpw1 UTSW 5 137,809,182 (GRCm39) missense probably damaging 1.00
R9337:Zcwpw1 UTSW 5 137,799,274 (GRCm39) missense probably benign 0.37
X0021:Zcwpw1 UTSW 5 137,809,869 (GRCm39) missense probably damaging 1.00
Posted On 2013-10-07