Incidental Mutation 'IGL01296:Zcwpw1'
ID 73129
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zcwpw1
Ensembl Gene ENSMUSG00000037108
Gene Name zinc finger, CW type with PWWP domain 1
Synonyms LOC381678
Accession Numbers
Essential gene? Probably non essential (E-score: 0.158) question?
Stock # IGL01296
Quality Score
Status
Chromosome 5
Chromosomal Location 137787798-137822621 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 137796799 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 86 (A86T)
Ref Sequence ENSEMBL: ENSMUSP00000048730 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035852]
AlphaFold Q6IR42
Predicted Effect probably benign
Transcript: ENSMUST00000035852
AA Change: A86T

PolyPhen 2 Score 0.423 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000048730
Gene: ENSMUSG00000037108
AA Change: A86T

DomainStartEndE-ValueType
Pfam:zf-CW 246 293 7.3e-18 PFAM
Pfam:PWWP 306 401 6.9e-22 PFAM
coiled coil region 440 462 N/A INTRINSIC
low complexity region 587 598 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127541
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128946
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200505
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acadl A G 1: 66,841,705 S301P probably damaging Het
Adam34 A G 8: 43,651,141 V489A possibly damaging Het
Adcy8 G A 15: 64,783,779 T617I probably damaging Het
Aggf1 T C 13: 95,353,971 D605G probably damaging Het
Atp10a T A 7: 58,813,625 F969I probably benign Het
Becn1 A T 11: 101,291,451 N97K probably damaging Het
Cd4 G A 6: 124,879,378 T50I probably benign Het
Crtac1 A T 19: 42,284,213 C578S probably damaging Het
Dcp1b A G 6: 119,215,358 K412E probably damaging Het
Dlg2 T A 7: 91,940,059 I327N probably damaging Het
Ehf T A 2: 103,268,155 probably null Het
Elavl4 T C 4: 110,206,612 N264S probably benign Het
Enpp2 A T 15: 54,875,669 I406N probably damaging Het
F10 A T 8: 13,055,383 Y316F possibly damaging Het
Fam20a A G 11: 109,685,351 I194T possibly damaging Het
Fcgbp T C 7: 28,089,647 V546A probably benign Het
Fras1 A T 5: 96,673,698 Q1438L probably null Het
Gm43638 T C 5: 87,460,592 I463V probably benign Het
Gm597 T C 1: 28,777,056 I632V probably benign Het
H2-T10 T C 17: 36,120,710 D84G probably benign Het
Itpr1 T C 6: 108,399,361 F1262L probably damaging Het
Lama1 A G 17: 67,745,051 N335D probably benign Het
Lasp1 T C 11: 97,836,190 V246A probably damaging Het
Lrrk2 A T 15: 91,683,142 I135L probably benign Het
Malrd1 G A 2: 16,101,957 probably null Het
Mctp2 T C 7: 72,228,526 K268R probably benign Het
Nbea A T 3: 56,031,536 H710Q probably benign Het
Notch3 G A 17: 32,166,757 R13C unknown Het
Ogfod1 A T 8: 94,055,671 probably benign Het
Olfr1465 A G 19: 13,314,126 L53P probably damaging Het
Olfr339 A G 2: 36,421,704 Y102C probably benign Het
Olfr924 T C 9: 38,848,252 I46T probably damaging Het
Pgm3 A G 9: 86,561,879 V324A probably damaging Het
Ppfia2 A T 10: 106,858,207 I681F probably damaging Het
Prss23 T C 7: 89,509,887 K325E possibly damaging Het
Psmd7 T A 8: 107,586,617 probably benign Het
Rfx2 T A 17: 56,808,317 M1L possibly damaging Het
Rpa1 T C 11: 75,312,315 Y418C probably damaging Het
Rps6kc1 C T 1: 190,773,678 R1029H probably damaging Het
Sept10 A G 10: 59,166,600 V391A probably benign Het
Skint6 A G 4: 113,236,440 F169L probably benign Het
Slc44a4 C T 17: 34,921,698 T289I probably benign Het
Srl T C 16: 4,497,682 D32G probably damaging Het
Stxbp3-ps T A 19: 9,557,892 noncoding transcript Het
Sult1b1 T C 5: 87,514,956 D295G probably benign Het
Tmprss7 A G 16: 45,684,574 V151A probably damaging Het
Trmo A G 4: 46,387,589 L84P probably damaging Het
Vmn2r98 T A 17: 19,065,185 I89N probably damaging Het
Zkscan16 A G 4: 58,956,690 H324R possibly damaging Het
Other mutations in Zcwpw1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02316:Zcwpw1 APN 5 137810010 unclassified probably benign
IGL02336:Zcwpw1 APN 5 137810114 missense probably damaging 0.96
R0103:Zcwpw1 UTSW 5 137810113 nonsense probably null
R0103:Zcwpw1 UTSW 5 137810113 nonsense probably null
R0295:Zcwpw1 UTSW 5 137817472 missense probably damaging 1.00
R0514:Zcwpw1 UTSW 5 137796683 missense probably benign 0.26
R0685:Zcwpw1 UTSW 5 137799592 missense probably benign 0.00
R0698:Zcwpw1 UTSW 5 137817521 missense probably benign
R0727:Zcwpw1 UTSW 5 137810807 unclassified probably benign
R1677:Zcwpw1 UTSW 5 137796760 missense probably damaging 0.99
R1780:Zcwpw1 UTSW 5 137796652 missense probably damaging 0.98
R1938:Zcwpw1 UTSW 5 137811622 missense probably damaging 0.99
R2875:Zcwpw1 UTSW 5 137810042 missense probably damaging 1.00
R4177:Zcwpw1 UTSW 5 137800133 missense probably damaging 0.99
R5073:Zcwpw1 UTSW 5 137795519 start codon destroyed probably null 0.81
R5913:Zcwpw1 UTSW 5 137800007 missense probably benign 0.31
R6224:Zcwpw1 UTSW 5 137812036 missense possibly damaging 0.63
R6542:Zcwpw1 UTSW 5 137812020 missense probably damaging 0.98
R7204:Zcwpw1 UTSW 5 137812084 missense probably damaging 0.98
R7542:Zcwpw1 UTSW 5 137819523 missense probably benign 0.00
R7600:Zcwpw1 UTSW 5 137800134 nonsense probably null
R7911:Zcwpw1 UTSW 5 137796770 missense probably null 1.00
R7972:Zcwpw1 UTSW 5 137801061 missense probably benign 0.13
R7988:Zcwpw1 UTSW 5 137817491 missense possibly damaging 0.69
R8174:Zcwpw1 UTSW 5 137819577 critical splice donor site probably null
R8713:Zcwpw1 UTSW 5 137799532 missense probably benign 0.06
R8851:Zcwpw1 UTSW 5 137822364 missense probably damaging 1.00
R9016:Zcwpw1 UTSW 5 137800078 missense probably damaging 0.98
R9131:Zcwpw1 UTSW 5 137810920 missense probably damaging 1.00
R9337:Zcwpw1 UTSW 5 137801012 missense probably benign 0.37
X0021:Zcwpw1 UTSW 5 137811607 missense probably damaging 1.00
Posted On 2013-10-07