Incidental Mutation 'R9733:Glp2r'
ID |
731566 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Glp2r
|
Ensembl Gene |
ENSMUSG00000049928 |
Gene Name |
glucagon-like peptide 2 receptor |
Synonyms |
GLP-2, 9530092J08Rik |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R9733 (G1)
|
Quality Score |
225.009 |
Status
|
Not validated
|
Chromosome |
11 |
Chromosomal Location |
67554877-67661979 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 67648367 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Alanine
at position 112
(T112A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000061560
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021289]
[ENSMUST00000051765]
|
AlphaFold |
Q5IXF8 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000021289
|
SMART Domains |
Protein: ENSMUSP00000021289 Gene: ENSMUSG00000049928
Domain | Start | End | E-Value | Type |
Pfam:7tm_2
|
17 |
225 |
4.8e-54 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000051765
AA Change: T112A
PolyPhen 2
Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
|
SMART Domains |
Protein: ENSMUSP00000061560 Gene: ENSMUSG00000049928 AA Change: T112A
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
Pfam:HRM
|
53 |
122 |
3.4e-16 |
PFAM |
Pfam:7tm_2
|
137 |
394 |
1.5e-79 |
PFAM |
|
Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 99.3%
- 20x: 98.3%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-coupled receptor that is closely related to the glucagon receptor and binds to glucagon-like peptide-2 (GLP2). Signalling through GLP2 stimulates intestinal growth and increases villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. [provided by RefSeq, Dec 2014] PHENOTYPE: Mice homozygous for a null mutation display defects in Paneth cell physiology, increased small bowel bacterial loads, and increased susceptibility to small bowel injury. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 76 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2610042L04Rik |
C |
T |
14: 15,712,825 (GRCm39) |
|
probably benign |
Het |
4930595D18Rik |
T |
A |
12: 111,128,254 (GRCm39) |
|
probably benign |
Het |
Adam34l |
T |
C |
8: 44,079,186 (GRCm39) |
N346S |
possibly damaging |
Het |
Alpi |
C |
T |
1: 87,028,516 (GRCm39) |
A125T |
probably benign |
Het |
Alppl2 |
T |
A |
1: 87,014,957 (GRCm39) |
H468L |
probably damaging |
Het |
Arhgef12 |
A |
T |
9: 42,901,294 (GRCm39) |
L836* |
probably null |
Het |
Arv1 |
T |
C |
8: 125,458,658 (GRCm39) |
Y261H |
probably damaging |
Het |
Atf6 |
C |
T |
1: 170,662,402 (GRCm39) |
S286N |
probably benign |
Het |
Atl3 |
G |
A |
19: 7,509,705 (GRCm39) |
G478R |
probably damaging |
Het |
Avil |
C |
T |
10: 126,843,711 (GRCm39) |
R184C |
probably damaging |
Het |
Bcl6b |
A |
G |
11: 70,119,323 (GRCm39) |
I131T |
probably damaging |
Het |
Bltp1 |
T |
A |
3: 37,102,732 (GRCm39) |
M1437K |
|
Het |
Catsper3 |
T |
C |
13: 55,946,752 (GRCm39) |
S150P |
probably damaging |
Het |
Cd7 |
A |
G |
11: 120,928,637 (GRCm39) |
S132P |
probably benign |
Het |
Cfh |
T |
C |
1: 140,016,533 (GRCm39) |
D1142G |
probably damaging |
Het |
Clca4b |
T |
G |
3: 144,621,272 (GRCm39) |
K601Q |
probably benign |
Het |
Cp |
A |
G |
3: 20,033,126 (GRCm39) |
H651R |
probably damaging |
Het |
Cyp2s1 |
T |
A |
7: 25,507,529 (GRCm39) |
T307S |
probably damaging |
Het |
Dcaf11 |
A |
G |
14: 55,803,170 (GRCm39) |
D328G |
probably damaging |
Het |
Eapp |
A |
T |
12: 54,739,741 (GRCm39) |
S25R |
probably damaging |
Het |
Ebag9 |
T |
A |
15: 44,491,033 (GRCm39) |
|
probably null |
Het |
Exog |
G |
A |
9: 119,291,586 (GRCm39) |
E288K |
possibly damaging |
Het |
Fads2 |
A |
T |
19: 10,047,940 (GRCm39) |
Y265N |
probably damaging |
Het |
Fam234b |
T |
A |
6: 135,194,008 (GRCm39) |
S220R |
possibly damaging |
Het |
Fcgbp |
T |
A |
7: 27,803,012 (GRCm39) |
C1539S |
probably damaging |
Het |
Fcsk |
T |
C |
8: 111,615,563 (GRCm39) |
T589A |
probably benign |
Het |
Fv1 |
C |
T |
4: 147,954,621 (GRCm39) |
R396W |
probably damaging |
Het |
Fv1 |
T |
C |
4: 147,954,654 (GRCm39) |
F407L |
probably benign |
Het |
Hydin |
T |
C |
8: 111,262,011 (GRCm39) |
I2704T |
probably benign |
Het |
Ighm |
T |
A |
12: 113,386,097 (GRCm39) |
E84D |
probably benign |
Het |
Ikzf5 |
A |
G |
7: 130,994,012 (GRCm39) |
V205A |
probably benign |
Het |
Kcnt1 |
G |
T |
2: 25,797,351 (GRCm39) |
V844L |
probably benign |
Het |
Kif2a |
A |
C |
13: 107,106,304 (GRCm39) |
S528R |
probably damaging |
Het |
Klhl29 |
G |
A |
12: 5,190,641 (GRCm39) |
T118M |
probably damaging |
Het |
Krt4 |
C |
A |
15: 101,827,564 (GRCm39) |
G492C |
unknown |
Het |
Lama1 |
T |
A |
17: 68,116,940 (GRCm39) |
I2441N |
|
Het |
Lin7a |
T |
C |
10: 107,247,905 (GRCm39) |
V192A |
possibly damaging |
Het |
Marchf8 |
T |
A |
6: 116,378,990 (GRCm39) |
V308D |
probably damaging |
Het |
Mgat5b |
T |
C |
11: 116,838,074 (GRCm39) |
S238P |
possibly damaging |
Het |
Mrps25 |
A |
G |
6: 92,155,715 (GRCm39) |
S73P |
probably damaging |
Het |
Muc6 |
G |
T |
7: 141,216,310 (GRCm39) |
P2788T |
unknown |
Het |
Ncf1 |
T |
C |
5: 134,250,899 (GRCm39) |
T347A |
probably benign |
Het |
Ndufaf4 |
T |
C |
4: 24,903,177 (GRCm39) |
M122T |
probably benign |
Het |
Nfil3 |
C |
T |
13: 53,121,591 (GRCm39) |
A438T |
probably damaging |
Het |
Noc2l |
T |
G |
4: 156,328,022 (GRCm39) |
I504S |
probably damaging |
Het |
Nphs1 |
T |
C |
7: 30,166,955 (GRCm39) |
C735R |
probably damaging |
Het |
Or10g6 |
A |
T |
9: 39,934,171 (GRCm39) |
S161C |
probably benign |
Het |
Or2y10 |
T |
C |
11: 49,454,961 (GRCm39) |
L71P |
probably damaging |
Het |
Or5d38 |
C |
A |
2: 87,955,000 (GRCm39) |
V110L |
probably damaging |
Het |
Or6b9 |
A |
C |
7: 106,555,846 (GRCm39) |
L99R |
possibly damaging |
Het |
Pcdhac1 |
A |
G |
18: 37,225,506 (GRCm39) |
H773R |
probably benign |
Het |
Pcnt |
A |
G |
10: 76,237,314 (GRCm39) |
V1324A |
probably benign |
Het |
Pcsk4 |
T |
C |
10: 80,158,034 (GRCm39) |
Y568C |
probably damaging |
Het |
Pdlim1 |
A |
T |
19: 40,219,040 (GRCm39) |
M197K |
probably damaging |
Het |
Plekho1 |
C |
T |
3: 95,903,091 (GRCm39) |
G7S |
probably benign |
Het |
Pramel17 |
A |
G |
4: 101,692,965 (GRCm39) |
V345A |
possibly damaging |
Het |
Prl7d1 |
A |
C |
13: 27,898,339 (GRCm39) |
S57A |
probably benign |
Het |
Prpf3 |
A |
G |
3: 95,741,512 (GRCm39) |
V548A |
possibly damaging |
Het |
Prss56 |
C |
T |
1: 87,111,219 (GRCm39) |
P2L |
possibly damaging |
Het |
Ric1 |
A |
G |
19: 29,580,030 (GRCm39) |
D1277G |
possibly damaging |
Het |
Rnf19b |
T |
A |
4: 128,977,812 (GRCm39) |
D676E |
probably damaging |
Het |
Rph3a |
T |
A |
5: 121,100,521 (GRCm39) |
T126S |
probably benign |
Het |
Sh3gl3 |
T |
C |
7: 81,917,562 (GRCm39) |
|
probably null |
Het |
Slc14a1 |
C |
A |
18: 78,152,807 (GRCm39) |
A367S |
probably damaging |
Het |
Slc35f2 |
T |
C |
9: 53,708,385 (GRCm39) |
V126A |
probably benign |
Het |
Snrnp200 |
A |
T |
2: 127,068,240 (GRCm39) |
Q860L |
probably damaging |
Het |
Srbd1 |
T |
C |
17: 86,422,711 (GRCm39) |
N435S |
probably damaging |
Het |
Tab2 |
A |
G |
10: 7,795,214 (GRCm39) |
S349P |
possibly damaging |
Het |
Tie1 |
A |
T |
4: 118,330,183 (GRCm39) |
W1040R |
probably null |
Het |
Tnni3k |
A |
T |
3: 154,562,244 (GRCm39) |
Y678N |
probably damaging |
Het |
Trav12-3 |
T |
C |
14: 53,859,474 (GRCm39) |
V40A |
possibly damaging |
Het |
Ttn |
G |
A |
2: 76,576,379 (GRCm39) |
S24838L |
probably damaging |
Het |
Ttn |
A |
G |
2: 76,725,660 (GRCm39) |
W6158R |
unknown |
Het |
Vegfa |
T |
C |
17: 46,335,401 (GRCm39) |
S298G |
probably damaging |
Het |
Zer1 |
T |
C |
2: 29,997,643 (GRCm39) |
K421R |
probably benign |
Het |
Zfp959 |
C |
A |
17: 56,204,866 (GRCm39) |
T301N |
probably benign |
Het |
|
Other mutations in Glp2r |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01018:Glp2r
|
APN |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
IGL02244:Glp2r
|
APN |
11 |
67,612,817 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02484:Glp2r
|
APN |
11 |
67,630,992 (GRCm39) |
missense |
possibly damaging |
0.90 |
R0013:Glp2r
|
UTSW |
11 |
67,600,538 (GRCm39) |
missense |
possibly damaging |
0.88 |
R0013:Glp2r
|
UTSW |
11 |
67,600,538 (GRCm39) |
missense |
possibly damaging |
0.88 |
R0195:Glp2r
|
UTSW |
11 |
67,600,534 (GRCm39) |
missense |
probably damaging |
0.99 |
R1612:Glp2r
|
UTSW |
11 |
67,633,033 (GRCm39) |
missense |
possibly damaging |
0.46 |
R1699:Glp2r
|
UTSW |
11 |
67,648,367 (GRCm39) |
missense |
probably benign |
0.09 |
R1944:Glp2r
|
UTSW |
11 |
67,637,618 (GRCm39) |
missense |
probably benign |
0.01 |
R3971:Glp2r
|
UTSW |
11 |
67,637,641 (GRCm39) |
missense |
possibly damaging |
0.65 |
R4417:Glp2r
|
UTSW |
11 |
67,555,342 (GRCm39) |
intron |
probably benign |
|
R4681:Glp2r
|
UTSW |
11 |
67,621,453 (GRCm39) |
splice site |
probably null |
|
R4914:Glp2r
|
UTSW |
11 |
67,648,419 (GRCm39) |
nonsense |
probably null |
|
R4918:Glp2r
|
UTSW |
11 |
67,648,419 (GRCm39) |
nonsense |
probably null |
|
R4938:Glp2r
|
UTSW |
11 |
67,648,419 (GRCm39) |
nonsense |
probably null |
|
R4940:Glp2r
|
UTSW |
11 |
67,648,419 (GRCm39) |
nonsense |
probably null |
|
R4941:Glp2r
|
UTSW |
11 |
67,637,529 (GRCm39) |
splice site |
probably null |
|
R4963:Glp2r
|
UTSW |
11 |
67,648,419 (GRCm39) |
nonsense |
probably null |
|
R4966:Glp2r
|
UTSW |
11 |
67,648,419 (GRCm39) |
nonsense |
probably null |
|
R5023:Glp2r
|
UTSW |
11 |
67,631,858 (GRCm39) |
missense |
possibly damaging |
0.82 |
R5121:Glp2r
|
UTSW |
11 |
67,612,926 (GRCm39) |
splice site |
probably null |
|
R5313:Glp2r
|
UTSW |
11 |
67,648,357 (GRCm39) |
missense |
probably damaging |
0.96 |
R5705:Glp2r
|
UTSW |
11 |
67,600,565 (GRCm39) |
missense |
probably benign |
0.30 |
R5790:Glp2r
|
UTSW |
11 |
67,655,625 (GRCm39) |
missense |
probably damaging |
1.00 |
R6074:Glp2r
|
UTSW |
11 |
67,637,640 (GRCm39) |
missense |
unknown |
|
R6595:Glp2r
|
UTSW |
11 |
67,655,603 (GRCm39) |
missense |
probably benign |
0.10 |
R6910:Glp2r
|
UTSW |
11 |
67,621,497 (GRCm39) |
missense |
probably benign |
0.28 |
R7511:Glp2r
|
UTSW |
11 |
67,648,417 (GRCm39) |
missense |
probably damaging |
0.98 |
R7627:Glp2r
|
UTSW |
11 |
67,637,589 (GRCm39) |
missense |
unknown |
|
R7681:Glp2r
|
UTSW |
11 |
67,600,505 (GRCm39) |
missense |
probably benign |
0.45 |
R7779:Glp2r
|
UTSW |
11 |
67,600,609 (GRCm39) |
nonsense |
probably null |
|
R8743:Glp2r
|
UTSW |
11 |
67,612,901 (GRCm39) |
missense |
probably damaging |
0.98 |
R8841:Glp2r
|
UTSW |
11 |
67,653,555 (GRCm39) |
missense |
probably damaging |
1.00 |
R9093:Glp2r
|
UTSW |
11 |
67,621,459 (GRCm39) |
nonsense |
probably null |
|
R9380:Glp2r
|
UTSW |
11 |
67,637,572 (GRCm39) |
missense |
possibly damaging |
0.67 |
R9576:Glp2r
|
UTSW |
11 |
67,655,622 (GRCm39) |
missense |
probably benign |
0.01 |
Z1186:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1186:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1186:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1186:Glp2r
|
UTSW |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
Z1186:Glp2r
|
UTSW |
11 |
67,600,472 (GRCm39) |
missense |
probably benign |
|
Z1186:Glp2r
|
UTSW |
11 |
67,630,949 (GRCm39) |
missense |
probably benign |
0.03 |
Z1186:Glp2r
|
UTSW |
11 |
67,630,993 (GRCm39) |
missense |
probably benign |
|
Z1186:Glp2r
|
UTSW |
11 |
67,631,878 (GRCm39) |
missense |
probably benign |
|
Z1186:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1186:Glp2r
|
UTSW |
11 |
67,633,129 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,633,129 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1187:Glp2r
|
UTSW |
11 |
67,631,878 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,630,993 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,600,472 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
Z1187:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1187:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1188:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1188:Glp2r
|
UTSW |
11 |
67,633,129 (GRCm39) |
missense |
probably benign |
|
Z1188:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1188:Glp2r
|
UTSW |
11 |
67,631,878 (GRCm39) |
missense |
probably benign |
|
Z1188:Glp2r
|
UTSW |
11 |
67,630,993 (GRCm39) |
missense |
probably benign |
|
Z1188:Glp2r
|
UTSW |
11 |
67,600,472 (GRCm39) |
missense |
probably benign |
|
Z1188:Glp2r
|
UTSW |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
Z1188:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1188:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1189:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1189:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1189:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1189:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1190:Glp2r
|
UTSW |
11 |
67,633,129 (GRCm39) |
missense |
probably benign |
|
Z1190:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1190:Glp2r
|
UTSW |
11 |
67,631,878 (GRCm39) |
missense |
probably benign |
|
Z1190:Glp2r
|
UTSW |
11 |
67,630,993 (GRCm39) |
missense |
probably benign |
|
Z1190:Glp2r
|
UTSW |
11 |
67,630,949 (GRCm39) |
missense |
probably benign |
0.03 |
Z1190:Glp2r
|
UTSW |
11 |
67,600,472 (GRCm39) |
missense |
probably benign |
|
Z1190:Glp2r
|
UTSW |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
Z1190:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1190:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1190:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,633,129 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1191:Glp2r
|
UTSW |
11 |
67,631,878 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,630,993 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,600,472 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
Z1191:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
Z1191:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1192:Glp2r
|
UTSW |
11 |
67,661,662 (GRCm39) |
missense |
probably benign |
0.01 |
Z1192:Glp2r
|
UTSW |
11 |
67,635,773 (GRCm39) |
missense |
probably benign |
|
Z1192:Glp2r
|
UTSW |
11 |
67,633,129 (GRCm39) |
missense |
probably benign |
|
Z1192:Glp2r
|
UTSW |
11 |
67,631,885 (GRCm39) |
missense |
probably benign |
0.00 |
Z1192:Glp2r
|
UTSW |
11 |
67,631,878 (GRCm39) |
missense |
probably benign |
|
Z1192:Glp2r
|
UTSW |
11 |
67,600,472 (GRCm39) |
missense |
probably benign |
|
Z1192:Glp2r
|
UTSW |
11 |
67,600,470 (GRCm39) |
missense |
probably benign |
|
Z1192:Glp2r
|
UTSW |
11 |
67,600,394 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Predicted Primers |
PCR Primer
(F):5'- ACCAATGGGAGTTGCTGTTC -3'
(R):5'- AAACGAAACCCTCTTTCCCTGG -3'
Sequencing Primer
(F):5'- CAATGGGAGTTGCTGTTCTGGTG -3'
(R):5'- GGGATTTTCCACAGCTTTTTAGC -3'
|
Posted On |
2022-11-14 |