Incidental Mutation 'R9735:Zfp51'
| ID |
731650 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp51
|
| Ensembl Gene |
ENSMUSG00000023892 |
| Gene Name |
zinc finger protein 51 |
| Synonyms |
zfec12, Zfp-51 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.452)
|
| Stock # |
R9735 (G1)
|
| Quality Score |
205.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
21670636-21685849 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
C to A
at 21685413 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Stop codon
at position 676
(S676*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000045684
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000039577]
|
| AlphaFold |
Q3U4L8 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000039577
AA Change: S676*
|
| SMART Domains |
Protein: ENSMUSP00000045684
Gene: ENSMUSG00000023892
AA Change: S676*
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
43 |
103 |
1.71e-22 |
SMART |
|
ZnF_C2H2
|
214 |
236 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
242 |
264 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
270 |
292 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
298 |
320 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
326 |
348 |
7.15e-2 |
SMART |
|
ZnF_C2H2
|
354 |
376 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
382 |
404 |
3.44e-4 |
SMART |
|
ZnF_C2H2
|
410 |
432 |
9.88e-5 |
SMART |
|
ZnF_C2H2
|
438 |
460 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
466 |
488 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
494 |
517 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
523 |
545 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
551 |
573 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
579 |
601 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
607 |
629 |
2.79e-4 |
SMART |
|
ZnF_C2H2
|
635 |
657 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
663 |
685 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
691 |
713 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
719 |
741 |
1.36e-2 |
SMART |
|
ZnF_C2H2
|
747 |
769 |
6.82e1 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.6%
- 10x: 99.1%
- 20x: 98.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adcy7 |
T |
C |
8: 89,037,262 (GRCm39) |
V215A |
probably benign |
Het |
| Arhgef12 |
G |
A |
9: 42,882,399 (GRCm39) |
R1482* |
probably null |
Het |
| Atp9b |
A |
T |
18: 80,838,629 (GRCm39) |
D428E |
|
Het |
| Bnip3l |
G |
A |
14: 67,246,214 (GRCm39) |
P7L |
possibly damaging |
Het |
| Cd6 |
A |
G |
19: 10,775,235 (GRCm39) |
S296P |
probably benign |
Het |
| Cpt1a |
A |
G |
19: 3,420,825 (GRCm39) |
R428G |
probably benign |
Het |
| Csmd2 |
A |
C |
4: 128,402,901 (GRCm39) |
T2330P |
|
Het |
| D6Ertd527e |
G |
C |
6: 87,088,839 (GRCm39) |
S334T |
unknown |
Het |
| Dcaf4 |
T |
A |
12: 83,572,939 (GRCm39) |
I18N |
probably benign |
Het |
| Ern1 |
A |
T |
11: 106,312,708 (GRCm39) |
Y224* |
probably null |
Het |
| Ero1a |
T |
A |
14: 45,533,435 (GRCm39) |
S224C |
possibly damaging |
Het |
| Fcgbpl1 |
T |
A |
7: 27,856,435 (GRCm39) |
V2074E |
probably damaging |
Het |
| Flg2 |
A |
G |
3: 93,127,669 (GRCm39) |
S2194G |
unknown |
Het |
| Fnip1 |
A |
T |
11: 54,394,273 (GRCm39) |
D903V |
probably damaging |
Het |
| Lss |
G |
T |
10: 76,382,615 (GRCm39) |
A497S |
probably benign |
Het |
| Mark3 |
T |
C |
12: 111,621,882 (GRCm39) |
F675L |
probably benign |
Het |
| Mylk |
T |
C |
16: 34,735,179 (GRCm39) |
F720L |
probably benign |
Het |
| Nup210 |
A |
C |
6: 91,030,630 (GRCm39) |
S884A |
probably benign |
Het |
| Or2j6 |
T |
A |
7: 139,980,378 (GRCm39) |
M194L |
probably benign |
Het |
| Or4p20 |
A |
T |
2: 88,253,501 (GRCm39) |
N289K |
probably damaging |
Het |
| Osbpl5 |
C |
T |
7: 143,248,673 (GRCm39) |
V630I |
possibly damaging |
Het |
| Pkd1l2 |
A |
G |
8: 117,772,820 (GRCm39) |
I1069T |
possibly damaging |
Het |
| Rnaseh2a |
C |
T |
8: 85,686,661 (GRCm39) |
V163M |
probably damaging |
Het |
| Septin9 |
T |
A |
11: 117,245,680 (GRCm39) |
V434E |
probably damaging |
Het |
| Slc36a3 |
A |
T |
11: 55,026,104 (GRCm39) |
I238N |
probably damaging |
Het |
| Spin1 |
T |
A |
13: 51,293,521 (GRCm39) |
L77Q |
probably damaging |
Het |
| Spint1 |
A |
G |
2: 119,076,897 (GRCm39) |
D327G |
probably damaging |
Het |
| Tmub2 |
A |
G |
11: 102,178,352 (GRCm39) |
D123G |
|
Het |
| Vps13a |
A |
T |
19: 16,701,111 (GRCm39) |
L686Q |
probably damaging |
Het |
|
| Other mutations in Zfp51 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00420:Zfp51
|
APN |
17 |
21,683,714 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL00971:Zfp51
|
APN |
17 |
21,683,844 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02002:Zfp51
|
APN |
17 |
21,684,221 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02268:Zfp51
|
APN |
17 |
21,683,681 (GRCm39) |
nonsense |
probably null |
|
|
IGL03249:Zfp51
|
APN |
17 |
21,683,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1569:Zfp51
|
UTSW |
17 |
21,676,642 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1853:Zfp51
|
UTSW |
17 |
21,684,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1989:Zfp51
|
UTSW |
17 |
21,676,582 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2285:Zfp51
|
UTSW |
17 |
21,684,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2407:Zfp51
|
UTSW |
17 |
21,684,093 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2890:Zfp51
|
UTSW |
17 |
21,684,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3918:Zfp51
|
UTSW |
17 |
21,683,702 (GRCm39) |
missense |
probably benign |
|
|
R4529:Zfp51
|
UTSW |
17 |
21,684,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4587:Zfp51
|
UTSW |
17 |
21,685,178 (GRCm39) |
nonsense |
probably null |
|
|
R4866:Zfp51
|
UTSW |
17 |
21,682,012 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4872:Zfp51
|
UTSW |
17 |
21,684,933 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4961:Zfp51
|
UTSW |
17 |
21,676,615 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5392:Zfp51
|
UTSW |
17 |
21,685,584 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R5611:Zfp51
|
UTSW |
17 |
21,684,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7109:Zfp51
|
UTSW |
17 |
21,683,831 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7129:Zfp51
|
UTSW |
17 |
21,681,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7269:Zfp51
|
UTSW |
17 |
21,683,960 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7303:Zfp51
|
UTSW |
17 |
21,684,058 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7514:Zfp51
|
UTSW |
17 |
21,683,762 (GRCm39) |
missense |
probably benign |
0.37 |
|
R7665:Zfp51
|
UTSW |
17 |
21,683,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8073:Zfp51
|
UTSW |
17 |
21,684,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8177:Zfp51
|
UTSW |
17 |
21,684,129 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8560:Zfp51
|
UTSW |
17 |
21,685,635 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8877:Zfp51
|
UTSW |
17 |
21,682,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9032:Zfp51
|
UTSW |
17 |
21,684,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9085:Zfp51
|
UTSW |
17 |
21,684,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9307:Zfp51
|
UTSW |
17 |
21,684,733 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9489:Zfp51
|
UTSW |
17 |
21,684,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9605:Zfp51
|
UTSW |
17 |
21,684,291 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9686:Zfp51
|
UTSW |
17 |
21,683,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9795:Zfp51
|
UTSW |
17 |
21,682,051 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0062:Zfp51
|
UTSW |
17 |
21,685,257 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTTTACCCAGGTCTCACA -3'
(R):5'- AGAGAAGCTTTTGACATAATAGGCA -3'
Sequencing Primer
(F):5'- CATCTTAGAACACATCAGAGAGTTC -3'
(R):5'- GGTATGTTTCACTCCAGTATGAACTC -3'
|
| Posted On |
2022-11-14 |
Incidental Mutation