Mutagenetix > Incidental Mutation

Incidental Mutation 'R9737:Trav13-1'

731706

Institutional Source

Beutler Lab

Gene Symbol

Trav13-1

Ensembl Gene

ENSMUSG00000076839

Gene Name

T cell receptor alpha variable 13-1

Synonyms

Gm16980

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.090) question?

Stock #

R9737 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

53782471-53782982 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 53782510 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 14 (T14S)

Ref Sequence

ENSEMBL: ENSMUSP00000100428 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103651]

AlphaFold

A0A075B644

Predicted Effect

probably benign
Transcript: ENSMUST00000103651
AA Change: T14S

PolyPhen 2 Score 0.068 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000100428
Gene: ENSMUSG00000076839
AA Change: T14S

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGv	38	109	1.6e-10	SMART

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 99.4%
20x: 98.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 18 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adnp	T	C	2: 168,026,918 (GRCm39)	K126E	possibly damaging	Het
Bnip3l	G	A	14: 67,246,214 (GRCm39)	P7L	possibly damaging	Het
Ccnjl	C	A	11: 43,476,166 (GRCm39)	T263K	probably benign	Het
Cfhr4	A	T	1: 139,708,872 (GRCm39)	I12N	probably damaging	Het
D6Ertd527e	G	C	6: 87,088,839 (GRCm39)	S334T	unknown	Het
Epha2	A	G	4: 141,045,814 (GRCm39)	E446G	probably benign	Het
Gtf2ird1	A	G	5: 134,408,794 (GRCm39)	Y702H	probably damaging	Het
Igkv10-96	T	C	6: 68,608,957 (GRCm39)	T113A	probably benign	Het
Jhy	T	C	9: 40,808,748 (GRCm39)	E671G	probably damaging	Het
Ngdn	A	G	14: 55,259,339 (GRCm39)	K161R	possibly damaging	Het
Pabpc4l	A	G	3: 46,401,267 (GRCm39)	S126P	probably damaging	Het
Phlpp2	G	A	8: 110,663,714 (GRCm39)	D918N	probably damaging	Het
Pkd2	A	T	5: 104,651,349 (GRCm39)	H899L	possibly damaging	Het
Pou6f1	A	G	15: 100,481,282 (GRCm39)	S301P	probably benign	Het
Sidt1	A	G	16: 44,102,243 (GRCm39)	Y306H	probably damaging	Het
Vmn2r99	A	C	17: 19,582,563 (GRCm39)	E56A	probably benign	Het
Vnn3	A	G	10: 23,741,813 (GRCm39)	M373V	probably benign	Het
Zkscan5	A	G	5: 145,142,136 (GRCm39)	H11R	probably benign	Het

Other mutations in Trav13-1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R6376:Trav13-1	UTSW	14	53,782,800 (GRCm39)	missense	probably benign	0.12
R9669:Trav13-1	UTSW	14	53,782,510 (GRCm39)	missense	probably benign	0.07

Predicted Primers

PCR Primer
(F):5'- TCTACCCAATCTCTCAGCGAGG -3'
(R):5'- AGATGGCTGTCACTGCAGTG -3'

Sequencing Primer
(F):5'- AATCTCTCAGCGAGGTCTTGCATG -3'
(R):5'- TGTCACTGCAGTGTCCACAGAG -3'

Posted On

2022-11-14