Incidental Mutation 'R9738:Cpxm1'
ID 731712
Institutional Source Beutler Lab
Gene Symbol Cpxm1
Ensembl Gene ENSMUSG00000027408
Gene Name carboxypeptidase X, M14 family member 1
Synonyms Cpx-1
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.462) question?
Stock # R9738 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 130232695-130239494 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 130235302 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000028897 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028897]
AlphaFold Q9Z100
Predicted Effect probably null
Transcript: ENSMUST00000028897
SMART Domains Protein: ENSMUSP00000028897
Gene: ENSMUSG00000027408

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 56 75 N/A INTRINSIC
FA58C 104 263 1.44e-28 SMART
Zn_pept 410 699 5.77e-50 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the protein appears to lack residues necessary for carboxypeptidase activity.[provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd12b A G 12: 70,216,039 (GRCm39) T199A probably benign Het
Ank2 A G 3: 126,737,121 (GRCm39) F2921S unknown Het
Atg12 A G 18: 46,874,505 (GRCm39) S37P probably benign Het
Bnip3l G A 14: 67,246,214 (GRCm39) P7L possibly damaging Het
Cdh5 A G 8: 104,863,329 (GRCm39) D413G probably damaging Het
Cdk8 A G 5: 146,236,539 (GRCm39) N318S probably benign Het
Clasp2 T A 9: 113,590,665 (GRCm39) L68* probably null Het
Cntnap2 CCACATAAACAACACACA CCACA 6: 45,992,373 (GRCm39) probably null Het
Cpne9 A C 6: 113,267,401 (GRCm39) N194T probably damaging Het
Crtc1 T C 8: 70,840,205 (GRCm39) N556S probably damaging Het
Gm12888 A T 4: 121,175,520 (GRCm39) C87* probably null Het
Hivep2 A G 10: 14,019,583 (GRCm39) E2118G probably damaging Het
Hrh4 A G 18: 13,155,270 (GRCm39) N270D possibly damaging Het
Iqsec1 G A 6: 90,671,672 (GRCm39) Q77* probably null Het
Lars1 A G 18: 42,350,649 (GRCm39) W887R probably damaging Het
Lgr5 A G 10: 115,288,527 (GRCm39) Y706H probably damaging Het
Ltn1 A T 16: 87,222,524 (GRCm39) F170I probably damaging Het
Msrb1 T C 17: 24,958,535 (GRCm39) S40P probably damaging Het
Myh6 T C 14: 55,189,759 (GRCm39) I1096V probably benign Het
Myh7b A G 2: 155,455,963 (GRCm39) Y116C probably damaging Het
Ndrg2 T C 14: 52,148,238 (GRCm39) H41R possibly damaging Het
Or5an11 A G 19: 12,245,869 (GRCm39) T92A probably benign Het
Spag17 A G 3: 99,934,526 (GRCm39) T603A possibly damaging Het
Sugp1 T A 8: 70,505,256 (GRCm39) H74Q probably benign Het
Tjp1 T C 7: 64,986,380 (GRCm39) T243A probably benign Het
Tsnaxip1 A G 8: 106,568,390 (GRCm39) E358G possibly damaging Het
Unc5d T A 8: 29,214,332 (GRCm39) H410L probably benign Het
Usp1 T C 4: 98,819,672 (GRCm39) V378A probably benign Het
Wdtc1 A G 4: 133,022,604 (GRCm39) S581P probably damaging Het
Zfp947 A G 17: 22,365,341 (GRCm39) V111A probably benign Het
Other mutations in Cpxm1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00264:Cpxm1 APN 2 130,237,863 (GRCm39) missense probably damaging 1.00
IGL01327:Cpxm1 APN 2 130,238,277 (GRCm39) missense probably benign 0.00
IGL01373:Cpxm1 APN 2 130,236,055 (GRCm39) missense probably damaging 1.00
IGL01622:Cpxm1 APN 2 130,233,191 (GRCm39) missense probably benign 0.00
IGL01623:Cpxm1 APN 2 130,233,191 (GRCm39) missense probably benign 0.00
IGL01981:Cpxm1 APN 2 130,236,060 (GRCm39) nonsense probably null
IGL02031:Cpxm1 APN 2 130,235,601 (GRCm39) missense probably damaging 1.00
IGL02369:Cpxm1 APN 2 130,238,344 (GRCm39) missense probably damaging 1.00
IGL03057:Cpxm1 APN 2 130,235,109 (GRCm39) missense probably damaging 1.00
BB007:Cpxm1 UTSW 2 130,236,982 (GRCm39) missense possibly damaging 0.95
BB017:Cpxm1 UTSW 2 130,236,982 (GRCm39) missense possibly damaging 0.95
R0316:Cpxm1 UTSW 2 130,235,091 (GRCm39) missense probably damaging 1.00
R0544:Cpxm1 UTSW 2 130,235,055 (GRCm39) missense probably damaging 1.00
R0726:Cpxm1 UTSW 2 130,232,859 (GRCm39) missense probably damaging 0.96
R0944:Cpxm1 UTSW 2 130,239,423 (GRCm39) missense probably damaging 1.00
R1334:Cpxm1 UTSW 2 130,235,483 (GRCm39) missense probably damaging 0.99
R1366:Cpxm1 UTSW 2 130,238,042 (GRCm39) missense probably damaging 1.00
R1429:Cpxm1 UTSW 2 130,238,364 (GRCm39) missense probably damaging 0.98
R1654:Cpxm1 UTSW 2 130,235,466 (GRCm39) missense possibly damaging 0.51
R1824:Cpxm1 UTSW 2 130,237,617 (GRCm39) missense probably damaging 0.99
R2144:Cpxm1 UTSW 2 130,239,330 (GRCm39) missense probably benign 0.00
R2200:Cpxm1 UTSW 2 130,235,117 (GRCm39) missense probably damaging 1.00
R2320:Cpxm1 UTSW 2 130,236,131 (GRCm39) missense probably damaging 1.00
R2434:Cpxm1 UTSW 2 130,236,004 (GRCm39) missense probably damaging 1.00
R3118:Cpxm1 UTSW 2 130,235,493 (GRCm39) missense possibly damaging 0.80
R4601:Cpxm1 UTSW 2 130,235,496 (GRCm39) missense possibly damaging 0.83
R5020:Cpxm1 UTSW 2 130,237,897 (GRCm39) splice site probably null
R5041:Cpxm1 UTSW 2 130,235,990 (GRCm39) missense probably damaging 1.00
R5727:Cpxm1 UTSW 2 130,232,883 (GRCm39) nonsense probably null
R5806:Cpxm1 UTSW 2 130,239,393 (GRCm39) missense probably damaging 1.00
R6660:Cpxm1 UTSW 2 130,238,069 (GRCm39) missense probably damaging 1.00
R7431:Cpxm1 UTSW 2 130,235,966 (GRCm39) missense probably benign 0.00
R7491:Cpxm1 UTSW 2 130,235,487 (GRCm39) missense probably benign 0.22
R7743:Cpxm1 UTSW 2 130,235,342 (GRCm39) missense probably benign 0.01
R7930:Cpxm1 UTSW 2 130,236,982 (GRCm39) missense possibly damaging 0.95
R8375:Cpxm1 UTSW 2 130,236,146 (GRCm39) missense probably damaging 1.00
R8783:Cpxm1 UTSW 2 130,237,643 (GRCm39) missense probably benign 0.01
R8900:Cpxm1 UTSW 2 130,235,360 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCGTTCATGCCTGGGAATACC -3'
(R):5'- GAGCTTGTGGTGTCCTATCC -3'

Sequencing Primer
(F):5'- TACCAAAGACACTGGTGTGC -3'
(R):5'- TCGACATGACTCGGACTCC -3'
Posted On 2022-11-14