Mutagenetix > Incidental Mutation

Incidental Mutation 'R9739:Gm17019'

731755

Institutional Source

Beutler Lab

Gene Symbol

Gm17019

Ensembl Gene

ENSMUSG00000091897

Gene Name

predicted gene 17019

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

R9739 (G1)

Quality Score

120.008

Status

Not validated

Chromosome

Chromosomal Location

15078964-15083012 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 15082841 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Stop codon at position 38 (R38*)

Ref Sequence

ENSEMBL: ENSMUSP00000127520 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167908]

AlphaFold

K7N6W5

Predicted Effect

probably null
Transcript: ENSMUST00000167908
AA Change: R38*

SMART Domains

Protein: ENSMUSP00000127520
Gene: ENSMUSG00000091897
AA Change: R38*

Domain	Start	End	E-Value	Type
Pfam:Takusan	50	134	1.1e-30	PFAM
low complexity region	247	254	N/A	INTRINSIC

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 99.4%
20x: 98.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb3	C	T	1: 25,592,849 (GRCm39)	V313M	probably damaging	Het
Alg6	G	A	4: 99,650,195 (GRCm39)	V472I	possibly damaging	Het
Atp8b2	A	G	3: 89,853,403 (GRCm39)	V728A	probably benign	Het
Bach2	T	A	4: 32,563,042 (GRCm39)	I503N	probably damaging	Het
Bend3	T	C	10: 43,385,847 (GRCm39)	L80P	possibly damaging	Het
Casq1	T	C	1: 172,043,051 (GRCm39)	D215G	possibly damaging	Het
Ccdc175	A	T	12: 72,186,792 (GRCm39)	Y351N	probably benign	Het
Cd200r4	A	T	16: 44,641,142 (GRCm39)		probably benign	Het
Ctnnal1	T	C	4: 56,816,200 (GRCm39)	D621G	probably damaging	Het
Esco1	T	A	18: 10,594,218 (GRCm39)	H356L	probably benign	Het
Fhod1	C	T	8: 106,064,378 (GRCm39)	V191M	unknown	Het
Fhod3	T	C	18: 24,903,566 (GRCm39)	L100P	probably damaging	Het
Fkbp4	T	C	6: 128,410,728 (GRCm39)	R234G	probably benign	Het
Flnb	A	T	14: 7,935,954 (GRCm38)	K2265*	probably null	Het
Fsip2	T	C	2: 82,823,896 (GRCm39)	F6543S	possibly damaging	Het
Fyb1	A	G	15: 6,670,063 (GRCm39)	N594S	probably benign	Het
Gm37240	A	G	3: 84,417,113 (GRCm39)		probably null	Het
Gm9195	C	T	14: 72,690,264 (GRCm39)	D1820N	probably damaging	Het
Mycbp2	A	G	14: 103,520,229 (GRCm39)	V729A	probably benign	Het
Or8g21	G	T	9: 38,906,302 (GRCm39)	S143*	probably null	Het
Or9s18	T	C	13: 65,300,442 (GRCm39)	S135P	probably damaging	Het
Pde12	T	C	14: 26,386,757 (GRCm39)	T584A	possibly damaging	Het
Pfkfb2	T	C	1: 130,624,815 (GRCm39)	Q515R	probably benign	Het
Pkhd1	T	C	1: 20,420,708 (GRCm39)	N2466S	probably damaging	Het
Plcd1	A	G	9: 118,901,195 (GRCm39)	V720A	possibly damaging	Het
Pramel24	T	A	4: 143,454,997 (GRCm39)	F432I	possibly damaging	Het
Rapgef6	A	G	11: 54,513,189 (GRCm39)	T285A	probably benign	Het
Scyl3	T	C	1: 163,771,419 (GRCm39)	F255S	probably damaging	Het
Sfrp5	T	A	19: 42,188,247 (GRCm39)	M191L	probably benign	Het
Snrpf	C	T	10: 93,419,390 (GRCm39)	C66Y	probably benign	Het
Syngr2	T	A	11: 117,703,298 (GRCm39)	I38N	probably damaging	Het
Thap1	C	T	8: 26,650,990 (GRCm39)	H87Y	probably benign	Het
Tubgcp3	A	G	8: 12,699,744 (GRCm39)	Y370H	probably benign	Het
Usp17la	A	T	7: 104,510,736 (GRCm39)	N447I	possibly damaging	Het
Zfp532	C	T	18: 65,757,894 (GRCm39)	T609M	probably benign	Het

Other mutations in Gm17019

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02034:Gm17019	APN	5	15,080,266 (GRCm39)	missense	possibly damaging	0.95
R3617:Gm17019	UTSW	5	15,081,081 (GRCm39)	missense	possibly damaging	0.88
R5175:Gm17019	UTSW	5	15,082,817 (GRCm39)	missense	possibly damaging	0.92
R5520:Gm17019	UTSW	5	15,082,819 (GRCm39)	missense	possibly damaging	0.77
R7424:Gm17019	UTSW	5	15,079,386 (GRCm39)	missense	probably damaging	1.00
R7758:Gm17019	UTSW	5	15,079,300 (GRCm39)	makesense	probably null
R7762:Gm17019	UTSW	5	15,081,006 (GRCm39)	missense	probably benign	0.00
R7842:Gm17019	UTSW	5	15,081,049 (GRCm39)	missense	possibly damaging	0.58
R8898:Gm17019	UTSW	5	15,081,798 (GRCm39)	missense	possibly damaging	0.88
R9127:Gm17019	UTSW	5	15,081,113 (GRCm39)	nonsense	probably null
Z1176:Gm17019	UTSW	5	15,083,011 (GRCm39)	start gained	probably benign
Z1177:Gm17019	UTSW	5	15,082,945 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACATAACAGCTTTGACCTTGCC -3'
(R):5'- ATGTCACCAGTGTTGTAGTGAC -3'

Sequencing Primer
(F):5'- CCTTAGGGGATGGAAAAGTACTGTTC -3'
(R):5'- TGTAGTGACAACAAACTCACTGAG -3'

Posted On

2022-11-14