Incidental Mutation 'IGL00422:Ifi209'
ID7319
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifi209
Ensembl Gene ENSMUSG00000043263
Gene Nameinterferon activated gene 209
SynonymsIfix, Pyhin1, Pyhin-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.125) question?
Stock #IGL00422
Quality Score
Status
Chromosome1
Chromosomal Location173630917-173647928 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 173638963 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 120 (D120E)
Ref Sequence ENSEMBL: ENSMUSP00000061900 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056071] [ENSMUST00000193727]
Predicted Effect possibly damaging
Transcript: ENSMUST00000056071
AA Change: D120E

PolyPhen 2 Score 0.880 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000061900
Gene: ENSMUSG00000043263
AA Change: D120E

DomainStartEndE-ValueType
PYRIN 6 83 3.54e-17 SMART
low complexity region 152 169 N/A INTRINSIC
Pfam:HIN 231 396 4.2e-75 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000193727
AA Change: D120E

PolyPhen 2 Score 0.828 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000142161
Gene: ENSMUSG00000043263
AA Change: D120E

DomainStartEndE-ValueType
PYRIN 6 83 1.7e-21 SMART
low complexity region 152 169 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200598
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim1 C T 19: 57,068,186 A359T probably damaging Het
Ajuba A T 14: 54,571,769 Y400* probably null Het
Cckar T A 5: 53,699,829 D342V possibly damaging Het
Cdc123 A G 2: 5,798,449 V253A probably benign Het
Cep162 T C 9: 87,227,167 D461G probably benign Het
Chd7 G A 4: 8,859,106 E2399K probably damaging Het
Cln8 G A 8: 14,896,637 C217Y probably benign Het
Dchs1 A G 7: 105,758,029 V2119A possibly damaging Het
Dhx33 T C 11: 71,001,620 S108G probably benign Het
Dip2a T A 10: 76,313,236 M194L probably benign Het
Dnah11 T C 12: 118,068,096 K1779R probably damaging Het
Fads3 T G 19: 10,055,681 F328V possibly damaging Het
Flad1 A G 3: 89,405,853 probably null Het
Gm5346 A G 8: 43,626,351 F279L probably damaging Het
Gm7535 G T 17: 17,911,888 probably benign Het
Gnpat A G 8: 124,885,013 E513G probably damaging Het
H2-M5 A G 17: 36,987,840 I238T probably damaging Het
Hoxd12 G A 2: 74,675,427 R114Q probably damaging Het
Ide T C 19: 37,276,532 I903V unknown Het
Map3k10 T C 7: 27,668,469 D248G probably damaging Het
Mat2b C A 11: 40,687,738 G41C probably damaging Het
Mfsd4a T C 1: 132,040,594 I369V probably benign Het
Myom1 T A 17: 71,126,098 V1480E probably damaging Het
Myom2 A T 8: 15,069,490 D127V probably damaging Het
Olfml2b T A 1: 170,669,066 V422E probably damaging Het
Pkn3 G A 2: 30,081,104 A228T probably damaging Het
Rad17 A T 13: 100,629,525 I365K probably benign Het
Rad17 A T 13: 100,629,523 S366T probably damaging Het
Rpp14 G A 14: 8,083,934 G30E possibly damaging Het
Slco1a6 A C 6: 142,161,017 C15G probably benign Het
Spag9 T A 11: 94,097,866 F571I probably benign Het
Ttc27 T A 17: 74,780,816 C459S probably damaging Het
Washc2 A G 6: 116,256,676 T888A probably benign Het
Zcchc7 A T 4: 44,931,318 H490L possibly damaging Het
Other mutations in Ifi209
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02598:Ifi209 APN 1 173644715 missense probably damaging 0.99
IGL02712:Ifi209 APN 1 173642701 missense possibly damaging 0.68
IGL03131:Ifi209 APN 1 173641234 missense possibly damaging 0.86
IGL03368:Ifi209 APN 1 173642491 missense possibly damaging 0.91
R0880:Ifi209 UTSW 1 173644813 missense probably damaging 1.00
R1317:Ifi209 UTSW 1 173637463 missense possibly damaging 0.96
R1640:Ifi209 UTSW 1 173637365 missense probably damaging 0.98
R1769:Ifi209 UTSW 1 173641162 missense probably benign 0.11
R2349:Ifi209 UTSW 1 173642556 missense probably damaging 1.00
R5096:Ifi209 UTSW 1 173644734 missense probably benign 0.17
R5369:Ifi209 UTSW 1 173637307 start codon destroyed probably null 1.00
R5484:Ifi209 UTSW 1 173641074 missense probably benign 0.18
R5532:Ifi209 UTSW 1 173638976 missense probably damaging 0.99
R5551:Ifi209 UTSW 1 173641197 missense probably benign 0.01
R5554:Ifi209 UTSW 1 173641197 missense probably benign 0.01
R5749:Ifi209 UTSW 1 173637327 missense probably damaging 1.00
R5960:Ifi209 UTSW 1 173638816 intron probably null
R6401:Ifi209 UTSW 1 173644703 missense probably damaging 0.99
R7042:Ifi209 UTSW 1 173642670 missense probably benign 0.34
R7304:Ifi209 UTSW 1 173642590 missense possibly damaging 0.88
R7521:Ifi209 UTSW 1 173642695 missense probably damaging 0.97
Z1088:Ifi209 UTSW 1 173637407 missense probably damaging 0.99
Z1088:Ifi209 UTSW 1 173641146 missense probably benign 0.00
Posted On2012-04-20