Incidental Mutation 'IGL01298:Olfr338'
ID73191
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr338
Ensembl Gene ENSMUSG00000068950
Gene Nameolfactory receptor 338
SynonymsMOR136-5, GA_x6K02T2NLDC-33070879-33071799
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.053) question?
Stock #IGL01298
Quality Score
Status
Chromosome2
Chromosomal Location36373519-36382433 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 36377448 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 224 (M224K)
Ref Sequence ENSEMBL: ENSMUSP00000149146 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072114] [ENSMUST00000091006] [ENSMUST00000217511]
Predicted Effect probably benign
Transcript: ENSMUST00000072114
AA Change: M224K

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000071985
Gene: ENSMUSG00000068950
AA Change: M224K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.3e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.8e-8 PFAM
Pfam:7tm_1 41 290 1.1e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000091006
AA Change: M224K

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000088528
Gene: ENSMUSG00000068950
AA Change: M224K

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 3.9e-56 PFAM
Pfam:7tm_1 39 288 4.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217511
AA Change: M224K

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adora2a G T 10: 75,333,492 W263C probably damaging Het
Agtpbp1 G A 13: 59,504,226 H424Y possibly damaging Het
Angpt2 T G 8: 18,710,528 N186T probably benign Het
Ank2 A G 3: 126,959,720 V304A possibly damaging Het
Atg3 T C 16: 45,171,673 M88T possibly damaging Het
Baz1a G T 12: 54,954,809 P142Q probably damaging Het
Btbd1 G T 7: 81,794,307 probably null Het
Cacnb3 T C 15: 98,639,853 Y70H probably damaging Het
Cd4 G A 6: 124,879,378 T50I probably benign Het
Cyp7a1 A T 4: 6,275,517 W19R probably damaging Het
Dock10 T A 1: 80,531,245 I1610F probably damaging Het
Gm11444 C A 11: 85,848,094 D58Y unknown Het
Gm7168 A T 17: 13,949,858 T496S probably benign Het
Gpc5 A G 14: 115,399,188 S428G probably benign Het
Haus8 T C 8: 71,253,113 E309G probably damaging Het
Ice1 A G 13: 70,604,904 L1021P possibly damaging Het
Krtap14 A T 16: 88,825,727 H121Q probably benign Het
Nwd1 T C 8: 72,662,331 V170A probably benign Het
Olfr803 T C 10: 129,692,029 Y4C probably damaging Het
Olfr938 G A 9: 39,078,724 T7I possibly damaging Het
Pfpl T C 19: 12,428,673 M96T possibly damaging Het
Pramel5 A G 4: 144,271,162 probably benign Het
Proc T C 18: 32,123,552 N354S probably benign Het
Prss40 T G 1: 34,560,766 I47L probably benign Het
Tmprss7 T C 16: 45,664,175 R541G probably benign Het
Togaram2 T C 17: 71,716,513 V788A possibly damaging Het
Trbv19 T C 6: 41,178,904 Y70H probably damaging Het
Ttk C T 9: 83,865,142 S678L probably benign Het
Vmn2r85 T C 10: 130,418,821 T665A probably benign Het
Other mutations in Olfr338
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Olfr338 APN 2 36376916 missense probably damaging 0.99
IGL01089:Olfr338 APN 2 36377166 missense probably damaging 1.00
IGL01300:Olfr338 APN 2 36377042 missense probably benign 0.13
IGL01632:Olfr338 APN 2 36377564 missense probably benign 0.02
IGL02480:Olfr338 APN 2 36377492 missense probably damaging 0.98
IGL02519:Olfr338 APN 2 36377313 missense possibly damaging 0.84
IGL02658:Olfr338 APN 2 36377060 missense probably damaging 0.97
IGL02716:Olfr338 APN 2 36377343 missense possibly damaging 0.88
IGL02983:Olfr338 APN 2 36377637 missense probably damaging 1.00
IGL03334:Olfr338 APN 2 36377051 missense possibly damaging 0.66
IGL03054:Olfr338 UTSW 2 36376932 missense possibly damaging 0.65
R0469:Olfr338 UTSW 2 36377462 missense probably benign 0.02
R1263:Olfr338 UTSW 2 36376994 missense probably damaging 0.99
R1500:Olfr338 UTSW 2 36377621 missense probably benign 0.04
R2444:Olfr338 UTSW 2 36377613 missense possibly damaging 0.59
R5571:Olfr338 UTSW 2 36377117 missense probably benign 0.01
R5999:Olfr338 UTSW 2 36377310 missense probably damaging 1.00
R6030:Olfr338 UTSW 2 36377544 missense probably damaging 0.97
R6030:Olfr338 UTSW 2 36377544 missense probably damaging 0.97
R6351:Olfr338 UTSW 2 36377196 missense possibly damaging 0.78
R6695:Olfr338 UTSW 2 36377105 missense probably benign 0.28
R6785:Olfr338 UTSW 2 36376842 missense probably benign 0.12
R6785:Olfr338 UTSW 2 36376951 nonsense probably null
R7795:Olfr338 UTSW 2 36377441 missense probably benign 0.05
R7814:Olfr338 UTSW 2 36376809 missense possibly damaging 0.48
R7878:Olfr338 UTSW 2 36377133 missense probably damaging 1.00
R8820:Olfr338 UTSW 2 36376994 missense probably damaging 1.00
Posted On2013-10-07