Incidental Mutation 'R9743:Or2a51'
ID 731921
Institutional Source Beutler Lab
Gene Symbol Or2a51
Ensembl Gene ENSMUSG00000048693
Gene Name olfactory receptor family 2 subfamily A member 51
Synonyms MOR261-5, GA_x6K02T2P3E9-4356476-4355535, Olfr435
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.137) question?
Stock # R9743 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 43178580-43179521 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43179229 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 217 (Y217C)
Ref Sequence ENSEMBL: ENSMUSP00000150935 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058118] [ENSMUST00000215565]
AlphaFold Q8VFS3
Predicted Effect probably benign
Transcript: ENSMUST00000058118
AA Change: Y217C

PolyPhen 2 Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000058912
Gene: ENSMUSG00000048693
AA Change: Y217C

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 3e-61 PFAM
Pfam:7tm_1 40 289 4.3e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215565
AA Change: Y217C

PolyPhen 2 Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl1 A G 2: 31,687,716 (GRCm39) H571R probably benign Het
Adamts13 T C 2: 26,886,812 (GRCm39) V983A probably benign Het
Adamts13 G A 2: 26,895,491 (GRCm39) probably null Het
AI661453 T A 17: 47,780,240 (GRCm39) N1181K unknown Het
Ank2 A T 3: 126,733,794 (GRCm39) N605K possibly damaging Het
Armc2 T G 10: 41,798,598 (GRCm39) K737T probably benign Het
Aspn A G 13: 49,705,150 (GRCm39) Y4C probably benign Het
B3galt2 T C 1: 143,522,847 (GRCm39) F328L probably benign Het
Brd10 A C 19: 29,694,261 (GRCm39) I1744S probably benign Het
Ccl3 T C 11: 83,539,428 (GRCm39) E52G probably damaging Het
Col5a1 C T 2: 27,864,505 (GRCm39) A728V unknown Het
Cyp1b1 T A 17: 80,017,808 (GRCm39) D449V probably benign Het
D130043K22Rik C T 13: 25,056,299 (GRCm39) P544S probably damaging Het
Dgkd T A 1: 87,861,850 (GRCm39) W28R Het
Emilin2 T C 17: 71,580,867 (GRCm39) T620A probably benign Het
Ercc6 T G 14: 32,298,943 (GRCm39) S1444A probably benign Het
Fam149b A G 14: 20,413,411 (GRCm39) H264R probably benign Het
Fbxo7 T C 10: 85,883,773 (GRCm39) V458A probably benign Het
Gria4 T G 9: 4,464,457 (GRCm39) T502P probably damaging Het
Hfm1 T C 5: 107,022,125 (GRCm39) T974A possibly damaging Het
Ifna16 T C 4: 88,594,930 (GRCm39) D55G probably damaging Het
Lyst T C 13: 13,809,323 (GRCm39) V331A possibly damaging Het
Mkks T C 2: 136,722,992 (GRCm39) Y55C probably benign Het
Muc4 T C 16: 32,601,194 (GRCm39) F1291L Het
Myo18a A G 11: 77,723,304 (GRCm39) N1183S probably benign Het
Olfm2 T C 9: 20,579,785 (GRCm39) D322G probably damaging Het
Or2a25 G A 6: 42,888,835 (GRCm39) C126Y probably damaging Het
Or5aq7 A G 2: 86,937,840 (GRCm39) V297A probably damaging Het
Or7h8 A G 9: 20,123,840 (GRCm39) N65S probably damaging Het
Pdik1l A T 4: 134,011,815 (GRCm39) D9E probably benign Het
Pdzrn3 C A 6: 101,354,678 (GRCm39) G58C probably damaging Het
Pex13 A T 11: 23,606,119 (GRCm39) L37* probably null Het
Pigr G A 1: 130,769,540 (GRCm39) R117Q possibly damaging Het
Ptprq T A 10: 107,520,982 (GRCm39) Y730F probably damaging Het
Rnase11 T A 14: 51,287,370 (GRCm39) K61N probably benign Het
Setdb2 T C 14: 59,651,002 (GRCm39) D427G probably benign Het
Slc22a21 A G 11: 53,842,575 (GRCm39) V518A probably benign Het
Slf2 T C 19: 44,930,572 (GRCm39) S550P probably benign Het
Supt16 T C 14: 52,408,939 (GRCm39) R812G probably damaging Het
Taf4 C T 2: 179,581,592 (GRCm39) V464M possibly damaging Het
Tas1r3 G A 4: 155,945,256 (GRCm39) T655I probably damaging Het
Tg G A 15: 66,561,839 (GRCm39) V1108I probably benign Het
Tmc7 C A 7: 118,150,452 (GRCm39) R360S probably damaging Het
Tor3a T C 1: 156,501,103 (GRCm39) T112A probably benign Het
Tsr3 T C 17: 25,460,674 (GRCm39) L180P possibly damaging Het
Unc5d T C 8: 29,209,801 (GRCm39) T512A possibly damaging Het
Vmn2r103 T A 17: 20,032,475 (GRCm39) Y750N probably damaging Het
Vmn2r20 A T 6: 123,373,369 (GRCm39) V491D probably damaging Het
Vmn2r52 T C 7: 9,904,606 (GRCm39) E411G possibly damaging Het
Zfp760 T A 17: 21,942,338 (GRCm39) S504R probably benign Het
Other mutations in Or2a51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02817:Or2a51 APN 6 43,178,993 (GRCm39) missense probably benign 0.01
IGL03385:Or2a51 APN 6 43,178,914 (GRCm39) missense probably benign 0.20
R0455:Or2a51 UTSW 6 43,179,006 (GRCm39) missense probably benign
R1977:Or2a51 UTSW 6 43,178,914 (GRCm39) missense possibly damaging 0.93
R2152:Or2a51 UTSW 6 43,179,003 (GRCm39) missense probably benign
R3821:Or2a51 UTSW 6 43,178,604 (GRCm39) missense probably benign 0.26
R7041:Or2a51 UTSW 6 43,178,837 (GRCm39) missense probably benign 0.05
R9212:Or2a51 UTSW 6 43,178,756 (GRCm39) nonsense probably null
R9533:Or2a51 UTSW 6 43,178,991 (GRCm39) missense probably benign 0.35
Predicted Primers PCR Primer
(F):5'- ACCATCATGGCTGCTGTTTC -3'
(R):5'- AAAGGATCTTCTGCAGCTCTTC -3'

Sequencing Primer
(F):5'- GGTCCATTTGGTCCTCATCCTGAG -3'
(R):5'- TCTGCAGCTCTTCAGGGTGC -3'
Posted On 2022-11-14