Mutagenetix > Incidental Mutation

Incidental Mutation 'R9743:Vmn2r103'

731947

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R9743 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 19812213 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Asparagine at position 750 (Y750N)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

AlphaFold

E9PWW0

Predicted Effect

probably damaging
Transcript: ENSMUST00000172203
AA Change: Y750N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: Y750N

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 99.4%
20x: 98.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9930021J03Rik	A	C	19: 29,716,861	I1744S	probably benign	Het
Abl1	A	G	2: 31,797,704	H571R	probably benign	Het
Adamts13	T	C	2: 26,996,800	V983A	probably benign	Het
Adamts13	G	A	2: 27,005,479		probably null	Het
AI661453	T	A	17: 47,469,315	N1181K	unknown	Het
Ank2	A	T	3: 126,940,145	N605K	possibly damaging	Het
Armc2	T	G	10: 41,922,602	K737T	probably benign	Het
Aspn	A	G	13: 49,551,674	Y4C	probably benign	Het
B3galt2	T	C	1: 143,647,109	F328L	probably benign	Het
Ccl3	T	C	11: 83,648,602	E52G	probably damaging	Het
Col5a1	C	T	2: 27,974,493	A728V	unknown	Het
Cyp1b1	T	A	17: 79,710,379	D449V	probably benign	Het
D130043K22Rik	C	T	13: 24,872,316	P544S	probably damaging	Het
Dgkd	T	A	1: 87,934,128	W28R		Het
Emilin2	T	C	17: 71,273,872	T620A	probably benign	Het
Ercc6	T	G	14: 32,576,986	S1444A	probably benign	Het
Fam149b	A	G	14: 20,363,343	H264R	probably benign	Het
Fbxo7	T	C	10: 86,047,909	V458A	probably benign	Het
Gria4	T	G	9: 4,464,457	T502P	probably damaging	Het
Hfm1	T	C	5: 106,874,259	T974A	possibly damaging	Het
Ifna16	T	C	4: 88,676,693	D55G	probably damaging	Het
Lyst	T	C	13: 13,634,738	V331A	possibly damaging	Het
Mkks	T	C	2: 136,881,072	Y55C	probably benign	Het
Muc4	T	C	16: 32,780,824	F1291L		Het
Myo18a	A	G	11: 77,832,478	N1183S	probably benign	Het
Olfm2	T	C	9: 20,668,489	D322G	probably damaging	Het
Olfr259	A	G	2: 87,107,496	V297A	probably damaging	Het
Olfr435	A	G	6: 43,202,295	Y217C	probably benign	Het
Olfr447	G	A	6: 42,911,901	C126Y	probably damaging	Het
Olfr871	A	G	9: 20,212,544	N65S	probably damaging	Het
Pdik1l	A	T	4: 134,284,504	D9E	probably benign	Het
Pdzrn3	C	A	6: 101,377,717	G58C	probably damaging	Het
Pex13	A	T	11: 23,656,119	L37*	probably null	Het
Pigr	G	A	1: 130,841,803	R117Q	possibly damaging	Het
Ptprq	T	A	10: 107,685,121	Y730F	probably damaging	Het
Rnase11	T	A	14: 51,049,913	K61N	probably benign	Het
Setdb2	T	C	14: 59,413,553	D427G	probably benign	Het
Slc22a21	A	G	11: 53,951,749	V518A	probably benign	Het
Slf2	T	C	19: 44,942,133	S550P	probably benign	Het
Supt16	T	C	14: 52,171,482	R812G	probably damaging	Het
Taf4	C	T	2: 179,939,799	V464M	possibly damaging	Het
Tas1r3	G	A	4: 155,860,799	T655I	probably damaging	Het
Tg	G	A	15: 66,689,990	V1108I	probably benign	Het
Tmc7	C	A	7: 118,551,229	R360S	probably damaging	Het
Tor3a	T	C	1: 156,673,533	T112A	probably benign	Het
Tsr3	T	C	17: 25,241,700	L180P	possibly damaging	Het
Unc5d	T	C	8: 28,719,773	T512A	possibly damaging	Het
Vmn2r20	A	T	6: 123,396,410	V491D	probably damaging	Het
Vmn2r52	T	C	7: 10,170,679	E411G	possibly damaging	Het
Zfp760	T	A	17: 21,723,357	S504R	probably benign	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19793102	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19794965	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19792997	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19792967	missense	probably benign
IGL01404:Vmn2r103	APN	17	19812434	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19794068	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19799208	missense	probably benign
IGL02251:Vmn2r103	APN	17	19793969	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19773369	missense	probably benign
IGL02555:Vmn2r103	APN	17	19811611	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19794127	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19793956	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19812248	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19773520	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19811979	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19811641	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19792859	missense	probably benign	0.06
R0375:Vmn2r103	UTSW	17	19793464	missense	probably benign	0.12
R0755:Vmn2r103	UTSW	17	19773568	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19793927	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19794247	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19792968	missense	probably benign
R1488:Vmn2r103	UTSW	17	19793660	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19773400	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19794234	missense	probably benign
R1928:Vmn2r103	UTSW	17	19811767	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19812300	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19793794	missense	probably benign
R2219:Vmn2r103	UTSW	17	19793647	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19773531	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19793600	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19812149	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19794233	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4660:Vmn2r103	UTSW	17	19811815	missense	probably damaging	1.00
R4801:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19811769	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19812171	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19793642	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19792989	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19794939	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19812453	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19794216	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19812325	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19812144	missense	probably benign
R6292:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19794082	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19811904	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19811977	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19793477	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19812052	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19794214	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19793123	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19799249	missense	probably damaging	1.00
R8031:Vmn2r103	UTSW	17	19793497	missense	probably benign	0.00
R8140:Vmn2r103	UTSW	17	19811796	missense	probably damaging	1.00
R8186:Vmn2r103	UTSW	17	19811943	missense	probably damaging	1.00
R8559:Vmn2r103	UTSW	17	19812384	missense	probably benign	0.01
R9413:Vmn2r103	UTSW	17	19811896	missense	possibly damaging	0.54
R9591:Vmn2r103	UTSW	17	19811659	missense	possibly damaging	0.70
R9652:Vmn2r103	UTSW	17	19793765	missense	probably benign	0.01
R9680:Vmn2r103	UTSW	17	19799263	nonsense	probably null
Z1088:Vmn2r103	UTSW	17	19795047	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- AGGGGTCCAAACTACATCATTCC -3'
(R):5'- TGGGACCAAATATGAAGGCC -3'

Sequencing Primer
(F):5'- GTCCAAACTACATCATTCCTATATGC -3'
(R):5'- AGTGCTATGCTGGAAGCC -3'

Posted On

2022-11-14