Incidental Mutation 'IGL01298:Olfr803'
ID73200
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr803
Ensembl Gene ENSMUSG00000046041
Gene Nameolfactory receptor 803
SynonymsGA_x6K02T2PULF-11370664-11369738, MOR111-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.054) question?
Stock #IGL01298
Quality Score
Status
Chromosome10
Chromosomal Location129690621-129694286 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 129692029 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Cysteine at position 4 (Y4C)
Ref Sequence ENSEMBL: ENSMUSP00000145400 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056736] [ENSMUST00000203785] [ENSMUST00000204641] [ENSMUST00000217576]
Predicted Effect probably damaging
Transcript: ENSMUST00000056736
AA Change: Y4C

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000055860
Gene: ENSMUSG00000046041
AA Change: Y4C

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 6.2e-51 PFAM
Pfam:7TM_GPCR_Srsx 33 303 3.8e-6 PFAM
Pfam:7tm_1 39 288 3.2e-22 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000157522
Predicted Effect probably benign
Transcript: ENSMUST00000203785
SMART Domains Protein: ENSMUSP00000144741
Gene: ENSMUSG00000093866

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 6.8e-56 PFAM
Pfam:7tm_1 39 288 2.5e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204641
AA Change: Y4C

PolyPhen 2 Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000145400
Gene: ENSMUSG00000046041
AA Change: Y4C

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 2.9e-49 PFAM
Pfam:7tm_1 39 288 8.3e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217576
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adora2a G T 10: 75,333,492 W263C probably damaging Het
Agtpbp1 G A 13: 59,504,226 H424Y possibly damaging Het
Angpt2 T G 8: 18,710,528 N186T probably benign Het
Ank2 A G 3: 126,959,720 V304A possibly damaging Het
Atg3 T C 16: 45,171,673 M88T possibly damaging Het
Baz1a G T 12: 54,954,809 P142Q probably damaging Het
Btbd1 G T 7: 81,794,307 probably null Het
Cacnb3 T C 15: 98,639,853 Y70H probably damaging Het
Cd4 G A 6: 124,879,378 T50I probably benign Het
Cyp7a1 A T 4: 6,275,517 W19R probably damaging Het
Dock10 T A 1: 80,531,245 I1610F probably damaging Het
Gm11444 C A 11: 85,848,094 D58Y unknown Het
Gm7168 A T 17: 13,949,858 T496S probably benign Het
Gpc5 A G 14: 115,399,188 S428G probably benign Het
Haus8 T C 8: 71,253,113 E309G probably damaging Het
Ice1 A G 13: 70,604,904 L1021P possibly damaging Het
Krtap14 A T 16: 88,825,727 H121Q probably benign Het
Nwd1 T C 8: 72,662,331 V170A probably benign Het
Olfr338 T A 2: 36,377,448 M224K probably benign Het
Olfr938 G A 9: 39,078,724 T7I possibly damaging Het
Pfpl T C 19: 12,428,673 M96T possibly damaging Het
Pramel5 A G 4: 144,271,162 probably benign Het
Proc T C 18: 32,123,552 N354S probably benign Het
Prss40 T G 1: 34,560,766 I47L probably benign Het
Tmprss7 T C 16: 45,664,175 R541G probably benign Het
Togaram2 T C 17: 71,716,513 V788A possibly damaging Het
Trbv19 T C 6: 41,178,904 Y70H probably damaging Het
Ttk C T 9: 83,865,142 S678L probably benign Het
Vmn2r85 T C 10: 130,418,821 T665A probably benign Het
Other mutations in Olfr803
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00922:Olfr803 APN 10 129691454 missense probably benign 0.00
IGL02008:Olfr803 APN 10 129692018 missense probably benign 0.02
IGL02166:Olfr803 APN 10 129691913 missense probably benign 0.12
IGL02598:Olfr803 APN 10 129691273 missense possibly damaging 0.89
IGL03158:Olfr803 APN 10 129691718 missense probably benign 0.01
IGL03393:Olfr803 APN 10 129691278 missense probably damaging 0.99
R2246:Olfr803 UTSW 10 129691943 missense probably damaging 1.00
R3749:Olfr803 UTSW 10 129691961 missense probably benign
R5060:Olfr803 UTSW 10 129691830 missense probably benign
R5116:Olfr803 UTSW 10 129691397 missense probably damaging 1.00
R5253:Olfr803 UTSW 10 129691732 missense probably damaging 0.99
R6166:Olfr803 UTSW 10 129691279 missense probably damaging 1.00
R6543:Olfr803 UTSW 10 129691990 missense probably benign 0.09
R6787:Olfr803 UTSW 10 129691522 missense possibly damaging 0.88
R6828:Olfr803 UTSW 10 129691994 missense probably damaging 1.00
R7284:Olfr803 UTSW 10 129691351 missense probably benign
R7510:Olfr803 UTSW 10 129691920 missense probably damaging 1.00
R8488:Olfr803 UTSW 10 129691474 missense probably damaging 1.00
Posted On2013-10-07