Incidental Mutation 'R9744:Vmn2r110'
| ID |
732002 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r110
|
| Ensembl Gene |
ENSMUSG00000091259 |
| Gene Name |
vomeronasal 2, receptor 110 |
| Synonyms |
EG224582 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.156)
|
| Stock # |
R9744 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
20794091-20816521 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 20794848 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 607
(V607A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129347
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095633]
[ENSMUST00000169559]
|
| AlphaFold |
E9PWD5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000095633
|
| SMART Domains |
Protein: ENSMUSP00000093293
Gene: ENSMUSG00000071273
| Domain | Start | End | E-Value | Type |
|---|
|
RRM
|
17 |
84 |
5.29e-5 |
SMART |
|
low complexity region
|
101 |
113 |
N/A |
INTRINSIC |
|
low complexity region
|
119 |
130 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
175 |
N/A |
INTRINSIC |
|
low complexity region
|
179 |
199 |
N/A |
INTRINSIC |
|
RRM
|
207 |
274 |
1.55e-11 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169559
AA Change: V607A
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000129347
Gene: ENSMUSG00000091259
AA Change: V607A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
3.1e-33 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
5.2e-22 |
PFAM |
|
Pfam:7tm_3
|
594 |
831 |
4.2e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 99.3%
- 20x: 98.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 49 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam7 |
T |
A |
14: 68,742,583 (GRCm39) |
M677L |
probably benign |
Het |
| Ankrd24 |
T |
G |
10: 81,482,951 (GRCm39) |
D966E |
possibly damaging |
Het |
| Arhgef28 |
A |
G |
13: 98,094,261 (GRCm39) |
L961P |
probably damaging |
Het |
| Atxn1 |
G |
A |
13: 45,721,299 (GRCm39) |
Q199* |
probably null |
Het |
| Bcl2a1c |
G |
A |
9: 114,159,341 (GRCm39) |
V40I |
probably benign |
Het |
| Cep41 |
A |
G |
6: 30,656,603 (GRCm39) |
V283A |
probably benign |
Het |
| Cerk |
A |
G |
15: 86,033,491 (GRCm39) |
Y311H |
probably damaging |
Het |
| Ciz1 |
A |
T |
2: 32,253,859 (GRCm39) |
Q13L |
unknown |
Het |
| Cpeb2 |
T |
C |
5: 43,391,268 (GRCm39) |
S155P |
|
Het |
| Dmbx1 |
T |
A |
4: 115,777,262 (GRCm39) |
E200D |
probably damaging |
Het |
| Epha8 |
G |
T |
4: 136,665,897 (GRCm39) |
L420M |
probably damaging |
Het |
| Erc1 |
T |
C |
6: 119,720,360 (GRCm39) |
Y747C |
probably damaging |
Het |
| Fhad1 |
T |
C |
4: 141,637,124 (GRCm39) |
E1114G |
probably damaging |
Het |
| Fndc3a |
C |
A |
14: 72,777,693 (GRCm39) |
E1171* |
probably null |
Het |
| Grip1 |
G |
A |
10: 119,874,569 (GRCm39) |
E778K |
possibly damaging |
Het |
| Gys2 |
A |
C |
6: 142,394,187 (GRCm39) |
D450E |
probably benign |
Het |
| Hmcn1 |
A |
T |
1: 150,623,941 (GRCm39) |
I1120N |
probably damaging |
Het |
| Ints3 |
G |
T |
3: 90,318,605 (GRCm39) |
T210K |
probably damaging |
Het |
| Itih5 |
T |
C |
2: 10,256,221 (GRCm39) |
Y896H |
probably damaging |
Het |
| Kcna7 |
A |
G |
7: 45,056,402 (GRCm39) |
D206G |
probably benign |
Het |
| Klhl10 |
T |
A |
11: 100,336,396 (GRCm39) |
C128S |
probably damaging |
Het |
| Klhl5 |
T |
C |
5: 65,320,255 (GRCm39) |
V603A |
probably damaging |
Het |
| Mapk15 |
T |
A |
15: 75,869,912 (GRCm39) |
I344N |
possibly damaging |
Het |
| Mdn1 |
T |
C |
4: 32,715,711 (GRCm39) |
F1993L |
possibly damaging |
Het |
| Myo1c |
T |
C |
11: 75,562,797 (GRCm39) |
L959P |
probably damaging |
Het |
| Nectin1 |
A |
G |
9: 43,715,240 (GRCm39) |
Q492R |
probably damaging |
Het |
| Nlrp14 |
A |
T |
7: 106,796,987 (GRCm39) |
L951F |
probably damaging |
Het |
| Nlrp5 |
T |
G |
7: 23,120,902 (GRCm39) |
S705R |
possibly damaging |
Het |
| Nlrp9a |
A |
G |
7: 26,267,266 (GRCm39) |
Y787C |
probably benign |
Het |
| Npsr1 |
A |
G |
9: 24,201,182 (GRCm39) |
T189A |
probably benign |
Het |
| Nup205 |
T |
C |
6: 35,209,510 (GRCm39) |
Y1606H |
probably damaging |
Het |
| Or2w4 |
A |
G |
13: 21,795,827 (GRCm39) |
F104S |
possibly damaging |
Het |
| Or4k48 |
C |
A |
2: 111,475,664 (GRCm39) |
R226L |
probably benign |
Het |
| Or6z5 |
A |
T |
7: 6,477,210 (GRCm39) |
I34L |
probably benign |
Het |
| Pitx2 |
A |
T |
3: 129,009,467 (GRCm39) |
T129S |
probably damaging |
Het |
| Pla2g2c |
T |
C |
4: 138,470,972 (GRCm39) |
S118P |
probably damaging |
Het |
| Polr1a |
A |
G |
6: 71,906,372 (GRCm39) |
N396S |
probably benign |
Het |
| Prl |
A |
T |
13: 27,248,338 (GRCm39) |
Q135L |
probably benign |
Het |
| Prrc2c |
A |
G |
1: 162,505,733 (GRCm39) |
L2555P |
possibly damaging |
Het |
| Psg29 |
A |
T |
7: 16,944,495 (GRCm39) |
D335V |
probably benign |
Het |
| Psme4 |
T |
C |
11: 30,765,294 (GRCm39) |
|
probably null |
Het |
| Ramp2 |
T |
A |
11: 101,137,913 (GRCm39) |
S52T |
unknown |
Het |
| Skint6 |
C |
T |
4: 112,666,360 (GRCm39) |
G1155D |
probably damaging |
Het |
| Sorcs1 |
G |
A |
19: 50,215,275 (GRCm39) |
R655C |
probably damaging |
Het |
| Syne1 |
A |
G |
10: 5,274,184 (GRCm39) |
C1867R |
probably benign |
Het |
| Tcf21 |
T |
C |
10: 22,695,726 (GRCm39) |
D26G |
probably benign |
Het |
| Tmem132a |
G |
A |
19: 10,840,678 (GRCm39) |
P418L |
probably damaging |
Het |
| Tob1 |
C |
T |
11: 94,105,054 (GRCm39) |
R197C |
probably damaging |
Het |
| Vmn2r30 |
A |
G |
7: 7,315,284 (GRCm39) |
S850P |
possibly damaging |
Het |
|
| Other mutations in Vmn2r110 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01774:Vmn2r110
|
APN |
17 |
20,803,889 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01824:Vmn2r110
|
APN |
17 |
20,794,929 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL01879:Vmn2r110
|
APN |
17 |
20,794,122 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02168:Vmn2r110
|
APN |
17 |
20,804,062 (GRCm39) |
splice site |
probably benign |
|
|
IGL02178:Vmn2r110
|
APN |
17 |
20,804,706 (GRCm39) |
splice site |
probably null |
|
|
IGL02322:Vmn2r110
|
APN |
17 |
20,794,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02323:Vmn2r110
|
APN |
17 |
20,816,399 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02415:Vmn2r110
|
APN |
17 |
20,804,033 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02491:Vmn2r110
|
APN |
17 |
20,816,400 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02876:Vmn2r110
|
APN |
17 |
20,794,558 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL03141:Vmn2r110
|
APN |
17 |
20,803,976 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03270:Vmn2r110
|
APN |
17 |
20,803,778 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03286:Vmn2r110
|
APN |
17 |
20,804,468 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03379:Vmn2r110
|
APN |
17 |
20,803,906 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4243001:Vmn2r110
|
UTSW |
17 |
20,802,379 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0040:Vmn2r110
|
UTSW |
17 |
20,816,346 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0195:Vmn2r110
|
UTSW |
17 |
20,794,317 (GRCm39) |
missense |
probably benign |
0.31 |
|
R0716:Vmn2r110
|
UTSW |
17 |
20,794,165 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1199:Vmn2r110
|
UTSW |
17 |
20,803,525 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1767:Vmn2r110
|
UTSW |
17 |
20,800,840 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2212:Vmn2r110
|
UTSW |
17 |
20,794,209 (GRCm39) |
splice site |
probably null |
|
|
R3056:Vmn2r110
|
UTSW |
17 |
20,803,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4093:Vmn2r110
|
UTSW |
17 |
20,803,642 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4418:Vmn2r110
|
UTSW |
17 |
20,803,951 (GRCm39) |
nonsense |
probably null |
|
|
R4598:Vmn2r110
|
UTSW |
17 |
20,804,029 (GRCm39) |
nonsense |
probably null |
|
|
R4754:Vmn2r110
|
UTSW |
17 |
20,816,458 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5283:Vmn2r110
|
UTSW |
17 |
20,800,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5421:Vmn2r110
|
UTSW |
17 |
20,803,882 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5672:Vmn2r110
|
UTSW |
17 |
20,816,494 (GRCm39) |
missense |
probably benign |
|
|
R5865:Vmn2r110
|
UTSW |
17 |
20,804,557 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6642:Vmn2r110
|
UTSW |
17 |
20,803,779 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6799:Vmn2r110
|
UTSW |
17 |
20,803,798 (GRCm39) |
missense |
probably benign |
|
|
R7167:Vmn2r110
|
UTSW |
17 |
20,794,441 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7291:Vmn2r110
|
UTSW |
17 |
20,794,471 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7320:Vmn2r110
|
UTSW |
17 |
20,816,316 (GRCm39) |
missense |
probably benign |
|
|
R7519:Vmn2r110
|
UTSW |
17 |
20,804,524 (GRCm39) |
missense |
probably benign |
|
|
R8089:Vmn2r110
|
UTSW |
17 |
20,803,807 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8234:Vmn2r110
|
UTSW |
17 |
20,804,691 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8272:Vmn2r110
|
UTSW |
17 |
20,816,490 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8307:Vmn2r110
|
UTSW |
17 |
20,803,319 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8506:Vmn2r110
|
UTSW |
17 |
20,804,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8516:Vmn2r110
|
UTSW |
17 |
20,794,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8555:Vmn2r110
|
UTSW |
17 |
20,804,618 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8691:Vmn2r110
|
UTSW |
17 |
20,803,404 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8859:Vmn2r110
|
UTSW |
17 |
20,794,560 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8935:Vmn2r110
|
UTSW |
17 |
20,803,957 (GRCm39) |
missense |
probably benign |
0.40 |
|
R8986:Vmn2r110
|
UTSW |
17 |
20,803,823 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9012:Vmn2r110
|
UTSW |
17 |
20,803,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9101:Vmn2r110
|
UTSW |
17 |
20,794,471 (GRCm39) |
missense |
|
|
|
R9803:Vmn2r110
|
UTSW |
17 |
20,803,730 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1088:Vmn2r110
|
UTSW |
17 |
20,803,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCACAGTGAATGCAACTCC -3'
(R):5'- AGATAGGGAATCAGTTCAACCTAG -3'
Sequencing Primer
(F):5'- CCAAATATGTTCTGCTGAAGGATGC -3'
(R):5'- GGGAATCAGTTCAACCTAGACTCATG -3'
|
| Posted On |
2022-11-14 |
Incidental Mutation