Incidental Mutation 'IGL01298:Gm7168'
| ID |
73211 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Gm7168
|
| Ensembl Gene |
ENSMUSG00000067941 |
| Gene Name |
predicted gene 7168 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
IGL01298
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
17 |
| Chromosomal Location |
14168635-14170940 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 14170120 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 496
(T496S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094997
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000088809]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000088809
AA Change: T496S
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000094997
Gene: ENSMUSG00000067941
AA Change: T496S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
20 |
N/A |
INTRINSIC |
|
S_TKc
|
28 |
276 |
5.25e-91 |
SMART |
|
UBA
|
296 |
333 |
4.39e-2 |
SMART |
|
low complexity region
|
436 |
451 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adora2a |
G |
T |
10: 75,169,326 (GRCm39) |
W263C |
probably damaging |
Het |
| Agtpbp1 |
G |
A |
13: 59,652,040 (GRCm39) |
H424Y |
possibly damaging |
Het |
| Angpt2 |
T |
G |
8: 18,760,544 (GRCm39) |
N186T |
probably benign |
Het |
| Ank2 |
A |
G |
3: 126,753,369 (GRCm39) |
V304A |
possibly damaging |
Het |
| Atg3 |
T |
C |
16: 44,992,036 (GRCm39) |
M88T |
possibly damaging |
Het |
| Baz1a |
G |
T |
12: 55,001,594 (GRCm39) |
P142Q |
probably damaging |
Het |
| Btbd1 |
G |
T |
7: 81,444,055 (GRCm39) |
|
probably null |
Het |
| Cacnb3 |
T |
C |
15: 98,537,734 (GRCm39) |
Y70H |
probably damaging |
Het |
| Cd4 |
G |
A |
6: 124,856,341 (GRCm39) |
T50I |
probably benign |
Het |
| Cyp7a1 |
A |
T |
4: 6,275,517 (GRCm39) |
W19R |
probably damaging |
Het |
| Dock10 |
T |
A |
1: 80,508,962 (GRCm39) |
I1610F |
probably damaging |
Het |
| Gm11444 |
C |
A |
11: 85,738,920 (GRCm39) |
D58Y |
unknown |
Het |
| Gpc5 |
A |
G |
14: 115,636,600 (GRCm39) |
S428G |
probably benign |
Het |
| Haus8 |
T |
C |
8: 71,705,757 (GRCm39) |
E309G |
probably damaging |
Het |
| Ice1 |
A |
G |
13: 70,753,023 (GRCm39) |
L1021P |
possibly damaging |
Het |
| Krtap14 |
A |
T |
16: 88,622,615 (GRCm39) |
H121Q |
probably benign |
Het |
| Nwd1 |
T |
C |
8: 73,388,959 (GRCm39) |
V170A |
probably benign |
Het |
| Or1j10 |
T |
A |
2: 36,267,460 (GRCm39) |
M224K |
probably benign |
Het |
| Or6c3b |
T |
C |
10: 129,527,898 (GRCm39) |
Y4C |
probably damaging |
Het |
| Or8g24 |
G |
A |
9: 38,990,020 (GRCm39) |
T7I |
possibly damaging |
Het |
| Pfpl |
T |
C |
19: 12,406,037 (GRCm39) |
M96T |
possibly damaging |
Het |
| Pramel5 |
A |
G |
4: 143,997,732 (GRCm39) |
|
probably benign |
Het |
| Proc |
T |
C |
18: 32,256,605 (GRCm39) |
N354S |
probably benign |
Het |
| Prss40 |
T |
G |
1: 34,599,847 (GRCm39) |
I47L |
probably benign |
Het |
| Tmprss7 |
T |
C |
16: 45,484,538 (GRCm39) |
R541G |
probably benign |
Het |
| Togaram2 |
T |
C |
17: 72,023,508 (GRCm39) |
V788A |
possibly damaging |
Het |
| Trbv19 |
T |
C |
6: 41,155,838 (GRCm39) |
Y70H |
probably damaging |
Het |
| Ttk |
C |
T |
9: 83,747,195 (GRCm39) |
S678L |
probably benign |
Het |
| Vmn2r85 |
T |
C |
10: 130,254,690 (GRCm39) |
T665A |
probably benign |
Het |
|
| Other mutations in Gm7168 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01392:Gm7168
|
APN |
17 |
14,169,169 (GRCm39) |
missense |
probably benign |
|
|
IGL01577:Gm7168
|
APN |
17 |
14,169,649 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01691:Gm7168
|
APN |
17 |
14,169,140 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0064:Gm7168
|
UTSW |
17 |
14,170,121 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0611:Gm7168
|
UTSW |
17 |
14,169,797 (GRCm39) |
missense |
probably benign |
|
|
R0737:Gm7168
|
UTSW |
17 |
14,169,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1789:Gm7168
|
UTSW |
17 |
14,169,846 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2864:Gm7168
|
UTSW |
17 |
14,170,117 (GRCm39) |
missense |
probably benign |
0.42 |
|
R2865:Gm7168
|
UTSW |
17 |
14,170,117 (GRCm39) |
missense |
probably benign |
0.42 |
|
R4179:Gm7168
|
UTSW |
17 |
14,169,265 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4652:Gm7168
|
UTSW |
17 |
14,170,069 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5174:Gm7168
|
UTSW |
17 |
14,168,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5722:Gm7168
|
UTSW |
17 |
14,169,824 (GRCm39) |
missense |
probably benign |
|
|
R6180:Gm7168
|
UTSW |
17 |
14,168,858 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7195:Gm7168
|
UTSW |
17 |
14,169,622 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7366:Gm7168
|
UTSW |
17 |
14,170,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7490:Gm7168
|
UTSW |
17 |
14,169,275 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7748:Gm7168
|
UTSW |
17 |
14,168,914 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8113:Gm7168
|
UTSW |
17 |
14,169,238 (GRCm39) |
nonsense |
probably null |
|
|
R8201:Gm7168
|
UTSW |
17 |
14,170,042 (GRCm39) |
missense |
probably benign |
|
|
R9197:Gm7168
|
UTSW |
17 |
14,169,489 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9260:Gm7168
|
UTSW |
17 |
14,169,488 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9520:Gm7168
|
UTSW |
17 |
14,169,506 (GRCm39) |
missense |
probably benign |
|
|
X0020:Gm7168
|
UTSW |
17 |
14,169,998 (GRCm39) |
missense |
probably benign |
0.04 |
|
Z1177:Gm7168
|
UTSW |
17 |
14,170,019 (GRCm39) |
missense |
probably benign |
0.22 |
|
Z1177:Gm7168
|
UTSW |
17 |
14,169,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Gm7168
|
UTSW |
17 |
14,169,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-10-07 |
Incidental Mutation