Incidental Mutation 'IGL01298:Gm7168'
ID 73211
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm7168
Ensembl Gene ENSMUSG00000067941
Gene Name predicted gene 7168
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # IGL01298
Quality Score
Status
Chromosome 17
Chromosomal Location 13948373-13950678 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 13949858 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 496 (T496S)
Ref Sequence ENSEMBL: ENSMUSP00000094997 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088809]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000088809
AA Change: T496S

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000094997
Gene: ENSMUSG00000067941
AA Change: T496S

DomainStartEndE-ValueType
low complexity region 6 20 N/A INTRINSIC
S_TKc 28 276 5.25e-91 SMART
UBA 296 333 4.39e-2 SMART
low complexity region 436 451 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adora2a G T 10: 75,333,492 W263C probably damaging Het
Agtpbp1 G A 13: 59,504,226 H424Y possibly damaging Het
Angpt2 T G 8: 18,710,528 N186T probably benign Het
Ank2 A G 3: 126,959,720 V304A possibly damaging Het
Atg3 T C 16: 45,171,673 M88T possibly damaging Het
Baz1a G T 12: 54,954,809 P142Q probably damaging Het
Btbd1 G T 7: 81,794,307 probably null Het
Cacnb3 T C 15: 98,639,853 Y70H probably damaging Het
Cd4 G A 6: 124,879,378 T50I probably benign Het
Cyp7a1 A T 4: 6,275,517 W19R probably damaging Het
Dock10 T A 1: 80,531,245 I1610F probably damaging Het
Gm11444 C A 11: 85,848,094 D58Y unknown Het
Gpc5 A G 14: 115,399,188 S428G probably benign Het
Haus8 T C 8: 71,253,113 E309G probably damaging Het
Ice1 A G 13: 70,604,904 L1021P possibly damaging Het
Krtap14 A T 16: 88,825,727 H121Q probably benign Het
Nwd1 T C 8: 72,662,331 V170A probably benign Het
Olfr338 T A 2: 36,377,448 M224K probably benign Het
Olfr803 T C 10: 129,692,029 Y4C probably damaging Het
Olfr938 G A 9: 39,078,724 T7I possibly damaging Het
Pfpl T C 19: 12,428,673 M96T possibly damaging Het
Pramel5 A G 4: 144,271,162 probably benign Het
Proc T C 18: 32,123,552 N354S probably benign Het
Prss40 T G 1: 34,560,766 I47L probably benign Het
Tmprss7 T C 16: 45,664,175 R541G probably benign Het
Togaram2 T C 17: 71,716,513 V788A possibly damaging Het
Trbv19 T C 6: 41,178,904 Y70H probably damaging Het
Ttk C T 9: 83,865,142 S678L probably benign Het
Vmn2r85 T C 10: 130,418,821 T665A probably benign Het
Other mutations in Gm7168
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01392:Gm7168 APN 17 13948907 missense probably benign
IGL01577:Gm7168 APN 17 13949387 missense probably damaging 0.99
IGL01691:Gm7168 APN 17 13948878 missense probably damaging 0.96
R0064:Gm7168 UTSW 17 13949859 missense probably benign 0.21
R0611:Gm7168 UTSW 17 13949535 missense probably benign
R0737:Gm7168 UTSW 17 13948983 missense probably damaging 1.00
R1789:Gm7168 UTSW 17 13949584 missense probably benign 0.03
R2864:Gm7168 UTSW 17 13949855 missense probably benign 0.42
R2865:Gm7168 UTSW 17 13949855 missense probably benign 0.42
R4179:Gm7168 UTSW 17 13949003 missense probably benign 0.00
R4652:Gm7168 UTSW 17 13949807 missense possibly damaging 0.88
R5174:Gm7168 UTSW 17 13948455 missense probably damaging 1.00
R5722:Gm7168 UTSW 17 13949562 missense probably benign
R6180:Gm7168 UTSW 17 13948596 missense probably damaging 0.98
R7195:Gm7168 UTSW 17 13949360 missense probably benign 0.01
R7366:Gm7168 UTSW 17 13949885 missense probably damaging 1.00
R7490:Gm7168 UTSW 17 13949013 missense probably benign 0.01
R7748:Gm7168 UTSW 17 13948652 missense probably benign 0.03
R8113:Gm7168 UTSW 17 13948976 nonsense probably null
R8201:Gm7168 UTSW 17 13949780 missense probably benign
R9197:Gm7168 UTSW 17 13949227 missense probably benign 0.13
R9260:Gm7168 UTSW 17 13949226 missense probably benign 0.01
R9520:Gm7168 UTSW 17 13949244 missense probably benign
X0020:Gm7168 UTSW 17 13949736 missense probably benign 0.04
Z1177:Gm7168 UTSW 17 13949082 missense probably damaging 1.00
Z1177:Gm7168 UTSW 17 13949670 missense probably damaging 1.00
Z1177:Gm7168 UTSW 17 13949757 missense probably benign 0.22
Posted On 2013-10-07