Incidental Mutation 'IGL01298:Or8g24'
ID 73215
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or8g24
Ensembl Gene ENSMUSG00000048501
Gene Name olfactory receptor family 8 subfamily G member 24
Synonyms MOR171-25, Olfr938, GA_x6K02T2PVTD-32774646-32773699
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # IGL01298
Quality Score
Chromosome 9
Chromosomal Location 38989092-38990039 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 38990020 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 7 (T7I)
Ref Sequence ENSEMBL: ENSMUSP00000055053 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056499]
AlphaFold Q9EQ93
Predicted Effect possibly damaging
Transcript: ENSMUST00000056499
AA Change: T7I

PolyPhen 2 Score 0.633 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000055053
Gene: ENSMUSG00000048501
AA Change: T7I

Pfam:7tm_4 31 308 8e-49 PFAM
Pfam:7tm_1 41 290 5.5e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175411
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215888
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adora2a G T 10: 75,169,326 (GRCm39) W263C probably damaging Het
Agtpbp1 G A 13: 59,652,040 (GRCm39) H424Y possibly damaging Het
Angpt2 T G 8: 18,760,544 (GRCm39) N186T probably benign Het
Ank2 A G 3: 126,753,369 (GRCm39) V304A possibly damaging Het
Atg3 T C 16: 44,992,036 (GRCm39) M88T possibly damaging Het
Baz1a G T 12: 55,001,594 (GRCm39) P142Q probably damaging Het
Btbd1 G T 7: 81,444,055 (GRCm39) probably null Het
Cacnb3 T C 15: 98,537,734 (GRCm39) Y70H probably damaging Het
Cd4 G A 6: 124,856,341 (GRCm39) T50I probably benign Het
Cyp7a1 A T 4: 6,275,517 (GRCm39) W19R probably damaging Het
Dock10 T A 1: 80,508,962 (GRCm39) I1610F probably damaging Het
Gm11444 C A 11: 85,738,920 (GRCm39) D58Y unknown Het
Gm7168 A T 17: 14,170,120 (GRCm39) T496S probably benign Het
Gpc5 A G 14: 115,636,600 (GRCm39) S428G probably benign Het
Haus8 T C 8: 71,705,757 (GRCm39) E309G probably damaging Het
Ice1 A G 13: 70,753,023 (GRCm39) L1021P possibly damaging Het
Krtap14 A T 16: 88,622,615 (GRCm39) H121Q probably benign Het
Nwd1 T C 8: 73,388,959 (GRCm39) V170A probably benign Het
Or1j10 T A 2: 36,267,460 (GRCm39) M224K probably benign Het
Or6c3b T C 10: 129,527,898 (GRCm39) Y4C probably damaging Het
Pfpl T C 19: 12,406,037 (GRCm39) M96T possibly damaging Het
Pramel5 A G 4: 143,997,732 (GRCm39) probably benign Het
Proc T C 18: 32,256,605 (GRCm39) N354S probably benign Het
Prss40 T G 1: 34,599,847 (GRCm39) I47L probably benign Het
Tmprss7 T C 16: 45,484,538 (GRCm39) R541G probably benign Het
Togaram2 T C 17: 72,023,508 (GRCm39) V788A possibly damaging Het
Trbv19 T C 6: 41,155,838 (GRCm39) Y70H probably damaging Het
Ttk C T 9: 83,747,195 (GRCm39) S678L probably benign Het
Vmn2r85 T C 10: 130,254,690 (GRCm39) T665A probably benign Het
Other mutations in Or8g24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01020:Or8g24 APN 9 38,989,747 (GRCm39) missense probably damaging 0.96
IGL02930:Or8g24 APN 9 38,989,308 (GRCm39) missense probably damaging 1.00
IGL03346:Or8g24 APN 9 38,989,257 (GRCm39) missense probably benign 0.35
IGL03346:Or8g24 APN 9 38,989,258 (GRCm39) missense probably damaging 0.99
IGL03399:Or8g24 APN 9 38,989,533 (GRCm39) nonsense probably null
R0536:Or8g24 UTSW 9 38,989,625 (GRCm39) missense probably benign 0.03
R1170:Or8g24 UTSW 9 38,989,525 (GRCm39) missense possibly damaging 0.50
R1951:Or8g24 UTSW 9 38,989,580 (GRCm39) missense probably benign 0.07
R1952:Or8g24 UTSW 9 38,989,580 (GRCm39) missense probably benign 0.07
R2066:Or8g24 UTSW 9 38,989,510 (GRCm39) missense probably damaging 1.00
R2906:Or8g24 UTSW 9 38,989,669 (GRCm39) missense probably benign 0.39
R4707:Or8g24 UTSW 9 38,989,558 (GRCm39) missense probably benign 0.00
R4767:Or8g24 UTSW 9 38,989,988 (GRCm39) missense possibly damaging 0.71
R4951:Or8g24 UTSW 9 38,989,555 (GRCm39) missense probably benign 0.10
R5888:Or8g24 UTSW 9 38,989,263 (GRCm39) nonsense probably null
R5905:Or8g24 UTSW 9 38,989,379 (GRCm39) missense probably damaging 1.00
R6028:Or8g24 UTSW 9 38,989,379 (GRCm39) missense probably damaging 1.00
R6329:Or8g24 UTSW 9 38,989,199 (GRCm39) missense probably benign 0.02
R7240:Or8g24 UTSW 9 38,989,906 (GRCm39) missense probably damaging 0.99
R7345:Or8g24 UTSW 9 38,989,630 (GRCm39) missense probably damaging 1.00
R8058:Or8g24 UTSW 9 38,989,862 (GRCm39) missense probably damaging 1.00
R9023:Or8g24 UTSW 9 38,989,307 (GRCm39) missense probably benign 0.09
R9547:Or8g24 UTSW 9 38,989,927 (GRCm39) missense probably damaging 0.99
R9682:Or8g24 UTSW 9 38,989,874 (GRCm39) missense possibly damaging 0.95
R9760:Or8g24 UTSW 9 38,989,271 (GRCm39) missense possibly damaging 0.95
X0062:Or8g24 UTSW 9 38,989,762 (GRCm39) missense probably benign 0.15
Posted On 2013-10-07