Incidental Mutation 'IGL01298:Olfr938'
ID73215
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr938
Ensembl Gene ENSMUSG00000048501
Gene Nameolfactory receptor 938
SynonymsGA_x6K02T2PVTD-32774646-32773699, MOR171-25
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #IGL01298
Quality Score
Status
Chromosome9
Chromosomal Location39077698-39078887 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 39078724 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Isoleucine at position 7 (T7I)
Ref Sequence ENSEMBL: ENSMUSP00000055053 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056499]
Predicted Effect possibly damaging
Transcript: ENSMUST00000056499
AA Change: T7I

PolyPhen 2 Score 0.633 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000055053
Gene: ENSMUSG00000048501
AA Change: T7I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 8e-49 PFAM
Pfam:7tm_1 41 290 5.5e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000175411
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215888
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adora2a G T 10: 75,333,492 W263C probably damaging Het
Agtpbp1 G A 13: 59,504,226 H424Y possibly damaging Het
Angpt2 T G 8: 18,710,528 N186T probably benign Het
Ank2 A G 3: 126,959,720 V304A possibly damaging Het
Atg3 T C 16: 45,171,673 M88T possibly damaging Het
Baz1a G T 12: 54,954,809 P142Q probably damaging Het
Btbd1 G T 7: 81,794,307 probably null Het
Cacnb3 T C 15: 98,639,853 Y70H probably damaging Het
Cd4 G A 6: 124,879,378 T50I probably benign Het
Cyp7a1 A T 4: 6,275,517 W19R probably damaging Het
Dock10 T A 1: 80,531,245 I1610F probably damaging Het
Gm11444 C A 11: 85,848,094 D58Y unknown Het
Gm7168 A T 17: 13,949,858 T496S probably benign Het
Gpc5 A G 14: 115,399,188 S428G probably benign Het
Haus8 T C 8: 71,253,113 E309G probably damaging Het
Ice1 A G 13: 70,604,904 L1021P possibly damaging Het
Krtap14 A T 16: 88,825,727 H121Q probably benign Het
Nwd1 T C 8: 72,662,331 V170A probably benign Het
Olfr338 T A 2: 36,377,448 M224K probably benign Het
Olfr803 T C 10: 129,692,029 Y4C probably damaging Het
Pfpl T C 19: 12,428,673 M96T possibly damaging Het
Pramel5 A G 4: 144,271,162 probably benign Het
Proc T C 18: 32,123,552 N354S probably benign Het
Prss40 T G 1: 34,560,766 I47L probably benign Het
Tmprss7 T C 16: 45,664,175 R541G probably benign Het
Togaram2 T C 17: 71,716,513 V788A possibly damaging Het
Trbv19 T C 6: 41,178,904 Y70H probably damaging Het
Ttk C T 9: 83,865,142 S678L probably benign Het
Vmn2r85 T C 10: 130,418,821 T665A probably benign Het
Other mutations in Olfr938
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01020:Olfr938 APN 9 39078451 missense probably damaging 0.96
IGL02930:Olfr938 APN 9 39078012 missense probably damaging 1.00
IGL03346:Olfr938 APN 9 39077962 missense probably damaging 0.99
IGL03346:Olfr938 APN 9 39077961 missense probably benign 0.35
IGL03399:Olfr938 APN 9 39078237 nonsense probably null
R0536:Olfr938 UTSW 9 39078329 missense probably benign 0.03
R1170:Olfr938 UTSW 9 39078229 missense possibly damaging 0.50
R1951:Olfr938 UTSW 9 39078284 missense probably benign 0.07
R1952:Olfr938 UTSW 9 39078284 missense probably benign 0.07
R2066:Olfr938 UTSW 9 39078214 missense probably damaging 1.00
R2906:Olfr938 UTSW 9 39078373 missense probably benign 0.39
R4707:Olfr938 UTSW 9 39078262 missense probably benign 0.00
R4767:Olfr938 UTSW 9 39078692 missense possibly damaging 0.71
R4951:Olfr938 UTSW 9 39078259 missense probably benign 0.10
R5888:Olfr938 UTSW 9 39077967 nonsense probably null
R5905:Olfr938 UTSW 9 39078083 missense probably damaging 1.00
R6028:Olfr938 UTSW 9 39078083 missense probably damaging 1.00
R6329:Olfr938 UTSW 9 39077903 missense probably benign 0.02
R7240:Olfr938 UTSW 9 39078610 missense probably damaging 0.99
R7345:Olfr938 UTSW 9 39078334 missense probably damaging 1.00
R8058:Olfr938 UTSW 9 39078566 missense probably damaging 1.00
X0062:Olfr938 UTSW 9 39078466 missense probably benign 0.15
Posted On2013-10-07