Mutagenetix > Incidental Mutation

Incidental Mutation 'R9747:Dchs1'

732219

Institutional Source

Beutler Lab

Gene Symbol

Dchs1

Ensembl Gene

ENSMUSG00000036862

Gene Name

dachsous cadherin related 1

Synonyms

3110041P15Rik, C130033F22Rik

MMRRC Submission

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R9747 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

105752990-105787654 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 105763475 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Glutamic Acid at position 1239 (D1239E)

Ref Sequence

ENSEMBL: ENSMUSP00000077574 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078482]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000078482
AA Change: D1239E

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000077574
Gene: ENSMUSG00000036862
AA Change: D1239E

Domain	Start	End	E-Value	Type
signal peptide	1	36	N/A	INTRINSIC
CA	58	135	5.2e-11	SMART
CA	159	247	6.1e-17	SMART
CA	271	354	2.6e-30	SMART
CA	382	464	7.8e-26	SMART
CA	489	570	1.2e-34	SMART
CA	594	677	1.9e-27	SMART
CA	701	782	5.3e-11	SMART
CA	806	886	1e-12	SMART
CA	910	990	3.3e-14	SMART
CA	1016	1097	3.6e-18	SMART
CA	1121	1203	3.1e-34	SMART
CA	1233	1307	8.8e-16	SMART
low complexity region	1323	1335	N/A	INTRINSIC
CA	1344	1427	9.9e-9	SMART
CA	1451	1537	1.5e-23	SMART
CA	1560	1640	7.2e-32	SMART
CA	1664	1742	1.8e-31	SMART
CA	1765	1846	7.8e-30	SMART
CA	1870	1951	3.7e-26	SMART
low complexity region	1957	1965	N/A	INTRINSIC
CA	1979	2059	1.1e-6	SMART
CA	2083	2162	2.7e-18	SMART
CA	2186	2268	2.2e-26	SMART
CA	2291	2367	1e-18	SMART
CA	2391	2473	1.8e-23	SMART
CA	2497	2593	3.5e-21	SMART
CA	2617	2697	1.2e-25	SMART
CA	2721	2804	1.9e-18	SMART
CA	2828	2919	3e-3	SMART
transmembrane domain	2932	2954	N/A	INTRINSIC
low complexity region	3001	3017	N/A	INTRINSIC
low complexity region	3046	3055	N/A	INTRINSIC
low complexity region	3088	3097	N/A	INTRINSIC
low complexity region	3185	3196	N/A	INTRINSIC
low complexity region	3237	3259	N/A	INTRINSIC

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 99.4%
20x: 98.6%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 100 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930562C15Rik	T	C	16: 4,850,847 (GRCm38)	S701P	probably damaging	Het
9930021J03Rik	C	A	19: 29,754,511 (GRCm38)	C367F	possibly damaging	Het
Acsl1	A	G	8: 46,508,360 (GRCm38)	K114R	probably benign	Het
Adam11	A	G	11: 102,772,669 (GRCm38)	N275D	probably damaging	Het
Adamts19	G	A	18: 58,890,415 (GRCm38)	R294H	possibly damaging	Het
Adamts20	C	T	15: 94,283,062 (GRCm38)	C1666Y	probably damaging	Het
Ahnak	A	T	19: 9,010,177 (GRCm38)	I2942L	possibly damaging	Het
Ank1	A	G	8: 23,086,977 (GRCm38)	H195R	probably damaging	Het
Ank2	T	C	3: 126,959,018 (GRCm38)	T350A	probably damaging	Het
Asb3	T	A	11: 31,058,946 (GRCm38)	N243K	possibly damaging	Het
Atp10b	C	T	11: 43,197,512 (GRCm38)	T315I	probably benign	Het
Avl9	C	T	6: 56,753,840 (GRCm38)	S583F	probably damaging	Het
Bclaf1	A	G	10: 20,332,146 (GRCm38)	K700E	possibly damaging	Het
Cacna1i	G	A	15: 80,362,117 (GRCm38)	E571K	probably benign	Het
Casp1	T	A	9: 5,299,322 (GRCm38)	V17E	probably damaging	Het
Ccdc115	A	T	1: 34,438,920 (GRCm38)	D76E	probably benign	Het
Ccdc150	A	T	1: 54,259,948 (GRCm38)	R28*	probably null	Het
Cd36	T	G	5: 17,814,734 (GRCm38)	E123A	probably benign	Het
Cd5l	A	C	3: 87,367,797 (GRCm38)	Q214H	probably benign	Het
Cfap46	T	A	7: 139,611,991 (GRCm38)	H2370L	unknown	Het
Cftr	C	A	6: 18,285,637 (GRCm38)	T1148K	possibly damaging	Het
Col15a1	T	A	4: 47,312,208 (GRCm38)	L1341Q	probably damaging	Het
Col6a6	T	C	9: 105,784,040 (GRCm38)	E290G	probably benign	Het
D6Wsu163e	A	G	6: 126,962,014 (GRCm38)	E404G	probably benign	Het
Dennd4b	C	T	3: 90,270,521 (GRCm38)	T430I	possibly damaging	Het
Dmgdh	C	T	13: 93,688,646 (GRCm38)	P159L	probably damaging	Het
Dmrt3	G	A	19: 25,622,639 (GRCm38)	D283N	probably damaging	Het
Dnttip1	A	G	2: 164,765,180 (GRCm38)	D247G	probably damaging	Het
Efhc1	A	T	1: 20,978,704 (GRCm38)	D447V	probably damaging	Het
Ehhadh	T	C	16: 21,766,388 (GRCm38)	K248E	probably benign	Het
Eif4enif1	T	C	11: 3,213,267 (GRCm38)	L34P	probably damaging	Het
Fer	T	C	17: 63,907,381 (GRCm38)	M103T	probably benign	Het
Gabrg1	T	C	5: 70,780,686 (GRCm38)	M197V	probably damaging	Het
Galnt5	C	A	2: 57,999,465 (GRCm38)	T359K	probably benign	Het
Gm8108	G	T	14: 4,110,527 (GRCm38)		probably benign	Het
Gna12	T	C	5: 140,760,847 (GRCm38)	N281S	probably damaging	Het
Golgb1	C	T	16: 36,893,407 (GRCm38)	T250I	probably damaging	Het
Gpd1	A	G	15: 99,720,123 (GRCm38)	K130E	probably benign	Het
Gys2	A	T	6: 142,449,455 (GRCm38)	M428K	possibly damaging	Het
Hey2	A	C	10: 30,833,828 (GRCm38)	S310A	probably benign	Het
Ifi47	T	C	11: 49,096,540 (GRCm38)	V378A	possibly damaging	Het
Ighv8-12	A	G	12: 115,648,020 (GRCm38)	S95P	probably damaging	Het
Igkv1-131	G	T	6: 67,766,231 (GRCm38)	T56K	probably damaging	Het
Igsf23	T	C	7: 19,941,914 (GRCm38)	N127S	probably benign	Het
Iqgap2	T	A	13: 95,684,997 (GRCm38)	N546I	probably damaging	Het
Irf9	A	G	14: 55,606,588 (GRCm38)	H270R	probably benign	Het
Itga6	C	T	2: 71,826,527 (GRCm38)	S375L	probably damaging	Het
Jak1	T	C	4: 101,158,890 (GRCm38)	E857G	probably benign	Het
Kbtbd8	A	G	6: 95,121,857 (GRCm38)	T116A	possibly damaging	Het
Kif5a	T	C	10: 127,238,753 (GRCm38)	I570V	probably benign	Het
Klhdc10	T	C	6: 30,439,860 (GRCm38)	M154T	possibly damaging	Het
Krtap6-2	A	G	16: 89,419,888 (GRCm38)	Y64H	unknown	Het
Lce1l	C	T	3: 92,850,521 (GRCm38)	C10Y	unknown	Het
Lrrc72	A	G	12: 36,214,372 (GRCm38)	Y29H	probably damaging	Het
Ltbp2	A	T	12: 84,868,741 (GRCm38)	N181K	probably damaging	Het
Ly75	A	G	2: 60,306,328 (GRCm38)		probably null	Het
Mpped1	A	G	15: 83,800,104 (GRCm38)	Y109C	probably damaging	Het
Mrgpra2a	C	T	7: 47,426,710 (GRCm38)	V267I	probably benign	Het
Muc4	T	A	16: 32,754,698 (GRCm38)	V1524E	probably benign	Het
Nabp2	T	A	10: 128,401,741 (GRCm38)	R208*	probably null	Het
Ndst3	A	G	3: 123,546,812 (GRCm38)	F786L	possibly damaging	Het
Nos2	C	T	11: 78,931,646 (GRCm38)	P123S	probably damaging	Het
Nrcam	T	A	12: 44,598,409 (GRCm38)	V1198E	probably damaging	Het
Oacyl	A	G	18: 65,747,891 (GRCm38)	Q592R	possibly damaging	Het
Olfr1111	T	A	2: 87,150,554 (GRCm38)	T36S	probably benign	Het
Olfr1331	C	T	4: 118,869,020 (GRCm38)	P80S	probably damaging	Het
Pcdhgc4	A	G	18: 37,817,973 (GRCm38)	Y814C	probably benign	Het
Pcm1	A	C	8: 41,304,098 (GRCm38)	H1349P	probably benign	Het
Pcsk6	T	A	7: 65,983,722 (GRCm38)	D567E	probably damaging	Het
Pdgfd	T	C	9: 6,337,310 (GRCm38)	V214A	probably benign	Het
Plekhg3	A	T	12: 76,564,593 (GRCm38)	N270I	probably damaging	Het
Rasgrf1	T	A	9: 89,994,994 (GRCm38)	V804E	probably benign	Het
Rbl1	G	T	2: 157,192,046 (GRCm38)	L371I	probably damaging	Het
Rcl1	T	A	19: 29,128,082 (GRCm38)	I223N	probably damaging	Het
Saa4	C	T	7: 46,731,653 (GRCm38)	G15E	probably damaging	Het
Selenbp1	T	C	3: 94,937,337 (GRCm38)	S102P	probably damaging	Het
Setx	G	T	2: 29,174,365 (GRCm38)	E232*	probably null	Het
Sik2	A	G	9: 50,898,758 (GRCm38)	F502L	possibly damaging	Het
Slamf9	A	T	1: 172,478,215 (GRCm38)	I272F	unknown	Het
Slc33a1	A	T	3: 63,954,003 (GRCm38)	D259E	probably benign	Het
Slc41a3	A	G	6: 90,644,156 (GRCm38)	I393V	probably benign	Het
Slk	A	G	19: 47,619,907 (GRCm38)	D433G	possibly damaging	Het
Spata13	C	T	14: 60,691,791 (GRCm38)	P266L	probably benign	Het
Speer4c	T	A	5: 15,711,654 (GRCm38)	Q105L	probably benign	Het
Srgap1	A	G	10: 121,792,674 (GRCm38)	S818P	probably benign	Het
Srgap1	T	A	10: 121,925,866 (GRCm38)	I126F	probably damaging	Het
Tbpl2	A	T	2: 24,091,092 (GRCm38)	C232*	probably null	Het
Tctn3	T	G	19: 40,611,299 (GRCm38)	N153T	possibly damaging	Het
Tdrd1	T	A	19: 56,858,669 (GRCm38)	V914E	probably benign	Het
Tmem200b	A	G	4: 131,922,048 (GRCm38)	H93R	possibly damaging	Het
Tmem33	T	G	5: 67,268,579 (GRCm38)	N155K	possibly damaging	Het
Tmprss15	T	C	16: 79,087,512 (GRCm38)	D94G	probably benign	Het
Tnpo2	A	G	8: 85,055,359 (GRCm38)	D869G	probably benign	Het
Traf6	C	T	2: 101,696,684 (GRCm38)	R260*	probably null	Het
Ttn	C	T	2: 76,763,949 (GRCm38)	V20552I	possibly damaging	Het
Vmn2r102	T	A	17: 19,677,867 (GRCm38)	D381E	probably benign	Het
Vmn2r92	T	C	17: 18,184,939 (GRCm38)	F782L	possibly damaging	Het
Zfc3h1	G	A	10: 115,408,916 (GRCm38)	D765N	possibly damaging	Het
Zfp472	T	A	17: 32,977,297 (GRCm38)	H115Q	possibly damaging	Het
Zmynd11	T	A	13: 9,689,208 (GRCm38)	N514I	probably benign	Het

Other mutations in Dchs1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00235:Dchs1	APN	7	105,758,743 (GRCm38)	missense	probably damaging	1.00
IGL00422:Dchs1	APN	7	105,758,029 (GRCm38)	missense	possibly damaging	0.88
IGL00427:Dchs1	APN	7	105,758,424 (GRCm38)	missense	probably damaging	0.98
IGL00469:Dchs1	APN	7	105,755,261 (GRCm38)	missense	probably damaging	1.00
IGL00470:Dchs1	APN	7	105,758,207 (GRCm38)	missense	probably damaging	1.00
IGL00534:Dchs1	APN	7	105,757,943 (GRCm38)	missense	probably benign
IGL01292:Dchs1	APN	7	105,760,891 (GRCm38)	missense	probably damaging	0.98
IGL01380:Dchs1	APN	7	105,762,211 (GRCm38)	missense	probably damaging	1.00
IGL01396:Dchs1	APN	7	105,772,283 (GRCm38)	missense	probably damaging	1.00
IGL01448:Dchs1	APN	7	105,771,927 (GRCm38)	missense	probably damaging	0.98
IGL01759:Dchs1	APN	7	105,755,302 (GRCm38)	missense	probably benign	0.00
IGL01829:Dchs1	APN	7	105,755,397 (GRCm38)	missense	probably damaging	0.99
IGL01946:Dchs1	APN	7	105,759,105 (GRCm38)	missense	probably damaging	1.00
IGL01955:Dchs1	APN	7	105,757,591 (GRCm38)	missense	probably benign	0.00
IGL02012:Dchs1	APN	7	105,764,297 (GRCm38)	missense	probably damaging	0.98
IGL02222:Dchs1	APN	7	105,764,887 (GRCm38)	missense	probably damaging	1.00
IGL02261:Dchs1	APN	7	105,772,569 (GRCm38)	missense	probably damaging	1.00
IGL02365:Dchs1	APN	7	105,755,188 (GRCm38)	missense	probably benign	0.22
IGL02430:Dchs1	APN	7	105,771,971 (GRCm38)	missense	probably benign	0.34
IGL02500:Dchs1	APN	7	105,755,806 (GRCm38)	missense	probably benign
IGL02741:Dchs1	APN	7	105,757,323 (GRCm38)	missense	probably damaging	1.00
IGL02890:Dchs1	APN	7	105,756,491 (GRCm38)	missense	probably damaging	1.00
IGL03213:Dchs1	APN	7	105,755,072 (GRCm38)	missense	probably damaging	1.00
G1patch:Dchs1	UTSW	7	105,758,793 (GRCm38)	missense	probably damaging	0.99
P0026:Dchs1	UTSW	7	105,758,405 (GRCm38)	missense	probably damaging	0.99
PIT4377001:Dchs1	UTSW	7	105,757,588 (GRCm38)	missense	probably damaging	1.00
PIT4791001:Dchs1	UTSW	7	105,758,971 (GRCm38)	missense	probably damaging	1.00
R0013:Dchs1	UTSW	7	105,755,836 (GRCm38)	missense	possibly damaging	0.90
R0090:Dchs1	UTSW	7	105,755,932 (GRCm38)	missense	probably benign	0.18
R0091:Dchs1	UTSW	7	105,766,094 (GRCm38)	splice site	probably benign
R0193:Dchs1	UTSW	7	105,764,983 (GRCm38)	missense	probably benign	0.40
R0395:Dchs1	UTSW	7	105,758,538 (GRCm38)	missense	probably damaging	1.00
R0448:Dchs1	UTSW	7	105,765,927 (GRCm38)	missense	probably benign	0.00
R0480:Dchs1	UTSW	7	105,771,489 (GRCm38)	missense	probably benign	0.14
R0485:Dchs1	UTSW	7	105,772,727 (GRCm38)	missense	probably benign	0.00
R0566:Dchs1	UTSW	7	105,759,195 (GRCm38)	missense	probably benign	0.00
R0571:Dchs1	UTSW	7	105,771,996 (GRCm38)	missense	probably damaging	1.00
R0573:Dchs1	UTSW	7	105,758,778 (GRCm38)	missense	probably damaging	0.98
R0577:Dchs1	UTSW	7	105,764,255 (GRCm38)	missense	possibly damaging	0.78
R0622:Dchs1	UTSW	7	105,763,449 (GRCm38)	missense	probably damaging	1.00
R0654:Dchs1	UTSW	7	105,772,349 (GRCm38)	missense	probably damaging	1.00
R0677:Dchs1	UTSW	7	105,764,984 (GRCm38)	missense	probably damaging	1.00
R1171:Dchs1	UTSW	7	105,757,714 (GRCm38)	missense	probably benign
R1241:Dchs1	UTSW	7	105,758,178 (GRCm38)	missense	probably damaging	1.00
R1389:Dchs1	UTSW	7	105,755,571 (GRCm38)	missense	probably benign	0.40
R1427:Dchs1	UTSW	7	105,766,191 (GRCm38)	missense	probably benign	0.06
R1458:Dchs1	UTSW	7	105,755,244 (GRCm38)	missense	probably damaging	1.00
R1513:Dchs1	UTSW	7	105,772,071 (GRCm38)	nonsense	probably null
R1524:Dchs1	UTSW	7	105,764,525 (GRCm38)	missense	probably damaging	1.00
R1525:Dchs1	UTSW	7	105,758,931 (GRCm38)	missense	probably damaging	1.00
R1534:Dchs1	UTSW	7	105,772,040 (GRCm38)	missense	probably damaging	0.98
R1567:Dchs1	UTSW	7	105,771,861 (GRCm38)	missense	probably benign	0.01
R1577:Dchs1	UTSW	7	105,765,955 (GRCm38)	missense	probably damaging	1.00
R1603:Dchs1	UTSW	7	105,762,770 (GRCm38)	missense	probably benign	0.24
R1676:Dchs1	UTSW	7	105,754,921 (GRCm38)	missense	probably benign	0.40
R1794:Dchs1	UTSW	7	105,771,720 (GRCm38)	missense	probably benign	0.02
R1826:Dchs1	UTSW	7	105,757,627 (GRCm38)	missense	probably damaging	1.00
R1892:Dchs1	UTSW	7	105,764,156 (GRCm38)	missense	probably benign	0.00
R1924:Dchs1	UTSW	7	105,772,280 (GRCm38)	missense	possibly damaging	0.81
R1932:Dchs1	UTSW	7	105,765,902 (GRCm38)	missense	probably damaging	1.00
R1962:Dchs1	UTSW	7	105,764,201 (GRCm38)	missense	probably damaging	1.00
R1985:Dchs1	UTSW	7	105,772,398 (GRCm38)	missense	possibly damaging	0.72
R1993:Dchs1	UTSW	7	105,762,548 (GRCm38)	missense	probably benign	0.00
R2007:Dchs1	UTSW	7	105,755,325 (GRCm38)	missense	probably damaging	1.00
R2316:Dchs1	UTSW	7	105,764,204 (GRCm38)	missense	possibly damaging	0.71
R2351:Dchs1	UTSW	7	105,754,094 (GRCm38)	missense	probably benign
R2474:Dchs1	UTSW	7	105,755,074 (GRCm38)	missense	probably benign	0.37
R2474:Dchs1	UTSW	7	105,772,838 (GRCm38)	missense	probably damaging	1.00
R3429:Dchs1	UTSW	7	105,756,504 (GRCm38)	missense	possibly damaging	0.85
R3430:Dchs1	UTSW	7	105,756,504 (GRCm38)	missense	possibly damaging	0.85
R3737:Dchs1	UTSW	7	105,762,316 (GRCm38)	missense	possibly damaging	0.88
R3767:Dchs1	UTSW	7	105,757,085 (GRCm38)	missense	possibly damaging	0.67
R3874:Dchs1	UTSW	7	105,761,635 (GRCm38)	missense	probably damaging	1.00
R3883:Dchs1	UTSW	7	105,762,563 (GRCm38)	missense	probably damaging	1.00
R4105:Dchs1	UTSW	7	105,765,140 (GRCm38)	missense	probably damaging	1.00
R4209:Dchs1	UTSW	7	105,766,190 (GRCm38)	missense	probably damaging	0.99
R4329:Dchs1	UTSW	7	105,753,759 (GRCm38)	missense	probably damaging	1.00
R4516:Dchs1	UTSW	7	105,754,852 (GRCm38)	missense	probably damaging	1.00
R4579:Dchs1	UTSW	7	105,758,973 (GRCm38)	missense	probably benign
R4579:Dchs1	UTSW	7	105,754,765 (GRCm38)	missense	probably damaging	1.00
R4588:Dchs1	UTSW	7	105,756,041 (GRCm38)	missense	probably benign
R4613:Dchs1	UTSW	7	105,772,724 (GRCm38)	missense	probably damaging	1.00
R4632:Dchs1	UTSW	7	105,754,355 (GRCm38)	missense	probably benign	0.02
R4696:Dchs1	UTSW	7	105,764,627 (GRCm38)	missense	probably damaging	1.00
R4725:Dchs1	UTSW	7	105,765,552 (GRCm38)	missense	probably damaging	1.00
R4725:Dchs1	UTSW	7	105,755,253 (GRCm38)	missense	probably damaging	0.98
R4738:Dchs1	UTSW	7	105,758,673 (GRCm38)	missense	probably damaging	0.96
R4768:Dchs1	UTSW	7	105,771,620 (GRCm38)	missense	possibly damaging	0.96
R4784:Dchs1	UTSW	7	105,765,926 (GRCm38)	missense	probably damaging	1.00
R4864:Dchs1	UTSW	7	105,755,253 (GRCm38)	missense	probably damaging	0.98
R4880:Dchs1	UTSW	7	105,755,730 (GRCm38)	missense	probably benign	0.00
R4909:Dchs1	UTSW	7	105,766,255 (GRCm38)	missense	probably damaging	1.00
R5102:Dchs1	UTSW	7	105,772,177 (GRCm38)	missense	probably benign	0.09
R5109:Dchs1	UTSW	7	105,765,014 (GRCm38)	missense	probably benign
R5126:Dchs1	UTSW	7	105,753,517 (GRCm38)	missense	probably damaging	1.00
R5149:Dchs1	UTSW	7	105,755,658 (GRCm38)	missense	probably damaging	0.98
R5330:Dchs1	UTSW	7	105,754,602 (GRCm38)	missense	probably damaging	1.00
R5384:Dchs1	UTSW	7	105,772,055 (GRCm38)	missense	probably damaging	1.00
R5384:Dchs1	UTSW	7	105,758,029 (GRCm38)	missense	probably damaging	1.00
R5386:Dchs1	UTSW	7	105,758,029 (GRCm38)	missense	probably damaging	1.00
R5622:Dchs1	UTSW	7	105,755,293 (GRCm38)	missense	probably benign	0.11
R5623:Dchs1	UTSW	7	105,772,769 (GRCm38)	missense	probably damaging	1.00
R5708:Dchs1	UTSW	7	105,772,809 (GRCm38)	missense	probably damaging	1.00
R5718:Dchs1	UTSW	7	105,755,748 (GRCm38)	missense	probably benign	0.01
R5743:Dchs1	UTSW	7	105,771,596 (GRCm38)	missense	probably benign
R5759:Dchs1	UTSW	7	105,764,176 (GRCm38)	missense	probably damaging	0.99
R5772:Dchs1	UTSW	7	105,773,040 (GRCm38)	missense	probably damaging	1.00
R5860:Dchs1	UTSW	7	105,772,035 (GRCm38)	missense	probably damaging	1.00
R5916:Dchs1	UTSW	7	105,759,166 (GRCm38)	missense	probably damaging	1.00
R5965:Dchs1	UTSW	7	105,755,925 (GRCm38)	missense	probably damaging	1.00
R5997:Dchs1	UTSW	7	105,754,095 (GRCm38)	missense	probably benign	0.08
R6065:Dchs1	UTSW	7	105,755,421 (GRCm38)	missense	probably damaging	1.00
R6136:Dchs1	UTSW	7	105,760,925 (GRCm38)	missense	probably benign
R6137:Dchs1	UTSW	7	105,765,106 (GRCm38)	missense	probably damaging	0.99
R6324:Dchs1	UTSW	7	105,764,938 (GRCm38)	missense	probably benign	0.05
R6363:Dchs1	UTSW	7	105,758,472 (GRCm38)	missense	probably benign	0.12
R6466:Dchs1	UTSW	7	105,764,541 (GRCm38)	missense	probably benign	0.09
R6544:Dchs1	UTSW	7	105,758,178 (GRCm38)	missense	probably damaging	1.00
R6572:Dchs1	UTSW	7	105,758,806 (GRCm38)	missense	possibly damaging	0.94
R6579:Dchs1	UTSW	7	105,762,913 (GRCm38)	missense	probably benign	0.17
R6632:Dchs1	UTSW	7	105,761,878 (GRCm38)	missense	probably damaging	1.00
R6725:Dchs1	UTSW	7	105,758,793 (GRCm38)	missense	probably damaging	0.99
R6789:Dchs1	UTSW	7	105,757,003 (GRCm38)	missense	possibly damaging	0.61
R6868:Dchs1	UTSW	7	105,763,503 (GRCm38)	missense	possibly damaging	0.91
R7058:Dchs1	UTSW	7	105,757,021 (GRCm38)	missense	probably benign
R7064:Dchs1	UTSW	7	105,763,185 (GRCm38)	missense	probably damaging	0.99
R7076:Dchs1	UTSW	7	105,761,871 (GRCm38)	missense	probably benign	0.04
R7191:Dchs1	UTSW	7	105,765,439 (GRCm38)	missense	possibly damaging	0.89
R7298:Dchs1	UTSW	7	105,755,131 (GRCm38)	nonsense	probably null
R7380:Dchs1	UTSW	7	105,758,628 (GRCm38)	missense	probably benign	0.35
R7438:Dchs1	UTSW	7	105,754,948 (GRCm38)	missense	probably benign	0.30
R7496:Dchs1	UTSW	7	105,761,859 (GRCm38)	missense	probably damaging	1.00
R7534:Dchs1	UTSW	7	105,772,373 (GRCm38)	missense	probably benign	0.00
R7604:Dchs1	UTSW	7	105,765,982 (GRCm38)	missense	probably damaging	1.00
R7631:Dchs1	UTSW	7	105,759,238 (GRCm38)	missense	probably benign
R7821:Dchs1	UTSW	7	105,765,145 (GRCm38)	missense	probably benign	0.00
R7834:Dchs1	UTSW	7	105,765,567 (GRCm38)	missense	probably benign	0.39
R7841:Dchs1	UTSW	7	105,762,973 (GRCm38)	missense	probably benign
R7913:Dchs1	UTSW	7	105,759,228 (GRCm38)	missense	possibly damaging	0.61
R8041:Dchs1	UTSW	7	105,755,188 (GRCm38)	missense	probably benign	0.45
R8076:Dchs1	UTSW	7	105,761,982 (GRCm38)	missense	probably damaging	1.00
R8076:Dchs1	UTSW	7	105,755,921 (GRCm38)	missense	possibly damaging	0.52
R8087:Dchs1	UTSW	7	105,753,499 (GRCm38)	missense	probably benign	0.41
R8125:Dchs1	UTSW	7	105,764,882 (GRCm38)	missense	possibly damaging	0.91
R8223:Dchs1	UTSW	7	105,762,617 (GRCm38)	missense	possibly damaging	0.81
R8239:Dchs1	UTSW	7	105,765,511 (GRCm38)	missense	probably benign	0.22
R8476:Dchs1	UTSW	7	105,758,808 (GRCm38)	missense	probably benign	0.05
R8497:Dchs1	UTSW	7	105,758,961 (GRCm38)	missense	probably damaging	1.00
R8770:Dchs1	UTSW	7	105,771,738 (GRCm38)	missense	probably damaging	1.00
R8856:Dchs1	UTSW	7	105,760,857 (GRCm38)	missense	probably damaging	1.00
R8866:Dchs1	UTSW	7	105,755,390 (GRCm38)	missense	probably benign	0.00
R8948:Dchs1	UTSW	7	105,759,005 (GRCm38)	missense	probably benign	0.30
R8950:Dchs1	UTSW	7	105,759,005 (GRCm38)	missense	probably benign	0.30
R9029:Dchs1	UTSW	7	105,753,712 (GRCm38)	missense	probably benign	0.13
R9039:Dchs1	UTSW	7	105,756,008 (GRCm38)	missense	probably benign	0.11
R9081:Dchs1	UTSW	7	105,754,429 (GRCm38)	missense	probably benign	0.00
R9134:Dchs1	UTSW	7	105,755,703 (GRCm38)	missense	probably damaging	0.96
R9159:Dchs1	UTSW	7	105,765,919 (GRCm38)	missense	probably benign
R9162:Dchs1	UTSW	7	105,765,525 (GRCm38)	missense	probably damaging	1.00
R9169:Dchs1	UTSW	7	105,772,907 (GRCm38)	missense	probably damaging	1.00
R9262:Dchs1	UTSW	7	105,755,626 (GRCm38)	missense	probably damaging	1.00
R9292:Dchs1	UTSW	7	105,753,913 (GRCm38)	missense	probably damaging	1.00
R9325:Dchs1	UTSW	7	105,766,195 (GRCm38)	missense	possibly damaging	0.51
R9376:Dchs1	UTSW	7	105,765,774 (GRCm38)	critical splice donor site	probably null
R9392:Dchs1	UTSW	7	105,772,662 (GRCm38)	missense	probably benign	0.09
R9619:Dchs1	UTSW	7	105,764,455 (GRCm38)	missense	probably benign	0.07
R9680:Dchs1	UTSW	7	105,762,418 (GRCm38)	missense	probably damaging	1.00
R9687:Dchs1	UTSW	7	105,757,984 (GRCm38)	missense	probably damaging	0.99
Z1177:Dchs1	UTSW	7	105,757,693 (GRCm38)	missense	probably damaging	1.00
Z1177:Dchs1	UTSW	7	105,758,551 (GRCm38)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TAACCAGGGATGCTGCTGTG -3'
(R):5'- TAGGTAAGAGAGACCACCTCC -3'

Sequencing Primer
(F):5'- TCCCCGGTGTGAGGATG -3'
(R):5'- GTAAGAGAGACCACCTCCTGGAAC -3'

Posted On

2022-11-14