Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01301:Tmem26'

73229

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tmem26

Ensembl Gene

ENSMUSG00000060044

Gene Name

transmembrane protein 26

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

IGL01301

Quality Score

Status

Chromosome

Chromosomal Location

68723646-68782650 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 68778606 bp

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Tyrosine at position 284 (N284Y)

Ref Sequence

ENSEMBL: ENSMUSP00000079789 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080995] [ENSMUST00000218918]

Predicted Effect

probably damaging
Transcript: ENSMUST00000080995
AA Change: N284Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000079789
Gene: ENSMUSG00000060044
AA Change: N284Y

Domain	Start	End	E-Value	Type
Pfam:Tmem26	3	304	5.6e-125	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000218918

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing multiple transmembrane helices. It is a selective surface protein marker of brite/beige adipocytes, which may coexist with classical brown adipocytes in brown adipose tissue. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1600012H06Rik	C	T	17: 14,943,919		probably null	Het
Acacb	A	T	5: 114,246,498	I2238L	probably benign	Het
Aldh1l2	T	C	10: 83,522,846	Y95C	probably damaging	Het
Asxl2	A	G	12: 3,501,425	T1056A	probably damaging	Het
B4galnt1	A	G	10: 127,169,779	T250A	possibly damaging	Het
Cela3b	A	T	4: 137,423,843		probably null	Het
Chst3	T	C	10: 60,185,832	T398A	probably damaging	Het
Cngb3	A	G	4: 19,425,625	T478A	probably damaging	Het
Cyp4a10	T	C	4: 115,518,455	L45P	probably damaging	Het
Defb21	A	G	2: 152,574,751	E49G	possibly damaging	Het
Dnajc1	T	C	2: 18,308,834	T159A	probably damaging	Het
Dnmbp	A	G	19: 43,902,354	S325P	probably benign	Het
Fam91a1	T	C	15: 58,442,871	F534L	probably damaging	Het
Fermt2	T	C	14: 45,464,863	E488G	probably damaging	Het
Filip1	T	C	9: 79,819,180	D719G	possibly damaging	Het
Gad1-ps	A	G	10: 99,445,151		noncoding transcript	Het
Glra3	C	A	8: 55,940,962	A36E	probably benign	Het
Gm9884	T	A	1: 25,830,648		probably benign	Het
Hectd2	T	C	19: 36,569,370		probably benign	Het
Hnrnpm	C	T	17: 33,669,168		probably null	Het
Lrrk2	T	A	15: 91,767,339	Y1733N	probably damaging	Het
Mindy1	T	C	3: 95,288,390	L148P	probably damaging	Het
Mkrn2	C	A	6: 115,611,789	Y164*	probably null	Het
Msra	T	C	14: 64,210,435	Y135C	probably damaging	Het
Ndst3	C	T	3: 123,548,916	A749T	probably damaging	Het
Ngdn	G	T	14: 55,017,114	A41S	probably benign	Het
Nlrp12	A	T	7: 3,240,092	S597T	probably damaging	Het
Olfr1451	A	T	19: 12,999,417	I144F	probably damaging	Het
Pabpc6	A	G	17: 9,667,970	S551P	probably benign	Het
Plekhg5	C	T	4: 152,112,553	A752V	probably benign	Het
Prpf4b	T	C	13: 34,884,291	S368P	probably benign	Het
Pus7	A	G	5: 23,746,424		probably null	Het
Rad23b	T	C	4: 55,366,774		probably benign	Het
Rgs13	T	C	1: 144,171,414		probably benign	Het
Sfpq	T	C	4: 127,026,760		probably benign	Het
Slc9a9	T	A	9: 95,055,459	S455T	probably benign	Het
Slco1a1	A	G	6: 141,932,530		probably benign	Het
Tmem87a	T	C	2: 120,380,769	I232V	probably benign	Het
Trpm2	A	G	10: 77,923,984	L1106P	probably damaging	Het
Vmn1r18	T	C	6: 57,389,667		probably benign	Het
Zfp213	G	T	17: 23,561,417	A43D	probably benign	Het
Zfp365	A	G	10: 67,909,354	V198A	probably damaging	Het
Zfp395	T	A	14: 65,394,751		probably null	Het
Zfp618	G	A	4: 63,132,826	V615M	probably damaging	Het

Other mutations in Tmem26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00155:Tmem26	APN	10	68775354	missense	probably damaging	1.00
IGL00471:Tmem26	APN	10	68778681	missense	possibly damaging	0.78
IGL01567:Tmem26	APN	10	68751231	missense	probably damaging	1.00
IGL02487:Tmem26	APN	10	68778733	missense	probably benign	0.00
IGL02713:Tmem26	APN	10	68751295	missense	probably damaging	1.00
IGL02828:Tmem26	APN	10	68775385	critical splice donor site	probably null
ANU18:Tmem26	UTSW	10	68778606	missense	probably damaging	1.00
P0027:Tmem26	UTSW	10	68778718	missense	probably benign	0.00
R1415:Tmem26	UTSW	10	68778661	missense	possibly damaging	0.93
R1649:Tmem26	UTSW	10	68751273	missense	probably damaging	1.00
R3871:Tmem26	UTSW	10	68778732	missense	probably benign	0.01
R5072:Tmem26	UTSW	10	68775348	missense	probably damaging	1.00
R5239:Tmem26	UTSW	10	68751266	missense	probably damaging	0.97
R6053:Tmem26	UTSW	10	68748484	missense	probably benign	0.00
R6607:Tmem26	UTSW	10	68778713	missense	probably benign	0.00
R6710:Tmem26	UTSW	10	68724054	missense	probably damaging	1.00
R7378:Tmem26	UTSW	10	68724092	critical splice donor site	probably null
T0722:Tmem26	UTSW	10	68778718	missense	probably benign	0.00
X0003:Tmem26	UTSW	10	68778718	missense	probably benign	0.00
Z1177:Tmem26	UTSW	10	68723963	missense	probably damaging	1.00

Posted On

2013-10-07