Incidental Mutation 'R9748:Lrp4'
| ID |
732292 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp4
|
| Ensembl Gene |
ENSMUSG00000027253 |
| Gene Name |
low density lipoprotein receptor-related protein 4 |
| Synonyms |
6430526J12Rik, Megf7, mdig |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.774)
|
| Stock # |
R9748 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
91287856-91344124 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 91316116 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Phenylalanine
at position 745
(L745F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028689]
|
| AlphaFold |
Q8VI56 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000028689
AA Change: L745F
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000028689
Gene: ENSMUSG00000027253
AA Change: L745F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
LDLa
|
26 |
68 |
5.77e-10 |
SMART |
|
LDLa
|
70 |
107 |
4.05e-14 |
SMART |
|
LDLa
|
109 |
145 |
1.9e-10 |
SMART |
|
LDLa
|
147 |
184 |
1.51e-13 |
SMART |
|
LDLa
|
190 |
227 |
6.83e-12 |
SMART |
|
LDLa
|
230 |
267 |
2.45e-13 |
SMART |
|
LDLa
|
269 |
306 |
6.32e-16 |
SMART |
|
LDLa
|
311 |
351 |
3.24e-13 |
SMART |
|
EGF
|
357 |
394 |
1.4e0 |
SMART |
|
EGF_CA
|
395 |
434 |
1.05e-8 |
SMART |
|
LY
|
460 |
502 |
7.01e-10 |
SMART |
|
LY
|
503 |
545 |
4.41e-16 |
SMART |
|
LY
|
546 |
589 |
1.04e-12 |
SMART |
|
LY
|
590 |
632 |
5.07e-16 |
SMART |
|
LY
|
633 |
674 |
3.12e-7 |
SMART |
|
EGF
|
701 |
737 |
9.27e-1 |
SMART |
|
LY
|
765 |
807 |
7.29e-8 |
SMART |
|
LY
|
808 |
850 |
1.92e-16 |
SMART |
|
LY
|
851 |
894 |
3.05e-10 |
SMART |
|
LY
|
895 |
937 |
6.69e-16 |
SMART |
|
LY
|
938 |
979 |
8.71e-6 |
SMART |
|
EGF
|
1005 |
1044 |
1.64e-1 |
SMART |
|
LY
|
1073 |
1115 |
2.58e-8 |
SMART |
|
LY
|
1116 |
1158 |
1.57e-12 |
SMART |
|
LY
|
1159 |
1202 |
7.4e-9 |
SMART |
|
LY
|
1203 |
1245 |
9.39e-11 |
SMART |
|
LY
|
1246 |
1285 |
6.11e-1 |
SMART |
|
EGF
|
1312 |
1349 |
1.53e-1 |
SMART |
|
LY
|
1377 |
1419 |
4.42e-7 |
SMART |
|
LY
|
1420 |
1462 |
1.04e-12 |
SMART |
|
LY
|
1463 |
1506 |
2.11e-13 |
SMART |
|
LY
|
1507 |
1549 |
4.66e-15 |
SMART |
|
LY
|
1550 |
1590 |
2.02e-1 |
SMART |
|
EGF_like
|
1616 |
1649 |
5.79e1 |
SMART |
|
low complexity region
|
1674 |
1690 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1724 |
1746 |
N/A |
INTRINSIC |
|
low complexity region
|
1857 |
1870 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 99.3%
- 20x: 98.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutations of this gene cause polysyndactyly. Additional phenotypes may include growth retardation, abnormal incisor development, kidney agenesis, and neonatal lethality associated with respiratory failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam5 |
T |
C |
8: 25,301,068 (GRCm39) |
T221A |
probably benign |
Het |
| Adamts12 |
G |
A |
15: 11,310,628 (GRCm39) |
V962I |
probably damaging |
Het |
| Ano3 |
T |
A |
2: 110,488,640 (GRCm39) |
I931F |
probably damaging |
Het |
| Anxa2r2 |
T |
A |
13: 120,488,200 (GRCm39) |
E116D |
possibly damaging |
Het |
| Arih1 |
T |
G |
9: 59,300,581 (GRCm39) |
D555A |
possibly damaging |
Het |
| Arsg |
A |
G |
11: 109,381,452 (GRCm39) |
D65G |
probably damaging |
Het |
| Atp8b3 |
G |
A |
10: 80,364,407 (GRCm39) |
T567I |
probably damaging |
Het |
| Camkk2 |
G |
C |
5: 122,872,182 (GRCm39) |
R575G |
probably benign |
Het |
| Ccdc168 |
G |
T |
1: 44,095,824 (GRCm39) |
S1758Y |
possibly damaging |
Het |
| Ccdc88b |
G |
T |
19: 6,831,461 (GRCm39) |
L494M |
probably damaging |
Het |
| Cdc7 |
A |
G |
5: 107,123,405 (GRCm39) |
K317E |
possibly damaging |
Het |
| Cfh |
A |
G |
1: 140,090,687 (GRCm39) |
|
probably null |
Het |
| Cp |
T |
G |
3: 20,043,335 (GRCm39) |
V1041G |
possibly damaging |
Het |
| Cpeb3 |
A |
G |
19: 37,151,926 (GRCm39) |
V150A |
probably benign |
Het |
| Cyp7a1 |
T |
A |
4: 6,269,216 (GRCm39) |
E352V |
probably damaging |
Het |
| Dnah9 |
T |
A |
11: 65,976,290 (GRCm39) |
H1253L |
possibly damaging |
Het |
| Dsg3 |
T |
C |
18: 20,672,761 (GRCm39) |
S811P |
possibly damaging |
Het |
| Efcab5 |
A |
T |
11: 77,007,022 (GRCm39) |
Y867* |
probably null |
Het |
| Eif2ak1 |
A |
G |
5: 143,819,031 (GRCm39) |
T231A |
probably damaging |
Het |
| Eif2ak4 |
T |
A |
2: 118,247,730 (GRCm39) |
C256S |
probably benign |
Het |
| Eif5b |
A |
G |
1: 38,090,241 (GRCm39) |
N1140S |
possibly damaging |
Het |
| Etnppl |
A |
T |
3: 130,414,002 (GRCm39) |
M34L |
probably benign |
Het |
| Fcrl5 |
T |
G |
3: 87,364,469 (GRCm39) |
C549W |
possibly damaging |
Het |
| Fhod1 |
G |
A |
8: 106,058,323 (GRCm39) |
A811V |
probably damaging |
Het |
| Flcn |
C |
T |
11: 59,692,980 (GRCm39) |
S198N |
probably benign |
Het |
| Fndc1 |
T |
A |
17: 7,991,929 (GRCm39) |
H589L |
unknown |
Het |
| Gm8108 |
G |
T |
14: 4,110,527 (GRCm38) |
|
probably benign |
Het |
| Hcn4 |
C |
T |
9: 58,730,996 (GRCm39) |
R68W |
unknown |
Het |
| Igfn1 |
A |
G |
1: 135,926,336 (GRCm39) |
L38P |
possibly damaging |
Het |
| Il1r1 |
A |
G |
1: 40,349,496 (GRCm39) |
T351A |
probably benign |
Het |
| Ildr2 |
T |
C |
1: 166,096,889 (GRCm39) |
L36P |
probably damaging |
Het |
| Itgb1bp1 |
C |
T |
12: 21,324,876 (GRCm39) |
C60Y |
probably damaging |
Het |
| Jrk |
A |
G |
15: 74,579,225 (GRCm39) |
L20P |
probably damaging |
Het |
| Kif5c |
C |
T |
2: 49,584,859 (GRCm39) |
A194V |
probably damaging |
Het |
| Ly9 |
A |
T |
1: 171,428,722 (GRCm39) |
D299E |
possibly damaging |
Het |
| Mfsd1 |
C |
T |
3: 67,499,910 (GRCm39) |
T185I |
possibly damaging |
Het |
| Mprip |
A |
G |
11: 59,656,348 (GRCm39) |
Y808C |
probably damaging |
Het |
| Mrps2 |
C |
A |
2: 28,359,594 (GRCm39) |
H150Q |
possibly damaging |
Het |
| Mtcl3 |
A |
T |
10: 29,024,398 (GRCm39) |
D438V |
probably damaging |
Het |
| Mturn |
A |
T |
6: 54,665,989 (GRCm39) |
|
probably null |
Het |
| Myo5a |
T |
C |
9: 75,091,965 (GRCm39) |
S1205P |
probably damaging |
Het |
| Nckap5 |
G |
A |
1: 125,953,939 (GRCm39) |
P871L |
probably damaging |
Het |
| Ndst3 |
T |
A |
3: 123,421,631 (GRCm39) |
I401F |
probably benign |
Het |
| Nek4 |
G |
A |
14: 30,709,114 (GRCm39) |
V723M |
possibly damaging |
Het |
| Nfe2l2 |
A |
G |
2: 75,506,667 (GRCm39) |
S478P |
probably damaging |
Het |
| Nol6 |
T |
C |
4: 41,123,538 (GRCm39) |
Y70C |
probably damaging |
Het |
| Nup88 |
T |
C |
11: 70,860,497 (GRCm39) |
E94G |
probably benign |
Het |
| Oas1h |
A |
T |
5: 121,005,088 (GRCm39) |
N179Y |
probably damaging |
Het |
| Or1o11 |
T |
G |
17: 37,756,595 (GRCm39) |
V61G |
probably benign |
Het |
| Or8b39 |
T |
A |
9: 37,996,353 (GRCm39) |
S74T |
probably benign |
Het |
| Otof |
T |
C |
5: 30,540,998 (GRCm39) |
D847G |
probably damaging |
Het |
| Pak1 |
C |
A |
7: 97,547,842 (GRCm39) |
D331E |
possibly damaging |
Het |
| Pkd1l3 |
T |
C |
8: 110,373,555 (GRCm39) |
W1374R |
probably benign |
Het |
| Pkdrej |
G |
T |
15: 85,704,871 (GRCm39) |
T355K |
possibly damaging |
Het |
| Pramel27 |
A |
G |
4: 143,579,892 (GRCm39) |
*492W |
probably null |
Het |
| Prkcd |
A |
T |
14: 30,320,800 (GRCm39) |
F607I |
possibly damaging |
Het |
| Prrc2c |
A |
G |
1: 162,535,435 (GRCm39) |
S775P |
unknown |
Het |
| Prss16 |
G |
T |
13: 22,192,504 (GRCm39) |
H154N |
possibly damaging |
Het |
| Psme2b |
T |
C |
11: 48,836,779 (GRCm39) |
D56G |
possibly damaging |
Het |
| Rapsn |
C |
T |
2: 90,875,823 (GRCm39) |
P400L |
probably damaging |
Het |
| Rptn |
A |
G |
3: 93,304,761 (GRCm39) |
D698G |
possibly damaging |
Het |
| Rragc |
T |
C |
4: 123,818,658 (GRCm39) |
V291A |
possibly damaging |
Het |
| Rras2 |
A |
G |
7: 113,716,629 (GRCm39) |
|
probably null |
Het |
| Rsf1 |
GGCG |
GGCGACGGCCGCG |
7: 97,229,113 (GRCm39) |
|
probably benign |
Het |
| Scyl2 |
A |
C |
10: 89,476,794 (GRCm39) |
M777R |
probably benign |
Het |
| Serhl |
G |
T |
15: 82,998,597 (GRCm39) |
V235L |
probably benign |
Het |
| Sh2b3 |
T |
C |
5: 121,955,874 (GRCm39) |
Y536C |
probably damaging |
Het |
| Sh3pxd2a |
T |
C |
19: 47,257,093 (GRCm39) |
M570V |
probably benign |
Het |
| Slamf8 |
C |
T |
1: 172,411,800 (GRCm39) |
V232M |
probably benign |
Het |
| Slc6a21 |
T |
A |
7: 44,929,941 (GRCm39) |
L143Q |
probably damaging |
Het |
| Snx9 |
T |
A |
17: 5,949,670 (GRCm39) |
D123E |
probably benign |
Het |
| Spopfm2 |
G |
A |
3: 94,083,155 (GRCm39) |
H219Y |
probably damaging |
Het |
| Supt6 |
C |
A |
11: 78,108,767 (GRCm39) |
R1178L |
probably damaging |
Het |
| Sycp2 |
T |
G |
2: 178,025,304 (GRCm39) |
E379D |
probably damaging |
Het |
| Tekt2 |
C |
T |
4: 126,217,444 (GRCm39) |
R207H |
probably damaging |
Het |
| Tg |
A |
G |
15: 66,719,008 (GRCm39) |
M2655V |
possibly damaging |
Het |
| Tiam2 |
C |
T |
17: 3,561,440 (GRCm39) |
T1335I |
probably benign |
Het |
| Tmem154 |
T |
A |
3: 84,573,693 (GRCm39) |
L12Q |
possibly damaging |
Het |
| Trpv3 |
A |
T |
11: 73,174,499 (GRCm39) |
I289F |
possibly damaging |
Het |
| Tubgcp3 |
A |
G |
8: 12,699,758 (GRCm39) |
L365P |
probably damaging |
Het |
| Tulp4 |
T |
C |
17: 6,291,480 (GRCm39) |
|
probably null |
Het |
| Tyr |
A |
G |
7: 87,142,072 (GRCm39) |
S163P |
possibly damaging |
Het |
| Usp42 |
A |
T |
5: 143,713,533 (GRCm39) |
|
probably null |
Het |
| Vmn2r94 |
A |
G |
17: 18,463,989 (GRCm39) |
M767T |
probably benign |
Het |
| Wasl |
A |
G |
6: 24,619,533 (GRCm39) |
V329A |
unknown |
Het |
| Wdr62 |
T |
A |
7: 29,953,466 (GRCm39) |
M635L |
possibly damaging |
Het |
| Wee1 |
G |
T |
7: 109,721,722 (GRCm39) |
E56* |
probably null |
Het |
| Zc3h12c |
C |
T |
9: 52,055,231 (GRCm39) |
G193S |
probably damaging |
Het |
| Zfp236 |
T |
A |
18: 82,637,008 (GRCm39) |
Q1426L |
possibly damaging |
Het |
| Zfp74 |
T |
C |
7: 29,634,751 (GRCm39) |
Y319C |
probably damaging |
Het |
|
| Other mutations in Lrp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00225:Lrp4
|
APN |
2 |
91,325,371 (GRCm39) |
missense |
probably benign |
|
|
IGL00509:Lrp4
|
APN |
2 |
91,316,519 (GRCm39) |
splice site |
probably benign |
|
|
IGL01145:Lrp4
|
APN |
2 |
91,317,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01287:Lrp4
|
APN |
2 |
91,304,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01531:Lrp4
|
APN |
2 |
91,341,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01534:Lrp4
|
APN |
2 |
91,303,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01544:Lrp4
|
APN |
2 |
91,307,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01761:Lrp4
|
APN |
2 |
91,312,326 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01885:Lrp4
|
APN |
2 |
91,331,452 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01909:Lrp4
|
APN |
2 |
91,324,529 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02111:Lrp4
|
APN |
2 |
91,336,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02385:Lrp4
|
APN |
2 |
91,305,065 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02403:Lrp4
|
APN |
2 |
91,338,927 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02431:Lrp4
|
APN |
2 |
91,306,982 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02452:Lrp4
|
APN |
2 |
91,304,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02798:Lrp4
|
APN |
2 |
91,307,055 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02828:Lrp4
|
APN |
2 |
91,305,639 (GRCm39) |
missense |
probably benign |
|
|
IGL02832:Lrp4
|
APN |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02893:Lrp4
|
APN |
2 |
91,305,161 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
artiodactyl
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bubalus
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
riverhorse
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wallow
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
F5770:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0137:Lrp4
|
UTSW |
2 |
91,325,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0265:Lrp4
|
UTSW |
2 |
91,321,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0368:Lrp4
|
UTSW |
2 |
91,308,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0531:Lrp4
|
UTSW |
2 |
91,305,523 (GRCm39) |
splice site |
probably benign |
|
|
R0827:Lrp4
|
UTSW |
2 |
91,325,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Lrp4
|
UTSW |
2 |
91,317,372 (GRCm39) |
splice site |
probably benign |
|
|
R1183:Lrp4
|
UTSW |
2 |
91,307,864 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1587:Lrp4
|
UTSW |
2 |
91,306,650 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1693:Lrp4
|
UTSW |
2 |
91,322,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Lrp4
|
UTSW |
2 |
91,322,966 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1863:Lrp4
|
UTSW |
2 |
91,328,708 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1908:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1909:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1932:Lrp4
|
UTSW |
2 |
91,327,700 (GRCm39) |
nonsense |
probably null |
|
|
R1934:Lrp4
|
UTSW |
2 |
91,310,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2358:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2433:Lrp4
|
UTSW |
2 |
91,336,360 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2698:Lrp4
|
UTSW |
2 |
91,305,557 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2919:Lrp4
|
UTSW |
2 |
91,321,075 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3105:Lrp4
|
UTSW |
2 |
91,331,394 (GRCm39) |
missense |
probably benign |
|
|
R3709:Lrp4
|
UTSW |
2 |
91,320,811 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R3711:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3735:Lrp4
|
UTSW |
2 |
91,328,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3808:Lrp4
|
UTSW |
2 |
91,307,047 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3894:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3895:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4397:Lrp4
|
UTSW |
2 |
91,342,015 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4741:Lrp4
|
UTSW |
2 |
91,341,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Lrp4
|
UTSW |
2 |
91,316,231 (GRCm39) |
missense |
probably benign |
|
|
R5050:Lrp4
|
UTSW |
2 |
91,322,767 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5096:Lrp4
|
UTSW |
2 |
91,316,137 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5110:Lrp4
|
UTSW |
2 |
91,327,417 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5141:Lrp4
|
UTSW |
2 |
91,309,023 (GRCm39) |
splice site |
probably benign |
|
|
R5439:Lrp4
|
UTSW |
2 |
91,327,418 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5725:Lrp4
|
UTSW |
2 |
91,325,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5795:Lrp4
|
UTSW |
2 |
91,304,816 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5820:Lrp4
|
UTSW |
2 |
91,322,960 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5883:Lrp4
|
UTSW |
2 |
91,318,778 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5919:Lrp4
|
UTSW |
2 |
91,303,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Lrp4
|
UTSW |
2 |
91,342,029 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6080:Lrp4
|
UTSW |
2 |
91,332,345 (GRCm39) |
missense |
probably benign |
|
|
R6189:Lrp4
|
UTSW |
2 |
91,305,579 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6192:Lrp4
|
UTSW |
2 |
91,338,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6319:Lrp4
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Lrp4
|
UTSW |
2 |
91,324,174 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6479:Lrp4
|
UTSW |
2 |
91,317,429 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6500:Lrp4
|
UTSW |
2 |
91,322,765 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6643:Lrp4
|
UTSW |
2 |
91,332,340 (GRCm39) |
missense |
probably benign |
|
|
R6657:Lrp4
|
UTSW |
2 |
91,322,398 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6696:Lrp4
|
UTSW |
2 |
91,327,690 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6714:Lrp4
|
UTSW |
2 |
91,306,710 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6734:Lrp4
|
UTSW |
2 |
91,316,242 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6770:Lrp4
|
UTSW |
2 |
91,327,648 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6774:Lrp4
|
UTSW |
2 |
91,341,849 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6957:Lrp4
|
UTSW |
2 |
91,317,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6978:Lrp4
|
UTSW |
2 |
91,322,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7065:Lrp4
|
UTSW |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7142:Lrp4
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7219:Lrp4
|
UTSW |
2 |
91,322,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7237:Lrp4
|
UTSW |
2 |
91,303,528 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7387:Lrp4
|
UTSW |
2 |
91,306,959 (GRCm39) |
missense |
probably benign |
|
|
R7585:Lrp4
|
UTSW |
2 |
91,322,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7835:Lrp4
|
UTSW |
2 |
91,325,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7872:Lrp4
|
UTSW |
2 |
91,321,061 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7968:Lrp4
|
UTSW |
2 |
91,324,424 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8222:Lrp4
|
UTSW |
2 |
91,305,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8338:Lrp4
|
UTSW |
2 |
91,322,713 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8342:Lrp4
|
UTSW |
2 |
91,318,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8435:Lrp4
|
UTSW |
2 |
91,307,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8720:Lrp4
|
UTSW |
2 |
91,324,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8774:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8774-TAIL:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8792:Lrp4
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8913:Lrp4
|
UTSW |
2 |
91,331,785 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9017:Lrp4
|
UTSW |
2 |
91,324,397 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9062:Lrp4
|
UTSW |
2 |
91,303,925 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9118:Lrp4
|
UTSW |
2 |
91,308,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9640:Lrp4
|
UTSW |
2 |
91,316,296 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9649:Lrp4
|
UTSW |
2 |
91,338,914 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9708:Lrp4
|
UTSW |
2 |
91,342,076 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9776:Lrp4
|
UTSW |
2 |
91,316,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7580:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7581:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7582:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7583:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
X0021:Lrp4
|
UTSW |
2 |
91,331,407 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCAGTGGAGTAAACTCTGCTC -3'
(R):5'- TTGGCCCTGCTGATGGTATC -3'
Sequencing Primer
(F):5'- TCTAACGTGTAATCCCCGAGG -3'
(R):5'- ATCAGTGCTGACATCTGTCCAATAC -3'
|
| Posted On |
2022-11-14 |
Incidental Mutation