Mutagenetix > Incidental Mutation

Incidental Mutation 'R9749:Vmn2r118'

732448

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

EG383258, Vmn2r119, EG668547

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

R9749 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

55592341-55624672 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

C to T at 55608415 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

probably null
Transcript: ENSMUST00000168440

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 99.3%
20x: 98.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 80 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933427D14Rik	T	A	11: 72,189,695	I382F	possibly damaging	Het
9030624J02Rik	C	A	7: 118,752,884	D195E	probably benign	Het
Adamtsl3	A	G	7: 82,450,186	S183G	probably benign	Het
Adamtsl4	T	C	3: 95,684,147	H170R	probably benign	Het
Adcy2	T	C	13: 68,625,855	D1023G	probably damaging	Het
Agrn	C	A	4: 156,173,657	V1083F	probably benign	Het
Arhgap21	T	C	2: 20,849,215	T1789A	probably benign	Het
Atr	T	C	9: 95,937,650		probably null	Het
Bcl2l13	T	C	6: 120,865,672	S109P	possibly damaging	Het
Bik	A	T	15: 83,541,339	T14S	possibly damaging	Het
Car7	A	G	8: 104,548,422	D164G	probably damaging	Het
Cat	T	A	2: 103,455,100	K499M	probably benign	Het
Ccar2	T	A	14: 70,151,279	Q161L	probably benign	Het
Cd109	T	G	9: 78,684,884	V760G	probably damaging	Het
Cep350	A	T	1: 155,953,239	H246Q	probably benign	Het
Chst13	T	C	6: 90,318,269	D54G	probably damaging	Het
Col4a4	A	G	1: 82,485,632	S1046P	unknown	Het
Col6a5	T	C	9: 105,861,991	Q2581R	probably damaging	Het
Csmd2	A	T	4: 128,496,128	I2219F		Het
Cux2	G	A	5: 121,869,717	S627L	possibly damaging	Het
Cyp2a22	A	T	7: 26,939,290	W24R	probably null	Het
Dhrs7c	A	T	11: 67,811,653	T156S	probably damaging	Het
Dnah9	A	G	11: 66,095,376	V1144A	probably damaging	Het
Folh1	T	C	7: 86,719,700	T740A	probably damaging	Het
Foxo4	G	A	X: 101,258,349	S209N	probably benign	Het
Gm10300	A	G	4: 132,074,718	T8A	unknown	Het
Gm11273	G	A	13: 21,501,345	A25V	probably benign	Het
Gns	T	A	10: 121,378,152	I244N	probably benign	Het
Gsdmd	A	G	15: 75,863,562	K52E	probably damaging	Het
H1f0	A	G	15: 79,029,017	D99G	probably benign	Het
Hapln4	T	C	8: 70,087,074	Y252H	probably damaging	Het
Hmcn1	A	C	1: 150,756,588	I866S	possibly damaging	Het
Hrnr	C	T	3: 93,324,077	R541C	unknown	Het
Ick	T	A	9: 78,153,717	V215E	probably damaging	Het
Igkv4-57-1	A	G	6: 69,544,424	I98T	probably damaging	Het
Itih3	T	A	14: 30,919,322	D253V	probably damaging	Het
Kansl1l	T	A	1: 66,721,811	E869D	probably damaging	Het
Kif13a	T	C	13: 46,760,751	Q502R	probably damaging	Het
Lama5	T	A	2: 180,183,640	Q2447L	probably benign	Het
Lcn6	A	T	2: 25,680,022	M1L	probably benign	Het
Lrrtm1	T	C	6: 77,243,872	V104A	probably damaging	Het
Maats1	A	G	16: 38,308,125	I496T	probably damaging	Het
Map3k13	T	C	16: 21,921,831	L636P	probably benign	Het
Melk	T	A	4: 44,307,067	H74Q	possibly damaging	Het
Mixl1	A	T	1: 180,694,746	M190K	probably benign	Het
Mttp	A	G	3: 138,125,228	S27P	probably damaging	Het
Myh6	T	C	14: 54,953,486	I911V	probably damaging	Het
Ncapd3	T	A	9: 27,045,577	I262N	probably benign	Het
Ncapg2	C	A	12: 116,447,748	S1051*	probably null	Het
Nckap1	G	A	2: 80,571,224	Q39*	probably null	Het
Nemp1	A	G	10: 127,688,329	D76G	probably benign	Het
Olfr1083-ps	T	C	2: 86,607,565	E2G	probably benign	Het
Olfr1145	A	C	2: 87,809,858	K13Q	probably benign	Het
Olfr1239	T	A	2: 89,418,318	I32F	possibly damaging	Het
Olfr166	A	T	16: 19,487,363	H175L	possibly damaging	Het
Olfr434	G	A	6: 43,217,324	W137*	probably null	Het
Osbpl5	C	A	7: 143,695,571	V578L	probably benign	Het
Peg10	CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG	CCACATCAGGATCCACATCAGGATGCACATCAG	6: 4,756,398		probably benign	Het
Rabl3	A	G	16: 37,556,828	D49G	possibly damaging	Het
Rngtt	A	G	4: 33,368,618	I384V	possibly damaging	Het
Robo1	T	C	16: 72,308,369		probably benign	Het
Rtcb	C	A	10: 85,949,589	R125L	probably damaging	Het
Rtn4rl2	C	A	2: 84,872,610	R206L	probably damaging	Het
Sbk2	A	T	7: 4,957,334	I279N	probably benign	Het
Scaf1	A	G	7: 45,007,152	S768P	unknown	Het
Slc6a9	A	G	4: 117,864,001	H316R	probably damaging	Het
Son	CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC	CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC	16: 91,656,691		probably benign	Het
Tas2r136	G	T	6: 132,778,143	T7K	probably damaging	Het
Tbc1d9	T	A	8: 83,241,710		probably null	Het
Tekt2	C	T	4: 126,323,651	R207H	probably damaging	Het
Tmem40	T	C	6: 115,742,345	D53G	probably benign	Het
Tram1	A	T	1: 13,570,014	V272D	possibly damaging	Het
Trpc4	G	A	3: 54,194,881	D67N	probably damaging	Het
Ttc6	A	T	12: 57,654,773	T591S	probably benign	Het
Ube2g1	A	T	11: 72,679,373	E144V	probably benign	Het
Unc80	A	G	1: 66,505,020	D434G	probably damaging	Het
Vmn1r168	C	A	7: 23,540,812	N31K	probably damaging	Het
Vmn1r79	A	T	7: 12,176,523	T111S	probably damaging	Het
Yy1	A	G	12: 108,806,491	D231G	possibly damaging	Het
Zfp748	A	G	13: 67,542,454	V229A	probably benign	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Vmn2r118	APN	17	55592708	missense	probably damaging	1.00
IGL00976:Vmn2r118	APN	17	55593204	missense	probably damaging	1.00
IGL01419:Vmn2r118	APN	17	55593000	missense	probably benign	0.01
IGL01796:Vmn2r118	APN	17	55608585	missense	probably benign	0.30
IGL01799:Vmn2r118	APN	17	55592990	missense	probably damaging	1.00
IGL02002:Vmn2r118	APN	17	55592619	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55610517	missense	probably benign	0.18
IGL02172:Vmn2r118	APN	17	55624598	missense	probably benign	0.00
IGL02529:Vmn2r118	APN	17	55610870	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55592655	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55607996	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55608616	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55610717	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55608643	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55611021	splice site	probably benign
R0513:Vmn2r118	UTSW	17	55610970	nonsense	probably null
R0627:Vmn2r118	UTSW	17	55610772	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55608466	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55608620	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55593237	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55610935	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55610643	missense	probably benign	0.25
R1550:Vmn2r118	UTSW	17	55608083	missense	probably damaging	1.00
R1779:Vmn2r118	UTSW	17	55611530	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55592456	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55610406	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55611556	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55592882	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55592925	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55624650	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55608421	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55610347	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55610665	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55610860	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55592581	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55592894	missense	probably damaging	0.98
R5384:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5385:Vmn2r118	UTSW	17	55611565	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55592765	missense	possibly damaging	0.46
R5740:Vmn2r118	UTSW	17	55593103	missense	probably benign	0.00
R5927:Vmn2r118	UTSW	17	55624494	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55592871	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55608093	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55592996	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55592714	missense	possibly damaging	0.92
R6794:Vmn2r118	UTSW	17	55592348	missense	possibly damaging	0.48
R6929:Vmn2r118	UTSW	17	55610440	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55608496	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55592853	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55593242	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55608484	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55610936	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55610423	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55608057	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55608642	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55610216	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55610835	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55611649	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55610207	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55592837	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55611009	missense	probably damaging	0.98
R9792:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55592496	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55593218	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55610655	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GCAACTGGCAGAATATTGTGAAAC -3'
(R):5'- TGCATTCTTGGAAAACATGCAG -3'

Sequencing Primer
(F):5'- GAACAAATTGAATTTAGTGCAATTGC -3'
(R):5'- GGAGATGTAGTGATCATTAATCAGC -3'

Posted On

2022-11-14