Incidental Mutation 'R9751:Nap1l4'
ID 732517
Institutional Source Beutler Lab
Gene Symbol Nap1l4
Ensembl Gene ENSMUSG00000059119
Gene Name nucleosome assembly protein 1-like 4
Synonyms 2810410H14Rik, Nap2, D7Wsu30e
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R9751 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 143067316-143102843 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to C at 143088132 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147062 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072727] [ENSMUST00000207870] [ENSMUST00000207948] [ENSMUST00000208093] [ENSMUST00000209098] [ENSMUST00000208190]
AlphaFold Q78ZA7
Predicted Effect probably benign
Transcript: ENSMUST00000072727
AA Change: V142G

PolyPhen 2 Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000072510
Gene: ENSMUSG00000059119
AA Change: V142G

DomainStartEndE-ValueType
Pfam:NAP 65 338 5e-103 PFAM
low complexity region 341 370 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083184
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207244
Predicted Effect probably benign
Transcript: ENSMUST00000207870
Predicted Effect probably benign
Transcript: ENSMUST00000207948
Predicted Effect probably benign
Transcript: ENSMUST00000208093
Predicted Effect probably benign
Transcript: ENSMUST00000209098
AA Change: V142G

PolyPhen 2 Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000208190
AA Change: V142G

PolyPhen 2 Score 0.084 (Sensitivity: 0.93; Specificity: 0.85)
Predicted Effect probably benign
Transcript: ENSMUST00000208317
Meta Mutation Damage Score 0.1381 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.5%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca4 A G 3: 121,881,126 (GRCm39) N514D probably benign Het
Adgre1 G A 17: 57,757,101 (GRCm39) R786H probably null Het
Ankrd7 G A 6: 18,868,024 (GRCm39) V97I probably damaging Het
Bltp1 A G 3: 37,065,889 (GRCm39) I54M Het
Bmper C T 9: 23,318,009 (GRCm39) P543S possibly damaging Het
Brwd1 A T 16: 95,795,015 (GRCm39) M2233K possibly damaging Het
C1s2 G T 6: 124,602,553 (GRCm39) P553T probably damaging Het
Cachd1 G A 4: 100,823,438 (GRCm39) V497I possibly damaging Het
Cacng4 A G 11: 107,626,019 (GRCm39) S191P probably damaging Het
Cd109 C A 9: 78,605,442 (GRCm39) T1015K probably damaging Het
Clstn2 A G 9: 97,339,703 (GRCm39) L756P probably damaging Het
Crybg3 A T 16: 59,377,887 (GRCm39) D1122E possibly damaging Het
Csf2 A T 11: 54,140,420 (GRCm39) L6* probably null Het
Csnk1g2 T A 10: 80,473,745 (GRCm39) Y71N possibly damaging Het
Dlg2 C A 7: 90,564,731 (GRCm39) H116N probably benign Het
Dnah14 C T 1: 181,619,610 (GRCm39) S3978L probably damaging Het
Dpp8 C T 9: 64,960,453 (GRCm39) T328I probably null Het
Dync2i1 T A 12: 116,205,403 (GRCm39) probably null Het
Dysf T C 6: 84,163,450 (GRCm39) V1625A probably damaging Het
Efcab3 G A 11: 104,783,911 (GRCm39) G2754E probably benign Het
Egf C A 3: 129,548,538 (GRCm39) V26F probably damaging Het
Eif1ad19 T C 12: 87,740,526 (GRCm39) N11S possibly damaging Het
Fam20a T A 11: 109,565,992 (GRCm39) Y414F probably damaging Het
Fsip2 T C 2: 82,818,241 (GRCm39) I4658T probably benign Het
Hycc1 C T 5: 24,196,748 (GRCm39) E47K probably benign Het
Igflr1 A T 7: 30,266,653 (GRCm39) Q167L possibly damaging Het
Krt79 T G 15: 101,839,196 (GRCm39) E424D probably benign Het
Map3k6 A G 4: 132,979,168 (GRCm39) probably null Het
Mcpt4 A G 14: 56,297,511 (GRCm39) I215T probably damaging Het
Med13 T C 11: 86,189,984 (GRCm39) Y975C probably damaging Het
Meioc T A 11: 102,566,419 (GRCm39) Y678* probably null Het
Myof T C 19: 37,924,818 (GRCm39) T1190A probably benign Het
Ncapg T C 5: 45,851,195 (GRCm39) V796A probably damaging Het
Or4c10b C T 2: 89,711,956 (GRCm39) T262I probably benign Het
Or4c119 C T 2: 88,986,782 (GRCm39) V246M possibly damaging Het
Or5d39 T A 2: 87,979,614 (GRCm39) I250L probably benign Het
Or5d40 T A 2: 88,015,260 (GRCm39) V13E possibly damaging Het
Or5p68 T C 7: 107,945,645 (GRCm39) Y181C probably benign Het
Paxbp1 A G 16: 90,824,188 (GRCm39) S515P probably benign Het
Pip4p1 A G 14: 51,165,436 (GRCm39) V257A probably benign Het
Plce1 C T 19: 38,717,414 (GRCm39) S1401F probably damaging Het
Rptor A G 11: 119,777,964 (GRCm39) K1043E probably benign Het
Rtn4rl2 T G 2: 84,711,039 (GRCm39) N75T probably damaging Het
Slc35f4 A G 14: 49,536,291 (GRCm39) I448T possibly damaging Het
Styk1 CTCTTCATGATTTTCTT CTCTT 6: 131,278,612 (GRCm39) probably benign Het
Tas2r115 A G 6: 132,714,918 (GRCm39) I11T possibly damaging Het
Tbc1d5 A G 17: 51,181,680 (GRCm39) V351A possibly damaging Het
Trim43b A T 9: 88,971,570 (GRCm39) D195E probably benign Het
Trim65 C A 11: 116,021,564 (GRCm39) A90S probably benign Het
Trip11 C T 12: 101,850,765 (GRCm39) V1100I possibly damaging Het
Tyrp1 A G 4: 80,759,012 (GRCm39) E295G probably null Het
Ube2g2 G A 10: 77,480,307 (GRCm39) V138I probably benign Het
Other mutations in Nap1l4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01483:Nap1l4 APN 7 143,081,053 (GRCm39) splice site probably null
IGL02696:Nap1l4 APN 7 143,077,898 (GRCm39) missense possibly damaging 0.67
IGL02710:Nap1l4 APN 7 143,077,998 (GRCm39) missense probably benign 0.00
IGL03059:Nap1l4 APN 7 143,080,902 (GRCm39) critical splice donor site probably null
IGL03164:Nap1l4 APN 7 143,091,953 (GRCm39) critical splice donor site probably null
IGL03240:Nap1l4 APN 7 143,091,982 (GRCm39) missense probably benign 0.00
Ballerina UTSW 7 143,088,200 (GRCm39) splice site probably null
R1576:Nap1l4 UTSW 7 143,091,953 (GRCm39) critical splice donor site probably null
R1705:Nap1l4 UTSW 7 143,095,497 (GRCm39) start codon destroyed probably null 1.00
R1967:Nap1l4 UTSW 7 143,088,024 (GRCm39) missense probably damaging 0.99
R1989:Nap1l4 UTSW 7 143,080,921 (GRCm39) missense probably damaging 0.99
R3734:Nap1l4 UTSW 7 143,088,132 (GRCm39) unclassified probably benign
R4799:Nap1l4 UTSW 7 143,088,200 (GRCm39) splice site probably null
R5367:Nap1l4 UTSW 7 143,088,035 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TACAAGAATCGGGCATCACC -3'
(R):5'- CAGAACTTGGTTGAAGCTGTG -3'

Sequencing Primer
(F):5'- GGCATCACCCCAGTCTCC -3'
(R):5'- TGTTCCTAATGATCCAAGAAAAGCC -3'
Posted On 2022-11-14