Incidental Mutation 'R9752:Ifi209'
ID 732549
Institutional Source Beutler Lab
Gene Symbol Ifi209
Ensembl Gene ENSMUSG00000043263
Gene Name interferon activated gene 209
Synonyms Ifix, Pyhin-1, Pyhin1
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.126) question?
Stock # R9752 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 173458483-173475494 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 173472235 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 359 (I359F)
Ref Sequence ENSEMBL: ENSMUSP00000061900 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056071] [ENSMUST00000193727]
AlphaFold Q8BV49
Predicted Effect probably damaging
Transcript: ENSMUST00000056071
AA Change: I359F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000061900
Gene: ENSMUSG00000043263
AA Change: I359F

DomainStartEndE-ValueType
PYRIN 6 83 3.54e-17 SMART
low complexity region 152 169 N/A INTRINSIC
Pfam:HIN 231 396 4.2e-75 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000193727
SMART Domains Protein: ENSMUSP00000142161
Gene: ENSMUSG00000043263

DomainStartEndE-ValueType
PYRIN 6 83 1.7e-21 SMART
low complexity region 152 169 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ano2 C T 6: 125,840,499 (GRCm39) T390I probably damaging Het
Cc2d2b T C 19: 40,781,271 (GRCm39) V772A probably damaging Het
Cd109 A G 9: 78,614,834 (GRCm39) I1294V probably benign Het
Cic A G 7: 24,971,403 (GRCm39) E378G probably damaging Het
Clhc1 C T 11: 29,507,778 (GRCm39) P175L probably benign Het
Clip1 T C 5: 123,760,009 (GRCm39) E783G probably damaging Het
Cnot1 A G 8: 96,488,019 (GRCm39) Y546H probably damaging Het
Cog7 C A 7: 121,580,639 (GRCm39) probably null Het
Cr2 T C 1: 194,823,575 (GRCm39) T1008A probably benign Het
Diaph1 T C 18: 38,036,124 (GRCm39) T196A unknown Het
Entr1 T C 2: 26,276,990 (GRCm39) N247D probably benign Het
Flg2 A T 3: 93,108,467 (GRCm39) D165V probably damaging Het
Fstl1 T G 16: 37,649,534 (GRCm39) N249K probably damaging Het
Gatad2a A G 8: 70,364,839 (GRCm39) V515A probably benign Het
Gbp2b A T 3: 142,313,917 (GRCm39) D399V probably benign Het
Gna14 G A 19: 16,586,781 (GRCm39) V319I probably benign Het
Grip1 A G 10: 119,871,256 (GRCm39) D661G possibly damaging Het
Gtf3c4 C A 2: 28,724,126 (GRCm39) L535F probably damaging Het
Haus8 A C 8: 71,715,731 (GRCm39) S36A probably damaging Het
Hectd4 A T 5: 121,448,744 (GRCm39) Y364F probably benign Het
Hectd4 C T 5: 121,472,415 (GRCm39) A2717V possibly damaging Het
Hsf5 C T 11: 87,513,709 (GRCm39) T258M probably benign Het
Ighmbp2 A G 19: 3,324,360 (GRCm39) V302A probably benign Het
Iqgap3 C A 3: 88,016,176 (GRCm39) F986L probably damaging Het
Itgav T A 2: 83,600,451 (GRCm39) probably null Het
Kcp A T 6: 29,497,754 (GRCm39) D502E probably damaging Het
Kif15 T C 9: 122,824,890 (GRCm39) probably null Het
Lipo2 C G 19: 33,723,221 (GRCm39) K189N possibly damaging Het
Lrch4 T A 5: 137,636,218 (GRCm39) S390T probably benign Het
Mast2 G T 4: 116,179,508 (GRCm39) H389N probably benign Het
Med13 A G 11: 86,174,147 (GRCm39) Y1784H possibly damaging Het
Micu3 A G 8: 40,833,751 (GRCm39) K462E possibly damaging Het
Mrps10 T C 17: 47,683,572 (GRCm39) probably null Het
Msh6 T C 17: 88,293,963 (GRCm39) L906P probably damaging Het
Nphp4 A G 4: 152,621,737 (GRCm39) E531G probably benign Het
Nrp2 A T 1: 62,851,726 (GRCm39) Y825F probably benign Het
Ntn1 C T 11: 68,276,712 (GRCm39) V79M possibly damaging Het
Nxnl2 A G 13: 51,325,507 (GRCm39) D50G probably damaging Het
Or1e16 T A 11: 73,286,479 (GRCm39) Y123F possibly damaging Het
Or2t26 T C 11: 49,039,681 (GRCm39) M199T probably benign Het
Or52h9 A T 7: 104,202,530 (GRCm39) I135F possibly damaging Het
Or52r1c T A 7: 102,735,669 (GRCm39) C310S probably benign Het
Or6c219 T C 10: 129,780,990 (GRCm39) R314G probably benign Het
Or7e176 G A 9: 20,171,204 (GRCm39) V23I probably benign Het
Ppp1r42 A G 1: 10,073,674 (GRCm39) probably benign Het
Ppp4r3a A T 12: 101,008,763 (GRCm39) N692K probably benign Het
Prr11 T C 11: 86,994,416 (GRCm39) T77A possibly damaging Het
Resf1 T A 6: 149,228,068 (GRCm39) N371K probably benign Het
Rrn3 A G 16: 13,631,095 (GRCm39) I644V probably benign Het
Scd4 T C 19: 44,322,475 (GRCm39) S23P probably benign Het
Slc26a2 T A 18: 61,335,010 (GRCm39) S148C probably benign Het
Slc7a8 T C 14: 54,995,931 (GRCm39) E157G probably benign Het
Spi1 A G 2: 90,943,666 (GRCm39) H70R probably benign Het
Styk1 CTCTTCATGATTTTCTT CTCTT 6: 131,278,612 (GRCm39) probably benign Het
Tlr4 A G 4: 66,757,912 (GRCm39) N235S probably benign Het
Trpc6 C A 9: 8,643,641 (GRCm39) S475R probably benign Het
Usp34 C T 11: 23,409,182 (GRCm39) P2674L probably benign Het
Usp48 G A 4: 137,341,137 (GRCm39) G379D probably damaging Het
Vkorc1l1 T A 5: 130,011,078 (GRCm39) C97* probably null Het
Wfikkn2 T C 11: 94,129,211 (GRCm39) E310G probably benign Het
Zfp266 T A 9: 20,411,496 (GRCm39) N227I probably benign Het
Zfp335 C T 2: 164,749,347 (GRCm39) probably null Het
Zfp677 T A 17: 21,618,511 (GRCm39) C523S probably damaging Het
Zrsr2 GCTCCTCCTCCTCCTCCT GCTCCTCCTCCTCCT X: 162,719,750 (GRCm39) probably benign Het
Other mutations in Ifi209
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Ifi209 APN 1 173,466,529 (GRCm39) missense possibly damaging 0.88
IGL02598:Ifi209 APN 1 173,472,281 (GRCm39) missense probably damaging 0.99
IGL02712:Ifi209 APN 1 173,470,267 (GRCm39) missense possibly damaging 0.68
IGL03131:Ifi209 APN 1 173,468,800 (GRCm39) missense possibly damaging 0.86
IGL03368:Ifi209 APN 1 173,470,057 (GRCm39) missense possibly damaging 0.91
R0880:Ifi209 UTSW 1 173,472,379 (GRCm39) missense probably damaging 1.00
R1317:Ifi209 UTSW 1 173,465,029 (GRCm39) missense possibly damaging 0.96
R1640:Ifi209 UTSW 1 173,464,931 (GRCm39) missense probably damaging 0.98
R1769:Ifi209 UTSW 1 173,468,728 (GRCm39) missense probably benign 0.11
R2349:Ifi209 UTSW 1 173,470,122 (GRCm39) missense probably damaging 1.00
R5096:Ifi209 UTSW 1 173,472,300 (GRCm39) missense probably benign 0.17
R5369:Ifi209 UTSW 1 173,464,873 (GRCm39) start codon destroyed probably null 1.00
R5484:Ifi209 UTSW 1 173,468,640 (GRCm39) missense probably benign 0.18
R5532:Ifi209 UTSW 1 173,466,542 (GRCm39) missense probably damaging 0.99
R5551:Ifi209 UTSW 1 173,468,763 (GRCm39) missense probably benign 0.01
R5554:Ifi209 UTSW 1 173,468,763 (GRCm39) missense probably benign 0.01
R5749:Ifi209 UTSW 1 173,464,893 (GRCm39) missense probably damaging 1.00
R5960:Ifi209 UTSW 1 173,466,382 (GRCm39) splice site probably null
R6401:Ifi209 UTSW 1 173,472,269 (GRCm39) missense probably damaging 0.99
R7042:Ifi209 UTSW 1 173,470,236 (GRCm39) missense probably benign 0.34
R7304:Ifi209 UTSW 1 173,470,156 (GRCm39) missense possibly damaging 0.88
R7521:Ifi209 UTSW 1 173,470,261 (GRCm39) missense probably damaging 0.97
R7742:Ifi209 UTSW 1 173,470,198 (GRCm39) missense probably damaging 1.00
R7763:Ifi209 UTSW 1 173,470,445 (GRCm39) missense probably damaging 1.00
R7975:Ifi209 UTSW 1 173,468,722 (GRCm39) missense probably benign 0.24
R8498:Ifi209 UTSW 1 173,470,069 (GRCm39) missense probably benign 0.05
R8873:Ifi209 UTSW 1 173,470,156 (GRCm39) missense probably damaging 1.00
R9178:Ifi209 UTSW 1 173,464,969 (GRCm39) missense probably damaging 1.00
R9673:Ifi209 UTSW 1 173,470,332 (GRCm39) missense probably damaging 1.00
Z1088:Ifi209 UTSW 1 173,468,712 (GRCm39) missense probably benign 0.00
Z1088:Ifi209 UTSW 1 173,464,973 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCAGGATTTGCAACCCAGAATC -3'
(R):5'- TATCCTGAAAGCATGACCCTTGG -3'

Sequencing Primer
(F):5'- GCAACCCAGAATCTGTTTTGC -3'
(R):5'- GGAGAATGTTCCCCTAGAGCACTC -3'
Posted On 2022-11-14