Mutagenetix > Incidental Mutation

Incidental Mutation 'R9753:Vmn2r98'

732654

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r98

Ensembl Gene

ENSMUSG00000096717

Gene Name

vomeronasal 2, receptor 98

Synonyms

EG224552

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.146) question?

Stock #

R9753 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

19053460-19082411 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 19065403 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Proline at position 162 (T162P)

Ref Sequence

ENSEMBL: ENSMUSP00000131261 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170424]

AlphaFold

E9PZ56

Predicted Effect

probably benign
Transcript: ENSMUST00000170424
AA Change: T162P

PolyPhen 2 Score 0.267 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000131261
Gene: ENSMUSG00000096717
AA Change: T162P

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	460	2.6e-35	PFAM
Pfam:NCD3G	509	562	7.4e-22	PFAM
Pfam:7tm_3	594	830	1.4e-52	PFAM
low complexity region	844	856	N/A	INTRINSIC

Coding Region Coverage

1x: 99.8%
3x: 99.7%
10x: 99.2%
20x: 98.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ak9	G	A	10: 41,383,500	V843I		Het
Bbs12	T	C	3: 37,319,531	C43R	possibly damaging	Het
Brwd1	T	C	16: 96,023,828	E1145G	probably damaging	Het
C2cd4c	A	C	10: 79,612,233	I360S	probably damaging	Het
Carmil2	A	G	8: 105,690,907	N599S	probably damaging	Het
Cd79b	A	G	11: 106,312,631		probably null	Het
Ces2c	A	G	8: 104,853,617	M489V	probably benign	Het
Clip4	A	G	17: 71,799,073	N84D	probably benign	Het
Cramp1l	T	C	17: 24,972,346	D1047G	possibly damaging	Het
Cyp2c69	C	T	19: 39,877,547	V201M	probably benign	Het
Dock2	A	G	11: 34,273,673	S1154P	possibly damaging	Het
Elk4	T	G	1: 132,018,143	V253G	probably benign	Het
Erbb4	T	A	1: 68,198,903	H809L	probably benign	Het
Ext1	A	T	15: 53,344,671	D231E	probably damaging	Het
Fam221b	T	C	4: 43,665,574	K295E	probably benign	Het
Fbrsl1	A	G	5: 110,378,969	F2L	unknown	Het
Fnip2	C	T	3: 79,508,104	R209H	probably benign	Het
Gart	C	T	16: 91,634,061	G371D	probably damaging	Het
Gata6	T	A	18: 11,064,706	V506D	possibly damaging	Het
Gba2	T	C	4: 43,568,716	Y620C	probably damaging	Het
Gm8857	A	T	5: 10,949,053	T53S		Het
Gprc6a	T	C	10: 51,628,268	N160S	probably benign	Het
Gstm3	A	G	3: 107,968,177	W46R	probably damaging	Het
Hcn4	G	A	9: 58,844,036	R315H	unknown	Het
Hydin	T	C	8: 110,490,766	F1429L	possibly damaging	Het
Iqgap3	C	A	3: 88,108,869	F986L	probably damaging	Het
Itgb1bp1	A	G	12: 21,276,889	S28P	unknown	Het
Krt10	A	G	11: 99,388,966	F123L	unknown	Het
Krt79	T	G	15: 101,930,761	E424D	probably benign	Het
Lingo4	C	T	3: 94,402,186	R144*	probably null	Het
Ltbr	G	A	6: 125,307,385	R365W	probably damaging	Het
Nrsn1	C	A	13: 25,253,580	V122L	probably benign	Het
Olfr1428	T	A	19: 12,108,692	M59L	probably benign	Het
Olfr1564	C	A	17: 33,215,714	G210V	possibly damaging	Het
Olfr456	T	C	6: 42,486,573	M207V	probably benign	Het
Pcgf6	T	C	19: 47,034,634	T353A	probably damaging	Het
Pcsk2	T	C	2: 143,793,230	Y342H	probably damaging	Het
Pou2af1	A	T	9: 51,238,336	N243Y	possibly damaging	Het
Prkcz	T	C	4: 155,293,202	D197G	probably benign	Het
Sec14l4	G	A	11: 4,039,982	E94K	probably benign	Het
Sik2	T	C	9: 50,895,839	E757G	probably damaging	Het
Sipa1l1	T	A	12: 82,416,989	S1154T	possibly damaging	Het
Ssb	T	C	2: 69,867,521	Y175H	probably damaging	Het
St6galnac6	T	C	2: 32,612,249	I50T	probably benign	Het
Styk1	CTCTTCATGATTTTCTT	CTCTT	6: 131,301,649		probably benign	Het
Tmcc1	G	C	6: 116,022,110	R323G	possibly damaging	Het
Unc13b	C	T	4: 43,182,842	R396*	probably null	Het
Vezt	A	G	10: 93,970,321	S743P	probably benign	Het
Vmn1r77	A	C	7: 12,041,732	N145T	probably damaging	Het

Other mutations in Vmn2r98

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00897:Vmn2r98	APN	17	19065745	splice site	probably benign
IGL01296:Vmn2r98	APN	17	19065185	missense	probably damaging	1.00
IGL01363:Vmn2r98	APN	17	19065758	missense	probably benign	0.01
IGL01618:Vmn2r98	APN	17	19065259	missense	possibly damaging	0.93
IGL01746:Vmn2r98	APN	17	19066451	missense	probably damaging	1.00
IGL01747:Vmn2r98	APN	17	19066440	missense	probably damaging	1.00
IGL01770:Vmn2r98	APN	17	19066440	missense	probably damaging	1.00
IGL01868:Vmn2r98	APN	17	19066286	missense	probably benign
IGL02123:Vmn2r98	APN	17	19080679	missense	probably damaging	1.00
IGL02323:Vmn2r98	APN	17	19065851	missense	probably damaging	0.99
IGL02543:Vmn2r98	APN	17	19065821	missense	probably benign
IGL02650:Vmn2r98	APN	17	19080961	missense	probably benign	0.00
IGL02676:Vmn2r98	APN	17	19065259	missense	probably benign	0.00
IGL02803:Vmn2r98	APN	17	19066013	missense	probably benign
IGL02807:Vmn2r98	APN	17	19081021	missense	probably damaging	1.00
IGL03307:Vmn2r98	APN	17	19065980	missense	possibly damaging	0.62
IGL03396:Vmn2r98	APN	17	19069845	missense	possibly damaging	0.92
PIT4131001:Vmn2r98	UTSW	17	19080961	missense	probably benign	0.00
R0122:Vmn2r98	UTSW	17	19066400	missense	probably benign	0.06
R0329:Vmn2r98	UTSW	17	19066347	missense	probably benign	0.21
R0330:Vmn2r98	UTSW	17	19066347	missense	probably benign	0.21
R0368:Vmn2r98	UTSW	17	19065827	nonsense	probably null
R0545:Vmn2r98	UTSW	17	19053613	missense	probably benign	0.15
R0635:Vmn2r98	UTSW	17	19080497	missense	probably benign	0.00
R0689:Vmn2r98	UTSW	17	19080520	missense	possibly damaging	0.83
R1035:Vmn2r98	UTSW	17	19080749	missense	possibly damaging	0.90
R1243:Vmn2r98	UTSW	17	19065948	missense	possibly damaging	0.52
R1421:Vmn2r98	UTSW	17	19065178	missense	probably damaging	1.00
R1629:Vmn2r98	UTSW	17	19067383	missense	possibly damaging	0.94
R1643:Vmn2r98	UTSW	17	19080908	missense	probably damaging	1.00
R1795:Vmn2r98	UTSW	17	19066440	missense	probably damaging	1.00
R1958:Vmn2r98	UTSW	17	19066418	missense	possibly damaging	0.70
R1962:Vmn2r98	UTSW	17	19065333	nonsense	probably null
R2165:Vmn2r98	UTSW	17	19081291	missense	unknown
R2238:Vmn2r98	UTSW	17	19065951	missense	probably damaging	1.00
R2252:Vmn2r98	UTSW	17	19080436	missense	probably benign	0.00
R2323:Vmn2r98	UTSW	17	19065819	missense	probably benign	0.18
R2887:Vmn2r98	UTSW	17	19081177	missense	possibly damaging	0.83
R2909:Vmn2r98	UTSW	17	19067402	missense	probably damaging	1.00
R3001:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3002:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3003:Vmn2r98	UTSW	17	19065863	missense	probably benign	0.01
R3788:Vmn2r98	UTSW	17	19080625	missense	probably benign	0.31
R4570:Vmn2r98	UTSW	17	19066092	missense	probably benign	0.11
R4706:Vmn2r98	UTSW	17	19069745	missense	probably damaging	1.00
R4723:Vmn2r98	UTSW	17	19066340	missense	probably benign	0.01
R5036:Vmn2r98	UTSW	17	19066157	missense	probably benign	0.00
R5072:Vmn2r98	UTSW	17	19066044	missense	probably benign	0.07
R5121:Vmn2r98	UTSW	17	19053553	missense	probably benign	0.13
R5283:Vmn2r98	UTSW	17	19080719	missense	probably benign	0.05
R5294:Vmn2r98	UTSW	17	19069754	nonsense	probably null
R5371:Vmn2r98	UTSW	17	19069753	missense	probably damaging	1.00
R5532:Vmn2r98	UTSW	17	19067383	missense	possibly damaging	0.94
R5598:Vmn2r98	UTSW	17	19080899	missense	probably benign	0.37
R5800:Vmn2r98	UTSW	17	19065998	missense	probably benign	0.17
R6089:Vmn2r98	UTSW	17	19066074	missense	probably benign	0.29
R6155:Vmn2r98	UTSW	17	19065881	missense	possibly damaging	0.87
R6853:Vmn2r98	UTSW	17	19065801	missense	probably benign	0.00
R6920:Vmn2r98	UTSW	17	19065248	missense	probably damaging	0.98
R7012:Vmn2r98	UTSW	17	19066268	missense	probably benign	0.06
R7042:Vmn2r98	UTSW	17	19080922	missense	probably benign
R7068:Vmn2r98	UTSW	17	19065313	missense	probably benign
R7607:Vmn2r98	UTSW	17	19067308	missense	possibly damaging	0.95
R7763:Vmn2r98	UTSW	17	19080535	missense	probably benign	0.00
R7771:Vmn2r98	UTSW	17	19067198	splice site	probably null
R7915:Vmn2r98	UTSW	17	19067231	missense	probably benign	0.10
R8028:Vmn2r98	UTSW	17	19053650	missense	probably benign	0.00
R8205:Vmn2r98	UTSW	17	19081163	missense	probably damaging	0.99
R8241:Vmn2r98	UTSW	17	19080769	missense	probably damaging	0.99
R8906:Vmn2r98	UTSW	17	19066270	missense	probably benign
R8952:Vmn2r98	UTSW	17	19065269	missense	possibly damaging	0.76
R9147:Vmn2r98	UTSW	17	19066121	missense	probably benign	0.04
R9148:Vmn2r98	UTSW	17	19066121	missense	probably benign	0.04
R9187:Vmn2r98	UTSW	17	19081219	missense	probably damaging	1.00
R9344:Vmn2r98	UTSW	17	19066515	missense	probably benign	0.14
R9467:Vmn2r98	UTSW	17	19067255	missense	probably benign	0.01
R9487:Vmn2r98	UTSW	17	19081234	missense	possibly damaging	0.78
Z1177:Vmn2r98	UTSW	17	19065136	critical splice acceptor site	probably null
Z1177:Vmn2r98	UTSW	17	19067423	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGCTCTGCAATTTGCCATTG -3'
(R):5'- GGACTTACCTGGCTTCATTTACTAC -3'

Sequencing Primer
(F):5'- CTCTGCAATTTGCCATTGAGGAGATC -3'
(R):5'- CTCTTACAAGCAAGAGAAAC -3'

Posted On

2022-11-14