Incidental Mutation 'R9755:Miip'
ID 732671
Institutional Source Beutler Lab
Gene Symbol Miip
Ensembl Gene ENSMUSG00000029022
Gene Name migration and invasion inhibitory protein
Synonyms D4Wsu114e
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.069) question?
Stock # R9755 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 147860778-147868816 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 147865862 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 92 (Y92*)
Ref Sequence ENSEMBL: ENSMUSP00000113897 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030886] [ENSMUST00000094481] [ENSMUST00000119975] [ENSMUST00000172710]
AlphaFold A2A7Y5
Predicted Effect probably null
Transcript: ENSMUST00000030886
AA Change: Y92*
SMART Domains Protein: ENSMUSP00000030886
Gene: ENSMUSG00000029022
AA Change: Y92*

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
low complexity region 60 69 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000094481
SMART Domains Protein: ENSMUSP00000092054
Gene: ENSMUSG00000070583

DomainStartEndE-ValueType
low complexity region 22 32 N/A INTRINSIC
coiled coil region 86 116 N/A INTRINSIC
low complexity region 438 451 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000119975
AA Change: Y92*
SMART Domains Protein: ENSMUSP00000113897
Gene: ENSMUSG00000029022
AA Change: Y92*

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
Pfam:MIIP 41 382 1.4e-142 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000172710
AA Change: Y92*
SMART Domains Protein: ENSMUSP00000134085
Gene: ENSMUSG00000029022
AA Change: Y92*

DomainStartEndE-ValueType
low complexity region 13 24 N/A INTRINSIC
low complexity region 60 69 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.8%
  • 3x: 99.7%
  • 10x: 99.1%
  • 20x: 97.8%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5830411N06Rik T A 7: 140,261,631 probably null Het
Acin1 A T 14: 54,651,835 M774K probably damaging Het
Adamts9 T C 6: 92,879,941 R906G probably benign Het
Adgrl4 A T 3: 151,510,781 T534S probably benign Het
Amph A T 13: 19,113,155 D357V probably damaging Het
Arhgap33 C T 7: 30,528,501 V452I possibly damaging Het
B4galnt2 G A 11: 95,883,975 Q160* probably null Het
C1galt1 T G 6: 7,867,019 N288K probably benign Het
Cacna1c T C 6: 118,674,598 D967G probably damaging Het
Cacul1 C T 19: 60,545,517 E216K probably damaging Het
Cenpq A T 17: 40,932,821 S45R probably benign Het
Cfap54 T A 10: 92,921,368 M2216L unknown Het
Cfhr1 A G 1: 139,560,151 F3S probably benign Het
Csf2rb T G 15: 78,348,624 Y710* probably null Het
Dhh A G 15: 98,895,058 V107A possibly damaging Het
Etl4 A T 2: 20,785,237 T849S probably benign Het
Gm765 A T 6: 98,248,186 N45K probably benign Het
Gnrh1 G A 14: 67,749,250 E78K possibly damaging Het
Golga3 A G 5: 110,192,981 T514A probably benign Het
Gramd1c T A 16: 43,983,516 K393N probably benign Het
Kcp T C 6: 29,492,461 Y844C probably damaging Het
Lrrc15 T A 16: 30,274,329 H64L possibly damaging Het
Mak G T 13: 41,046,147 Q339K probably benign Het
Mdfic G T 6: 15,799,759 C295F probably damaging Het
Mfsd14b C A 13: 65,073,600 V293L probably benign Het
Mycbp2 A T 14: 103,314,370 S175T probably benign Het
Nacad A G 11: 6,599,374 probably null Het
Ndnf T G 6: 65,703,518 D260E probably benign Het
Nphp1 G A 2: 127,754,031 Q505* probably null Het
Olfr1126 C A 2: 87,457,375 A70E probably damaging Het
Olfr947-ps1 A G 9: 39,289,674 V72A possibly damaging Het
Plcg1 G A 2: 160,731,860 G15D probably benign Het
Ppm1h A G 10: 122,802,260 Y145C probably damaging Het
Prickle2 C T 6: 92,422,338 C186Y probably damaging Het
Prmt6 A C 3: 110,250,043 L310R probably damaging Het
Psg25 A T 7: 18,526,535 I146N probably benign Het
Sapcd1 A G 17: 35,026,424 S128P probably benign Het
Sema3b T C 9: 107,601,585 S331G probably damaging Het
Shank1 G A 7: 44,312,918 S71N unknown Het
Skil A G 3: 31,097,395 E22G probably benign Het
Slc13a1 T C 6: 24,134,408 I159V probably benign Het
Slc44a4 A G 17: 34,917,355 I41V probably benign Het
Taar2 T C 10: 23,941,140 F193L probably damaging Het
Taar8a A G 10: 24,077,097 I200V probably benign Het
Trpc4 A G 3: 54,315,794 Y717C probably damaging Het
Vmn2r116 A T 17: 23,401,091 T600S probably damaging Het
Vwa1 G A 4: 155,772,879 P154L probably damaging Het
Zfp318 A G 17: 46,411,129 T1353A probably damaging Het
Zfp830 C T 11: 82,764,979 T203I possibly damaging Het
Other mutations in Miip
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00531:Miip APN 4 147865865 missense probably damaging 1.00
IGL02134:Miip APN 4 147865278 splice site probably benign
IGL02829:Miip APN 4 147863061 missense probably benign 0.01
IGL03350:Miip APN 4 147862522 missense probably benign 0.01
R0200:Miip UTSW 4 147862263 missense probably damaging 0.99
R1647:Miip UTSW 4 147865234 missense probably benign 0.02
R1783:Miip UTSW 4 147865774 missense probably damaging 1.00
R1848:Miip UTSW 4 147863092 missense probably damaging 0.99
R1944:Miip UTSW 4 147865965 missense probably benign 0.15
R3615:Miip UTSW 4 147865914 missense probably benign 0.00
R3616:Miip UTSW 4 147865914 missense probably benign 0.00
R3882:Miip UTSW 4 147861052 missense possibly damaging 0.93
R4579:Miip UTSW 4 147861061 missense probably damaging 1.00
R5183:Miip UTSW 4 147863069 missense probably damaging 1.00
R6054:Miip UTSW 4 147865678 missense probably benign 0.00
R6056:Miip UTSW 4 147862335 missense probably damaging 1.00
R6304:Miip UTSW 4 147863083 missense probably benign 0.12
R6568:Miip UTSW 4 147865915 missense probably benign
R6603:Miip UTSW 4 147865923 missense possibly damaging 0.92
R7639:Miip UTSW 4 147862564 missense probably benign 0.22
R7701:Miip UTSW 4 147862914 missense probably null 0.86
R7795:Miip UTSW 4 147862918 missense probably benign 0.17
R7796:Miip UTSW 4 147862918 missense probably benign 0.17
R7797:Miip UTSW 4 147862918 missense probably benign 0.17
R7872:Miip UTSW 4 147862918 missense probably benign 0.17
R7920:Miip UTSW 4 147862918 missense probably benign 0.17
R8468:Miip UTSW 4 147861471 missense probably damaging 1.00
R8492:Miip UTSW 4 147861424 missense probably damaging 1.00
R8677:Miip UTSW 4 147863046 missense probably damaging 1.00
R8852:Miip UTSW 4 147866382 start gained probably benign
R8860:Miip UTSW 4 147866382 start gained probably benign
Predicted Primers PCR Primer
(F):5'- ACCTTGGGACCTGTGTCTTG -3'
(R):5'- CAGGGTAAATTACAAGGTCCACAG -3'

Sequencing Primer
(F):5'- GTGTCTTGTCAGGTCCCAGAC -3'
(R):5'- GTCCACAGCAAGCCAGAGTG -3'
Posted On 2022-11-14