Incidental Mutation 'R9756:Zmym4'
| ID |
732724 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zmym4
|
| Ensembl Gene |
ENSMUSG00000042446 |
| Gene Name |
zinc finger, MYM-type 4 |
| Synonyms |
Zfp262, 6330503C17Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.586)
|
| Stock # |
R9756 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
126755732-126861928 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 126771502 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 1291
(F1291L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101714
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106108]
|
| AlphaFold |
A2A791 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106108
AA Change: F1291L
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000101714
Gene: ENSMUSG00000042446
AA Change: F1291L
| Domain | Start | End | E-Value | Type |
|---|
|
TRASH
|
341 |
377 |
6.53e-4 |
SMART |
|
TRASH
|
389 |
429 |
7.22e-6 |
SMART |
|
TRASH
|
441 |
479 |
1.77e0 |
SMART |
|
TRASH
|
486 |
525 |
4.95e-4 |
SMART |
|
TRASH
|
531 |
569 |
1.05e-2 |
SMART |
|
TRASH
|
579 |
615 |
2.82e1 |
SMART |
|
low complexity region
|
640 |
649 |
N/A |
INTRINSIC |
|
TRASH
|
687 |
723 |
8.49e-3 |
SMART |
|
TRASH
|
729 |
764 |
1.14e-3 |
SMART |
|
TRASH
|
772 |
810 |
4.48e-2 |
SMART |
|
TRASH
|
816 |
851 |
2.06e-1 |
SMART |
|
low complexity region
|
974 |
993 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1021 |
N/A |
INTRINSIC |
|
Pfam:DUF3504
|
1357 |
1527 |
1.7e-68 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000120813
Gene: ENSMUSG00000042446
AA Change: F950L
| Domain | Start | End | E-Value | Type |
|---|
|
TRASH
|
90 |
126 |
6.53e-4 |
SMART |
|
TRASH
|
138 |
178 |
7.22e-6 |
SMART |
|
TRASH
|
190 |
228 |
1.77e0 |
SMART |
|
TRASH
|
235 |
274 |
3.05e-4 |
SMART |
|
low complexity region
|
300 |
309 |
N/A |
INTRINSIC |
|
TRASH
|
347 |
383 |
8.49e-3 |
SMART |
|
TRASH
|
389 |
424 |
1.14e-3 |
SMART |
|
TRASH
|
432 |
470 |
4.48e-2 |
SMART |
|
TRASH
|
476 |
511 |
2.06e-1 |
SMART |
|
low complexity region
|
634 |
653 |
N/A |
INTRINSIC |
|
low complexity region
|
662 |
681 |
N/A |
INTRINSIC |
|
Pfam:DUF3504
|
1017 |
1187 |
1.5e-68 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.8%
- 3x: 99.7%
- 10x: 99.2%
- 20x: 98.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 65 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700066M21Rik |
A |
T |
1: 57,421,906 (GRCm39) |
Y94F |
possibly damaging |
Het |
| Abcb5 |
A |
G |
12: 118,881,873 (GRCm39) |
S619P |
probably damaging |
Het |
| Adgrf5 |
A |
G |
17: 43,761,137 (GRCm39) |
N944S |
probably benign |
Het |
| Ano1 |
T |
A |
7: 144,162,666 (GRCm39) |
M689L |
probably benign |
Het |
| Antxr1 |
T |
A |
6: 87,217,936 (GRCm39) |
H314L |
probably benign |
Het |
| Atp13a5 |
CA |
C |
16: 29,051,583 (GRCm39) |
|
probably null |
Het |
| Blmh |
T |
A |
11: 76,859,509 (GRCm39) |
M370K |
probably damaging |
Het |
| Cdh8 |
G |
A |
8: 99,759,976 (GRCm39) |
T591M |
probably damaging |
Het |
| Cep290 |
G |
A |
10: 100,352,034 (GRCm39) |
E747K |
probably damaging |
Het |
| Chd6 |
T |
C |
2: 160,802,259 (GRCm39) |
S2192G |
probably benign |
Het |
| Cldn8 |
T |
G |
16: 88,359,917 (GRCm39) |
T3P |
probably benign |
Het |
| Crtac1 |
A |
G |
19: 42,286,780 (GRCm39) |
L421P |
probably damaging |
Het |
| Ddx59 |
G |
T |
1: 136,345,069 (GRCm39) |
A247S |
probably damaging |
Het |
| Defa38 |
C |
T |
8: 21,585,943 (GRCm39) |
V42I |
possibly damaging |
Het |
| Dennd5a |
A |
G |
7: 109,496,174 (GRCm39) |
V1164A |
possibly damaging |
Het |
| Dnhd1 |
A |
T |
7: 105,353,135 (GRCm39) |
T2763S |
probably benign |
Het |
| Evpl |
T |
C |
11: 116,112,077 (GRCm39) |
D1871G |
probably damaging |
Het |
| Fat1 |
T |
A |
8: 45,496,974 (GRCm39) |
I4153N |
probably damaging |
Het |
| Fbxl17 |
A |
G |
17: 63,367,310 (GRCm39) |
Y688H |
probably damaging |
Het |
| Fntb |
A |
G |
12: 76,966,938 (GRCm39) |
E424G |
probably benign |
Het |
| Gabra4 |
A |
G |
5: 71,729,067 (GRCm39) |
M571T |
probably damaging |
Het |
| Hoxb5 |
T |
C |
11: 96,194,449 (GRCm39) |
Y4H |
probably damaging |
Het |
| Htr1a |
T |
C |
13: 105,581,450 (GRCm39) |
V230A |
probably damaging |
Het |
| Idh2 |
TCCCAGG |
T |
7: 79,748,079 (GRCm39) |
|
probably benign |
Het |
| Ighv3-4 |
T |
C |
12: 114,217,448 (GRCm39) |
T48A |
probably damaging |
Het |
| Il15ra |
A |
G |
2: 11,728,259 (GRCm39) |
M53V |
probably benign |
Het |
| Ipo9 |
A |
C |
1: 135,314,057 (GRCm39) |
D945E |
probably benign |
Het |
| Klk1b22 |
A |
T |
7: 43,765,254 (GRCm39) |
|
probably null |
Het |
| Klkb1 |
T |
C |
8: 45,735,811 (GRCm39) |
N184S |
possibly damaging |
Het |
| Lbhd2 |
G |
A |
12: 111,376,774 (GRCm39) |
A74T |
probably damaging |
Het |
| Lpcat3 |
A |
G |
6: 124,679,967 (GRCm39) |
|
probably null |
Het |
| Luzp1 |
T |
C |
4: 136,270,048 (GRCm39) |
I757T |
probably damaging |
Het |
| Mbd5 |
C |
A |
2: 49,169,283 (GRCm39) |
P1485T |
probably benign |
Het |
| Mfsd14b |
C |
A |
13: 65,221,414 (GRCm39) |
V293L |
probably benign |
Het |
| Mical2 |
C |
T |
7: 111,902,928 (GRCm39) |
T133I |
probably damaging |
Het |
| Mylk |
T |
C |
16: 34,734,387 (GRCm39) |
S663P |
probably damaging |
Het |
| Or2ag13 |
A |
T |
7: 106,313,002 (GRCm39) |
N295K |
probably benign |
Het |
| Or2j3 |
A |
G |
17: 38,615,971 (GRCm39) |
V127A |
probably benign |
Het |
| Or4x11 |
A |
T |
2: 89,867,674 (GRCm39) |
N137I |
probably benign |
Het |
| Or5ak22 |
T |
A |
2: 85,230,682 (GRCm39) |
H65L |
probably damaging |
Het |
| Or5b119 |
G |
A |
19: 13,456,986 (GRCm39) |
T192I |
probably benign |
Het |
| Or8b12 |
G |
A |
9: 37,658,314 (GRCm39) |
D295N |
possibly damaging |
Het |
| Patj |
G |
T |
4: 98,565,535 (GRCm39) |
A1656S |
probably benign |
Het |
| Peg10 |
GC |
GCGCC |
6: 4,756,452 (GRCm39) |
|
probably benign |
Het |
| Pigz |
G |
T |
16: 31,763,787 (GRCm39) |
G282C |
probably damaging |
Het |
| Pomk |
G |
A |
8: 26,472,918 (GRCm39) |
T345M |
possibly damaging |
Het |
| Psap |
T |
C |
10: 60,130,784 (GRCm39) |
S205P |
possibly damaging |
Het |
| Ptpn6 |
A |
T |
6: 124,705,592 (GRCm39) |
F186L |
probably damaging |
Het |
| Rnase2b |
T |
C |
14: 51,400,302 (GRCm39) |
S128P |
probably damaging |
Het |
| Rnf112 |
C |
T |
11: 61,340,667 (GRCm39) |
V536I |
probably damaging |
Het |
| Rnf31 |
A |
T |
14: 55,836,582 (GRCm39) |
E805D |
probably damaging |
Het |
| Rps6kc1 |
A |
T |
1: 190,604,021 (GRCm39) |
D200E |
probably benign |
Het |
| Rufy2 |
T |
C |
10: 62,818,519 (GRCm39) |
L25P |
probably damaging |
Het |
| Sec14l2 |
T |
A |
11: 4,053,978 (GRCm39) |
K230* |
probably null |
Het |
| Senp1 |
A |
G |
15: 97,957,806 (GRCm39) |
I364T |
possibly damaging |
Het |
| Sod1 |
T |
A |
16: 90,017,753 (GRCm39) |
M3K |
probably benign |
Het |
| Stab2 |
T |
C |
10: 86,803,553 (GRCm39) |
D332G |
possibly damaging |
Het |
| Tcf4 |
G |
T |
18: 69,790,830 (GRCm39) |
E408* |
probably null |
Het |
| Tdrd1 |
T |
C |
19: 56,831,662 (GRCm39) |
M351T |
probably benign |
Het |
| Tmem39a |
T |
C |
16: 38,396,126 (GRCm39) |
Y120H |
probably benign |
Het |
| Trav16 |
C |
A |
14: 53,980,886 (GRCm39) |
T25K |
possibly damaging |
Het |
| Unc13c |
T |
A |
9: 73,839,526 (GRCm39) |
N442Y |
probably benign |
Het |
| Vmn2r71 |
A |
T |
7: 85,268,573 (GRCm39) |
K259* |
probably null |
Het |
| Yipf1 |
T |
C |
4: 107,176,247 (GRCm39) |
V47A |
probably benign |
Het |
| Zeb2 |
T |
C |
2: 44,887,414 (GRCm39) |
T548A |
possibly damaging |
Het |
|
| Other mutations in Zmym4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00537:Zmym4
|
APN |
4 |
126,783,851 (GRCm39) |
missense |
probably benign |
|
|
IGL00845:Zmym4
|
APN |
4 |
126,794,406 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL01122:Zmym4
|
APN |
4 |
126,758,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01374:Zmym4
|
APN |
4 |
126,762,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01564:Zmym4
|
APN |
4 |
126,805,073 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02014:Zmym4
|
APN |
4 |
126,794,462 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02187:Zmym4
|
APN |
4 |
126,764,066 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02887:Zmym4
|
APN |
4 |
126,842,268 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03371:Zmym4
|
APN |
4 |
126,808,881 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03400:Zmym4
|
APN |
4 |
126,816,920 (GRCm39) |
missense |
probably benign |
0.12 |
|
arriba
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
|
foreclosed
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Foreshortened
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
levantese
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
|
terminated
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
BB004:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
|
BB014:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0149:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0361:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0423:Zmym4
|
UTSW |
4 |
126,776,112 (GRCm39) |
splice site |
probably benign |
|
|
R0532:Zmym4
|
UTSW |
4 |
126,792,194 (GRCm39) |
nonsense |
probably null |
|
|
R0745:Zmym4
|
UTSW |
4 |
126,796,496 (GRCm39) |
splice site |
probably benign |
|
|
R1183:Zmym4
|
UTSW |
4 |
126,819,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1401:Zmym4
|
UTSW |
4 |
126,804,962 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1446:Zmym4
|
UTSW |
4 |
126,776,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1491:Zmym4
|
UTSW |
4 |
126,776,105 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1566:Zmym4
|
UTSW |
4 |
126,804,940 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1962:Zmym4
|
UTSW |
4 |
126,796,463 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R2398:Zmym4
|
UTSW |
4 |
126,816,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2930:Zmym4
|
UTSW |
4 |
126,819,316 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3891:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3892:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4659:Zmym4
|
UTSW |
4 |
126,842,221 (GRCm39) |
splice site |
probably null |
|
|
R4702:Zmym4
|
UTSW |
4 |
126,816,958 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5160:Zmym4
|
UTSW |
4 |
126,763,977 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5614:Zmym4
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5773:Zmym4
|
UTSW |
4 |
126,799,163 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6450:Zmym4
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6741:Zmym4
|
UTSW |
4 |
126,808,878 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7023:Zmym4
|
UTSW |
4 |
126,762,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7315:Zmym4
|
UTSW |
4 |
126,776,385 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7468:Zmym4
|
UTSW |
4 |
126,776,029 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7546:Zmym4
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7609:Zmym4
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7764:Zmym4
|
UTSW |
4 |
126,819,409 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7897:Zmym4
|
UTSW |
4 |
126,783,332 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R7918:Zmym4
|
UTSW |
4 |
126,804,797 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7927:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8129:Zmym4
|
UTSW |
4 |
126,808,956 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8240:Zmym4
|
UTSW |
4 |
126,798,188 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8248:Zmym4
|
UTSW |
4 |
126,799,162 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8261:Zmym4
|
UTSW |
4 |
126,798,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8313:Zmym4
|
UTSW |
4 |
126,804,762 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8353:Zmym4
|
UTSW |
4 |
126,800,905 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8747:Zmym4
|
UTSW |
4 |
126,787,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8787:Zmym4
|
UTSW |
4 |
126,816,953 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8795:Zmym4
|
UTSW |
4 |
126,799,819 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8948:Zmym4
|
UTSW |
4 |
126,758,060 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9218:Zmym4
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9233:Zmym4
|
UTSW |
4 |
126,776,310 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9286:Zmym4
|
UTSW |
4 |
126,783,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9468:Zmym4
|
UTSW |
4 |
126,800,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9542:Zmym4
|
UTSW |
4 |
126,799,164 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9776:Zmym4
|
UTSW |
4 |
126,804,942 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
U24488:Zmym4
|
UTSW |
4 |
126,819,453 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
Z1177:Zmym4
|
UTSW |
4 |
126,801,005 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GACTTTAAATTGGAGCAGTTCACC -3'
(R):5'- TGTGACCCAATACAGTGTTGG -3'
Sequencing Primer
(F):5'- CTCAGATGATGAAACCAATCA -3'
(R):5'- TTGGGCACACTAGTGCTT -3'
|
| Posted On |
2022-11-14 |
Incidental Mutation