Mutagenetix > Incidental Mutation

Incidental Mutation 'R9759:Gm19410'

732902

Institutional Source

Beutler Lab

Gene Symbol

Gm19410

Ensembl Gene

ENSMUSG00000109372

Gene Name

predicted gene, 19410

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.145) question?

Stock #

R9759 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

36232944-36285201 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 36252938 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 628 (R628G)

Ref Sequence

ENSEMBL: ENSMUSP00000147162 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000207505]

AlphaFold

A0A140LJC7

Predicted Effect

possibly damaging
Transcript: ENSMUST00000207505
AA Change: R628G

PolyPhen 2 Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)

Coding Region Coverage

1x: 99.9%
3x: 99.8%
10x: 99.4%
20x: 98.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	G	T	13: 119,615,989 (GRCm39)	W508L	probably damaging	Het
Abt1	G	T	13: 23,606,439 (GRCm39)	Q172K	probably damaging	Het
Aoah	C	A	13: 21,000,738 (GRCm39)	H57Q	probably damaging	Het
Cpxm2	T	C	7: 131,756,242 (GRCm39)	E34G	probably benign	Het
Ddx25	C	T	9: 35,457,265 (GRCm39)	R350Q	probably benign	Het
Dnah9	G	A	11: 65,965,944 (GRCm39)	H1691Y	probably null	Het
Doc2g	A	T	19: 4,056,571 (GRCm39)	H319L	probably benign	Het
Enah	A	C	1: 181,841,911 (GRCm39)	V6G	unknown	Het
Fam135b	T	G	15: 71,335,689 (GRCm39)	T502P	probably benign	Het
Frem2	A	G	3: 53,562,918 (GRCm39)	S530P	possibly damaging	Het
Hdac7	T	C	15: 97,699,989 (GRCm39)	T614A	probably benign	Het
Ift88	T	A	14: 57,672,256 (GRCm39)	L32*	probably null	Het
Insm2	C	T	12: 55,647,390 (GRCm39)	T378M	possibly damaging	Het
Kctd3	G	A	1: 188,710,786 (GRCm39)	T459M	probably damaging	Het
Khsrp	A	G	17: 57,332,925 (GRCm39)	L188P	probably benign	Het
Kynu	A	G	2: 43,569,881 (GRCm39)	I388V	probably benign	Het
Met	T	C	6: 17,555,561 (GRCm39)	V1090A	probably damaging	Het
Mier1	C	T	4: 103,019,725 (GRCm39)	T483I	probably benign	Het
Mthfsd	A	G	8: 121,824,615 (GRCm39)	S297P	probably benign	Het
P2rx5	A	T	11: 73,058,341 (GRCm39)	I259F	probably damaging	Het
Pax3	A	G	1: 78,170,415 (GRCm39)	L138P	probably damaging	Het
Pfpl	G	C	19: 12,406,297 (GRCm39)	E183Q	probably damaging	Het
Rbm12	A	T	2: 155,938,546 (GRCm39)	H575Q	probably benign	Het
Scube1	C	T	15: 83,492,465 (GRCm39)	R953H	probably benign	Het
Sirt1	A	G	10: 63,156,516 (GRCm39)	S705P	probably benign	Het
Slc23a3	ATT	ATTT	1: 75,109,925 (GRCm39)		probably null	Het
Slc46a3	T	C	5: 147,823,234 (GRCm39)	T203A	probably benign	Het
Snta1	G	T	2: 154,222,889 (GRCm39)	T278K	probably benign	Het
Stac3	A	G	10: 127,344,083 (GRCm39)	D327G	possibly damaging	Het
Timm44	C	A	8: 4,317,707 (GRCm39)	E205*	probably null	Het
Timm8a2	A	T	14: 122,272,216 (GRCm39)	T40S	probably damaging	Het
Vmn2r116	A	G	17: 23,620,360 (GRCm39)	N698S	possibly damaging	Het
Zik1	A	C	7: 10,223,716 (GRCm39)	C460W	possibly damaging	Het
Zmynd8	A	C	2: 165,680,746 (GRCm39)	I229S	possibly damaging	Het

Other mutations in Gm19410

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
BB009:Gm19410	UTSW	8	36,262,753 (GRCm39)	missense	probably damaging	0.98
BB019:Gm19410	UTSW	8	36,262,753 (GRCm39)	missense	probably damaging	0.98
R0046:Gm19410	UTSW	8	36,269,799 (GRCm39)	missense	probably benign	0.31
R6026:Gm19410	UTSW	8	36,279,580 (GRCm39)	missense	probably benign	0.03
R6039:Gm19410	UTSW	8	36,276,518 (GRCm39)	missense	probably benign	0.44
R6039:Gm19410	UTSW	8	36,276,518 (GRCm39)	missense	probably benign	0.44
R6185:Gm19410	UTSW	8	36,274,664 (GRCm39)	missense	possibly damaging	0.87
R6239:Gm19410	UTSW	8	36,245,918 (GRCm39)	missense	probably damaging	0.98
R6303:Gm19410	UTSW	8	36,274,714 (GRCm39)	missense	possibly damaging	0.96
R6377:Gm19410	UTSW	8	36,270,736 (GRCm39)	nonsense	probably null
R6545:Gm19410	UTSW	8	36,257,652 (GRCm39)	missense	possibly damaging	0.93
R6700:Gm19410	UTSW	8	36,274,664 (GRCm39)	missense	possibly damaging	0.87
R6720:Gm19410	UTSW	8	36,274,730 (GRCm39)	missense	probably benign	0.12
R6795:Gm19410	UTSW	8	36,262,676 (GRCm39)	missense	probably damaging	0.98
R6808:Gm19410	UTSW	8	36,239,733 (GRCm39)	missense	probably damaging	0.99
R6810:Gm19410	UTSW	8	36,239,733 (GRCm39)	missense	probably damaging	0.99
R6811:Gm19410	UTSW	8	36,239,733 (GRCm39)	missense	probably damaging	0.99
R6966:Gm19410	UTSW	8	36,285,127 (GRCm39)	missense	possibly damaging	0.84
R7264:Gm19410	UTSW	8	36,252,920 (GRCm39)	missense	probably benign	0.01
R7267:Gm19410	UTSW	8	36,281,997 (GRCm39)	missense	possibly damaging	0.80
R7355:Gm19410	UTSW	8	36,274,226 (GRCm39)	missense	probably benign	0.00
R7423:Gm19410	UTSW	8	36,271,761 (GRCm39)	missense	probably benign	0.28
R7494:Gm19410	UTSW	8	36,262,684 (GRCm39)	missense	probably damaging	0.99
R7516:Gm19410	UTSW	8	36,263,433 (GRCm39)	missense	probably benign	0.30
R7517:Gm19410	UTSW	8	36,240,772 (GRCm39)	missense	possibly damaging	0.45
R7526:Gm19410	UTSW	8	36,257,766 (GRCm39)	missense	probably damaging	0.98
R7527:Gm19410	UTSW	8	36,269,386 (GRCm39)	missense	probably damaging	0.99
R7545:Gm19410	UTSW	8	36,269,779 (GRCm39)	missense	probably damaging	0.99
R7549:Gm19410	UTSW	8	36,266,500 (GRCm39)	missense	probably benign	0.20
R7564:Gm19410	UTSW	8	36,274,151 (GRCm39)	missense	probably benign	0.00
R7615:Gm19410	UTSW	8	36,263,513 (GRCm39)	missense	probably damaging	1.00
R7622:Gm19410	UTSW	8	36,277,501 (GRCm39)	missense	possibly damaging	0.91
R7655:Gm19410	UTSW	8	36,276,253 (GRCm39)	missense	probably benign
R7656:Gm19410	UTSW	8	36,276,253 (GRCm39)	missense	probably benign
R7703:Gm19410	UTSW	8	36,266,539 (GRCm39)	missense	probably damaging	0.98
R7750:Gm19410	UTSW	8	36,274,652 (GRCm39)	missense	possibly damaging	0.68
R7760:Gm19410	UTSW	8	36,269,491 (GRCm39)	missense	probably damaging	0.99
R7837:Gm19410	UTSW	8	36,276,134 (GRCm39)	missense	possibly damaging	0.91
R7932:Gm19410	UTSW	8	36,262,753 (GRCm39)	missense	probably damaging	0.98
R7942:Gm19410	UTSW	8	36,238,940 (GRCm39)	missense	probably damaging	0.98
R7970:Gm19410	UTSW	8	36,282,801 (GRCm39)	missense	probably benign	0.00
R8088:Gm19410	UTSW	8	36,273,995 (GRCm39)	missense	probably benign	0.45
R8228:Gm19410	UTSW	8	36,252,992 (GRCm39)	missense	possibly damaging	0.53
R8382:Gm19410	UTSW	8	36,276,302 (GRCm39)	missense	probably damaging	0.99
R8757:Gm19410	UTSW	8	36,276,119 (GRCm39)	missense	possibly damaging	0.83
R8879:Gm19410	UTSW	8	36,239,022 (GRCm39)	missense	probably damaging	0.99
R9010:Gm19410	UTSW	8	36,282,011 (GRCm39)	missense	probably benign	0.02
R9060:Gm19410	UTSW	8	36,269,480 (GRCm39)	missense	probably damaging	1.00
R9088:Gm19410	UTSW	8	36,240,766 (GRCm39)	missense	probably damaging	1.00
R9104:Gm19410	UTSW	8	36,247,621 (GRCm39)	missense	probably damaging	0.99
R9186:Gm19410	UTSW	8	36,282,629 (GRCm39)	missense	possibly damaging	0.90
R9290:Gm19410	UTSW	8	36,269,386 (GRCm39)	missense	probably damaging	0.99
R9334:Gm19410	UTSW	8	36,270,722 (GRCm39)	nonsense	probably null
R9398:Gm19410	UTSW	8	36,272,356 (GRCm39)	missense	probably benign	0.00
R9439:Gm19410	UTSW	8	36,248,810 (GRCm39)	missense	probably damaging	0.96
R9445:Gm19410	UTSW	8	36,239,652 (GRCm39)	missense	possibly damaging	0.75
R9511:Gm19410	UTSW	8	36,257,848 (GRCm39)	missense	probably damaging	0.99
R9520:Gm19410	UTSW	8	36,262,637 (GRCm39)	missense	probably benign	0.15
R9523:Gm19410	UTSW	8	36,257,608 (GRCm39)	missense	probably benign	0.01
R9669:Gm19410	UTSW	8	36,247,493 (GRCm39)	missense	possibly damaging	0.45
R9711:Gm19410	UTSW	8	36,279,493 (GRCm39)	missense	possibly damaging	0.85
R9728:Gm19410	UTSW	8	36,247,594 (GRCm39)	missense	possibly damaging	0.95
Z1176:Gm19410	UTSW	8	36,259,765 (GRCm39)	missense	possibly damaging	0.79
Z1177:Gm19410	UTSW	8	36,276,119 (GRCm39)	missense	possibly damaging	0.83

Predicted Primers

PCR Primer
(F):5'- CAAATAACCTGTGTCTTTAGAGGC -3'
(R):5'- GAAAAGATGCCTGCCACAGC -3'

Sequencing Primer
(F):5'- GCTCATGTATGTATGCTGCAGAG -3'
(R):5'- CAGCTCACCTGTTTGCTGGG -3'

Posted On

2022-11-14