Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01302:Mos'

73298

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mos

Ensembl Gene

ENSMUSG00000078365

Gene Name

Moloney sarcoma oncogene

Synonyms

c-mos

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01302

Quality Score

Status

Chromosome

Chromosomal Location

3870658-3872105 bp(-) (GRCm39)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

T to C at 3871815 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000100789 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105158]

AlphaFold

P00536

Predicted Effect

probably benign
Transcript: ENSMUST00000105158

SMART Domains

Protein: ENSMUSP00000100789
Gene: ENSMUSG00000078365

Domain	Start	End	E-Value	Type
low complexity region	39	54	N/A	INTRINSIC
Pfam:Pkinase_Tyr	63	335	9e-41	PFAM
Pfam:Pkinase	64	334	6.3e-43	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
PHENOTYPE: Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	A	11: 9,349,470 (GRCm39)		probably benign	Het
Abcb5	T	A	12: 118,881,935 (GRCm39)	D598V	probably damaging	Het
Adss1	T	C	12: 112,601,170 (GRCm39)		probably benign	Het
Akap9	T	A	5: 4,020,711 (GRCm39)	S1141T	probably benign	Het
Avil	T	C	10: 126,852,903 (GRCm39)		probably null	Het
Avl9	C	A	6: 56,702,075 (GRCm39)	H77N	probably damaging	Het
Cacna1e	A	G	1: 154,319,653 (GRCm39)	V1349A	probably damaging	Het
Cdc23	A	C	18: 34,767,697 (GRCm39)	S483A	probably benign	Het
Cep192	C	T	18: 67,991,974 (GRCm39)	P1951S	probably benign	Het
Cp	A	G	3: 20,020,531 (GRCm39)	T175A	probably damaging	Het
Dubr	A	C	16: 50,552,998 (GRCm39)		noncoding transcript	Het
Eif4g2	G	T	7: 110,673,920 (GRCm39)	Q695K	possibly damaging	Het
Endod1	A	T	9: 14,268,535 (GRCm39)	S317T	possibly damaging	Het
Ep400	T	C	5: 110,889,914 (GRCm39)	T450A	probably benign	Het
Erc1	A	C	6: 119,699,264 (GRCm39)	V790G	probably damaging	Het
Fam222a	T	A	5: 114,732,514 (GRCm39)	L23Q	possibly damaging	Het
Fancf	A	G	7: 51,511,035 (GRCm39)	V323A	probably benign	Het
Grik2	T	A	10: 49,120,426 (GRCm39)	Q621L	probably damaging	Het
Gsk3b	G	T	16: 38,040,380 (GRCm39)	R319L	probably benign	Het
Ikzf1	A	G	11: 11,718,923 (GRCm39)	Y297C	probably damaging	Het
Katnal2	T	C	18: 77,134,863 (GRCm39)		probably benign	Het
Lrba	G	T	3: 86,202,707 (GRCm39)	C289F	probably damaging	Het
Mycn	T	C	12: 12,987,587 (GRCm39)	D270G	possibly damaging	Het
Or52e15	A	T	7: 104,645,928 (GRCm39)	M61K	probably damaging	Het
Or6c207	T	A	10: 129,104,392 (GRCm39)	I267F	probably benign	Het
Pclo	A	G	5: 14,726,013 (GRCm39)		probably benign	Het
Pgm1	A	G	4: 99,786,803 (GRCm39)	D14G	probably damaging	Het
Pramel7	T	A	2: 87,321,717 (GRCm39)	D106V	possibly damaging	Het
Prdm9	G	T	17: 15,773,608 (GRCm39)	H263N	probably benign	Het
Psd4	T	A	2: 24,286,799 (GRCm39)		probably null	Het
Ptprc	G	A	1: 138,027,369 (GRCm39)	T493I	possibly damaging	Het
Rbbp8	T	A	18: 11,855,036 (GRCm39)	S420R	probably benign	Het
Sap30bp	A	G	11: 115,853,373 (GRCm39)	T219A	probably damaging	Het
Shld2	C	T	14: 33,981,684 (GRCm39)	V485I	probably benign	Het
Slc2a7	T	A	4: 150,242,021 (GRCm39)	L200Q	probably damaging	Het
Slc38a6	T	A	12: 73,335,299 (GRCm39)		probably null	Het
Tatdn2	T	A	6: 113,680,985 (GRCm39)		probably benign	Het
Thrb	A	G	14: 18,011,056 (GRCm38)		probably benign	Het
Timp4	T	C	6: 115,223,269 (GRCm39)	Y218C	possibly damaging	Het
Tlr5	A	G	1: 182,802,313 (GRCm39)	D525G	probably benign	Het
Usp32	G	T	11: 84,879,308 (GRCm39)	T1467N	probably benign	Het
Vmn2r78	A	G	7: 86,564,569 (GRCm39)	I5V	unknown	Het
Zbtb43	T	C	2: 33,344,103 (GRCm39)	H374R	probably benign	Het
Zfhx4	C	A	3: 5,308,628 (GRCm39)	T618K	probably damaging	Het

Other mutations in Mos

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00848:Mos	APN	4	3,871,459 (GRCm39)	missense	probably damaging	1.00
IGL01739:Mos	APN	4	3,871,816 (GRCm39)	utr 5 prime	probably benign
IGL01867:Mos	APN	4	3,870,845 (GRCm39)	missense	probably benign	0.33
IGL02647:Mos	APN	4	3,870,961 (GRCm39)	missense	probably damaging	1.00
PIT4418001:Mos	UTSW	4	3,870,814 (GRCm39)	missense	possibly damaging	0.86
R0967:Mos	UTSW	4	3,870,932 (GRCm39)	missense	probably benign
R4927:Mos	UTSW	4	3,871,093 (GRCm39)	missense	probably damaging	1.00
R5729:Mos	UTSW	4	3,870,971 (GRCm39)	missense	probably benign	0.01
R6947:Mos	UTSW	4	3,871,585 (GRCm39)	missense	probably damaging	1.00
R8359:Mos	UTSW	4	3,871,097 (GRCm39)	missense	probably damaging	1.00
R8526:Mos	UTSW	4	3,871,709 (GRCm39)	missense	probably damaging	0.99
R9106:Mos	UTSW	4	3,871,457 (GRCm39)	missense	probably benign	0.44
R9336:Mos	UTSW	4	3,870,886 (GRCm39)	missense	probably damaging	1.00
R9347:Mos	UTSW	4	3,871,763 (GRCm39)	missense	probably benign	0.02
R9683:Mos	UTSW	4	3,871,186 (GRCm39)	missense	probably benign	0.02

Posted On

2013-10-07