Incidental Mutation 'R9760:Olfr119'
ID 732982
Institutional Source Beutler Lab
Gene Symbol Olfr119
Ensembl Gene ENSMUSG00000059964
Gene Name olfactory receptor 119
Synonyms MOR263-7, GA_x6K02T2PSCP-2159633-2160598
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R9760 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 37696564-37702124 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 37701543 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 291 (L291P)
Ref Sequence ENSEMBL: ENSMUSP00000092919 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080483] [ENSMUST00000213732]
AlphaFold Q7TRJ5
Predicted Effect probably damaging
Transcript: ENSMUST00000080483
AA Change: L291P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000092919
Gene: ENSMUSG00000059964
AA Change: L291P

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 5.6e-59 PFAM
Pfam:7TM_GPCR_Srsx 41 311 1.7e-5 PFAM
Pfam:7tm_1 47 296 3.1e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213732
AA Change: L291P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 99.1%
  • 20x: 97.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abat T C 16: 8,581,930 probably null Het
Adamts4 G A 1: 171,258,765 D709N probably benign Het
Arhgef12 G T 9: 42,992,022 D745E probably damaging Het
BC005561 T C 5: 104,519,235 V541A probably benign Het
Cep250 A G 2: 155,976,553 K883E probably benign Het
Cfdp1 T C 8: 111,768,783 I268V probably benign Het
Cgnl1 G T 9: 71,645,571 S1037* probably null Het
Clca3b T C 3: 144,846,849 N142S probably benign Het
Col6a6 A T 9: 105,782,054 I564N probably damaging Het
Coq4 G T 2: 29,788,470 R36L probably benign Het
Dact3 G A 7: 16,886,206 S542N unknown Het
Dcaf1 A G 9: 106,874,267 D1480G unknown Het
Dcdc2a C T 13: 25,205,460 T457I probably damaging Het
Ddi2 A G 4: 141,683,885 V572A probably damaging Het
Ddx54 C T 5: 120,623,607 R483C probably benign Het
Dennd5b G A 6: 149,068,499 S152F probably benign Het
Efcab14 C T 4: 115,758,875 H252Y probably benign Het
Efhb A T 17: 53,463,270 F4I probably damaging Het
Esrrg A G 1: 188,043,372 D32G probably benign Het
Fam126a T C 5: 23,979,574 Q302R possibly damaging Het
Fam160b2 A C 14: 70,590,181 V158G possibly damaging Het
Far2 C A 6: 148,158,950 A267E probably damaging Het
Flnb T C 14: 7,929,846 I1992T probably damaging Het
Fmnl2 A G 2: 53,054,515 S169G Het
Galnt10 G A 11: 57,765,688 V233I probably benign Het
Gbf1 C A 19: 46,255,698 N210K probably benign Het
Gbp3 T G 3: 142,570,522 S460A probably benign Het
Gm12185 T A 11: 48,915,341 H341L probably benign Het
Gm14025 A T 2: 129,038,579 S476T Het
Gm5592 A T 7: 41,289,810 I839F possibly damaging Het
Gnptab A G 10: 88,431,448 D467G probably damaging Het
Grin3a A T 4: 49,714,213 M844K probably damaging Het
Gtf2a1l A G 17: 88,711,592 D368G probably benign Het
Herc2 G C 7: 56,163,911 probably null Het
Ins2 T A 7: 142,679,448 H29L probably damaging Het
Ipo13 T A 4: 117,905,581 Y275F probably benign Het
Kcnj15 T A 16: 95,295,624 M35K probably benign Het
Kif21b G A 1: 136,148,683 V321M probably damaging Het
Lcmt1 T A 7: 123,430,152 Y332* probably null Het
Malt1 A G 18: 65,448,212 Q237R probably benign Het
Micall1 G A 15: 79,120,832 C168Y unknown Het
Muc5ac A G 7: 141,807,248 K1432R probably benign Het
Nacad A G 11: 6,601,662 S510P probably benign Het
Nub1 T C 5: 24,692,967 L117P possibly damaging Het
Olfr312 A G 11: 58,832,026 R291G probably damaging Het
Olfr938 A T 9: 39,077,975 F257I possibly damaging Het
Pkdrej T C 15: 85,821,067 K223E probably benign Het
Prkdc T A 16: 15,839,180 Y4046* probably null Het
Prpf8 A G 11: 75,503,431 N1767D probably benign Het
Prr27 C A 5: 87,843,135 P202Q probably benign Het
R3hdm2 G T 10: 127,444,313 M18I unknown Het
Rab35 C A 5: 115,640,165 D63E probably damaging Het
Ribc2 T A 15: 85,143,367 Y350N probably benign Het
Sec63 A G 10: 42,828,948 I733V probably benign Het
Slc23a3 ATT ATTT 1: 75,133,281 probably null Het
Slc38a4 T C 15: 96,998,451 K512E probably damaging Het
Stk35 G A 2: 129,800,685 V49I probably benign Het
Tango6 A G 8: 106,850,279 E1055G probably damaging Het
Tas2r137 A G 6: 40,492,102 I289V probably benign Het
Tll2 C T 19: 41,130,645 V215M probably damaging Het
Tmem30a A T 9: 79,780,592 N98K probably benign Het
Trav9n-4 C A 14: 53,294,833 A48E probably benign Het
Vmn1r192 A G 13: 22,187,840 F70S probably damaging Het
Wdr89 A G 12: 75,633,252 V76A probably damaging Het
Zfp229 A T 17: 21,746,294 T502S probably damaging Het
Other mutations in Olfr119
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02209:Olfr119 APN 17 37700992 missense probably damaging 1.00
IGL03339:Olfr119 APN 17 37700791 missense probably damaging 0.99
R0092:Olfr119 UTSW 17 37700805 missense probably damaging 0.98
R0207:Olfr119 UTSW 17 37701058 nonsense probably null
R0378:Olfr119 UTSW 17 37701041 missense probably damaging 1.00
R0408:Olfr119 UTSW 17 37701299 missense probably benign
R0483:Olfr119 UTSW 17 37701297 missense probably benign 0.01
R1595:Olfr119 UTSW 17 37701113 missense probably benign 0.03
R1901:Olfr119 UTSW 17 37701421 missense probably damaging 1.00
R1902:Olfr119 UTSW 17 37701421 missense probably damaging 1.00
R2845:Olfr119 UTSW 17 37700823 missense probably damaging 1.00
R2846:Olfr119 UTSW 17 37700823 missense probably damaging 1.00
R4356:Olfr119 UTSW 17 37700899 missense probably damaging 0.97
R4381:Olfr119 UTSW 17 37700899 missense probably damaging 0.97
R6744:Olfr119 UTSW 17 37701445 nonsense probably null
R7674:Olfr119 UTSW 17 37700682 missense probably benign 0.03
R7677:Olfr119 UTSW 17 37701066 missense probably damaging 1.00
R7994:Olfr119 UTSW 17 37701435 missense probably damaging 0.99
R8305:Olfr119 UTSW 17 37701498 missense probably benign 0.10
R8512:Olfr119 UTSW 17 37701180 missense probably damaging 1.00
R9300:Olfr119 UTSW 17 37700924 missense probably damaging 1.00
Z1177:Olfr119 UTSW 17 37701053 missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- TACATCCCAAAATGAGGCTGC -3'
(R):5'- GCAGACAAAAGAATGTACCAGTTTG -3'

Sequencing Primer
(F):5'- CCAAAATGAGGCTGCAATTTTTGTGG -3'
(R):5'- GTACCAGTTTGTATTTGTTTCATCTG -3'
Posted On 2022-11-14