Mutagenetix > Incidental Mutation

Incidental Mutation 'R9760:Or10al3'

732982

Institutional Source

Beutler Lab

Gene Symbol

Or10al3

Ensembl Gene

ENSMUSG00000059964

Gene Name

olfactory receptor family 10 subfamily AL member 3

Synonyms

GA_x6K02T2PSCP-2159633-2160598, MOR263-7, Olfr119

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

R9760 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

38007576-38012611 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 38012434 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 291 (L291P)

Ref Sequence

ENSEMBL: ENSMUSP00000092919 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080483] [ENSMUST00000213732]

AlphaFold

Q7TRJ5

Predicted Effect

probably damaging
Transcript: ENSMUST00000080483
AA Change: L291P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000092919
Gene: ENSMUSG00000059964
AA Change: L291P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	37	314	5.6e-59	PFAM
Pfam:7TM_GPCR_Srsx	41	311	1.7e-5	PFAM
Pfam:7tm_1	47	296	3.1e-23	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000213732
AA Change: L291P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 99.9%
3x: 99.7%
10x: 99.1%
20x: 97.7%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abat	T	C	16: 8,399,794 (GRCm39)		probably null	Het
Adamts4	G	A	1: 171,086,334 (GRCm39)	D709N	probably benign	Het
Arhgef12	G	T	9: 42,903,318 (GRCm39)	D745E	probably damaging	Het
Cep250	A	G	2: 155,818,473 (GRCm39)	K883E	probably benign	Het
Cfdp1	T	C	8: 112,495,415 (GRCm39)	I268V	probably benign	Het
Cgnl1	G	T	9: 71,552,853 (GRCm39)	S1037*	probably null	Het
Clca3b	T	C	3: 144,552,610 (GRCm39)	N142S	probably benign	Het
Col6a6	A	T	9: 105,659,253 (GRCm39)	I564N	probably damaging	Het
Coq4	G	T	2: 29,678,482 (GRCm39)	R36L	probably benign	Het
Dact3	G	A	7: 16,620,131 (GRCm39)	S542N	unknown	Het
Dcaf1	A	G	9: 106,751,466 (GRCm39)	D1480G	unknown	Het
Dcdc2a	C	T	13: 25,389,443 (GRCm39)	T457I	probably damaging	Het
Ddi2	A	G	4: 141,411,196 (GRCm39)	V572A	probably damaging	Het
Ddx54	C	T	5: 120,761,672 (GRCm39)	R483C	probably benign	Het
Dennd5b	G	A	6: 148,969,997 (GRCm39)	S152F	probably benign	Het
Efcab14	C	T	4: 115,616,072 (GRCm39)	H252Y	probably benign	Het
Efhb	A	T	17: 53,770,298 (GRCm39)	F4I	probably damaging	Het
Esrrg	A	G	1: 187,775,569 (GRCm39)	D32G	probably benign	Het
Far2	C	A	6: 148,060,448 (GRCm39)	A267E	probably damaging	Het
Fhip2b	A	C	14: 70,827,621 (GRCm39)	V158G	possibly damaging	Het
Flnb	T	C	14: 7,929,846 (GRCm38)	I1992T	probably damaging	Het
Fmnl2	A	G	2: 52,944,527 (GRCm39)	S169G		Het
Galnt10	G	A	11: 57,656,514 (GRCm39)	V233I	probably benign	Het
Gbf1	C	A	19: 46,244,137 (GRCm39)	N210K	probably benign	Het
Gbp3	T	G	3: 142,276,283 (GRCm39)	S460A	probably benign	Het
Gm12185	T	A	11: 48,806,168 (GRCm39)	H341L	probably benign	Het
Gm5592	A	T	7: 40,939,234 (GRCm39)	I839F	possibly damaging	Het
Gnptab	A	G	10: 88,267,310 (GRCm39)	D467G	probably damaging	Het
Grin3a	A	T	4: 49,714,213 (GRCm39)	M844K	probably damaging	Het
Gtf2a1l	A	G	17: 89,019,020 (GRCm39)	D368G	probably benign	Het
Herc2	G	C	7: 55,813,659 (GRCm39)		probably null	Het
Hycc1	T	C	5: 24,184,572 (GRCm39)	Q302R	possibly damaging	Het
Ins2	T	A	7: 142,233,185 (GRCm39)	H29L	probably damaging	Het
Ipo13	T	A	4: 117,762,778 (GRCm39)	Y275F	probably benign	Het
Kcnj15	T	A	16: 95,096,483 (GRCm39)	M35K	probably benign	Het
Kif21b	G	A	1: 136,076,421 (GRCm39)	V321M	probably damaging	Het
Lcmt1	T	A	7: 123,029,375 (GRCm39)	Y332*	probably null	Het
Malt1	A	G	18: 65,581,283 (GRCm39)	Q237R	probably benign	Het
Micall1	G	A	15: 79,005,032 (GRCm39)	C168Y	unknown	Het
Muc5ac	A	G	7: 141,360,985 (GRCm39)	K1432R	probably benign	Het
Nacad	A	G	11: 6,551,662 (GRCm39)	S510P	probably benign	Het
Nub1	T	C	5: 24,897,965 (GRCm39)	L117P	possibly damaging	Het
Or5af1	A	G	11: 58,722,852 (GRCm39)	R291G	probably damaging	Het
Or8g24	A	T	9: 38,989,271 (GRCm39)	F257I	possibly damaging	Het
Pkdrej	T	C	15: 85,705,268 (GRCm39)	K223E	probably benign	Het
Prkdc	T	A	16: 15,657,044 (GRCm39)	Y4046*	probably null	Het
Prpf8	A	G	11: 75,394,257 (GRCm39)	N1767D	probably benign	Het
Prr27	C	A	5: 87,990,994 (GRCm39)	P202Q	probably benign	Het
R3hdm2	G	T	10: 127,280,182 (GRCm39)	M18I	unknown	Het
Rab35	C	A	5: 115,778,224 (GRCm39)	D63E	probably damaging	Het
Ribc2	T	A	15: 85,027,568 (GRCm39)	Y350N	probably benign	Het
Sec63	A	G	10: 42,704,944 (GRCm39)	I733V	probably benign	Het
Slc23a3	ATT	ATTT	1: 75,109,925 (GRCm39)		probably null	Het
Slc38a4	T	C	15: 96,896,332 (GRCm39)	K512E	probably damaging	Het
Stk35	G	A	2: 129,642,605 (GRCm39)	V49I	probably benign	Het
Tango6	A	G	8: 107,576,911 (GRCm39)	E1055G	probably damaging	Het
Tas2r140	A	G	6: 40,469,036 (GRCm39)	I289V	probably benign	Het
Thoc2l	T	C	5: 104,667,101 (GRCm39)	V541A	probably benign	Het
Tll2	C	T	19: 41,119,084 (GRCm39)	V215M	probably damaging	Het
Tmem30a	A	T	9: 79,687,874 (GRCm39)	N98K	probably benign	Het
Trav9n-4	C	A	14: 53,532,290 (GRCm39)	A48E	probably benign	Het
Vinac1	A	T	2: 128,880,499 (GRCm39)	S476T		Het
Vmn1r192	A	G	13: 22,372,010 (GRCm39)	F70S	probably damaging	Het
Wdr89	A	G	12: 75,680,026 (GRCm39)	V76A	probably damaging	Het
Zfp229	A	T	17: 21,965,275 (GRCm39)	T502S	probably damaging	Het

Other mutations in Or10al3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02209:Or10al3	APN	17	38,011,883 (GRCm39)	missense	probably damaging	1.00
IGL03339:Or10al3	APN	17	38,011,682 (GRCm39)	missense	probably damaging	0.99
R0092:Or10al3	UTSW	17	38,011,696 (GRCm39)	missense	probably damaging	0.98
R0207:Or10al3	UTSW	17	38,011,949 (GRCm39)	nonsense	probably null
R0378:Or10al3	UTSW	17	38,011,932 (GRCm39)	missense	probably damaging	1.00
R0408:Or10al3	UTSW	17	38,012,190 (GRCm39)	missense	probably benign
R0483:Or10al3	UTSW	17	38,012,188 (GRCm39)	missense	probably benign	0.01
R1595:Or10al3	UTSW	17	38,012,004 (GRCm39)	missense	probably benign	0.03
R1901:Or10al3	UTSW	17	38,012,312 (GRCm39)	missense	probably damaging	1.00
R1902:Or10al3	UTSW	17	38,012,312 (GRCm39)	missense	probably damaging	1.00
R2845:Or10al3	UTSW	17	38,011,714 (GRCm39)	missense	probably damaging	1.00
R2846:Or10al3	UTSW	17	38,011,714 (GRCm39)	missense	probably damaging	1.00
R4356:Or10al3	UTSW	17	38,011,790 (GRCm39)	missense	probably damaging	0.97
R4381:Or10al3	UTSW	17	38,011,790 (GRCm39)	missense	probably damaging	0.97
R6744:Or10al3	UTSW	17	38,012,336 (GRCm39)	nonsense	probably null
R7674:Or10al3	UTSW	17	38,011,573 (GRCm39)	missense	probably benign	0.03
R7677:Or10al3	UTSW	17	38,011,957 (GRCm39)	missense	probably damaging	1.00
R7994:Or10al3	UTSW	17	38,012,326 (GRCm39)	missense	probably damaging	0.99
R8305:Or10al3	UTSW	17	38,012,389 (GRCm39)	missense	probably benign	0.10
R8512:Or10al3	UTSW	17	38,012,071 (GRCm39)	missense	probably damaging	1.00
R9300:Or10al3	UTSW	17	38,011,815 (GRCm39)	missense	probably damaging	1.00
Z1177:Or10al3	UTSW	17	38,011,944 (GRCm39)	missense	possibly damaging	0.93

Predicted Primers

PCR Primer
(F):5'- TACATCCCAAAATGAGGCTGC -3'
(R):5'- GCAGACAAAAGAATGTACCAGTTTG -3'

Sequencing Primer
(F):5'- CCAAAATGAGGCTGCAATTTTTGTGG -3'
(R):5'- GTACCAGTTTGTATTTGTTTCATCTG -3'

Posted On

2022-11-14