Incidental Mutation 'R9762:Mtcl1'
| ID |
733114 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mtcl1
|
| Ensembl Gene |
ENSMUSG00000052105 |
| Gene Name |
microtubule crosslinking factor 1 |
| Synonyms |
1110012J17Rik, Soga2, t8219b25 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.126)
|
| Stock # |
R9762 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
66643977-66756745 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 66673347 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Aspartic acid
at position 1121
(N1121D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000083899
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086693]
[ENSMUST00000097291]
[ENSMUST00000145347]
[ENSMUST00000177034]
|
| AlphaFold |
Q3UHU5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000086693
AA Change: N1121D
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000083899
Gene: ENSMUSG00000052105
AA Change: N1121D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
166 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
SCOP:d1fxkc_
|
332 |
466 |
3e-7 |
SMART |
|
Blast:BRLZ
|
339 |
362 |
1e-5 |
BLAST |
|
Pfam:DUF3166
|
493 |
587 |
1.8e-34 |
PFAM |
|
Pfam:DUF3166
|
622 |
714 |
3.8e-39 |
PFAM |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1120 |
1159 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
1220 |
1344 |
3e-40 |
PFAM |
|
low complexity region
|
1464 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1672 |
1681 |
N/A |
INTRINSIC |
|
low complexity region
|
1912 |
1924 |
N/A |
INTRINSIC |
|
low complexity region
|
1931 |
1943 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097291
AA Change: N1121D
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000094894
Gene: ENSMUSG00000052105
AA Change: N1121D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
166 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
SCOP:d1fxkc_
|
332 |
466 |
3e-7 |
SMART |
|
Blast:BRLZ
|
339 |
362 |
1e-5 |
BLAST |
|
Pfam:DUF3166
|
492 |
588 |
1.8e-43 |
PFAM |
|
Pfam:DUF3166
|
621 |
716 |
5e-19 |
PFAM |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1120 |
1159 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
1220 |
1392 |
3.9e-49 |
PFAM |
|
low complexity region
|
1464 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1672 |
1681 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145347
AA Change: N672D
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000121387
Gene: ENSMUSG00000052105
AA Change: N672D
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3166
|
43 |
139 |
9.1e-44 |
PFAM |
|
Pfam:DUF3166
|
172 |
267 |
2.5e-19 |
PFAM |
|
low complexity region
|
394 |
410 |
N/A |
INTRINSIC |
|
low complexity region
|
447 |
461 |
N/A |
INTRINSIC |
|
low complexity region
|
513 |
524 |
N/A |
INTRINSIC |
|
low complexity region
|
600 |
613 |
N/A |
INTRINSIC |
|
coiled coil region
|
671 |
710 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
771 |
910 |
4.6e-49 |
PFAM |
|
low complexity region
|
1015 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1232 |
N/A |
INTRINSIC |
|
low complexity region
|
1463 |
1475 |
N/A |
INTRINSIC |
|
low complexity region
|
1482 |
1494 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177034
AA Change: N810D
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000135690
Gene: ENSMUSG00000052105
AA Change: N810D
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3166
|
140 |
236 |
1.5e-43 |
PFAM |
|
Pfam:DUF3166
|
269 |
364 |
4e-19 |
PFAM |
|
low complexity region
|
491 |
507 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
558 |
N/A |
INTRINSIC |
|
low complexity region
|
610 |
621 |
N/A |
INTRINSIC |
|
coiled coil region
|
642 |
674 |
N/A |
INTRINSIC |
|
low complexity region
|
738 |
751 |
N/A |
INTRINSIC |
|
coiled coil region
|
809 |
848 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
909 |
1042 |
4e-49 |
PFAM |
|
low complexity region
|
1161 |
1173 |
N/A |
INTRINSIC |
|
low complexity region
|
1369 |
1378 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.8%
- 10x: 99.4%
- 20x: 98.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Global or Purkinje cell-specific homozygous knockout affects Purkinje cell axon and dendrite morphology, resulting in abnormal motor function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ablim1 |
G |
T |
19: 57,025,691 (GRCm39) |
R851S |
probably damaging |
Het |
| Acap2 |
C |
A |
16: 30,929,763 (GRCm39) |
A407S |
probably damaging |
Het |
| Adam26a |
A |
T |
8: 44,021,635 (GRCm39) |
S618R |
probably benign |
Het |
| Adamtsl5 |
T |
C |
10: 80,180,896 (GRCm39) |
Y89C |
probably damaging |
Het |
| Aebp2 |
T |
A |
6: 140,588,021 (GRCm39) |
S364T |
probably damaging |
Het |
| Ankfy1 |
A |
G |
11: 72,621,401 (GRCm39) |
E229G |
probably benign |
Het |
| Arhgap27 |
G |
T |
11: 103,251,511 (GRCm39) |
D72E |
probably benign |
Het |
| Arhgap33 |
T |
C |
7: 30,230,950 (GRCm39) |
E191G |
probably null |
Het |
| Atp6v0a1 |
C |
T |
11: 100,946,427 (GRCm39) |
H807Y |
possibly damaging |
Het |
| Ccdc113 |
A |
C |
8: 96,272,605 (GRCm39) |
E237D |
probably benign |
Het |
| Cd200r2 |
T |
A |
16: 44,729,420 (GRCm39) |
I25K |
probably benign |
Het |
| Cd300c2 |
A |
G |
11: 114,887,775 (GRCm39) |
V209A |
probably damaging |
Het |
| Cdkn2d |
T |
A |
9: 21,200,383 (GRCm39) |
E129D |
probably benign |
Het |
| Cfap251 |
A |
G |
5: 123,460,533 (GRCm39) |
Y1165C |
probably damaging |
Het |
| Chd9 |
A |
T |
8: 91,712,741 (GRCm39) |
N855Y |
unknown |
Het |
| Cntn3 |
A |
G |
6: 102,254,196 (GRCm39) |
C249R |
probably damaging |
Het |
| Col12a1 |
T |
C |
9: 79,527,266 (GRCm39) |
E2688G |
possibly damaging |
Het |
| Copb2 |
C |
T |
9: 98,464,901 (GRCm39) |
T612I |
probably benign |
Het |
| Cplx1 |
A |
T |
5: 108,673,378 (GRCm39) |
D29E |
possibly damaging |
Het |
| Cracd |
A |
G |
5: 77,006,555 (GRCm39) |
K972R |
unknown |
Het |
| Cstf3 |
A |
T |
2: 104,494,684 (GRCm39) |
R645* |
probably null |
Het |
| Ctdp1 |
A |
T |
18: 80,492,550 (GRCm39) |
Y648* |
probably null |
Het |
| Daam1 |
T |
A |
12: 71,990,855 (GRCm39) |
D156E |
unknown |
Het |
| Dbn1 |
G |
A |
13: 55,622,824 (GRCm39) |
P599L |
probably damaging |
Het |
| Diaph1 |
C |
A |
18: 37,987,589 (GRCm39) |
V1056F |
probably damaging |
Het |
| Dzip3 |
A |
T |
16: 48,748,707 (GRCm39) |
D870E |
probably damaging |
Het |
| Efcab12 |
T |
C |
6: 115,800,331 (GRCm39) |
T231A |
possibly damaging |
Het |
| Efl1 |
A |
C |
7: 82,412,596 (GRCm39) |
D995A |
probably benign |
Het |
| Fam186a |
T |
C |
15: 99,842,393 (GRCm39) |
T1284A |
possibly damaging |
Het |
| Fbxo33 |
T |
C |
12: 59,251,708 (GRCm39) |
E269G |
probably benign |
Het |
| Foxj3 |
T |
A |
4: 119,483,540 (GRCm39) |
M604K |
unknown |
Het |
| Gabra4 |
A |
G |
5: 71,814,463 (GRCm39) |
S86P |
unknown |
Het |
| Gnas |
G |
A |
2: 174,140,639 (GRCm39) |
W269* |
probably null |
Het |
| Gpc6 |
T |
G |
14: 118,202,258 (GRCm39) |
N489K |
probably damaging |
Het |
| Gprin3 |
T |
C |
6: 59,331,236 (GRCm39) |
K357R |
possibly damaging |
Het |
| Grip1 |
G |
T |
10: 119,811,906 (GRCm39) |
A286S |
possibly damaging |
Het |
| Grm4 |
A |
T |
17: 27,721,688 (GRCm39) |
V151E |
probably damaging |
Het |
| Gucy1b1 |
A |
T |
3: 81,942,065 (GRCm39) |
S565T |
possibly damaging |
Het |
| Hace1 |
T |
C |
10: 45,525,014 (GRCm39) |
V260A |
probably benign |
Het |
| Hepacam2 |
A |
G |
6: 3,486,940 (GRCm39) |
I139T |
probably damaging |
Het |
| Hspa4l |
T |
C |
3: 40,727,057 (GRCm39) |
I486T |
probably benign |
Het |
| Igkv8-19 |
T |
C |
6: 70,317,866 (GRCm39) |
Y120C |
probably damaging |
Het |
| Iglv2 |
C |
T |
16: 19,079,548 (GRCm39) |
|
probably benign |
Het |
| Igsf10 |
A |
T |
3: 59,237,106 (GRCm39) |
L1025H |
probably damaging |
Het |
| Itpkb |
A |
G |
1: 180,161,752 (GRCm39) |
N626S |
probably benign |
Het |
| Jarid2 |
C |
T |
13: 45,068,253 (GRCm39) |
R1092W |
possibly damaging |
Het |
| Klc3 |
C |
T |
7: 19,132,023 (GRCm39) |
W118* |
probably null |
Het |
| Klhl25 |
C |
T |
7: 75,516,741 (GRCm39) |
T549I |
probably damaging |
Het |
| Krtap6-2 |
T |
A |
16: 89,216,763 (GRCm39) |
Y68F |
unknown |
Het |
| Ncbp3 |
A |
G |
11: 72,961,668 (GRCm39) |
K314R |
probably benign |
Het |
| Nop2 |
T |
C |
6: 125,121,272 (GRCm39) |
W685R |
probably benign |
Het |
| Orc1 |
T |
A |
4: 108,447,874 (GRCm39) |
D40E |
probably benign |
Het |
| Pappa2 |
G |
T |
1: 158,684,948 (GRCm39) |
N730K |
probably damaging |
Het |
| Parpbp |
A |
G |
10: 87,960,815 (GRCm39) |
S224P |
possibly damaging |
Het |
| Pdgfc |
A |
G |
3: 80,944,792 (GRCm39) |
R17G |
probably benign |
Het |
| Pfpl |
G |
C |
19: 12,406,297 (GRCm39) |
E183Q |
probably damaging |
Het |
| Pik3r6 |
T |
A |
11: 68,424,358 (GRCm39) |
L321* |
probably null |
Het |
| Pnp2 |
T |
C |
14: 51,197,006 (GRCm39) |
W31R |
probably damaging |
Het |
| Prr12 |
T |
C |
7: 44,696,954 (GRCm39) |
Y987C |
unknown |
Het |
| Prr27 |
C |
A |
5: 87,990,994 (GRCm39) |
P202Q |
probably benign |
Het |
| Prss23 |
T |
C |
7: 89,159,683 (GRCm39) |
I129V |
probably damaging |
Het |
| Rhno1 |
T |
C |
6: 128,336,119 (GRCm39) |
T39A |
probably damaging |
Het |
| Rps2 |
A |
T |
17: 24,940,810 (GRCm39) |
R279* |
probably null |
Het |
| Ski |
T |
C |
4: 155,244,344 (GRCm39) |
K427R |
probably damaging |
Het |
| Slc23a3 |
ATT |
ATTT |
1: 75,109,925 (GRCm39) |
|
probably null |
Het |
| Slc26a7 |
C |
T |
4: 14,546,372 (GRCm39) |
G319D |
probably damaging |
Het |
| Slc7a6os |
A |
G |
8: 106,937,523 (GRCm39) |
V8A |
probably damaging |
Het |
| Smim8 |
A |
C |
4: 34,771,265 (GRCm39) |
I43S |
probably damaging |
Het |
| Sox5 |
T |
C |
6: 143,819,842 (GRCm39) |
K400R |
probably damaging |
Het |
| Tab1 |
G |
A |
15: 80,032,943 (GRCm39) |
V76M |
probably damaging |
Het |
| Taf2 |
A |
C |
15: 54,894,440 (GRCm39) |
|
probably null |
Het |
| Taf5 |
G |
A |
19: 47,059,434 (GRCm39) |
V193M |
probably damaging |
Het |
| Tm2d1 |
A |
T |
4: 98,246,261 (GRCm39) |
S180R |
probably damaging |
Het |
| Ttc12 |
A |
G |
9: 49,368,166 (GRCm39) |
F287S |
probably damaging |
Het |
| Ubqln4 |
G |
A |
3: 88,473,185 (GRCm39) |
|
probably null |
Het |
| Ubr3 |
T |
C |
2: 69,839,497 (GRCm39) |
V1537A |
probably benign |
Het |
| Ugt8a |
A |
G |
3: 125,708,900 (GRCm39) |
L70P |
probably damaging |
Het |
| Vps26a |
A |
T |
10: 62,316,433 (GRCm39) |
N51K |
probably benign |
Het |
| Xkr5 |
T |
A |
8: 18,990,749 (GRCm39) |
T173S |
probably benign |
Het |
| Zfp354c |
A |
G |
11: 50,706,239 (GRCm39) |
C279R |
probably damaging |
Het |
| Zfp65 |
T |
A |
13: 67,856,478 (GRCm39) |
H267L |
probably damaging |
Het |
|
| Other mutations in Mtcl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Mtcl1
|
APN |
17 |
66,651,314 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01774:Mtcl1
|
APN |
17 |
66,692,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01918:Mtcl1
|
APN |
17 |
66,675,263 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL02000:Mtcl1
|
APN |
17 |
66,661,185 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02074:Mtcl1
|
APN |
17 |
66,673,463 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02338:Mtcl1
|
APN |
17 |
66,686,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02597:Mtcl1
|
APN |
17 |
66,645,016 (GRCm39) |
missense |
probably benign |
|
|
IGL03034:Mtcl1
|
APN |
17 |
66,651,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Mtcl1
|
APN |
17 |
66,686,378 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03184:Mtcl1
|
APN |
17 |
66,661,209 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03240:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03294:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Mtcl1
|
UTSW |
17 |
66,745,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4520001:Mtcl1
|
UTSW |
17 |
66,692,907 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R0110:Mtcl1
|
UTSW |
17 |
66,665,109 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R0113:Mtcl1
|
UTSW |
17 |
66,661,237 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0321:Mtcl1
|
UTSW |
17 |
66,686,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0366:Mtcl1
|
UTSW |
17 |
66,645,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0629:Mtcl1
|
UTSW |
17 |
66,645,137 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1466:Mtcl1
|
UTSW |
17 |
66,687,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Mtcl1
|
UTSW |
17 |
66,687,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Mtcl1
|
UTSW |
17 |
66,755,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Mtcl1
|
UTSW |
17 |
66,755,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Mtcl1
|
UTSW |
17 |
66,686,143 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1650:Mtcl1
|
UTSW |
17 |
66,692,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1754:Mtcl1
|
UTSW |
17 |
66,687,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Mtcl1
|
UTSW |
17 |
66,686,509 (GRCm39) |
missense |
probably benign |
|
|
R1882:Mtcl1
|
UTSW |
17 |
66,686,315 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1935:Mtcl1
|
UTSW |
17 |
66,686,409 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2063:Mtcl1
|
UTSW |
17 |
66,653,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Mtcl1
|
UTSW |
17 |
66,650,618 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2197:Mtcl1
|
UTSW |
17 |
66,673,427 (GRCm39) |
missense |
probably benign |
|
|
R3196:Mtcl1
|
UTSW |
17 |
66,650,829 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3877:Mtcl1
|
UTSW |
17 |
66,649,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4116:Mtcl1
|
UTSW |
17 |
66,673,476 (GRCm39) |
missense |
probably benign |
|
|
R4204:Mtcl1
|
UTSW |
17 |
66,745,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4373:Mtcl1
|
UTSW |
17 |
66,687,074 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4396:Mtcl1
|
UTSW |
17 |
66,651,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4591:Mtcl1
|
UTSW |
17 |
66,655,506 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4610:Mtcl1
|
UTSW |
17 |
66,684,882 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4681:Mtcl1
|
UTSW |
17 |
66,756,139 (GRCm39) |
missense |
unknown |
|
|
R4922:Mtcl1
|
UTSW |
17 |
66,655,474 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4992:Mtcl1
|
UTSW |
17 |
66,649,834 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5169:Mtcl1
|
UTSW |
17 |
66,650,818 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5542:Mtcl1
|
UTSW |
17 |
66,691,354 (GRCm39) |
intron |
probably benign |
|
|
R5804:Mtcl1
|
UTSW |
17 |
66,650,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5998:Mtcl1
|
UTSW |
17 |
66,675,275 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6163:Mtcl1
|
UTSW |
17 |
66,686,326 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6191:Mtcl1
|
UTSW |
17 |
66,650,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6254:Mtcl1
|
UTSW |
17 |
66,665,129 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6260:Mtcl1
|
UTSW |
17 |
66,650,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6524:Mtcl1
|
UTSW |
17 |
66,655,280 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6884:Mtcl1
|
UTSW |
17 |
66,745,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7199:Mtcl1
|
UTSW |
17 |
66,647,534 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7431:Mtcl1
|
UTSW |
17 |
66,649,901 (GRCm39) |
nonsense |
probably null |
|
|
R7479:Mtcl1
|
UTSW |
17 |
66,686,485 (GRCm39) |
missense |
probably benign |
|
|
R7564:Mtcl1
|
UTSW |
17 |
66,678,322 (GRCm39) |
missense |
probably benign |
|
|
R7608:Mtcl1
|
UTSW |
17 |
66,650,300 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7691:Mtcl1
|
UTSW |
17 |
66,687,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7847:Mtcl1
|
UTSW |
17 |
66,651,328 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Mtcl1
|
UTSW |
17 |
66,678,325 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8262:Mtcl1
|
UTSW |
17 |
66,650,653 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8324:Mtcl1
|
UTSW |
17 |
66,743,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8477:Mtcl1
|
UTSW |
17 |
66,684,942 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8927:Mtcl1
|
UTSW |
17 |
66,755,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8928:Mtcl1
|
UTSW |
17 |
66,755,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9016:Mtcl1
|
UTSW |
17 |
66,651,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9048:Mtcl1
|
UTSW |
17 |
66,678,331 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9059:Mtcl1
|
UTSW |
17 |
66,650,606 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9221:Mtcl1
|
UTSW |
17 |
66,650,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9327:Mtcl1
|
UTSW |
17 |
66,645,130 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9398:Mtcl1
|
UTSW |
17 |
66,755,462 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
X0065:Mtcl1
|
UTSW |
17 |
66,686,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Mtcl1
|
UTSW |
17 |
66,650,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
Z1176:Mtcl1
|
UTSW |
17 |
66,686,455 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Mtcl1
|
UTSW |
17 |
66,651,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TACGGTCCTAAGCTATGGGC -3'
(R):5'- ATCCAGAGAATGTGCCTGGG -3'
Sequencing Primer
(F):5'- TGGGCTAACCAGATGAATAGAC -3'
(R):5'- AGAATGTGCCTGGGCTTGC -3'
|
| Posted On |
2022-11-14 |
Incidental Mutation