Incidental Mutation 'R9765:Zbtb37'
ID 733183
Institutional Source Beutler Lab
Gene Symbol Zbtb37
Ensembl Gene ENSMUSG00000043467
Gene Name zinc finger and BTB domain containing 37
Synonyms D430004I08Rik
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.123) question?
Stock # R9765 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 160830492-160862419 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 160859432 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 291 (Y291C)
Ref Sequence ENSEMBL: ENSMUSP00000125417 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159250] [ENSMUST00000160056] [ENSMUST00000162226] [ENSMUST00000163079] [ENSMUST00000171748] [ENSMUST00000172044] [ENSMUST00000177003]
AlphaFold Q8C3U9
Predicted Effect probably damaging
Transcript: ENSMUST00000159250
AA Change: Y291C

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000125417
Gene: ENSMUSG00000043467
AA Change: Y291C

DomainStartEndE-ValueType
BTB 34 128 1.39e-23 SMART
ZnF_C2H2 375 397 5.99e-4 SMART
ZnF_C2H2 403 425 6.88e-4 SMART
ZnF_C2H2 431 454 1.16e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000160056
AA Change: Y291C

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000134769
Gene: ENSMUSG00000043467
AA Change: Y291C

DomainStartEndE-ValueType
BTB 34 128 1.39e-23 SMART
ZnF_C2H2 375 397 5.99e-4 SMART
ZnF_C2H2 403 425 6.88e-4 SMART
ZnF_C2H2 431 454 1.16e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000162226
AA Change: Y291C

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000125253
Gene: ENSMUSG00000043467
AA Change: Y291C

DomainStartEndE-ValueType
BTB 34 128 1.39e-23 SMART
ZnF_C2H2 375 397 5.99e-4 SMART
ZnF_C2H2 403 425 6.88e-4 SMART
ZnF_C2H2 431 454 1.16e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000163079
AA Change: Y291C

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000134753
Gene: ENSMUSG00000043467
AA Change: Y291C

DomainStartEndE-ValueType
BTB 34 128 1.39e-23 SMART
ZnF_C2H2 375 397 5.99e-4 SMART
ZnF_C2H2 403 425 6.88e-4 SMART
ZnF_C2H2 431 454 1.16e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000171748
AA Change: Y291C

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000129965
Gene: ENSMUSG00000043467
AA Change: Y291C

DomainStartEndE-ValueType
BTB 34 128 1.39e-23 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000172044
AA Change: Y291C

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000131576
Gene: ENSMUSG00000043467
AA Change: Y291C

DomainStartEndE-ValueType
BTB 34 128 1.39e-23 SMART
ZnF_C2H2 375 397 5.99e-4 SMART
ZnF_C2H2 403 425 6.88e-4 SMART
ZnF_C2H2 431 454 1.16e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000177003
SMART Domains Protein: ENSMUSP00000134816
Gene: ENSMUSG00000043467

DomainStartEndE-ValueType
BTB 34 99 1.31e-1 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930505A04Rik C T 11: 30,404,829 (GRCm39) V25I probably benign Het
Actr1b T A 1: 36,741,677 (GRCm39) H65L probably benign Het
Adgrf5 G A 17: 43,748,491 (GRCm39) G440E probably damaging Het
Ash1l T A 3: 88,930,500 (GRCm39) D1992E probably damaging Het
Cacng4 A G 11: 107,632,809 (GRCm39) F81S probably damaging Het
Cdca8 A G 4: 124,814,122 (GRCm39) I223T probably benign Het
Cdh19 A G 1: 110,823,111 (GRCm39) probably null Het
Ces2f A G 8: 105,676,678 (GRCm39) D124G probably damaging Het
Cks1brt A G 8: 85,898,234 (GRCm39) Y29C probably damaging Het
Cntnap4 T C 8: 113,484,110 (GRCm39) S388P probably benign Het
Cntnap4 T C 8: 113,568,496 (GRCm39) I844T probably damaging Het
Col4a3 G A 1: 82,646,678 (GRCm39) W396* probably null Het
Cul9 A T 17: 46,850,224 (GRCm39) S449T probably benign Het
Cux2 G A 5: 122,007,195 (GRCm39) P822L probably benign Het
Cyp3a13 G C 5: 137,909,883 (GRCm39) P147A probably damaging Het
Dennd2a C T 6: 39,473,907 (GRCm39) probably null Het
Dgkg T C 16: 22,298,157 (GRCm39) M743V possibly damaging Het
Dhx35 C T 2: 158,671,501 (GRCm39) R311W probably benign Het
Dnase1l2 A T 17: 24,660,049 (GRCm39) V273E probably damaging Het
Dock8 T G 19: 25,146,832 (GRCm39) I1437S possibly damaging Het
Dpy19l3 T C 7: 35,408,056 (GRCm39) D450G probably benign Het
Dsg4 G A 18: 20,604,334 (GRCm39) V934I probably benign Het
Eef2 T A 10: 81,015,010 (GRCm39) F236L possibly damaging Het
Eml4 A G 17: 83,747,498 (GRCm39) I247V probably damaging Het
Evi5 A C 5: 107,947,120 (GRCm39) C451G probably benign Het
Fam124a T G 14: 62,824,883 (GRCm39) W126G probably damaging Het
Fbxw21 A G 9: 108,975,625 (GRCm39) I257T possibly damaging Het
Fn3krp A G 11: 121,312,304 (GRCm39) K6E probably benign Het
Gcn1 G A 5: 115,735,131 (GRCm39) W1149* probably null Het
Glud1 C T 14: 34,060,795 (GRCm39) R453* probably null Het
Gtf2f1 G A 17: 57,318,125 (GRCm39) probably benign Het
Gtpbp4 T A 13: 9,024,994 (GRCm39) D532V probably benign Het
Ifnar2 G A 16: 91,184,975 (GRCm39) R122H possibly damaging Het
Ift70b A T 2: 75,768,467 (GRCm39) Y95* probably null Het
Ipo11 A G 13: 107,061,556 (GRCm39) W35R probably damaging Het
Iqgap3 G A 3: 88,017,361 (GRCm39) R1115Q possibly damaging Het
Kifc5b A G 17: 27,142,239 (GRCm39) E239G probably damaging Het
Map3k7 A T 4: 32,019,519 (GRCm39) E553D probably damaging Het
Mdh1 G T 11: 21,512,926 (GRCm39) S146* probably null Het
Muc16 C A 9: 18,548,494 (GRCm39) W5933L probably benign Het
Myo16 C A 8: 10,620,401 (GRCm39) P1651T probably damaging Het
Naip5 C G 13: 100,367,269 (GRCm39) A276P probably damaging Het
Noxo1 G T 17: 24,915,386 (GRCm39) probably benign Het
Or4k49 T A 2: 111,495,230 (GRCm39) Y220N probably benign Het
Pcdhgb6 A T 18: 37,876,054 (GRCm39) N254I possibly damaging Het
Peli3 A T 19: 4,991,850 (GRCm39) C30* probably null Het
Plb1 T A 5: 32,512,731 (GRCm39) M1363K probably damaging Het
Ppp4r4 G T 12: 103,550,346 (GRCm39) E257* probably null Het
Rbm20 T G 19: 53,840,060 (GRCm39) S1016R probably benign Het
Rcn1 A T 2: 105,225,026 (GRCm39) L143Q possibly damaging Het
Retreg1 G A 15: 25,940,985 (GRCm39) G3D unknown Het
Rrm2 A G 12: 24,758,956 (GRCm39) N65D probably benign Het
Samhd1 G T 2: 156,965,219 (GRCm39) H199N probably damaging Het
Slain2 T A 5: 73,114,969 (GRCm39) L400* probably null Het
Slc26a7 A T 4: 14,522,862 (GRCm39) M486K probably benign Het
Slc30a4 A T 2: 122,536,456 (GRCm39) Y133N probably damaging Het
Spef2 A T 15: 9,601,945 (GRCm39) F1439Y unknown Het
Srpra T C 9: 35,122,670 (GRCm39) V29A possibly damaging Het
St3gal1 T C 15: 66,981,499 (GRCm39) T226A possibly damaging Het
Tas2r136 T A 6: 132,754,813 (GRCm39) I105F probably benign Het
Tmem208 A G 8: 106,061,506 (GRCm39) *177W probably null Het
Utrn T A 10: 12,610,921 (GRCm39) N478I probably damaging Het
Zc3h3 T G 15: 75,709,459 (GRCm39) H470P probably benign Het
Zfp40 A T 17: 23,395,863 (GRCm39) Y241* probably null Het
Zfp457 T C 13: 67,440,874 (GRCm39) N567S probably benign Het
Zfp458 C T 13: 67,408,217 (GRCm39) V33M probably damaging Het
Zfp953 A T 13: 67,491,478 (GRCm39) I158N possibly damaging Het
Other mutations in Zbtb37
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0241:Zbtb37 UTSW 1 160,847,939 (GRCm39) missense probably benign
R0241:Zbtb37 UTSW 1 160,847,939 (GRCm39) missense probably benign
R0330:Zbtb37 UTSW 1 160,860,066 (GRCm39) missense probably benign 0.01
R0442:Zbtb37 UTSW 1 160,859,918 (GRCm39) missense possibly damaging 0.51
R1370:Zbtb37 UTSW 1 160,859,592 (GRCm39) missense probably benign 0.32
R1716:Zbtb37 UTSW 1 160,847,814 (GRCm39) missense probably benign 0.07
R6644:Zbtb37 UTSW 1 160,859,643 (GRCm39) nonsense probably null
R7257:Zbtb37 UTSW 1 160,860,231 (GRCm39) missense probably damaging 1.00
R7718:Zbtb37 UTSW 1 160,859,802 (GRCm39) missense possibly damaging 0.90
R7934:Zbtb37 UTSW 1 160,857,305 (GRCm39) missense probably damaging 1.00
R8145:Zbtb37 UTSW 1 160,847,654 (GRCm39) missense probably damaging 0.98
R9095:Zbtb37 UTSW 1 160,847,941 (GRCm39) nonsense probably null
R9563:Zbtb37 UTSW 1 160,847,840 (GRCm39) missense possibly damaging 0.62
Z1177:Zbtb37 UTSW 1 160,857,235 (GRCm39) missense probably benign 0.29
Predicted Primers PCR Primer
(F):5'- CCAGTCTCCCAAAGTAAGCTG -3'
(R):5'- TCGAATCAACAGAGCAGGAC -3'

Sequencing Primer
(F):5'- GTCTCCCAAAGTAAGCTGAATAAG -3'
(R):5'- TATGTGGAAACAGGACTAGCAGACC -3'
Posted On 2022-11-14