Incidental Mutation 'IGL01303:Npy4r'
ID73325
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Npy4r
Ensembl Gene ENSMUSG00000048337
Gene Nameneuropeptide Y receptor Y4
SynonymsNYYR-D, Y4, Ppyr1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.107) question?
Stock #IGL01303
Quality Score
Status
Chromosome14
Chromosomal Location34143992-34152489 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 34146657 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 225 (I225F)
Ref Sequence ENSEMBL: ENSMUSP00000056576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052164]
Predicted Effect possibly damaging
Transcript: ENSMUST00000052164
AA Change: I225F

PolyPhen 2 Score 0.557 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000056576
Gene: ENSMUSG00000048337
AA Change: I225F

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 52 337 2.5e-6 PFAM
Pfam:7tm_1 58 322 1.6e-48 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele exhibit decreased weight, increased drinking behavior, decreased food intake, aggression towards other mice, decreased white adipose tissue, and accelerated lobuloalveolar development during pregnancy. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5430419D17Rik A G 7: 131,194,331 T72A possibly damaging Het
Adamts7 A C 9: 90,171,734 I111L possibly damaging Het
Ankrd13a A T 5: 114,786,002 H53L possibly damaging Het
Becn1 T C 11: 101,294,985 D145G possibly damaging Het
Bod1l A G 5: 41,817,599 V2124A probably benign Het
Celsr1 C T 15: 86,030,491 A1094T probably damaging Het
Clstn2 A T 9: 97,483,075 Y459* probably null Het
Cnksr3 A G 10: 7,154,281 probably null Het
Cux2 A T 5: 121,865,928 F1048L probably benign Het
Cybrd1 A G 2: 71,129,706 K83E probably damaging Het
Dpp8 A T 9: 65,055,012 probably benign Het
Eef2 T A 10: 81,181,943 V813E possibly damaging Het
Eef2 A T 10: 81,181,982 probably null Het
Etnk1 T G 6: 143,180,666 I79S probably damaging Het
Fam151a A G 4: 106,747,593 N384S possibly damaging Het
Fam83c A G 2: 155,834,442 L136P probably damaging Het
Gfra2 G A 14: 70,895,852 V41I probably benign Het
Gm960 T C 19: 4,659,482 T318A possibly damaging Het
Mroh9 A G 1: 163,080,575 I2T probably benign Het
Muc2 A G 7: 141,752,395 I274V probably benign Het
Nacad T G 11: 6,598,279 E1456A possibly damaging Het
Olfr401 T G 11: 74,121,334 F15C probably damaging Het
Pik3c2a T C 7: 116,373,803 D719G possibly damaging Het
Pparg G T 6: 115,472,954 V305L possibly damaging Het
Rictor A G 15: 6,708,638 N19D probably benign Het
Slc4a1 T C 11: 102,357,964 T292A probably benign Het
Slc6a11 C T 6: 114,134,665 T103M probably damaging Het
Sorl1 A G 9: 42,024,478 probably benign Het
Tal1 T C 4: 115,068,292 V186A probably benign Het
Trpm1 T A 7: 64,210,830 probably benign Het
Tyw5 A T 1: 57,388,553 Y297* probably null Het
Unc79 C A 12: 103,161,867 Q2131K possibly damaging Het
Other mutations in Npy4r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01449:Npy4r APN 14 34146365 missense probably damaging 1.00
IGL01982:Npy4r APN 14 34147325 missense possibly damaging 0.73
IGL03126:Npy4r APN 14 34146333 missense probably benign 0.00
R0011:Npy4r UTSW 14 34146723 missense probably damaging 0.99
R0011:Npy4r UTSW 14 34146723 missense probably damaging 0.99
R0579:Npy4r UTSW 14 34146683 missense probably benign 0.16
R2012:Npy4r UTSW 14 34147197 missense possibly damaging 0.58
R3735:Npy4r UTSW 14 34147269 missense probably benign 0.00
R4093:Npy4r UTSW 14 34147141 missense probably benign 0.21
R4650:Npy4r UTSW 14 34146224 missense possibly damaging 0.55
R4861:Npy4r UTSW 14 34146883 nonsense probably null
R4861:Npy4r UTSW 14 34146883 nonsense probably null
R4953:Npy4r UTSW 14 34146480 missense probably damaging 1.00
R4963:Npy4r UTSW 14 34147016 missense probably damaging 1.00
R5387:Npy4r UTSW 14 34146983 missense probably benign 0.21
R5973:Npy4r UTSW 14 34146707 missense probably benign 0.00
R6948:Npy4r UTSW 14 34146774 missense probably benign
R7251:Npy4r UTSW 14 34146915 missense probably damaging 1.00
Posted On2013-10-07