Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01303:Clstn2'

73332

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Clstn2

Ensembl Gene

ENSMUSG00000032452

Gene Name

calsyntenin 2

Synonyms

2900042C18Rik, Cst-2, CS2, CSTN2

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01303

Quality Score

Status

Chromosome

Chromosomal Location

97326448-97915234 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 97365128 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 459 (Y459*)

Ref Sequence

ENSEMBL: ENSMUSP00000124081 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035027] [ENSMUST00000162295]

AlphaFold

Q9ER65

Predicted Effect

probably null
Transcript: ENSMUST00000035027
AA Change: Y459*

SMART Domains

Protein: ENSMUSP00000035027
Gene: ENSMUSG00000032452
AA Change: Y459*

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
CA	67	160	2e-10	SMART
CA	183	261	1.18e-3	SMART
SCOP:d1a8d_1	358	538	5e-21	SMART
Blast:LamG	380	529	3e-41	BLAST
transmembrane domain	835	857	N/A	INTRINSIC
low complexity region	901	935	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000162295
AA Change: Y459*

SMART Domains

Protein: ENSMUSP00000124081
Gene: ENSMUSG00000032452
AA Change: Y459*

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
CA	67	160	2e-10	SMART
CA	183	261	1.18e-3	SMART
Pfam:Laminin_G_3	356	533	1.4e-9	PFAM
transmembrane domain	835	857	N/A	INTRINSIC
low complexity region	901	935	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Homozygous KO mice display deficiency in spatial learning and memory in Morris water and Barnes maze tasks and increased locomotor activity in open field test. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts7	A	C	9: 90,053,787 (GRCm39)	I111L	possibly damaging	Het
Ankrd13a	A	T	5: 114,924,063 (GRCm39)	H53L	possibly damaging	Het
Becn1	T	C	11: 101,185,811 (GRCm39)	D145G	possibly damaging	Het
Bod1l	A	G	5: 41,974,942 (GRCm39)	V2124A	probably benign	Het
Cdcp3	A	G	7: 130,796,060 (GRCm39)	T72A	possibly damaging	Het
Celsr1	C	T	15: 85,914,692 (GRCm39)	A1094T	probably damaging	Het
Cnksr3	A	G	10: 7,104,281 (GRCm39)		probably null	Het
Cux2	A	T	5: 122,003,991 (GRCm39)	F1048L	probably benign	Het
Cybrd1	A	G	2: 70,960,050 (GRCm39)	K83E	probably damaging	Het
Dpp8	A	T	9: 64,962,294 (GRCm39)		probably benign	Het
Eef2	T	A	10: 81,017,777 (GRCm39)	V813E	possibly damaging	Het
Eef2	A	T	10: 81,017,816 (GRCm39)		probably null	Het
Etnk1	T	G	6: 143,126,392 (GRCm39)	I79S	probably damaging	Het
Fam151a	A	G	4: 106,604,790 (GRCm39)	N384S	possibly damaging	Het
Fam83c	A	G	2: 155,676,362 (GRCm39)	L136P	probably damaging	Het
Gfra2	G	A	14: 71,133,292 (GRCm39)	V41I	probably benign	Het
Mroh9	A	G	1: 162,908,144 (GRCm39)	I2T	probably benign	Het
Muc2	A	G	7: 141,306,132 (GRCm39)	I274V	probably benign	Het
Nacad	T	G	11: 6,548,279 (GRCm39)	E1456A	possibly damaging	Het
Npy4r	T	A	14: 33,868,614 (GRCm39)	I225F	possibly damaging	Het
Or3a1b	T	G	11: 74,012,160 (GRCm39)	F15C	probably damaging	Het
Pik3c2a	T	C	7: 115,973,038 (GRCm39)	D719G	possibly damaging	Het
Pparg	G	T	6: 115,449,915 (GRCm39)	V305L	possibly damaging	Het
Rictor	A	G	15: 6,738,119 (GRCm39)	N19D	probably benign	Het
Slc4a1	T	C	11: 102,248,790 (GRCm39)	T292A	probably benign	Het
Slc6a11	C	T	6: 114,111,626 (GRCm39)	T103M	probably damaging	Het
Sorl1	A	G	9: 41,935,774 (GRCm39)		probably benign	Het
Tal1	T	C	4: 114,925,489 (GRCm39)	V186A	probably benign	Het
Top6bl	T	C	19: 4,709,510 (GRCm39)	T318A	possibly damaging	Het
Trpm1	T	A	7: 63,860,578 (GRCm39)		probably benign	Het
Tyw5	A	T	1: 57,427,712 (GRCm39)	Y297*	probably null	Het
Unc79	C	A	12: 103,128,126 (GRCm39)	Q2131K	possibly damaging	Het

Other mutations in Clstn2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00562:Clstn2	APN	9	97,464,505 (GRCm39)	splice site	probably benign
IGL00563:Clstn2	APN	9	97,464,505 (GRCm39)	splice site	probably benign
IGL00733:Clstn2	APN	9	97,365,102 (GRCm39)	missense	probably damaging	1.00
IGL01935:Clstn2	APN	9	97,345,521 (GRCm39)	missense	probably damaging	1.00
IGL02157:Clstn2	APN	9	97,423,928 (GRCm39)	missense	probably benign
IGL02974:Clstn2	APN	9	97,414,760 (GRCm39)	missense	probably damaging	1.00
IGL03164:Clstn2	APN	9	97,681,462 (GRCm39)	missense	possibly damaging	0.50
IGL03298:Clstn2	APN	9	97,338,625 (GRCm39)	missense	probably damaging	1.00
R0653:Clstn2	UTSW	9	97,340,257 (GRCm39)	missense	probably damaging	1.00
R0845:Clstn2	UTSW	9	97,452,681 (GRCm39)	missense	probably benign	0.39
R0992:Clstn2	UTSW	9	97,327,765 (GRCm39)	missense	probably benign	0.00
R1105:Clstn2	UTSW	9	97,465,552 (GRCm39)	splice site	probably null
R1112:Clstn2	UTSW	9	97,340,281 (GRCm39)	missense	possibly damaging	0.92
R1264:Clstn2	UTSW	9	97,339,662 (GRCm39)	missense	probably benign	0.28
R1275:Clstn2	UTSW	9	97,339,483 (GRCm39)	missense	probably benign	0.00
R1329:Clstn2	UTSW	9	97,340,227 (GRCm39)	missense	probably damaging	1.00
R1396:Clstn2	UTSW	9	97,343,446 (GRCm39)	missense	probably benign	0.02
R1556:Clstn2	UTSW	9	97,338,558 (GRCm39)	missense	probably benign	0.41
R1703:Clstn2	UTSW	9	97,340,290 (GRCm39)	missense	possibly damaging	0.90
R1837:Clstn2	UTSW	9	97,465,593 (GRCm39)	missense	probably benign	0.00
R2911:Clstn2	UTSW	9	97,414,775 (GRCm39)	missense	probably damaging	1.00
R3434:Clstn2	UTSW	9	97,336,768 (GRCm39)	missense	probably benign	0.17
R3771:Clstn2	UTSW	9	97,464,615 (GRCm39)	missense	probably damaging	1.00
R3772:Clstn2	UTSW	9	97,464,615 (GRCm39)	missense	probably damaging	1.00
R3854:Clstn2	UTSW	9	97,345,648 (GRCm39)	nonsense	probably null
R4049:Clstn2	UTSW	9	97,339,613 (GRCm39)	missense	possibly damaging	0.59
R4334:Clstn2	UTSW	9	97,345,581 (GRCm39)	missense	probably damaging	1.00
R4705:Clstn2	UTSW	9	97,345,612 (GRCm39)	missense	possibly damaging	0.95
R4755:Clstn2	UTSW	9	97,327,726 (GRCm39)	missense	probably benign	0.01
R4884:Clstn2	UTSW	9	97,681,448 (GRCm39)	missense	probably damaging	1.00
R5017:Clstn2	UTSW	9	97,365,139 (GRCm39)	missense	probably damaging	1.00
R5076:Clstn2	UTSW	9	97,365,132 (GRCm39)	missense	probably damaging	1.00
R5122:Clstn2	UTSW	9	97,343,474 (GRCm39)	missense	probably damaging	1.00
R5155:Clstn2	UTSW	9	97,338,484 (GRCm39)	missense	probably benign	0.02
R5560:Clstn2	UTSW	9	97,351,872 (GRCm39)	missense	possibly damaging	0.95
R6009:Clstn2	UTSW	9	97,338,579 (GRCm39)	missense	probably benign	0.05
R6011:Clstn2	UTSW	9	97,338,579 (GRCm39)	missense	probably benign	0.05
R6029:Clstn2	UTSW	9	97,338,634 (GRCm39)	missense	probably benign	0.00
R6093:Clstn2	UTSW	9	97,340,263 (GRCm39)	missense	probably damaging	1.00
R6284:Clstn2	UTSW	9	97,336,727 (GRCm39)	missense	probably benign
R6676:Clstn2	UTSW	9	97,343,584 (GRCm39)	missense	probably damaging	1.00
R6902:Clstn2	UTSW	9	97,351,875 (GRCm39)	missense	probably damaging	1.00
R6946:Clstn2	UTSW	9	97,351,875 (GRCm39)	missense	probably damaging	1.00
R6966:Clstn2	UTSW	9	97,408,459 (GRCm39)	nonsense	probably null
R7329:Clstn2	UTSW	9	97,343,422 (GRCm39)	missense	probably benign	0.00
R7330:Clstn2	UTSW	9	97,343,422 (GRCm39)	missense	probably benign	0.00
R7382:Clstn2	UTSW	9	97,681,451 (GRCm39)	nonsense	probably null
R7410:Clstn2	UTSW	9	97,423,920 (GRCm39)	missense	probably benign	0.06
R7549:Clstn2	UTSW	9	97,464,597 (GRCm39)	missense	probably benign	0.01
R7879:Clstn2	UTSW	9	97,351,817 (GRCm39)	missense	possibly damaging	0.90
R8070:Clstn2	UTSW	9	97,681,523 (GRCm39)	missense	possibly damaging	0.79
R8193:Clstn2	UTSW	9	97,465,683 (GRCm39)	missense	probably damaging	1.00
R8422:Clstn2	UTSW	9	97,340,239 (GRCm39)	missense	probably benign	0.39
R9190:Clstn2	UTSW	9	97,414,815 (GRCm39)	missense	probably damaging	1.00
R9221:Clstn2	UTSW	9	97,343,395 (GRCm39)	missense	probably benign	0.00
R9305:Clstn2	UTSW	9	97,343,537 (GRCm39)	missense	probably damaging	1.00
R9347:Clstn2	UTSW	9	97,464,654 (GRCm39)	missense	probably damaging	1.00
R9520:Clstn2	UTSW	9	97,414,763 (GRCm39)	missense	probably damaging	1.00
R9751:Clstn2	UTSW	9	97,339,703 (GRCm39)	missense	probably damaging	0.98
X0027:Clstn2	UTSW	9	97,408,452 (GRCm39)	missense	probably damaging	1.00
Z1177:Clstn2	UTSW	9	97,343,409 (GRCm39)	missense	probably benign

Posted On

2013-10-07