Incidental Mutation 'R9767:Prss27'
ID 733352
Institutional Source Beutler Lab
Gene Symbol Prss27
Ensembl Gene ENSMUSG00000050762
Gene Name serine protease 27
Synonyms Pancreasin, Mpn, marapsin, CAPH2
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9767 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 24257217-24264923 bp(+) (GRCm39)
Type of Mutation start codon destroyed
DNA Base Change (assembly) G to T at 24257283 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 1 (M1I)
Ref Sequence ENSEMBL: ENSMUSP00000056483 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059482]
AlphaFold Q8BJR6
Predicted Effect probably null
Transcript: ENSMUST00000059482
AA Change: M1I

PolyPhen 2 Score 0.332 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000056483
Gene: ENSMUSG00000050762
AA Change: M1I

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Tryp_SPc 37 275 2.29e-92 SMART
low complexity region 283 301 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.3%
  • 20x: 98.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is located within a large protease gene cluster on chromosome 16. It belongs to the group-1 subfamily of serine proteases. The encoded protein is a secreted tryptic serine protease and is expressed mainly in the pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Mice homozygous for a gene trap allele develop normally and are fertile. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrl4 A T 3: 151,207,394 (GRCm39) M314L probably benign Het
Ank3 T C 10: 69,823,799 (GRCm39) S41P probably damaging Het
Aox4 A C 1: 58,274,357 (GRCm39) N381T probably benign Het
Bnip3l G A 14: 67,246,214 (GRCm39) P7L possibly damaging Het
Bpifb6 G A 2: 153,751,148 (GRCm39) probably null Het
Cep350 A G 1: 155,739,018 (GRCm39) V2275A probably benign Het
Cntn4 G A 6: 106,655,395 (GRCm39) G831E probably benign Het
D6Ertd527e G C 6: 87,088,839 (GRCm39) S334T unknown Het
Dchs2 A G 3: 83,212,206 (GRCm39) I2002V probably benign Het
Dennd2a G A 6: 39,483,709 (GRCm39) R384C probably damaging Het
Dock1 A G 7: 134,342,796 (GRCm39) T136A possibly damaging Het
Eif2s2 A T 2: 154,730,125 (GRCm39) D57E probably benign Het
Eml2 C T 7: 18,920,083 (GRCm39) T129I probably benign Het
Flad1 A C 3: 89,310,718 (GRCm39) I443S probably benign Het
Glis1 A T 4: 107,491,794 (GRCm39) T741S probably benign Het
Gpr156 A G 16: 37,818,297 (GRCm39) Y331C probably damaging Het
Lrwd1 C T 5: 136,162,856 (GRCm39) V122M possibly damaging Het
Ndufs2 G T 1: 171,068,643 (GRCm39) P89Q probably damaging Het
Nkx1-2 C T 7: 132,199,402 (GRCm39) V120I probably benign Het
Or2t35 C T 14: 14,407,929 (GRCm38) R234W probably damaging Het
Or7a41 T C 10: 78,870,765 (GRCm39) L45P possibly damaging Het
Pcdhga3 T A 18: 37,808,096 (GRCm39) I183N probably benign Het
Pkhd1 T C 1: 20,484,636 (GRCm39) D1973G probably benign Het
Ppp1r3a A G 6: 14,718,101 (GRCm39) S938P probably benign Het
Rai14 T C 15: 10,610,127 (GRCm39) T74A probably benign Het
Rcc2 C T 4: 140,435,331 (GRCm39) R117W probably damaging Het
Rpl31 T A 1: 39,410,189 (GRCm39) *130R probably null Het
Rplp0 T C 5: 115,699,563 (GRCm39) S213P probably benign Het
Sdcbp2 T C 2: 151,429,057 (GRCm39) I152T probably damaging Het
Senp3 T C 11: 69,569,013 (GRCm39) T383A possibly damaging Het
Sod2 C A 17: 13,227,180 (GRCm39) Q45K probably benign Het
Speg A T 1: 75,403,825 (GRCm39) I2669F possibly damaging Het
Stat4 T G 1: 52,141,653 (GRCm39) F577V probably damaging Het
Tex9 C A 9: 72,368,518 (GRCm39) E377* probably null Het
Tmprss15 A T 16: 78,875,977 (GRCm39) V119D probably damaging Het
Unc79 T C 12: 103,079,234 (GRCm39) S1800P probably benign Het
Vldlr A G 19: 27,212,274 (GRCm39) D96G probably damaging Het
Vmn2r51 G T 7: 9,839,407 (GRCm39) N60K probably benign Het
Vps13b A G 15: 35,910,403 (GRCm39) D3389G probably damaging Het
Vps13d C T 4: 144,879,306 (GRCm39) E1506K Het
Zfp1 A G 8: 112,396,203 (GRCm39) N75D probably benign Het
Other mutations in Prss27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01574:Prss27 APN 17 24,257,345 (GRCm39) splice site probably benign
IGL01633:Prss27 APN 17 24,264,650 (GRCm39) missense probably damaging 1.00
IGL02096:Prss27 APN 17 24,263,951 (GRCm39) missense possibly damaging 0.94
IGL02318:Prss27 APN 17 24,264,571 (GRCm39) missense probably benign 0.01
IGL02491:Prss27 APN 17 24,263,229 (GRCm39) splice site probably benign
IGL02715:Prss27 APN 17 24,263,953 (GRCm39) missense possibly damaging 0.94
R1582:Prss27 UTSW 17 24,263,877 (GRCm39) missense probably benign 0.11
R5078:Prss27 UTSW 17 24,263,414 (GRCm39) nonsense probably null
R5468:Prss27 UTSW 17 24,257,287 (GRCm39) missense possibly damaging 0.53
R6415:Prss27 UTSW 17 24,261,882 (GRCm39) nonsense probably null
R6450:Prss27 UTSW 17 24,263,988 (GRCm39) nonsense probably null
R6477:Prss27 UTSW 17 24,263,235 (GRCm39) missense probably damaging 1.00
R7143:Prss27 UTSW 17 24,264,632 (GRCm39) missense probably damaging 1.00
R7285:Prss27 UTSW 17 24,264,665 (GRCm39) missense probably benign 0.01
R7447:Prss27 UTSW 17 24,264,683 (GRCm39) missense probably damaging 1.00
R7825:Prss27 UTSW 17 24,261,932 (GRCm39) missense probably damaging 1.00
R8240:Prss27 UTSW 17 24,263,919 (GRCm39) missense probably benign 0.04
R9371:Prss27 UTSW 17 24,257,141 (GRCm39) start gained probably benign
Predicted Primers PCR Primer
(F):5'- ACCTCCTTCCTGCCAAAGAG -3'
(R):5'- ACTGAGTATATTCTCTGGGAACCC -3'

Sequencing Primer
(F):5'- TTCCTGCCAAAGAGGAGCTG -3'
(R):5'- AACTCACCAGATCTGAGC -3'
Posted On 2022-11-14