Incidental Mutation 'R9771:Tada3'
ID 733442
Institutional Source Beutler Lab
Gene Symbol Tada3
Ensembl Gene ENSMUSG00000048930
Gene Name transcriptional adaptor 3
Synonyms 1110004B19Rik, ADA3, Tada3l
MMRRC Submission
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9771 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 113343594-113354799 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 113349319 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 244 (S244A)
Ref Sequence ENSEMBL: ENSMUSP00000032410 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032410] [ENSMUST00000043333] [ENSMUST00000099118] [ENSMUST00000193384]
AlphaFold Q8R0L9
Predicted Effect probably benign
Transcript: ENSMUST00000032410
AA Change: S244A

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000032410
Gene: ENSMUSG00000048930
AA Change: S244A

DomainStartEndE-ValueType
coiled coil region 47 67 N/A INTRINSIC
low complexity region 108 121 N/A INTRINSIC
Pfam:Ada3 309 430 1e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000043333
AA Change: S225A

PolyPhen 2 Score 0.044 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000043363
Gene: ENSMUSG00000048930
AA Change: S225A

DomainStartEndE-ValueType
coiled coil region 47 67 N/A INTRINSIC
low complexity region 108 121 N/A INTRINSIC
Pfam:Ada3 289 413 2e-31 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000099118
AA Change: S44A

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000108736
Gene: ENSMUSG00000048930
AA Change: S44A

DomainStartEndE-ValueType
Pfam:Ada3 108 232 6.7e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000193384
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.3%
  • 20x: 98.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality between E3.5 and E8.5 associated with impaired proliferation of trophoblast cells and absence of inner cell mass. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503B20Rik A G 3: 146,356,743 (GRCm39) I55T possibly damaging Het
Aldh1l1 A G 6: 90,575,310 (GRCm39) T866A probably benign Het
Alg12 A T 15: 88,700,373 (GRCm39) V21E probably damaging Het
Bod1l C A 5: 41,949,206 (GRCm39) R2972L probably damaging Het
Card6 T A 15: 5,129,693 (GRCm39) I568F probably benign Het
Ccdc89 A G 7: 90,075,810 (GRCm39) T7A probably benign Het
Cep112 A G 11: 108,573,517 (GRCm39) probably benign Het
Dnmbp T C 19: 43,855,031 (GRCm39) I297M probably damaging Het
Dpysl2 T C 14: 67,066,833 (GRCm39) E200G probably damaging Het
Etl4 T C 2: 20,811,537 (GRCm39) S1575P probably benign Het
Gm18596 A C 10: 77,577,962 (GRCm39) S171A unknown Het
Gmip T A 8: 70,266,718 (GRCm39) C278S probably benign Het
Gngt2 G T 11: 95,728,124 (GRCm39) probably benign Het
Gnptab G A 10: 88,268,485 (GRCm39) D531N probably damaging Het
Iqgap3 C A 3: 88,016,176 (GRCm39) F986L probably damaging Het
Kcnh7 A G 2: 62,569,719 (GRCm39) C726R probably damaging Het
Map4k4 T C 1: 40,025,877 (GRCm39) I289T unknown Het
Ndufb10 T C 17: 24,943,158 (GRCm39) probably null Het
Ngef G A 1: 87,431,010 (GRCm39) P269L probably damaging Het
Nol11 C A 11: 107,069,914 (GRCm39) W312L probably damaging Het
Or11i1 A T 3: 106,729,060 (GRCm39) Y272N possibly damaging Het
Or1p1c G A 11: 74,160,635 (GRCm39) R140H probably benign Het
Osbpl10 G A 9: 114,896,356 (GRCm39) R30Q probably benign Het
Osbpl6 T C 2: 76,423,771 (GRCm39) L878P possibly damaging Het
Pde6h T G 6: 136,936,359 (GRCm39) F34C probably damaging Het
Pkhd1l1 A G 15: 44,358,883 (GRCm39) H364R probably benign Het
Polr1f A G 12: 33,487,828 (GRCm39) T248A probably benign Het
Prss56 T C 1: 87,113,365 (GRCm39) I231T possibly damaging Het
Ptcd3 G A 6: 71,872,903 (GRCm39) R263* probably null Het
Ptprq T A 10: 107,521,085 (GRCm39) I696F probably damaging Het
Sdk1 A T 5: 142,082,624 (GRCm39) I1341F probably damaging Het
Sema3d A G 5: 12,613,207 (GRCm39) Y428C probably damaging Het
Sh3tc1 A C 5: 35,873,654 (GRCm39) F217C probably damaging Het
Sptb G A 12: 76,650,353 (GRCm39) T1788I probably damaging Het
Stard13 G A 5: 150,983,048 (GRCm39) P672L probably damaging Het
Styk1 CTCTTCATGATTTTCTT CTCTT 6: 131,278,612 (GRCm39) probably benign Het
Tnc T A 4: 63,925,600 (GRCm39) I979F probably damaging Het
Usp10 CAA CAAA 8: 120,658,620 (GRCm39) probably null Het
Vmn1r177 T C 7: 23,565,657 (GRCm39) N73S probably damaging Het
Vmn2r1 A G 3: 63,997,559 (GRCm39) E405G possibly damaging Het
Vmn2r2 T C 3: 64,042,079 (GRCm39) H212R possibly damaging Het
Wdfy3 A G 5: 102,000,195 (GRCm39) L3015P probably damaging Het
Wdr11 T C 7: 129,206,851 (GRCm39) S255P probably damaging Het
Ypel3 T C 7: 126,379,226 (GRCm39) Y100H probably damaging Het
Other mutations in Tada3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01635:Tada3 APN 6 113,352,973 (GRCm39) missense probably benign 0.41
IGL03256:Tada3 APN 6 113,352,092 (GRCm39) missense possibly damaging 0.83
R0208:Tada3 UTSW 6 113,343,968 (GRCm39) missense probably damaging 1.00
R0542:Tada3 UTSW 6 113,352,175 (GRCm39) missense probably damaging 0.99
R0698:Tada3 UTSW 6 113,343,968 (GRCm39) missense probably damaging 1.00
R2120:Tada3 UTSW 6 113,347,976 (GRCm39) missense possibly damaging 0.50
R4384:Tada3 UTSW 6 113,347,340 (GRCm39) missense probably damaging 1.00
R7844:Tada3 UTSW 6 113,347,921 (GRCm39) missense probably benign 0.05
R8402:Tada3 UTSW 6 113,351,774 (GRCm39) missense probably damaging 1.00
R9289:Tada3 UTSW 6 113,347,264 (GRCm39) missense possibly damaging 0.92
Z1176:Tada3 UTSW 6 113,352,823 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTCGAGCCTGTGTGTAAATG -3'
(R):5'- ATGGGCAGTGTTTACCTCTCAG -3'

Sequencing Primer
(F):5'- GATTGAACTTGAGCTAAGAGCCTCTG -3'
(R):5'- GCAGTGTTTACCTCTCAGAGCTG -3'
Posted On 2022-11-14