Incidental Mutation 'R9771:Styk1'
ID 733443
Institutional Source Beutler Lab
Gene Symbol Styk1
Ensembl Gene ENSMUSG00000032899
Gene Name serine/threonine/tyrosine kinase 1
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.311) question?
Stock # R9771 (G1)
Quality Score 217.468
Status Not validated
Chromosome 6
Chromosomal Location 131276096-131330532 bp(-) (GRCm39)
Type of Mutation small deletion (4 aa in frame mutation)
DNA Base Change (assembly) CTCTTCATGATTTTCTT to CTCTT at 131278612 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000112900 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049150] [ENSMUST00000121078]
AlphaFold Q6J9G1
Predicted Effect probably benign
Transcript: ENSMUST00000049150
SMART Domains Protein: ENSMUSP00000044098
Gene: ENSMUSG00000032899

DomainStartEndE-ValueType
transmembrane domain 31 53 N/A INTRINSIC
Pfam:Pkinase 119 387 3.2e-31 PFAM
Pfam:Pkinase_Tyr 119 387 1.8e-59 PFAM
low complexity region 399 410 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000121078
SMART Domains Protein: ENSMUSP00000112900
Gene: ENSMUSG00000032899

DomainStartEndE-ValueType
transmembrane domain 31 53 N/A INTRINSIC
Pfam:Pkinase_Tyr 67 298 2.5e-53 PFAM
Pfam:Pkinase 68 298 5.7e-29 PFAM
low complexity region 310 321 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.3%
  • 20x: 98.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503B20Rik A G 3: 146,356,743 (GRCm39) I55T possibly damaging Het
Aldh1l1 A G 6: 90,575,310 (GRCm39) T866A probably benign Het
Alg12 A T 15: 88,700,373 (GRCm39) V21E probably damaging Het
Bod1l C A 5: 41,949,206 (GRCm39) R2972L probably damaging Het
Card6 T A 15: 5,129,693 (GRCm39) I568F probably benign Het
Ccdc89 A G 7: 90,075,810 (GRCm39) T7A probably benign Het
Cep112 A G 11: 108,573,517 (GRCm39) probably benign Het
Dnmbp T C 19: 43,855,031 (GRCm39) I297M probably damaging Het
Dpysl2 T C 14: 67,066,833 (GRCm39) E200G probably damaging Het
Etl4 T C 2: 20,811,537 (GRCm39) S1575P probably benign Het
Gm18596 A C 10: 77,577,962 (GRCm39) S171A unknown Het
Gmip T A 8: 70,266,718 (GRCm39) C278S probably benign Het
Gngt2 G T 11: 95,728,124 (GRCm39) probably benign Het
Gnptab G A 10: 88,268,485 (GRCm39) D531N probably damaging Het
Iqgap3 C A 3: 88,016,176 (GRCm39) F986L probably damaging Het
Kcnh7 A G 2: 62,569,719 (GRCm39) C726R probably damaging Het
Map4k4 T C 1: 40,025,877 (GRCm39) I289T unknown Het
Ndufb10 T C 17: 24,943,158 (GRCm39) probably null Het
Ngef G A 1: 87,431,010 (GRCm39) P269L probably damaging Het
Nol11 C A 11: 107,069,914 (GRCm39) W312L probably damaging Het
Or11i1 A T 3: 106,729,060 (GRCm39) Y272N possibly damaging Het
Or1p1c G A 11: 74,160,635 (GRCm39) R140H probably benign Het
Osbpl10 G A 9: 114,896,356 (GRCm39) R30Q probably benign Het
Osbpl6 T C 2: 76,423,771 (GRCm39) L878P possibly damaging Het
Pde6h T G 6: 136,936,359 (GRCm39) F34C probably damaging Het
Pkhd1l1 A G 15: 44,358,883 (GRCm39) H364R probably benign Het
Polr1f A G 12: 33,487,828 (GRCm39) T248A probably benign Het
Prss56 T C 1: 87,113,365 (GRCm39) I231T possibly damaging Het
Ptcd3 G A 6: 71,872,903 (GRCm39) R263* probably null Het
Ptprq T A 10: 107,521,085 (GRCm39) I696F probably damaging Het
Sdk1 A T 5: 142,082,624 (GRCm39) I1341F probably damaging Het
Sema3d A G 5: 12,613,207 (GRCm39) Y428C probably damaging Het
Sh3tc1 A C 5: 35,873,654 (GRCm39) F217C probably damaging Het
Sptb G A 12: 76,650,353 (GRCm39) T1788I probably damaging Het
Stard13 G A 5: 150,983,048 (GRCm39) P672L probably damaging Het
Tada3 A C 6: 113,349,319 (GRCm39) S244A probably benign Het
Tnc T A 4: 63,925,600 (GRCm39) I979F probably damaging Het
Usp10 CAA CAAA 8: 120,658,620 (GRCm39) probably null Het
Vmn1r177 T C 7: 23,565,657 (GRCm39) N73S probably damaging Het
Vmn2r1 A G 3: 63,997,559 (GRCm39) E405G possibly damaging Het
Vmn2r2 T C 3: 64,042,079 (GRCm39) H212R possibly damaging Het
Wdfy3 A G 5: 102,000,195 (GRCm39) L3015P probably damaging Het
Wdr11 T C 7: 129,206,851 (GRCm39) S255P probably damaging Het
Ypel3 T C 7: 126,379,226 (GRCm39) Y100H probably damaging Het
Other mutations in Styk1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00822:Styk1 APN 6 131,278,625 (GRCm39) missense possibly damaging 0.75
IGL01370:Styk1 APN 6 131,278,615 (GRCm39) missense probably damaging 1.00
IGL01833:Styk1 APN 6 131,279,329 (GRCm39) splice site probably benign
IGL02705:Styk1 APN 6 131,289,546 (GRCm39) missense probably benign 0.02
IGL03029:Styk1 APN 6 131,277,523 (GRCm39) missense probably benign 0.27
conviction UTSW 6 131,289,539 (GRCm39) missense probably benign 0.01
will UTSW 6 131,289,880 (GRCm39) critical splice donor site probably null
R0201:Styk1 UTSW 6 131,278,693 (GRCm39) splice site probably benign
R2267:Styk1 UTSW 6 131,289,539 (GRCm39) missense probably benign 0.01
R2268:Styk1 UTSW 6 131,289,539 (GRCm39) missense probably benign 0.01
R2269:Styk1 UTSW 6 131,289,539 (GRCm39) missense probably benign 0.01
R2919:Styk1 UTSW 6 131,289,967 (GRCm39) start gained probably benign
R3153:Styk1 UTSW 6 131,286,975 (GRCm39) nonsense probably null
R3154:Styk1 UTSW 6 131,286,975 (GRCm39) nonsense probably null
R4041:Styk1 UTSW 6 131,289,880 (GRCm39) critical splice donor site probably null
R4650:Styk1 UTSW 6 131,277,532 (GRCm39) missense probably damaging 1.00
R4739:Styk1 UTSW 6 131,277,429 (GRCm39) missense probably damaging 1.00
R5079:Styk1 UTSW 6 131,278,676 (GRCm39) missense probably damaging 1.00
R5497:Styk1 UTSW 6 131,281,670 (GRCm39) missense probably damaging 0.97
R5637:Styk1 UTSW 6 131,277,381 (GRCm39) missense possibly damaging 0.82
R6137:Styk1 UTSW 6 131,287,979 (GRCm39) missense probably damaging 1.00
R6429:Styk1 UTSW 6 131,287,027 (GRCm39) missense possibly damaging 0.93
R7522:Styk1 UTSW 6 131,289,803 (GRCm39) splice site probably null
R8188:Styk1 UTSW 6 131,281,848 (GRCm39) missense probably benign 0.43
R9255:Styk1 UTSW 6 131,286,946 (GRCm39) missense probably damaging 1.00
R9704:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9705:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9712:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9714:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9715:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9725:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9725:Styk1 UTSW 6 131,278,610 (GRCm39) small deletion probably benign
R9750:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9751:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9752:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9753:Styk1 UTSW 6 131,278,612 (GRCm39) small deletion probably benign
R9778:Styk1 UTSW 6 131,287,992 (GRCm39) nonsense probably null
X0021:Styk1 UTSW 6 131,284,032 (GRCm39) critical splice donor site probably null
X0026:Styk1 UTSW 6 131,287,902 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GTGAACAAACTAAGTGCTCCTG -3'
(R):5'- CCCATGGTTATGCTTTAGAGGC -3'

Sequencing Primer
(F):5'- CTGCACCATAATGGAACTGTG -3'
(R):5'- AGAGGCTGCTTTTCAGGTCACAG -3'
Posted On 2022-11-14