Incidental Mutation 'R9773:Fry'
ID 733522
Institutional Source Beutler Lab
Gene Symbol Fry
Ensembl Gene ENSMUSG00000056602
Gene Name FRY microtubule binding protein
Synonyms cg003, 9330186A19Rik
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.460) question?
Stock # R9773 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 150042110-150421218 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 150322728 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 1040 (L1040P)
Ref Sequence ENSEMBL: ENSMUSP00000084454 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087204]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000087204
AA Change: L1040P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000084454
Gene: ENSMUSG00000056602
AA Change: L1040P

DomainStartEndE-ValueType
Pfam:MOR2-PAG1_N 165 697 5.3e-170 PFAM
low complexity region 1014 1040 N/A INTRINSIC
Pfam:MOR2-PAG1_mid 1188 1380 1.2e-15 PFAM
Pfam:MOR2-PAG1_mid 1398 1534 1.5e-5 PFAM
Pfam:MOR2-PAG1_mid 1632 1704 1.8e-7 PFAM
Pfam:MOR2-PAG1_mid 1772 1906 4.9e-10 PFAM
low complexity region 1936 1956 N/A INTRINSIC
low complexity region 1962 1980 N/A INTRINSIC
Pfam:MOR2-PAG1_C 2050 2303 1.9e-74 PFAM
low complexity region 2369 2385 N/A INTRINSIC
low complexity region 2463 2482 N/A INTRINSIC
low complexity region 2525 2534 N/A INTRINSIC
low complexity region 2836 2852 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.5%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik T C 16: 4,668,057 (GRCm39) Y483H possibly damaging Het
Abca17 A G 17: 24,508,565 (GRCm39) L990P probably damaging Het
Ankrd65 A C 4: 155,877,424 (GRCm39) T312P probably damaging Het
Atp23 G A 10: 126,734,763 (GRCm39) T103M possibly damaging Het
Bmpr2 T A 1: 59,907,497 (GRCm39) S863R probably damaging Het
Cacna1c T A 6: 118,647,371 (GRCm39) N992I Het
Cacnb2 A G 2: 14,976,452 (GRCm39) E291G probably damaging Het
Calcrl T C 2: 84,200,462 (GRCm39) Q106R probably benign Het
Clip2 C T 5: 134,533,616 (GRCm39) R487Q probably benign Het
Cngb1 G A 8: 95,975,042 (GRCm39) H1144Y probably damaging Het
Cnot4 A T 6: 35,056,920 (GRCm39) N50K probably damaging Het
Coasy T C 11: 100,975,163 (GRCm39) L240P probably damaging Het
D7Ertd443e G A 7: 133,959,803 (GRCm39) T12M probably benign Het
Exoc3l2 A G 7: 19,203,697 (GRCm39) I96M Het
Fbn2 A G 18: 58,143,481 (GRCm39) L2858P probably benign Het
Fbxw21 A G 9: 108,977,128 (GRCm39) S194P possibly damaging Het
Gimap8 C T 6: 48,633,568 (GRCm39) P300S unknown Het
Gm10801 T G 2: 98,494,345 (GRCm39) F141V probably benign Het
Gm21903 G A 17: 39,353,541 (GRCm39) T25I unknown Het
Gucy2d T C 7: 98,099,048 (GRCm39) V288A possibly damaging Het
Hs6st3 A T 14: 120,106,948 (GRCm39) D452V probably benign Het
Igkv5-43 T A 6: 69,752,858 (GRCm39) I75F probably damaging Het
Itgad G A 7: 127,789,222 (GRCm39) R562H probably damaging Het
Kbtbd12 T A 6: 88,524,744 (GRCm39) D613V probably damaging Het
Kcnn2 A G 18: 45,788,365 (GRCm39) T363A probably damaging Het
Kyat3 A G 3: 142,431,820 (GRCm39) I213M probably damaging Het
Lrig2 A T 3: 104,368,838 (GRCm39) H948Q probably benign Het
Marchf7 C T 2: 60,064,785 (GRCm39) R354* probably null Het
Mcm5 C T 8: 75,844,168 (GRCm39) S313F probably benign Het
Myh4 C T 11: 67,137,263 (GRCm39) H495Y probably damaging Het
Or13a23-ps1 T C 7: 140,118,649 (GRCm39) V73A probably benign Het
Or4d10b A T 19: 12,036,939 (GRCm39) M59K possibly damaging Het
Or6c69c T A 10: 129,910,360 (GRCm39) I27N possibly damaging Het
Plcb2 T C 2: 118,541,274 (GRCm39) E1021G probably damaging Het
Plekhg2 G A 7: 28,069,743 (GRCm39) P97S probably damaging Het
Pon1 T C 6: 5,177,339 (GRCm39) Y190C possibly damaging Het
Pth1r C A 9: 110,556,233 (GRCm39) R213S possibly damaging Het
Ptprg A G 14: 12,199,806 (GRCm38) D848G probably damaging Het
Rnpepl1 C A 1: 92,847,559 (GRCm39) D715E probably damaging Het
Serpinb3b C A 1: 107,085,416 (GRCm39) K108N possibly damaging Het
Slc1a1 C T 19: 28,870,283 (GRCm39) A94V probably damaging Het
Slc22a30 A T 19: 8,321,754 (GRCm39) Y437N probably benign Het
Slc2a7 C T 4: 150,234,044 (GRCm39) T53I possibly damaging Het
Spag1 A G 15: 36,234,711 (GRCm39) T824A probably benign Het
Spmip7 G A 11: 11,438,572 (GRCm39) V272M unknown Het
Synj2 T A 17: 6,094,232 (GRCm39) Y1153N probably benign Het
Ttll2 A T 17: 7,618,676 (GRCm39) I417K probably benign Het
Ttn C T 2: 76,715,357 (GRCm39) E7912K unknown Het
Uevld A G 7: 46,597,659 (GRCm39) probably null Het
Vmn2r38 A G 7: 9,097,806 (GRCm39) S96P probably damaging Het
Vmn2r92 A G 17: 18,386,949 (GRCm39) N96S probably damaging Het
Vmn2r97 T A 17: 19,168,221 (GRCm39) I825N probably benign Het
Vps13d T A 4: 144,818,619 (GRCm39) M3083L Het
Wdr35 A G 12: 9,039,990 (GRCm39) N365S probably benign Het
Other mutations in Fry
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00327:Fry APN 5 150,263,869 (GRCm39) nonsense probably null
IGL00328:Fry APN 5 150,263,869 (GRCm39) nonsense probably null
IGL00841:Fry APN 5 150,346,189 (GRCm39) missense probably benign
IGL00938:Fry APN 5 150,293,645 (GRCm39) missense probably damaging 1.00
IGL01015:Fry APN 5 150,346,252 (GRCm39) missense probably benign 0.18
IGL01401:Fry APN 5 150,362,253 (GRCm39) missense probably benign
IGL01616:Fry APN 5 150,323,064 (GRCm39) missense probably damaging 1.00
IGL01616:Fry APN 5 150,362,276 (GRCm39) splice site probably null
IGL01748:Fry APN 5 150,269,116 (GRCm39) splice site probably benign
IGL01965:Fry APN 5 150,305,086 (GRCm39) missense probably damaging 1.00
IGL02030:Fry APN 5 150,395,083 (GRCm39) splice site probably benign
IGL02079:Fry APN 5 150,323,089 (GRCm39) missense probably damaging 0.97
IGL02087:Fry APN 5 150,327,059 (GRCm39) missense probably benign 0.23
IGL02113:Fry APN 5 150,323,070 (GRCm39) missense probably benign
IGL02209:Fry APN 5 150,360,491 (GRCm39) missense probably benign 0.00
IGL02250:Fry APN 5 150,326,899 (GRCm39) splice site probably benign
IGL02265:Fry APN 5 150,360,618 (GRCm39) missense probably damaging 1.00
IGL02486:Fry APN 5 150,414,642 (GRCm39) missense probably damaging 0.99
IGL02552:Fry APN 5 150,304,375 (GRCm39) missense probably damaging 1.00
IGL02881:Fry APN 5 150,282,516 (GRCm39) missense probably damaging 0.99
IGL03008:Fry APN 5 150,269,021 (GRCm39) missense possibly damaging 0.82
IGL03140:Fry APN 5 150,419,166 (GRCm39) missense probably damaging 0.98
IGL03171:Fry APN 5 150,304,274 (GRCm39) missense probably damaging 1.00
IGL03389:Fry APN 5 150,317,696 (GRCm39) missense probably damaging 1.00
IGL03404:Fry APN 5 150,249,633 (GRCm39) missense probably damaging 1.00
Brook UTSW 5 150,249,597 (GRCm39) missense probably damaging 1.00
haydn UTSW 5 150,341,929 (GRCm39) missense possibly damaging 0.94
miracle UTSW 5 150,360,624 (GRCm39) missense probably damaging 0.99
quickening UTSW 5 150,358,241 (GRCm39) missense probably damaging 1.00
seasons UTSW 5 150,389,902 (GRCm39) missense probably benign 0.06
Vivaldi UTSW 5 150,317,603 (GRCm39) missense possibly damaging 0.80
R0023:Fry UTSW 5 150,374,563 (GRCm39) missense possibly damaging 0.78
R0024:Fry UTSW 5 150,304,268 (GRCm39) missense probably benign 0.03
R0030:Fry UTSW 5 150,296,034 (GRCm39) nonsense probably null
R0053:Fry UTSW 5 150,384,842 (GRCm39) splice site probably benign
R0089:Fry UTSW 5 150,263,892 (GRCm39) missense possibly damaging 0.91
R0212:Fry UTSW 5 150,419,862 (GRCm39) missense probably damaging 0.99
R0241:Fry UTSW 5 150,183,811 (GRCm39) intron probably benign
R0265:Fry UTSW 5 150,358,241 (GRCm39) missense probably damaging 1.00
R0317:Fry UTSW 5 150,394,933 (GRCm39) missense probably damaging 1.00
R0532:Fry UTSW 5 150,402,226 (GRCm39) splice site probably benign
R0532:Fry UTSW 5 150,357,172 (GRCm39) unclassified probably benign
R0599:Fry UTSW 5 150,360,624 (GRCm39) missense probably damaging 0.99
R0631:Fry UTSW 5 150,419,817 (GRCm39) missense possibly damaging 0.82
R0723:Fry UTSW 5 150,419,825 (GRCm39) missense probably damaging 1.00
R0766:Fry UTSW 5 150,326,897 (GRCm39) splice site probably benign
R0790:Fry UTSW 5 150,389,902 (GRCm39) missense probably benign 0.06
R0928:Fry UTSW 5 150,360,549 (GRCm39) missense probably damaging 1.00
R1104:Fry UTSW 5 150,419,754 (GRCm39) missense probably damaging 1.00
R1144:Fry UTSW 5 150,341,929 (GRCm39) missense possibly damaging 0.94
R1172:Fry UTSW 5 150,404,959 (GRCm39) nonsense probably null
R1312:Fry UTSW 5 150,326,897 (GRCm39) splice site probably benign
R1347:Fry UTSW 5 150,419,283 (GRCm39) missense probably damaging 1.00
R1347:Fry UTSW 5 150,419,283 (GRCm39) missense probably damaging 1.00
R1437:Fry UTSW 5 150,233,890 (GRCm39) missense possibly damaging 0.92
R1458:Fry UTSW 5 150,304,324 (GRCm39) missense probably damaging 1.00
R1542:Fry UTSW 5 150,328,431 (GRCm39) missense probably benign 0.13
R1692:Fry UTSW 5 150,293,692 (GRCm39) missense probably damaging 1.00
R1826:Fry UTSW 5 150,360,174 (GRCm39) missense possibly damaging 0.82
R1874:Fry UTSW 5 150,269,386 (GRCm39) missense probably damaging 1.00
R1875:Fry UTSW 5 150,249,597 (GRCm39) missense probably damaging 1.00
R1881:Fry UTSW 5 150,401,511 (GRCm39) missense probably damaging 0.97
R1884:Fry UTSW 5 150,326,985 (GRCm39) missense probably benign 0.00
R1929:Fry UTSW 5 150,324,389 (GRCm39) missense probably null 0.02
R2066:Fry UTSW 5 150,293,584 (GRCm39) splice site probably benign
R2270:Fry UTSW 5 150,324,389 (GRCm39) missense probably null 0.02
R2356:Fry UTSW 5 150,394,897 (GRCm39) missense probably benign
R3720:Fry UTSW 5 150,378,037 (GRCm39) missense probably damaging 1.00
R3773:Fry UTSW 5 150,321,663 (GRCm39) missense probably damaging 0.96
R3824:Fry UTSW 5 150,419,884 (GRCm39) missense possibly damaging 0.94
R3902:Fry UTSW 5 150,269,392 (GRCm39) missense probably damaging 1.00
R3923:Fry UTSW 5 150,336,814 (GRCm39) missense probably benign
R4250:Fry UTSW 5 150,233,825 (GRCm39) missense probably damaging 0.99
R4332:Fry UTSW 5 150,305,128 (GRCm39) missense probably damaging 1.00
R4495:Fry UTSW 5 150,233,928 (GRCm39) missense probably damaging 1.00
R4610:Fry UTSW 5 150,309,569 (GRCm39) missense probably damaging 1.00
R4682:Fry UTSW 5 150,346,219 (GRCm39) missense probably damaging 1.00
R4732:Fry UTSW 5 150,309,472 (GRCm39) missense
R4733:Fry UTSW 5 150,309,472 (GRCm39) missense
R4755:Fry UTSW 5 150,321,719 (GRCm39) missense probably damaging 0.99
R4788:Fry UTSW 5 150,323,101 (GRCm39) missense probably benign 0.00
R4803:Fry UTSW 5 150,322,998 (GRCm39) missense probably benign 0.31
R4858:Fry UTSW 5 150,325,108 (GRCm39) missense possibly damaging 0.78
R4872:Fry UTSW 5 150,317,704 (GRCm39) critical splice donor site probably null
R4902:Fry UTSW 5 150,419,168 (GRCm39) missense probably benign 0.43
R4915:Fry UTSW 5 150,402,328 (GRCm39) missense probably benign 0.30
R4938:Fry UTSW 5 150,401,454 (GRCm39) missense probably damaging 1.00
R4983:Fry UTSW 5 150,321,719 (GRCm39) missense probably damaging 1.00
R5004:Fry UTSW 5 150,357,069 (GRCm39) missense probably benign 0.16
R5040:Fry UTSW 5 150,312,319 (GRCm39) missense probably damaging 0.99
R5145:Fry UTSW 5 150,293,689 (GRCm39) missense probably damaging 0.98
R5170:Fry UTSW 5 150,353,319 (GRCm39) missense probably benign 0.03
R5233:Fry UTSW 5 150,393,185 (GRCm39) missense possibly damaging 0.71
R5428:Fry UTSW 5 150,328,824 (GRCm39) missense possibly damaging 0.89
R5468:Fry UTSW 5 150,323,053 (GRCm39) missense probably benign 0.44
R5481:Fry UTSW 5 150,183,784 (GRCm39) missense probably benign 0.01
R5494:Fry UTSW 5 150,314,132 (GRCm39) missense probably damaging 1.00
R5538:Fry UTSW 5 150,419,313 (GRCm39) missense probably damaging 1.00
R5638:Fry UTSW 5 150,282,546 (GRCm39) missense possibly damaging 0.46
R5645:Fry UTSW 5 150,304,332 (GRCm39) missense probably damaging 1.00
R5716:Fry UTSW 5 150,293,686 (GRCm39) nonsense probably null
R5812:Fry UTSW 5 150,323,136 (GRCm39) missense probably damaging 0.99
R5813:Fry UTSW 5 150,323,136 (GRCm39) missense probably damaging 0.99
R5873:Fry UTSW 5 150,302,350 (GRCm39) missense probably damaging 1.00
R5933:Fry UTSW 5 150,314,265 (GRCm39) intron probably benign
R6037:Fry UTSW 5 150,351,644 (GRCm39) missense probably benign 0.03
R6037:Fry UTSW 5 150,351,644 (GRCm39) missense probably benign 0.03
R6158:Fry UTSW 5 150,378,037 (GRCm39) missense probably damaging 1.00
R6178:Fry UTSW 5 150,377,987 (GRCm39) missense probably damaging 1.00
R6481:Fry UTSW 5 150,309,479 (GRCm39) missense probably damaging 1.00
R6562:Fry UTSW 5 150,249,614 (GRCm39) missense probably damaging 1.00
R6676:Fry UTSW 5 150,304,387 (GRCm39) missense probably benign 0.22
R6717:Fry UTSW 5 150,419,777 (GRCm39) missense probably benign 0.00
R6828:Fry UTSW 5 150,389,911 (GRCm39) splice site probably null
R6874:Fry UTSW 5 150,360,768 (GRCm39) missense probably benign 0.00
R6930:Fry UTSW 5 150,351,695 (GRCm39) missense probably benign 0.00
R6963:Fry UTSW 5 150,381,309 (GRCm39) missense probably benign 0.17
R6965:Fry UTSW 5 150,339,685 (GRCm39) missense possibly damaging 0.79
R7051:Fry UTSW 5 150,318,634 (GRCm39) missense possibly damaging 0.93
R7085:Fry UTSW 5 150,362,214 (GRCm39) missense probably benign 0.02
R7108:Fry UTSW 5 150,414,555 (GRCm39) missense
R7108:Fry UTSW 5 150,319,251 (GRCm39) missense probably damaging 1.00
R7115:Fry UTSW 5 150,309,532 (GRCm39) missense probably damaging 1.00
R7116:Fry UTSW 5 150,319,334 (GRCm39) critical splice donor site probably null
R7197:Fry UTSW 5 150,393,232 (GRCm39) missense
R7256:Fry UTSW 5 150,390,251 (GRCm39) missense
R7318:Fry UTSW 5 150,360,458 (GRCm39) missense probably damaging 0.98
R7323:Fry UTSW 5 150,419,814 (GRCm39) missense
R7358:Fry UTSW 5 150,339,788 (GRCm39) missense probably benign
R7361:Fry UTSW 5 150,360,312 (GRCm39) missense possibly damaging 0.92
R7395:Fry UTSW 5 150,304,348 (GRCm39) missense possibly damaging 0.82
R7487:Fry UTSW 5 150,338,039 (GRCm39) missense possibly damaging 0.79
R7491:Fry UTSW 5 150,389,791 (GRCm39) missense
R7574:Fry UTSW 5 150,304,359 (GRCm39) missense probably benign 0.00
R7582:Fry UTSW 5 150,419,847 (GRCm39) missense
R7586:Fry UTSW 5 150,349,683 (GRCm39) missense probably damaging 1.00
R7650:Fry UTSW 5 150,336,883 (GRCm39) missense probably damaging 1.00
R7699:Fry UTSW 5 150,328,792 (GRCm39) missense probably damaging 0.98
R7700:Fry UTSW 5 150,328,792 (GRCm39) missense probably damaging 0.98
R7972:Fry UTSW 5 150,233,861 (GRCm39) missense probably benign 0.05
R8058:Fry UTSW 5 150,419,232 (GRCm39) missense
R8070:Fry UTSW 5 150,401,472 (GRCm39) missense
R8159:Fry UTSW 5 150,322,998 (GRCm39) missense probably benign 0.31
R8202:Fry UTSW 5 150,355,202 (GRCm39) missense probably damaging 1.00
R8261:Fry UTSW 5 150,369,372 (GRCm39) missense probably damaging 1.00
R8279:Fry UTSW 5 150,419,726 (GRCm39) missense
R8338:Fry UTSW 5 150,282,516 (GRCm39) missense probably damaging 0.99
R8370:Fry UTSW 5 150,319,284 (GRCm39) missense probably damaging 1.00
R8673:Fry UTSW 5 150,318,576 (GRCm39) missense possibly damaging 0.91
R8786:Fry UTSW 5 150,317,501 (GRCm39) missense probably benign 0.00
R8815:Fry UTSW 5 150,317,603 (GRCm39) missense possibly damaging 0.80
R8847:Fry UTSW 5 150,309,472 (GRCm39) missense
R9023:Fry UTSW 5 150,360,768 (GRCm39) missense probably benign 0.00
R9025:Fry UTSW 5 150,219,273 (GRCm39) intron probably benign
R9125:Fry UTSW 5 150,269,525 (GRCm39) missense probably damaging 0.97
R9172:Fry UTSW 5 150,336,793 (GRCm39) missense probably benign
R9262:Fry UTSW 5 150,305,109 (GRCm39) missense probably damaging 1.00
R9263:Fry UTSW 5 150,322,728 (GRCm39) missense probably damaging 1.00
R9293:Fry UTSW 5 150,419,297 (GRCm39) missense
R9368:Fry UTSW 5 150,401,403 (GRCm39) missense
R9401:Fry UTSW 5 150,302,403 (GRCm39) missense probably damaging 1.00
R9402:Fry UTSW 5 150,360,318 (GRCm39) missense probably damaging 1.00
R9402:Fry UTSW 5 150,357,161 (GRCm39) missense possibly damaging 0.91
R9420:Fry UTSW 5 150,356,994 (GRCm39) missense possibly damaging 0.72
R9557:Fry UTSW 5 150,389,781 (GRCm39) missense
R9647:Fry UTSW 5 150,292,984 (GRCm39) missense probably damaging 1.00
R9650:Fry UTSW 5 150,369,375 (GRCm39) missense probably damaging 1.00
R9655:Fry UTSW 5 150,362,251 (GRCm39) missense possibly damaging 0.90
R9664:Fry UTSW 5 150,282,488 (GRCm39) missense probably damaging 0.98
R9668:Fry UTSW 5 150,282,318 (GRCm39) missense probably damaging 1.00
R9732:Fry UTSW 5 150,328,758 (GRCm39) missense probably benign 0.00
Z1177:Fry UTSW 5 150,233,902 (GRCm39) missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- GATAACTGGCATTGTCCCCAC -3'
(R):5'- AGTTCACGTGGCAATTTTGG -3'

Sequencing Primer
(F):5'- TTGTCCCCACCTCTTAGGAAGAAAG -3'
(R):5'- GGTTTTTATGCACATTATACAGGGG -3'
Posted On 2022-11-14