Incidental Mutation 'IGL01304:Zfp870'
ID73355
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp870
Ensembl Gene ENSMUSG00000095325
Gene Namezinc finger protein 870
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #IGL01304
Quality Score
Status
Chromosome17
Chromosomal Location32879219-32891590 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 32883006 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Serine at position 450 (C450S)
Ref Sequence ENSEMBL: ENSMUSP00000136197 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178401] [ENSMUST00000228075]
Predicted Effect possibly damaging
Transcript: ENSMUST00000178401
AA Change: C450S

PolyPhen 2 Score 0.717 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000136197
Gene: ENSMUSG00000095325
AA Change: C450S

DomainStartEndE-ValueType
KRAB 3 60 1.01e-19 SMART
ZnF_C2H2 193 215 4.5e1 SMART
ZnF_C2H2 221 241 6.4e0 SMART
ZnF_C2H2 277 299 2.24e-3 SMART
ZnF_C2H2 305 327 9.58e-3 SMART
ZnF_C2H2 333 355 2.86e-1 SMART
ZnF_C2H2 361 383 6.42e-4 SMART
ZnF_C2H2 389 411 1.18e-2 SMART
ZnF_C2H2 417 439 3.89e-3 SMART
ZnF_C2H2 445 467 5.5e-3 SMART
ZnF_C2H2 473 495 4.47e-3 SMART
ZnF_C2H2 501 523 5.9e-3 SMART
ZnF_C2H2 529 551 3.11e-2 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000228075
AA Change: C451S

PolyPhen 2 Score 0.669 (Sensitivity: 0.86; Specificity: 0.91)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228410
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim1 A T 19: 57,215,721 D79E probably benign Het
Aplf A C 6: 87,641,900 S421A possibly damaging Het
Arnt T G 3: 95,448,385 D13E probably damaging Het
Asap1 T C 15: 64,312,449 E45G probably damaging Het
C2cd2l T C 9: 44,319,587 N101S probably damaging Het
Chmp7 G A 14: 69,718,613 P402L probably benign Het
Cir1 A T 2: 73,287,724 probably null Het
Clock A G 5: 76,266,355 probably null Het
Col18a1 T G 10: 77,076,141 probably benign Het
Csf2ra G A 19: 61,226,833 H115Y possibly damaging Het
Cspg5 T A 9: 110,256,168 L469H probably damaging Het
Dapk2 T C 9: 66,231,857 probably benign Het
F13a1 T C 13: 36,988,878 D176G probably benign Het
Fbn2 T C 18: 58,061,745 E1448G probably damaging Het
Gtf2b C T 3: 142,781,598 S265L probably benign Het
Hmcn1 C T 1: 150,622,924 G4068D probably damaging Het
Krt81 G A 15: 101,463,388 H104Y probably benign Het
Ksr1 T C 11: 79,027,642 Q562R probably damaging Het
Lrif1 C T 3: 106,731,733 P20S probably damaging Het
Mamdc4 T C 2: 25,563,576 T1194A possibly damaging Het
Med18 C A 4: 132,459,619 A190S probably damaging Het
Mia2 G A 12: 59,104,538 E105K probably damaging Het
Mnt T A 11: 74,842,185 Y48N probably damaging Het
Mpp4 A C 1: 59,149,519 probably null Het
Olfr1272 G A 2: 90,282,081 P165S possibly damaging Het
Popdc3 T G 10: 45,317,909 S269A probably benign Het
Ppp6r3 A T 19: 3,467,261 M662K probably damaging Het
Qser1 C A 2: 104,787,631 Q945H probably damaging Het
Rad52 A G 6: 119,918,633 E198G probably damaging Het
Ranbp17 A G 11: 33,266,147 V867A possibly damaging Het
Rdh16 G T 10: 127,813,496 A274S probably benign Het
Slco1a5 G T 6: 142,242,150 Q488K probably benign Het
Snai2 T C 16: 14,706,771 I47T probably benign Het
Snw1 T C 12: 87,453,915 D358G possibly damaging Het
Speg T C 1: 75,428,197 F2878L probably benign Het
Spert T A 14: 75,592,645 D36V possibly damaging Het
Spg11 T C 2: 122,072,290 Y1386C probably damaging Het
Tgfb2 A C 1: 186,625,473 I435S probably damaging Het
Ttc9b G A 7: 27,655,985 D227N probably benign Het
Txndc2 T C 17: 65,638,453 E243G possibly damaging Het
Usp28 A G 9: 49,026,819 D563G probably damaging Het
Vmn1r77 T C 7: 12,042,035 V178A probably damaging Het
Zfp316 A G 5: 143,254,426 F613L probably benign Het
Other mutations in Zfp870
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1591:Zfp870 UTSW 17 32884016 missense probably damaging 1.00
R1892:Zfp870 UTSW 17 32883889 missense possibly damaging 0.66
R1941:Zfp870 UTSW 17 32882804 missense possibly damaging 0.71
R1997:Zfp870 UTSW 17 32884053 missense possibly damaging 0.66
R2289:Zfp870 UTSW 17 32883360 missense probably benign 0.27
R4240:Zfp870 UTSW 17 32885736 missense probably benign 0.00
R4860:Zfp870 UTSW 17 32883340 nonsense probably null
R4860:Zfp870 UTSW 17 32883340 nonsense probably null
R5306:Zfp870 UTSW 17 32883653 missense probably damaging 1.00
R6425:Zfp870 UTSW 17 32883071 missense possibly damaging 0.66
R6736:Zfp870 UTSW 17 32883596 missense probably benign
R7054:Zfp870 UTSW 17 32883482 missense probably damaging 0.97
R7291:Zfp870 UTSW 17 32883854 missense probably damaging 0.97
R7466:Zfp870 UTSW 17 32883762 missense possibly damaging 0.66
R7681:Zfp870 UTSW 17 32882690 missense probably benign
R8230:Zfp870 UTSW 17 32883689 missense possibly damaging 0.46
Posted On2013-10-07