Incidental Mutation 'IGL01304:Vmn1r77'
ID73377
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r77
Ensembl Gene ENSMUSG00000095864
Gene Namevomeronasal 1 receptor 77
SynonymsGm6935
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.059) question?
Stock #IGL01304
Quality Score
Status
Chromosome7
Chromosomal Location12036752-12049295 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 12042035 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 178 (V178A)
Ref Sequence ENSEMBL: ENSMUSP00000154253 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164446] [ENSMUST00000226525] [ENSMUST00000227320] [ENSMUST00000228213]
Predicted Effect probably damaging
Transcript: ENSMUST00000164446
AA Change: V246A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000130869
Gene: ENSMUSG00000095864
AA Change: V246A

DomainStartEndE-ValueType
Pfam:TAS2R 1 300 1.9e-12 PFAM
Pfam:V1R 35 299 5.3e-26 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226525
AA Change: V178A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000227320
AA Change: V246A

PolyPhen 2 Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000228213
AA Change: V178A

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ablim1 A T 19: 57,215,721 D79E probably benign Het
Aplf A C 6: 87,641,900 S421A possibly damaging Het
Arnt T G 3: 95,448,385 D13E probably damaging Het
Asap1 T C 15: 64,312,449 E45G probably damaging Het
C2cd2l T C 9: 44,319,587 N101S probably damaging Het
Chmp7 G A 14: 69,718,613 P402L probably benign Het
Cir1 A T 2: 73,287,724 probably null Het
Clock A G 5: 76,266,355 probably null Het
Col18a1 T G 10: 77,076,141 probably benign Het
Csf2ra G A 19: 61,226,833 H115Y possibly damaging Het
Cspg5 T A 9: 110,256,168 L469H probably damaging Het
Dapk2 T C 9: 66,231,857 probably benign Het
F13a1 T C 13: 36,988,878 D176G probably benign Het
Fbn2 T C 18: 58,061,745 E1448G probably damaging Het
Gtf2b C T 3: 142,781,598 S265L probably benign Het
Hmcn1 C T 1: 150,622,924 G4068D probably damaging Het
Krt81 G A 15: 101,463,388 H104Y probably benign Het
Ksr1 T C 11: 79,027,642 Q562R probably damaging Het
Lrif1 C T 3: 106,731,733 P20S probably damaging Het
Mamdc4 T C 2: 25,563,576 T1194A possibly damaging Het
Med18 C A 4: 132,459,619 A190S probably damaging Het
Mia2 G A 12: 59,104,538 E105K probably damaging Het
Mnt T A 11: 74,842,185 Y48N probably damaging Het
Mpp4 A C 1: 59,149,519 probably null Het
Olfr1272 G A 2: 90,282,081 P165S possibly damaging Het
Popdc3 T G 10: 45,317,909 S269A probably benign Het
Ppp6r3 A T 19: 3,467,261 M662K probably damaging Het
Qser1 C A 2: 104,787,631 Q945H probably damaging Het
Rad52 A G 6: 119,918,633 E198G probably damaging Het
Ranbp17 A G 11: 33,266,147 V867A possibly damaging Het
Rdh16 G T 10: 127,813,496 A274S probably benign Het
Slco1a5 G T 6: 142,242,150 Q488K probably benign Het
Snai2 T C 16: 14,706,771 I47T probably benign Het
Snw1 T C 12: 87,453,915 D358G possibly damaging Het
Speg T C 1: 75,428,197 F2878L probably benign Het
Spert T A 14: 75,592,645 D36V possibly damaging Het
Spg11 T C 2: 122,072,290 Y1386C probably damaging Het
Tgfb2 A C 1: 186,625,473 I435S probably damaging Het
Ttc9b G A 7: 27,655,985 D227N probably benign Het
Txndc2 T C 17: 65,638,453 E243G possibly damaging Het
Usp28 A G 9: 49,026,819 D563G probably damaging Het
Zfp316 A G 5: 143,254,426 F613L probably benign Het
Zfp870 A T 17: 32,883,006 C450S possibly damaging Het
Other mutations in Vmn1r77
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00965:Vmn1r77 APN 7 12041296 critical splice acceptor site probably null
IGL00990:Vmn1r77 APN 7 12041476 missense probably benign 0.05
IGL00990:Vmn1r77 APN 7 12041768 missense probably benign 0.00
IGL01360:Vmn1r77 APN 7 12041388 missense probably benign 0.06
IGL01714:Vmn1r77 APN 7 12041350 missense probably benign 0.03
IGL01829:Vmn1r77 APN 7 12041431 missense probably damaging 1.00
IGL02336:Vmn1r77 APN 7 12041296 critical splice acceptor site probably null
R0456:Vmn1r77 UTSW 7 12041738 nonsense probably null
R0622:Vmn1r77 UTSW 7 12041388 missense probably benign 0.06
R1244:Vmn1r77 UTSW 7 12041920 missense possibly damaging 0.59
R1696:Vmn1r77 UTSW 7 12041620 nonsense probably null
R1836:Vmn1r77 UTSW 7 12041411 missense probably benign 0.00
R1898:Vmn1r77 UTSW 7 12041623 missense probably damaging 1.00
R4533:Vmn1r77 UTSW 7 12041829 missense probably benign 0.02
R4668:Vmn1r77 UTSW 7 12041431 missense probably damaging 1.00
R5381:Vmn1r77 UTSW 7 12042025 missense probably damaging 1.00
R6290:Vmn1r77 UTSW 7 12041809 missense probably damaging 1.00
R6675:Vmn1r77 UTSW 7 12041455 missense probably damaging 1.00
R7032:Vmn1r77 UTSW 7 12042090 nonsense probably null
R7044:Vmn1r77 UTSW 7 12041834 missense probably benign 0.06
R7302:Vmn1r77 UTSW 7 12042056 missense possibly damaging 0.94
R7417:Vmn1r77 UTSW 7 12041684 missense probably damaging 1.00
R7436:Vmn1r77 UTSW 7 12041767 missense probably benign 0.01
Z1176:Vmn1r77 UTSW 7 12041581 missense
Z1176:Vmn1r77 UTSW 7 12041597 missense probably benign 0.36
Z1176:Vmn1r77 UTSW 7 12041747 missense
Z1176:Vmn1r77 UTSW 7 12041768 missense probably benign 0.00
Z1177:Vmn1r77 UTSW 7 12041597 missense probably benign 0.36
Z1177:Vmn1r77 UTSW 7 12041747 missense
Z1177:Vmn1r77 UTSW 7 12041768 missense probably benign 0.00
Posted On2013-10-07