Incidental Mutation 'R9777:Or14c39'
ID 733778
Institutional Source Beutler Lab
Gene Symbol Or14c39
Ensembl Gene ENSMUSG00000060688
Gene Name olfactory receptor family 14 subfamily C member 39
Synonyms Olfr292, MOR220-2, GA_x6K02T2NHDJ-9425121-9424195
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R9777 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 86337549-86344592 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 86343988 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 108 (V108A)
Ref Sequence ENSEMBL: ENSMUSP00000079060 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080165]
AlphaFold F8VQ84
Predicted Effect probably benign
Transcript: ENSMUST00000080165
AA Change: V108A

PolyPhen 2 Score 0.116 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000079060
Gene: ENSMUSG00000060688
AA Change: V108A

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 2.6e-48 PFAM
Pfam:7tm_1 39 288 2.7e-22 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgb A C 10: 10,283,214 (GRCm39) M164R possibly damaging Het
Alg10b T A 15: 90,111,656 (GRCm39) C167S probably benign Het
Ap2m1 C A 16: 20,358,113 (GRCm39) R44S probably damaging Het
Atrip T C 9: 108,902,964 (GRCm39) S37G probably benign Het
Bicra C T 7: 15,705,987 (GRCm39) V1485M probably benign Het
Brca2 C T 5: 150,480,579 (GRCm39) T2755I probably damaging Het
C1qtnf7 A T 5: 43,673,313 (GRCm39) probably benign Het
Ccdc7a C T 8: 129,618,860 (GRCm39) A895T possibly damaging Het
Cep290 T C 10: 100,354,529 (GRCm39) M871T probably benign Het
Col19a1 A G 1: 24,318,904 (GRCm39) V1062A unknown Het
Col24a1 T A 3: 145,021,103 (GRCm39) Y491* probably null Het
Cyp2c66 A T 19: 39,102,520 (GRCm39) I50F probably benign Het
Dbn1 C A 13: 55,625,639 (GRCm39) R261L probably benign Het
Dlat G A 9: 50,562,208 (GRCm39) A272V probably damaging Het
Dlgap3 A T 4: 127,130,127 (GRCm39) E967V possibly damaging Het
Dnhd1 A G 7: 105,369,456 (GRCm39) M4360V probably benign Het
Dock7 C T 4: 98,877,464 (GRCm39) R1058Q unknown Het
Dpp4 T A 2: 62,195,340 (GRCm39) I313F probably benign Het
Dus1l C T 11: 120,683,858 (GRCm39) V197I possibly damaging Het
Eef2k TATTCATTCATTCATTCATTCATTCATTCA TATTCATTCATTCATTCATTCATTCA 7: 120,499,453 (GRCm39) probably benign Het
Fat3 A G 9: 15,826,537 (GRCm39) S324P probably benign Het
Fkbp9 C T 6: 56,855,181 (GRCm39) H567Y possibly damaging Het
Galnt10 C A 11: 57,672,065 (GRCm39) P452T probably damaging Het
Glb1 A T 9: 114,246,084 (GRCm39) D45V probably damaging Het
Grm1 A T 10: 10,573,826 (GRCm39) V904E possibly damaging Het
Gsdma3 T G 11: 98,526,071 (GRCm39) V274G probably damaging Het
Gsn A G 2: 35,194,600 (GRCm39) E681G probably damaging Het
Hpdl A G 4: 116,678,062 (GRCm39) L133P probably damaging Het
Ighv1-75 A G 12: 115,797,655 (GRCm39) L89P probably damaging Het
Igsf21 T A 4: 139,755,407 (GRCm39) Q416L probably damaging Het
Il23a G C 10: 128,132,829 (GRCm39) R143G probably benign Het
Ildr1 A G 16: 36,528,659 (GRCm39) T35A probably benign Het
Ints13 G T 6: 146,463,326 (GRCm39) H235Q probably damaging Het
Lama4 C T 10: 38,924,101 (GRCm39) T503I probably benign Het
Mapk13 T A 17: 28,997,075 (GRCm39) L289Q probably damaging Het
Med13l T C 5: 118,887,024 (GRCm39) S1642P probably benign Het
Megf6 T A 4: 154,343,617 (GRCm39) S713R probably damaging Het
Mical3 A G 6: 120,959,529 (GRCm39) V922A possibly damaging Het
Mug1 C T 6: 121,857,864 (GRCm39) T1119M probably damaging Het
Myo18a T A 11: 77,733,080 (GRCm39) M1370K possibly damaging Het
Ndufa12 A G 10: 94,056,692 (GRCm39) E140G probably damaging Het
Nek4 T A 14: 30,706,401 (GRCm39) D696E probably benign Het
Oas1f A G 5: 120,994,429 (GRCm39) T317A probably benign Het
Or2r11 A G 6: 42,437,029 (GRCm39) I308T probably benign Het
Or6c210 T C 10: 129,495,705 (GRCm39) I10T probably benign Het
Pcdh17 C T 14: 84,683,683 (GRCm39) P50L probably benign Het
Pgs1 A G 11: 117,894,256 (GRCm39) E261G probably benign Het
Pira12 T G 7: 3,897,612 (GRCm39) R494S probably damaging Het
Ppp1r1a T C 15: 103,439,857 (GRCm39) E145G possibly damaging Het
Ppp1r37 T C 7: 19,295,783 (GRCm39) E58G probably benign Het
Ptprc A T 1: 138,047,901 (GRCm39) V77E Het
Rhag A G 17: 41,139,416 (GRCm39) E117G probably benign Het
Sh3d19 C T 3: 86,028,483 (GRCm39) S653L probably benign Het
Sirpd C A 3: 15,385,813 (GRCm39) E30* probably null Het
Slc35a5 C T 16: 44,972,939 (GRCm39) probably null Het
Smc4 C T 3: 68,929,655 (GRCm39) R510* probably null Het
Sorcs1 A G 19: 50,248,190 (GRCm39) probably null Het
Sp140 A G 1: 85,569,461 (GRCm39) N357S probably damaging Het
Spic T A 10: 88,514,421 (GRCm39) T60S possibly damaging Het
Steap1 C A 5: 5,786,517 (GRCm39) A307S probably benign Het
Stk3 A T 15: 35,114,791 (GRCm39) S40R probably damaging Het
Taar1 T C 10: 23,796,676 (GRCm39) C125R probably damaging Het
Tep1 T A 14: 51,076,443 (GRCm39) K1664* probably null Het
Tmem198b C A 10: 128,638,273 (GRCm39) V97L possibly damaging Het
Xirp2 C A 2: 67,347,379 (GRCm39) P3207T possibly damaging Het
Zbtb38 C G 9: 96,570,355 (GRCm39) S243T possibly damaging Het
Zbtb38 T A 9: 96,570,356 (GRCm39) S243C probably damaging Het
Zfp692 C T 11: 58,199,638 (GRCm39) R76W probably benign Het
Zwilch A T 9: 64,054,170 (GRCm39) L509H probably damaging Het
Other mutations in Or14c39
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01575:Or14c39 APN 7 86,344,501 (GRCm39) missense probably benign 0.10
IGL01751:Or14c39 APN 7 86,343,997 (GRCm39) missense probably benign
IGL02417:Or14c39 APN 7 86,344,027 (GRCm39) missense probably damaging 1.00
IGL02534:Or14c39 APN 7 86,343,939 (GRCm39) missense probably benign 0.17
IGL02830:Or14c39 APN 7 86,344,382 (GRCm39) missense probably damaging 1.00
R0281:Or14c39 UTSW 7 86,344,068 (GRCm39) missense probably benign 0.00
R0423:Or14c39 UTSW 7 86,344,434 (GRCm39) missense possibly damaging 0.95
R0555:Or14c39 UTSW 7 86,344,516 (GRCm39) missense probably damaging 1.00
R0609:Or14c39 UTSW 7 86,344,084 (GRCm39) missense possibly damaging 0.85
R0662:Or14c39 UTSW 7 86,343,838 (GRCm39) missense possibly damaging 0.88
R1710:Or14c39 UTSW 7 86,344,318 (GRCm39) missense probably benign 0.00
R2144:Or14c39 UTSW 7 86,344,488 (GRCm39) missense probably damaging 0.98
R4400:Or14c39 UTSW 7 86,343,798 (GRCm39) missense probably benign 0.10
R4615:Or14c39 UTSW 7 86,343,936 (GRCm39) missense probably damaging 1.00
R4762:Or14c39 UTSW 7 86,344,329 (GRCm39) missense probably benign 0.01
R4785:Or14c39 UTSW 7 86,343,736 (GRCm39) missense probably damaging 1.00
R4823:Or14c39 UTSW 7 86,343,796 (GRCm39) missense probably damaging 0.99
R4908:Or14c39 UTSW 7 86,344,395 (GRCm39) missense probably benign 0.00
R4983:Or14c39 UTSW 7 86,343,687 (GRCm39) missense probably benign 0.01
R5010:Or14c39 UTSW 7 86,343,793 (GRCm39) missense possibly damaging 0.95
R5024:Or14c39 UTSW 7 86,344,089 (GRCm39) missense probably benign 0.05
R5157:Or14c39 UTSW 7 86,344,440 (GRCm39) missense probably benign 0.19
R5627:Or14c39 UTSW 7 86,344,347 (GRCm39) missense possibly damaging 0.93
R6327:Or14c39 UTSW 7 86,343,760 (GRCm39) missense probably benign 0.09
R6375:Or14c39 UTSW 7 86,344,267 (GRCm39) missense probably benign 0.01
R6775:Or14c39 UTSW 7 86,344,357 (GRCm39) missense probably benign 0.02
R7257:Or14c39 UTSW 7 86,344,012 (GRCm39) missense probably damaging 0.99
R7383:Or14c39 UTSW 7 86,343,960 (GRCm39) missense probably damaging 0.97
R8475:Or14c39 UTSW 7 86,344,361 (GRCm39) missense probably benign 0.21
R9034:Or14c39 UTSW 7 86,343,969 (GRCm39) missense probably benign 0.41
R9134:Or14c39 UTSW 7 86,344,588 (GRCm39) nonsense probably null
R9588:Or14c39 UTSW 7 86,343,948 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGTTGACCAGACCCTGAAC -3'
(R):5'- CTCAGCAAAGAGGGGATATCAC -3'

Sequencing Primer
(F):5'- GAACACACCCATGTACTTCTTCC -3'
(R):5'- CTGAGGGACTATATTAGAGTGACAG -3'
Posted On 2022-11-14