Incidental Mutation 'R9778:Snx29'
ID 733868
Institutional Source Beutler Lab
Gene Symbol Snx29
Ensembl Gene ENSMUSG00000071669
Gene Name sorting nexin 29
Synonyms Rundc2a, Gm11170, LOC385605, LOC381035, 4933437K13Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9778 (G1)
Quality Score 225.009
Status Not validated
Chromosome 16
Chromosomal Location 11140772-11573336 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 11223609 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 18 (E18G)
Ref Sequence ENSEMBL: ENSMUSP00000093993 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096273] [ENSMUST00000115814] [ENSMUST00000122168] [ENSMUST00000180792]
AlphaFold Q9D3S3
Predicted Effect possibly damaging
Transcript: ENSMUST00000096273
AA Change: E18G

PolyPhen 2 Score 0.900 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000093993
Gene: ENSMUSG00000071669
AA Change: E18G

DomainStartEndE-ValueType
low complexity region 103 120 N/A INTRINSIC
coiled coil region 125 206 N/A INTRINSIC
PX 319 422 3.13e-9 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115814
SMART Domains Protein: ENSMUSP00000111481
Gene: ENSMUSG00000071669

DomainStartEndE-ValueType
low complexity region 64 74 N/A INTRINSIC
RUN 115 178 7.89e-26 SMART
internal_repeat_1 192 211 2.98e-5 PROSPERO
internal_repeat_1 203 222 2.98e-5 PROSPERO
low complexity region 252 262 N/A INTRINSIC
low complexity region 270 275 N/A INTRINSIC
low complexity region 314 323 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000122168
SMART Domains Protein: ENSMUSP00000113595
Gene: ENSMUSG00000071669

DomainStartEndE-ValueType
low complexity region 88 105 N/A INTRINSIC
coiled coil region 110 191 N/A INTRINSIC
Blast:PX 301 326 1e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000180792
SMART Domains Protein: ENSMUSP00000138025
Gene: ENSMUSG00000071669

DomainStartEndE-ValueType
low complexity region 64 74 N/A INTRINSIC
RUN 115 178 7.89e-26 SMART
internal_repeat_1 192 211 2.63e-5 PROSPERO
internal_repeat_1 203 222 2.63e-5 PROSPERO
low complexity region 252 262 N/A INTRINSIC
low complexity region 270 275 N/A INTRINSIC
low complexity region 314 323 N/A INTRINSIC
low complexity region 445 462 N/A INTRINSIC
coiled coil region 467 548 N/A INTRINSIC
PX 661 764 3.13e-9 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.5%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022B05Rik A T 8: 125,366,098 (GRCm39) I215N probably damaging Het
Aig1 T C 10: 13,528,757 (GRCm39) probably null Het
Atp8b2 T A 3: 89,861,865 (GRCm39) K82N possibly damaging Het
Cacnb4 T G 2: 52,359,615 (GRCm39) Y131S probably damaging Het
Cep170b G A 12: 112,697,864 (GRCm39) S62N possibly damaging Het
Crmp1 A G 5: 37,422,619 (GRCm39) D142G probably benign Het
Csf1r A G 18: 61,260,957 (GRCm39) Q716R possibly damaging Het
Cyp2u1 T C 3: 131,087,133 (GRCm39) T483A possibly damaging Het
D930020B18Rik T C 10: 121,503,565 (GRCm39) F247L probably benign Het
Dcaf13 T C 15: 39,008,586 (GRCm39) L396P probably damaging Het
Dnhd1 A G 7: 105,353,240 (GRCm39) M2798V probably benign Het
E030018B13Rik A T 7: 63,569,125 (GRCm39) T58S unknown Het
Eipr1 T C 12: 28,897,657 (GRCm39) probably null Het
Elf1 C T 14: 79,817,948 (GRCm39) T526M possibly damaging Het
Gm8369 GTGTGTGTGTGTGTGTGTGTG GTGTGTGTGTGTGTGTGTGTGTG 19: 11,489,128 (GRCm39) probably null Het
Got1 A G 19: 43,504,284 (GRCm39) S46P probably benign Het
Inpp4b T C 8: 82,775,160 (GRCm39) I786T probably benign Het
Kdm1a T C 4: 136,279,892 (GRCm39) I703M probably damaging Het
Krt222 A T 11: 99,125,838 (GRCm39) S264R probably benign Het
Lrrd1 A C 5: 3,899,982 (GRCm39) S96R possibly damaging Het
Ltb C A 17: 35,414,906 (GRCm39) Y235* probably null Het
Mbd2 T A 18: 70,751,050 (GRCm39) C362S probably damaging Het
Mlycd T A 8: 120,129,325 (GRCm39) I264N probably damaging Het
Mri1 C T 8: 84,980,933 (GRCm39) C199Y possibly damaging Het
Muc5ac A T 7: 141,349,021 (GRCm39) K487* probably null Het
Myh13 T C 11: 67,249,016 (GRCm39) I1274T probably damaging Het
Ncdn G A 4: 126,642,467 (GRCm39) R397W probably damaging Het
Ncf1 T A 5: 134,258,444 (GRCm39) probably benign Het
Nipbl C A 15: 8,321,032 (GRCm39) A2692S probably benign Het
Odf2l C T 3: 144,854,789 (GRCm39) T542I possibly damaging Het
Or10a49 A G 7: 108,467,698 (GRCm39) I221T probably damaging Het
Or10al2 T A 17: 37,983,145 (GRCm39) I77N probably damaging Het
Oxsm T C 14: 16,242,629 (GRCm38) T47A possibly damaging Het
Pcdhga3 A T 18: 37,807,786 (GRCm39) S80C probably benign Het
Pcnx2 T C 8: 126,512,176 (GRCm39) T1377A probably benign Het
Phactr3 C A 2: 177,924,805 (GRCm39) Q252K possibly damaging Het
Phf2 T C 13: 48,973,101 (GRCm39) H385R unknown Het
Pkd1l3 A T 8: 110,357,937 (GRCm39) T820S probably benign Het
Plekhg1 T A 10: 3,887,966 (GRCm39) H353Q Het
Prss37 T A 6: 40,494,713 (GRCm39) E24V probably damaging Het
Reln A G 5: 22,155,943 (GRCm39) F2183S probably damaging Het
Slc20a2 A G 8: 23,051,407 (GRCm39) D480G probably damaging Het
Slc8a2 C T 7: 15,887,124 (GRCm39) T672M probably damaging Het
Slf2 A G 19: 44,961,666 (GRCm39) T1062A probably benign Het
Spata31e1 C T 13: 49,939,542 (GRCm39) V723M possibly damaging Het
Srf C A 17: 46,860,079 (GRCm39) G482V possibly damaging Het
Styk1 G A 6: 131,287,992 (GRCm39) Q124* probably null Het
Tcf7l1 G T 6: 72,608,226 (GRCm39) A385E probably damaging Het
Thbs4 A G 13: 92,913,495 (GRCm39) S142P probably benign Het
Tlr1 G A 5: 65,083,371 (GRCm39) S402F probably damaging Het
Tnrc6a A G 7: 122,769,635 (GRCm39) H475R probably benign Het
Trmt10b A T 4: 45,314,374 (GRCm39) N272I probably damaging Het
Ubxn7 A T 16: 32,200,471 (GRCm39) N409I probably benign Het
Vcan T C 13: 89,837,930 (GRCm39) E2538G probably damaging Het
Vmn1r65 C T 7: 6,011,387 (GRCm39) W282* probably null Het
Vmn2r4 A G 3: 64,322,497 (GRCm39) I74T probably benign Het
Wdr97 T A 15: 76,241,125 (GRCm39) F574I Het
Zfp949 T C 9: 88,449,340 (GRCm39) probably null Het
Other mutations in Snx29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00733:Snx29 APN 16 11,221,366 (GRCm39) missense probably damaging 0.97
IGL02207:Snx29 APN 16 11,556,216 (GRCm39) missense probably damaging 1.00
PIT1430001:Snx29 UTSW 16 11,221,488 (GRCm39) missense probably benign 0.00
PIT4810001:Snx29 UTSW 16 11,218,845 (GRCm39) missense probably damaging 1.00
R0240:Snx29 UTSW 16 11,478,417 (GRCm39) missense probably damaging 1.00
R0240:Snx29 UTSW 16 11,478,417 (GRCm39) missense probably damaging 1.00
R0276:Snx29 UTSW 16 11,556,237 (GRCm39) missense probably benign 0.01
R0506:Snx29 UTSW 16 11,213,167 (GRCm39) missense probably benign 0.15
R0621:Snx29 UTSW 16 11,223,651 (GRCm39) splice site probably null
R0975:Snx29 UTSW 16 11,165,735 (GRCm39) missense possibly damaging 0.66
R1225:Snx29 UTSW 16 11,238,550 (GRCm39) intron probably benign
R1406:Snx29 UTSW 16 11,217,657 (GRCm39) missense probably benign 0.38
R1406:Snx29 UTSW 16 11,217,657 (GRCm39) missense probably benign 0.38
R1452:Snx29 UTSW 16 11,449,335 (GRCm39) missense probably damaging 1.00
R1515:Snx29 UTSW 16 11,217,701 (GRCm39) critical splice donor site probably null
R1874:Snx29 UTSW 16 11,185,545 (GRCm39) missense probably benign 0.01
R1953:Snx29 UTSW 16 11,217,647 (GRCm39) nonsense probably null
R1978:Snx29 UTSW 16 11,185,588 (GRCm39) missense probably benign 0.23
R2054:Snx29 UTSW 16 11,449,356 (GRCm39) missense probably damaging 1.00
R2105:Snx29 UTSW 16 11,328,898 (GRCm39) missense possibly damaging 0.72
R2128:Snx29 UTSW 16 11,218,835 (GRCm39) missense probably damaging 0.98
R2152:Snx29 UTSW 16 11,218,707 (GRCm39) missense possibly damaging 0.95
R2912:Snx29 UTSW 16 11,265,317 (GRCm39) missense probably damaging 0.99
R2913:Snx29 UTSW 16 11,265,317 (GRCm39) missense probably damaging 0.99
R2914:Snx29 UTSW 16 11,265,317 (GRCm39) missense probably damaging 0.99
R4468:Snx29 UTSW 16 11,238,565 (GRCm39) splice site probably null
R4469:Snx29 UTSW 16 11,238,565 (GRCm39) splice site probably null
R4612:Snx29 UTSW 16 11,265,359 (GRCm39) missense probably damaging 0.99
R4744:Snx29 UTSW 16 11,167,773 (GRCm39) nonsense probably null
R4798:Snx29 UTSW 16 11,238,600 (GRCm39) missense probably damaging 1.00
R5000:Snx29 UTSW 16 11,221,371 (GRCm39) missense probably damaging 0.99
R5165:Snx29 UTSW 16 11,238,639 (GRCm39) missense probably damaging 0.98
R5207:Snx29 UTSW 16 11,556,227 (GRCm39) missense probably damaging 1.00
R5235:Snx29 UTSW 16 11,231,110 (GRCm39) missense possibly damaging 0.94
R5274:Snx29 UTSW 16 11,556,268 (GRCm39) missense probably damaging 1.00
R5277:Snx29 UTSW 16 11,217,688 (GRCm39) missense possibly damaging 0.82
R5462:Snx29 UTSW 16 11,328,876 (GRCm39) missense possibly damaging 0.89
R5655:Snx29 UTSW 16 11,573,185 (GRCm39) missense probably damaging 1.00
R6036:Snx29 UTSW 16 11,556,301 (GRCm39) splice site probably null
R6036:Snx29 UTSW 16 11,556,301 (GRCm39) splice site probably null
R6326:Snx29 UTSW 16 11,221,430 (GRCm39) missense probably benign
R6576:Snx29 UTSW 16 11,532,920 (GRCm39) critical splice donor site probably null
R7406:Snx29 UTSW 16 11,573,180 (GRCm39) missense probably damaging 1.00
R7552:Snx29 UTSW 16 11,238,649 (GRCm39) critical splice donor site probably null
R7555:Snx29 UTSW 16 11,218,806 (GRCm39) missense probably benign 0.02
R7736:Snx29 UTSW 16 11,185,588 (GRCm39) missense probably benign 0.23
R7962:Snx29 UTSW 16 11,231,221 (GRCm39) critical splice donor site probably null
R8101:Snx29 UTSW 16 11,389,580 (GRCm39) missense probably benign 0.16
R8415:Snx29 UTSW 16 11,265,291 (GRCm39) missense probably damaging 1.00
R8549:Snx29 UTSW 16 11,532,920 (GRCm39) critical splice donor site probably null
R9010:Snx29 UTSW 16 11,449,391 (GRCm39) missense probably benign 0.00
R9091:Snx29 UTSW 16 11,213,155 (GRCm39) missense probably benign 0.33
R9099:Snx29 UTSW 16 11,478,435 (GRCm39) missense probably damaging 1.00
R9176:Snx29 UTSW 16 11,236,728 (GRCm39) missense probably benign
R9258:Snx29 UTSW 16 11,532,799 (GRCm39) missense possibly damaging 0.78
R9270:Snx29 UTSW 16 11,213,155 (GRCm39) missense probably benign 0.33
R9672:Snx29 UTSW 16 11,478,515 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTGTGAGTCAATGCCTGAGC -3'
(R):5'- ATACTGGATAAAGCGGGATCC -3'

Sequencing Primer
(F):5'- AGTCAATGCCTGAGCCCCAG -3'
(R):5'- GGGATCCGGCACCAAAG -3'
Posted On 2022-11-14