Incidental Mutation 'R9778:Olfr118'
ID 733871
Institutional Source Beutler Lab
Gene Symbol Olfr118
Ensembl Gene ENSMUSG00000080990
Gene Name olfactory receptor 118
Synonyms MOR263-13, GA_x6K02T2PSCP-2131124-2132089
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R9778 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 37666988-37673476 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 37672254 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 77 (I77N)
Ref Sequence ENSEMBL: ENSMUSP00000150176 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122036] [ENSMUST00000215811] [ENSMUST00000216551]
AlphaFold Q7TRJ6
Predicted Effect probably damaging
Transcript: ENSMUST00000122036
AA Change: I77N

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000113988
Gene: ENSMUSG00000080990
AA Change: I77N

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 32 173 2e-6 PFAM
Pfam:7tm_4 37 314 2.1e-57 PFAM
Pfam:7TM_GPCR_Srsx 41 311 5.8e-6 PFAM
Pfam:7tm_1 47 296 1.4e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215811
AA Change: I77N

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000216551
AA Change: I77N

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.4%
  • 20x: 98.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310022B05Rik A T 8: 124,639,359 I215N probably damaging Het
Aig1 T C 10: 13,653,013 probably null Het
Atp8b2 T A 3: 89,954,558 K82N possibly damaging Het
Cacnb4 T G 2: 52,469,603 Y131S probably damaging Het
Cep170b G A 12: 112,731,430 S62N possibly damaging Het
Crmp1 A G 5: 37,265,275 D142G probably benign Het
Csf1r A G 18: 61,127,885 Q716R possibly damaging Het
Cyp2u1 T C 3: 131,293,484 T483A possibly damaging Het
D930020B18Rik T C 10: 121,667,660 F247L probably benign Het
Dcaf13 T C 15: 39,145,191 L396P probably damaging Het
Dnhd1 A G 7: 105,704,033 M2798V probably benign Het
E030018B13Rik A T 7: 63,919,377 T58S unknown Het
Eipr1 T C 12: 28,847,658 probably null Het
Elf1 C T 14: 79,580,508 T526M possibly damaging Het
Gm30302 C T 13: 49,786,066 V723M possibly damaging Het
Gm35339 T A 15: 76,356,925 F574I Het
Gm8369 GTGTGTGTGTGTGTGTGTGTG GTGTGTGTGTGTGTGTGTGTGTG 19: 11,511,764 probably null Het
Got1 A G 19: 43,515,845 S46P probably benign Het
Inpp4b T C 8: 82,048,531 I786T probably benign Het
Kdm1a T C 4: 136,552,581 I703M probably damaging Het
Krt222 A T 11: 99,235,012 S264R probably benign Het
Lrrd1 A C 5: 3,849,982 S96R possibly damaging Het
Ltb C A 17: 35,195,930 Y235* probably null Het
Mbd2 T A 18: 70,617,979 C362S probably damaging Het
Mlycd T A 8: 119,402,586 I264N probably damaging Het
Mri1 C T 8: 84,254,304 C199Y possibly damaging Het
Muc5ac A T 7: 141,795,284 K487* probably null Het
Myh13 T C 11: 67,358,190 I1274T probably damaging Het
Ncdn G A 4: 126,748,674 R397W probably damaging Het
Ncf1 T A 5: 134,229,590 probably benign Het
Nipbl C A 15: 8,291,548 A2692S probably benign Het
Odf2l C T 3: 145,149,028 T542I possibly damaging Het
Olfr517 A G 7: 108,868,491 I221T probably damaging Het
Oxsm T C 14: 16,242,629 T47A possibly damaging Het
Pcdhga3 A T 18: 37,674,733 S80C probably benign Het
Pcnx2 T C 8: 125,785,437 T1377A probably benign Het
Phactr3 C A 2: 178,283,012 Q252K possibly damaging Het
Phf2 T C 13: 48,819,625 H385R unknown Het
Pkd1l3 A T 8: 109,631,305 T820S probably benign Het
Plekhg1 T A 10: 3,937,966 H353Q Het
Prss37 T A 6: 40,517,779 E24V probably damaging Het
Reln A G 5: 21,950,945 F2183S probably damaging Het
Slc20a2 A G 8: 22,561,391 D480G probably damaging Het
Slc8a2 C T 7: 16,153,199 T672M probably damaging Het
Slf2 A G 19: 44,973,227 T1062A probably benign Het
Snx29 A G 16: 11,405,745 E18G possibly damaging Het
Srf C A 17: 46,549,153 G482V possibly damaging Het
Styk1 G A 6: 131,311,029 Q124* probably null Het
Tcf7l1 G T 6: 72,631,243 A385E probably damaging Het
Thbs4 A G 13: 92,776,987 S142P probably benign Het
Tlr1 G A 5: 64,926,028 S402F probably damaging Het
Tnrc6a A G 7: 123,170,412 H475R probably benign Het
Trmt10b A T 4: 45,314,374 N272I probably damaging Het
Ubxn7 A T 16: 32,381,653 N409I probably benign Het
Vcan T C 13: 89,689,811 E2538G probably damaging Het
Vmn1r65 C T 7: 6,008,388 W282* probably null Het
Vmn2r4 A G 3: 64,415,076 I74T probably benign Het
Zfp949 T C 9: 88,567,287 probably null Het
Other mutations in Olfr118
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01300:Olfr118 APN 17 37672887 missense probably damaging 1.00
IGL02456:Olfr118 APN 17 37672449 missense possibly damaging 0.90
IGL02750:Olfr118 APN 17 37672609 nonsense probably null
IGL03083:Olfr118 APN 17 37672660 nonsense probably null
IGL03339:Olfr118 APN 17 37672557 missense possibly damaging 0.87
R0032:Olfr118 UTSW 17 37672487 missense probably damaging 1.00
R1457:Olfr118 UTSW 17 37672925 nonsense probably null
R1542:Olfr118 UTSW 17 37672251 missense probably damaging 1.00
R1771:Olfr118 UTSW 17 37672663 missense probably damaging 1.00
R1893:Olfr118 UTSW 17 37672856 nonsense probably null
R2395:Olfr118 UTSW 17 37672696 nonsense probably null
R3619:Olfr118 UTSW 17 37672640 missense probably benign 0.05
R3917:Olfr118 UTSW 17 37672793 missense probably damaging 1.00
R3937:Olfr118 UTSW 17 37672967 missense probably benign 0.01
R5600:Olfr118 UTSW 17 37672285 missense possibly damaging 0.91
R6415:Olfr118 UTSW 17 37672557 missense possibly damaging 0.87
R6462:Olfr118 UTSW 17 37672220 missense probably damaging 1.00
R7355:Olfr118 UTSW 17 37672410 missense probably benign 0.02
R7861:Olfr118 UTSW 17 37672517 missense possibly damaging 0.91
R7913:Olfr118 UTSW 17 37672108 missense probably benign
R7952:Olfr118 UTSW 17 37672817 missense probably damaging 1.00
R7969:Olfr118 UTSW 17 37672656 missense probably damaging 1.00
R8879:Olfr118 UTSW 17 37672411 nonsense probably null
R8923:Olfr118 UTSW 17 37672811 missense probably benign 0.00
R9253:Olfr118 UTSW 17 37672746 missense probably benign 0.00
R9789:Olfr118 UTSW 17 37672168 missense probably damaging 1.00
RF003:Olfr118 UTSW 17 37672858 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAGTGTCAACTGCTCTCTGTG -3'
(R):5'- GGGAGCATATGGCCATGTAG -3'

Sequencing Primer
(F):5'- TGCTCTCTGTGGCAGGAGAAC -3'
(R):5'- AGCATATGGCCATGTAGCGGTC -3'
Posted On 2022-11-14