Incidental Mutation 'R9782:Slc22a28'
ID 734144
Institutional Source Beutler Lab
Gene Symbol Slc22a28
Ensembl Gene ENSMUSG00000063590
Gene Name solute carrier family 22, member 28
Synonyms Gm5631
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.299) question?
Stock # R9782 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 8039574-8109346 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 8041813 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 465 (R465G)
Ref Sequence ENSEMBL: ENSMUSP00000067114 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065651]
AlphaFold B2RT89
Predicted Effect probably null
Transcript: ENSMUST00000065651
AA Change: R465G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000067114
Gene: ENSMUSG00000063590
AA Change: R465G

DomainStartEndE-ValueType
transmembrane domain 13 35 N/A INTRINSIC
Pfam:Sugar_tr 99 527 1.4e-26 PFAM
Pfam:MFS_1 140 375 1.1e-15 PFAM
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.8%
  • 10x: 99.3%
  • 20x: 98.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610040J01Rik T A 5: 64,053,796 (GRCm39) M1K probably null Het
Atoh8 A T 6: 72,200,848 (GRCm39) L281M possibly damaging Het
Bckdha A G 7: 25,340,880 (GRCm39) probably null Het
Chil6 A T 3: 106,296,121 (GRCm39) Y371* probably null Het
Cilk1 A T 9: 78,048,520 (GRCm39) Q108L probably damaging Het
Fbxw18 G T 9: 109,522,376 (GRCm39) H164Q probably benign Het
Gucd1 T G 10: 75,345,650 (GRCm39) D135A probably benign Het
Hacd1 A G 2: 14,040,751 (GRCm39) I168T possibly damaging Het
Hfm1 T C 5: 107,021,896 (GRCm39) E1013G probably benign Het
Hsf4 G A 8: 105,999,217 (GRCm39) probably null Het
Ift140 G T 17: 25,264,151 (GRCm39) probably null Het
Igsf3 A T 3: 101,338,612 (GRCm39) I309F probably benign Het
Imp4 T A 1: 34,482,901 (GRCm39) L164Q probably damaging Het
Jazf1 C T 6: 52,747,311 (GRCm39) V204I probably benign Het
Kmt2d T A 15: 98,764,597 (GRCm39) D2V probably damaging Het
Knl1 T C 2: 118,899,910 (GRCm39) V537A probably benign Het
Mep1b A T 18: 21,208,720 (GRCm39) D32V possibly damaging Het
Mki67 A G 7: 135,306,066 (GRCm39) probably null Het
Morn3 C T 5: 123,175,822 (GRCm39) V189M probably damaging Het
Mri1 C T 8: 84,980,933 (GRCm39) C199Y possibly damaging Het
Mtmr2 T C 9: 13,713,293 (GRCm39) M490T probably benign Het
Muc16 T C 9: 18,548,066 (GRCm39) T6076A possibly damaging Het
Myo1c A G 11: 75,549,273 (GRCm39) E113G probably damaging Het
Nat8f4 A T 6: 85,878,052 (GRCm39) V157D probably damaging Het
Nectin4 T C 1: 171,214,192 (GRCm39) V449A probably damaging Het
Ogdhl C T 14: 32,061,909 (GRCm39) T528M probably damaging Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,237,059 (GRCm39) probably benign Het
Or4c100 G A 2: 88,356,835 (GRCm39) V303M probably benign Het
Or52l1 A G 7: 104,830,067 (GRCm39) V166A probably damaging Het
Pcdhb12 AT A 18: 37,570,393 (GRCm39) probably null Het
Pigo T C 4: 43,023,475 (GRCm39) D233G probably damaging Het
Pkn2 A C 3: 142,516,237 (GRCm39) V562G possibly damaging Het
Plxna1 C A 6: 89,333,817 (GRCm39) A271S probably benign Het
Ppp1r3a C T 6: 14,718,766 (GRCm39) S716N probably damaging Het
Prss12 G A 3: 123,271,762 (GRCm39) G256S probably benign Het
Psg28 A T 7: 18,164,331 (GRCm39) M127K probably benign Het
Psmf1 T C 2: 151,577,533 (GRCm39) D48G possibly damaging Het
Rabggta T A 14: 55,955,944 (GRCm39) M438L possibly damaging Het
Rapgef3 T C 15: 97,643,479 (GRCm39) I911V probably damaging Het
Rbck1 T C 2: 152,165,113 (GRCm39) E297G probably damaging Het
Rras A T 7: 44,669,945 (GRCm39) I126F probably damaging Het
Slc28a2b T A 2: 122,352,338 (GRCm39) I365N probably damaging Het
Snx19 A G 9: 30,340,172 (GRCm39) T437A probably benign Het
Son A T 16: 91,444,838 (GRCm39) S15C probably damaging Het
Spata31e1 C T 13: 49,939,542 (GRCm39) V723M possibly damaging Het
Sptbn4 G T 7: 27,107,993 (GRCm39) Q810K probably benign Het
Tmtc2 T C 10: 105,026,062 (GRCm39) Y802C probably damaging Het
Trrap T A 5: 144,758,716 (GRCm39) M2181K probably damaging Het
Ttc23l A G 15: 10,530,767 (GRCm39) S282P probably damaging Het
Zbtb7a G A 10: 80,979,910 (GRCm39) D35N probably damaging Het
Zc3h3 C A 15: 75,681,489 (GRCm39) V531L probably damaging Het
Zfhx4 A G 3: 5,466,514 (GRCm39) D2249G probably benign Het
Zfp87 T C 13: 74,520,932 (GRCm39) K49E probably benign Het
Zfp942 T C 17: 22,147,463 (GRCm39) T389A probably benign Het
Other mutations in Slc22a28
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Slc22a28 APN 19 8,107,567 (GRCm39) missense possibly damaging 0.89
IGL00515:Slc22a28 APN 19 8,094,428 (GRCm39) missense probably benign 0.34
IGL01025:Slc22a28 APN 19 8,094,272 (GRCm39) splice site probably benign
IGL02697:Slc22a28 APN 19 8,094,491 (GRCm39) missense probably benign 0.06
PIT4378001:Slc22a28 UTSW 19 8,049,279 (GRCm39) missense probably damaging 0.96
R0744:Slc22a28 UTSW 19 8,094,197 (GRCm39) missense possibly damaging 0.94
R0836:Slc22a28 UTSW 19 8,094,197 (GRCm39) missense possibly damaging 0.94
R1398:Slc22a28 UTSW 19 8,107,566 (GRCm39) nonsense probably null
R1456:Slc22a28 UTSW 19 8,049,223 (GRCm39) missense possibly damaging 0.50
R1603:Slc22a28 UTSW 19 8,040,674 (GRCm39) missense probably damaging 1.00
R1993:Slc22a28 UTSW 19 8,094,488 (GRCm39) missense possibly damaging 0.79
R2254:Slc22a28 UTSW 19 8,041,858 (GRCm39) missense probably benign
R2262:Slc22a28 UTSW 19 8,048,573 (GRCm39) missense probably benign 0.00
R4078:Slc22a28 UTSW 19 8,078,777 (GRCm39) missense probably benign 0.15
R4165:Slc22a28 UTSW 19 8,040,773 (GRCm39) missense possibly damaging 0.95
R4612:Slc22a28 UTSW 19 8,078,770 (GRCm39) missense probably damaging 1.00
R4947:Slc22a28 UTSW 19 8,108,816 (GRCm39) missense probably benign 0.03
R5573:Slc22a28 UTSW 19 8,048,462 (GRCm39) missense possibly damaging 0.50
R5611:Slc22a28 UTSW 19 8,040,698 (GRCm39) missense probably damaging 1.00
R5621:Slc22a28 UTSW 19 8,048,376 (GRCm39) missense probably benign 0.00
R5671:Slc22a28 UTSW 19 8,108,795 (GRCm39) missense probably damaging 1.00
R6063:Slc22a28 UTSW 19 8,094,386 (GRCm39) missense probably benign 0.01
R6358:Slc22a28 UTSW 19 8,049,253 (GRCm39) missense probably damaging 0.99
R6385:Slc22a28 UTSW 19 8,078,844 (GRCm39) missense probably damaging 0.99
R6680:Slc22a28 UTSW 19 8,078,757 (GRCm39) missense probably benign 0.07
R6767:Slc22a28 UTSW 19 8,094,409 (GRCm39) missense probably damaging 1.00
R6865:Slc22a28 UTSW 19 8,041,856 (GRCm39) nonsense probably null
R6947:Slc22a28 UTSW 19 8,041,875 (GRCm39) missense possibly damaging 0.58
R7049:Slc22a28 UTSW 19 8,049,270 (GRCm39) missense probably benign
R7269:Slc22a28 UTSW 19 8,094,491 (GRCm39) missense probably benign 0.06
R7484:Slc22a28 UTSW 19 8,048,492 (GRCm39) missense probably benign
R7823:Slc22a28 UTSW 19 8,041,890 (GRCm39) missense probably benign 0.38
R7856:Slc22a28 UTSW 19 8,040,698 (GRCm39) missense probably damaging 1.00
R7980:Slc22a28 UTSW 19 8,078,837 (GRCm39) missense probably damaging 0.99
R8323:Slc22a28 UTSW 19 8,108,788 (GRCm39) missense probably damaging 1.00
R8404:Slc22a28 UTSW 19 8,108,793 (GRCm39) nonsense probably null
R8435:Slc22a28 UTSW 19 8,048,565 (GRCm39) missense probably benign 0.13
R8529:Slc22a28 UTSW 19 8,040,778 (GRCm39) missense probably benign 0.01
R9149:Slc22a28 UTSW 19 8,049,205 (GRCm39) missense probably benign 0.00
R9727:Slc22a28 UTSW 19 8,108,818 (GRCm39) missense probably benign
Z1088:Slc22a28 UTSW 19 8,039,763 (GRCm39) missense probably damaging 0.96
Z1176:Slc22a28 UTSW 19 8,039,748 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TATGCCATGCCCATATAAAATTGCC -3'
(R):5'- CTTGCACACACCTCTGATGAG -3'

Sequencing Primer
(F):5'- ACAAATTTAGAGTGTGCTGTTGC -3'
(R):5'- CTTTGTTTTGGGAATTGAGAACTAC -3'
Posted On 2022-11-14